International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alzheimer disease and instead are at-risk. https://t.co/MLPCp4qQJB #CTAD24 https://t.co/GnfbyjJlF2
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Nov 2024 – Mar 2025Where it's discussed
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X / Twitter100 posts
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News29 articles
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Facebook8 posts
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Blogs6 articles
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AI synopsis
What people are saying
Many posts highlight the critical nature of the discussion around the definition of Alzheimer's disease, reflecting a shared understanding of the complexities involved. For instance, phrases like 'very important discussion' and 'the danger of a purely biomedical approach' emphasize the urgency and significance of these evolving definitions, while the reiteration of terms like 'clinical-biological approach' indicates a consensus on moving towards a more nuanced understanding of the disease.
The majority of discussions show strong support for redefining Alzheimer's disease based on the article's recommendations.
Posts indicate a high level of curiosity about the evolving definitions and implications of Alzheimer's diagnosis.
While some posts delve deeply into the implications of the definitions, others maintain a more surface-level engagement with the subject.
There is a widespread belief that the publication could significantly influence how Alzheimer's disease is understood and diagnosed in the medical community.
Abstract in brief
- * Concerns are raised about purely biological definitions being used in clinical settings, especially since many biomarker-positive but cognitively normal individuals may never develop symptoms, complicating diagnosis and patient understanding.
- * The authors advocate for a combined clinical-biological definition of AD that accommodates at-risk and presymptomatic stages, emphasizing the need for caution in diagnosing AD without fully understanding the implications for patients.
Top posts
Most liked on X and BlueskyInternational Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alzheimer disease and instead are at-risk. https://t.co/4E4sc0nLdv #CTAD24 https://t.co/IPwkRGs50b
Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomics) are pathological processes, not hallmarks of a unique disease. AD is a complex disease. Delighted to join this IWG in @JAMANeuro
International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alzheimer disease and instead are at-risk. https://t.co/wXX84R7oVz https://t.co/O6jnUrJU1p
【備忘】 JAMA Neurol誌に、バイオマーカーのみでアルツハイマー病と診断できるとしたアルツハイマー協会定義への疑義。著者は各国専門家からなる “International Working Group”。 https://t.co/oE96bpsotG 随伴論説 https://t.co/6gGZSsRNm6 https://t.co/b3l890TQgv
Professor of Neurosciences Howard Feldman, M.D., recently presented new criteria for establishing Alzheimer's diagnoses at the CTAD Conference on behalf of the International Working Group (IWG).
All mentions
Redefining Alzheimer's Disease: Clinical and Biological Insights
This video features an interview with Giovanni B. Frisoni, MD, discussing the shift towards defining Alzheimer’s disease through biological biomarkers. Concerns about the implications of purely biological definitions in…
Defining Alzheimer’s Disease: Clinical vs. Biological Perspectives
Can we define Alzheimer’s disease as a purely biological entity? Dr. Nicolas Villain discusses the importance of considering both clinical symptoms and biological findings in diagnosing Alzheimer’s disease to ensure a…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alzheimer disease and instead are at-risk. https://t.co/wXX84R7oVz https://t.co/O6jnUrJU1p
A vey important discussion as we move towards (relatively) easily accessible biomarker’s, simplifying the methods to identify biological signs of possible AD. Alzheimer Disease as a Clinical-Biological Construct https://t.co/fgM6e12k71
#Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation | Dementia and Cognitive Impairment. #neurology #dementia https://t.co/mGSfgGDFNa
RT @Archisaurus_YMB: Today's JAMA article, released to coincide with a presentation at CTAD 2024, bodes poorly for MABs yet, IMHO, very wel…
❗ Biomarkers ≠Alzheimer Disease Expert IWG in this paper provide a wonderful LEXICON for AD in this biomarker era. doi:10.1001/jamaneurol.2024.3770
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
Link to the study: https://t.co/Z5p41HJPgA
❗ Biomarkers ≠Alzheimer Disease. Expert IWG in this paper provide a wonderful LEXICON for AD in this biomarker era. doi:10.1001/jamaneurol.2024.3770
This is a critical debate: Should Alzheimer's disease (AD) be defined biologically & diagnosed solely through biomarkers? Or, as the authors of a intl working group argue, should biomarker positivity mean that cognitively intact individuals are *at risk* for AD? pubmed.ncbi.nlm.nih.gov/39483064/
Alzheimer Disease as a Clinical-Biological Construct https://t.co/fDOYPsEuz2
RT @Saludteca: Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation https://t.co/CKMf7lbrmD…
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation https://t.co/CKMf7lbrmD
RT @FarmaMadridAP: (JAMA Neurology) La enfermedad de Alzheimer como construcción clínico-biológica: recomendación de un grupo de trabajo in…
RT @LACCD9:
@ReDLat_Dementia members contribute to a groundbreaking study on Alzheimer’s, suggesting we move beyond biomarkers alone! Defining Alzheimer’s through a clinical-biological approach may lead to more personalized care https://t.co/20eixcyLB4 https://t.co/ouYXnYbSDE
RT @altuna_miren:
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network https://t.co/LyZGyav3i9
No hay Alzheimer sin sintomas. https://t.co/vzaxGgIBzf
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alzheimer disease and instead are at-risk. https://t.co/4E4sc0nLdv #CTAD24 https://t.co/IPwkRGs50b
Professor of Neurosciences Howard Feldman, M.D., recently presented new criteria for establishing Alzheimer's diagnoses at the CTAD Conference on behalf of the International Working Group (IWG).
