Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach.
Elahe Haghighi, Samira Sadat Abolmaali, Ali Dehshahri, Seyed Ali Mousavi Shaegh, Negar Azarpira, Ali Mohammad Tamaddon
November 2024 J NanobiotechnologySynopsis of Social media discussions
Discussions revolve around technical aspects like immune recognition pathways and nanoparticle engineering, with words like 'significant challenge,' 'advances in delivery,' and 'immune sensing' highlighting both interest and perceived impact. The tone suggests a recognition of the importance of overcoming biological hurdles to improve RNA therapeutics, with some examples referencing the targeting of immune responses to improve vaccine efficacy.
Agreement
Moderate agreementMost discussions recognize the significance of lipid nanoparticles and RNA delivery strategies, showing general support for the research.
Interest
High level of interestThe discussions highlight curiosity about advanced delivery methods and immune recognition, indicating high interest.
Engagement
Moderate level of engagementParticipants delve into details such as immune sensing mechanisms and engineering strategies, reflecting moderate engagement.
Impact
Moderate level of impactThe posts suggest these findings could influence future RNA therapies and vaccine development, demonstrating potential impact.
Social Mentions
YouTube
4 Videos
2 Posts
Metrics
Video Views
2,148
Total Likes
41
Extended Reach
16,491
Social Features
6
Timeline: Posts about article
Top Social Media Posts
Rick²
@JesperKitos @chrismartenson @andrew7rd @sduncanhealth @returns8143 @TerryTerroriser @delboy00789 @lavalmxhr @Panthon61Lee @HDBreakout17 @Mike6150817700 @ckellywpg @71832Afterparty @hammerlane46077 @GeezercitizenX @Geekonomicon @TakethatCt @TnAlistair @hauxton @TruthHurts02160 @Tanglewizard @human_frozen_ @saltbeefsandwch @shedLifeMatterz @spursonfifa @A_Shufflebotham @rotor_motor13b @Millska21 @mesonparticle @Burki677 @Unity_Coach @SeanCzambel @DaveAnotherdave @ShifftyAdam @Gandalf_Rules @Tdillon06 @cakealda @anon5standingby @LetsGeuxBrandon @MyracleTom @dill1_keith @Gameoptions1 @bepeco @trillionofcells @Ztx294 @EyeOfTheMagi @bruch_amy @Timothy86527378 @Barbara36205196 @Gigi69030829 https://t.co/w0pFRp2gGx
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Gaute Adler Nilsen
Immune recognition of mRNA vaccines
Synthetic mRNA is sensed by innate immune cells through three major categories:
(1) uridine-based RNA identification,
(2) dsRNA recognition, and
(3) sensing of mRNA’s uncapped 5′ terminus.
https://t.co/n1dOSqd5oS https://t.co/4voKfheFWS
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Posts referencing the article
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May 29, 2025
618 views
Designing Scientific Graphical Abstracts for RNA Delivery Research
This video covers the creation of scientific graphical abstracts, focusing on lipid nanoparticles used for targeted RNA therapeutics delivery, emphasizing quality-by-design strategies and image creation for scientific communication.
May 24, 2025
345 views
Effective Design of Lipid Nanoparticles for RNA Therapeutic Delivery
This video explores the complexities of designing lipid nanoparticles for targeted RNA delivery, highlighting strategies to overcome challenges such as degradation and cellular uptake, crucial for advancing RNA therapeutics like mRNA, siRNA, and CRISPR-Cas9.
May 26, 2025
111 views
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@JesperKitos @chrismartenson @andrew7rd @sduncanhealth @returns8143 @TerryTerroriser @delboy00789 @lavalmxhr @Panthon61Lee @HDBreakout17 @Mike6150817700 @ckellywpg @71832Afterparty @hammerlane46077 @GeezercitizenX @Geekonomicon @TakethatCt @TnAlistair @hauxton @TruthHurts02160 @Tanglewizard @human_frozen_ @saltbeefsandwch @shedLifeMatterz @spursonfifa @A_Shufflebotham @rotor_motor13b @Millska21 @mesonparticle @Burki677 @Unity_Coach @SeanCzambel @DaveAnotherdave @ShifftyAdam @Gandalf_Rules @Tdillon06 @cakealda @anon5standingby @LetsGeuxBrandon @MyracleTom @dill1_keith @Gameoptions1 @bepeco @trillionofcells @Ztx294 @EyeOfTheMagi @bruch_amy @Timothy86527378 @Barbara36205196 @Gigi69030829 https://t.co/w0pFRp2gGx
view full postAugust 10, 2025
3
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Gaute Adler Nilsen
@GauteNilsen (Twitter)Immune recognition of mRNA vaccines Synthetic mRNA is sensed by innate immune cells through three major categories: (1) uridine-based RNA identification, (2) dsRNA recognition, and (3) sensing of mRNA’s uncapped 5′ terminus. https://t.co/n1dOSqd5oS https://t.co/4voKfheFWS
view full postJanuary 25, 2025
1
Abstract Synopsis
- RNA therapeutics like mRNA, siRNA, and CRISPR-Cas9 hold promise for treating various diseases but face challenges with degradation and cellular uptake, necessitating effective delivery systems.
- Lipid nanoparticles (LNPs) are a favorable option for RNA delivery due to their ability to protect RNA, enhance uptake, and promote endosomal escape, though they require careful engineering and targeting to improve their in vivo performance.
- This review discusses the properties of LNPs, their limitations in targeted delivery, and strategies for overcoming these hurdles, while also examining their current clinical applications and future potential in RNA therapies.
Rick²
@NexusSwords (Twitter)