Very interesting opinion piece on frameworks for Alzheimer’s detection. https://t.co/xu50C0a9zD
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
(JAMA Neurology) La enfermedad de Alzheimer como construcción clínico-biológica: recomendación de un grupo de trabajo internacional. https://t.co/moMqacdoMV ‼️ Biomarcadores de patología amiloide: determinación útil para establecer riesgo, pero no para diagnosticar.
DW. The danger of a purely biomedical approach to diagnosis is starkly illustrated in this article on diagnosing Alzheimer's disease purely on tau or amyloid markers. Another example where disease definition could lead to screening and significant harm. https://t.co/Bo9Ztx0HqH
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @wjdeardorff: "Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation" (JAMA Neuro 2024) - "…
RT @EWidera: An International Working Group Recommendation: #Alzheimer’s disease should be defined as a clinical-biological entity where d…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AgustinMIbanez: Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomi…
RT @AgustinMIbanez: Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomi…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @osmachope: Alzheimer Disease as a Clinical-Biological Construct https://t.co/FOVNRzwRcu
RT @AgustinMIbanez: Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomi…
RT @AgustinMIbanez: Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomi…
RT @AgustinMIbanez: Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomi…
Why any Alzheimer's definition needs a clinical-cognitive-biological approach. Biomarkers (ATN & others, i.e., proteomics) are pathological processes, not hallmarks of a unique disease. AD is a complex disease. Delighted to join this IWG in @JAMANeuro
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @gglinskii: VERY IMPORTANT Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation. https:/…
RT @gglinskii: Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation. https://t.co/5DcqU9EHJa
VERY IMPORTANT Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation. https://t.co/5DcqU9EHJa
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation. https://t.co/5DcqU9EHJa
【備忘】 JAMA Neurol誌に、バイオマーカーのみでアルツハイマー病と診断できるとしたアルツハイマー協会定義への疑義。著者は各国専門家からなる “International Working Group”。 https://t.co/oE96bpsotG 随伴論説 https://t.co/6gGZSsRNm6 https://t.co/b3l890TQgv
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: An International Working Group Recommendation: #Alzheimer’s disease should be defined as a clinical-biological entity where d…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: An International Working Group Recommendation: #Alzheimer’s disease should be defined as a clinical-biological entity where d…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
RT @JAMANeuro: International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alz…
International Working Group suggests biomarker positive cognitively normal individuals should not be diagnosed as having Alzheimer disease and instead are at-risk. https://t.co/MLPCp4qQJB #CTAD24 https://t.co/GnfbyjJlF2
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: An International Working Group Recommendation: #Alzheimer’s disease should be defined as a clinical-biological entity where d…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @AlbertoEspay: This is progress. Expert IWG #Alzheimers clinicians recommend against the disease-without-symptoms 'biologically defined'…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation | Dementia and Cognitive Impairment | JAMA Neurology | JAMA Network https://t.co/kFY1224YFb
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
RT @EWidera: Two competing definitions of #Alzheimer’s are being proposed. One sees anyone with amyloid in the brain as having the disease,…
Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation https://t.co/NPZHytZRaY