Circulation January 2025 PMID 39569515

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.

Wouter Derks, Julian Rode, Sofia Collin, Fabian Rost, Paula Heinke, Anjana Hariharan, Lauren Pickel, Irina Simonova, Enikő Lázár, Evan Graham, Ramadan Jashari, Michaela Andrä, Anders Jeppsson, Mehran Salehpour, Kanar Alkass

Mentions

128
Peak: 39 in Nov 2024
across 8 sources since Oct 2023

Extended reach

174,153
potential audience

Total likes

157

Video views

3,543

Mentions per month

Oct 2023 – Dec 2025

Where it's discussed

  • X / Twitter52 posts
  • Instagram47 posts
  • Facebook11 posts
  • News8 articles
  • Blogs4 articles
  • Reddit3 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

This collection of discussions strongly supports the research's promising findings, with enthusiastic remarks such as 'transformative research' and 'potential therapeutic avenue,' suggesting widespread excitement about the implications. People reference the substantial increases in regeneration in LVAD patients, the possible shift in treatment paradigms, and the collaborative nature of the work, showing both deep engagement and recognition of high-impact potential.

AgreementStrong agreement

Most discussions express strong support, emphasizing the potential of heart regeneration therapies, with phrases like 'promising new avenues' and 'transformative research'.

InterestHigh interest

The posts highlight high engagement with terms like 'excited', 'thrilled', and references to new findings, indicating strong interest.

EngagementModerate engagement

Participants reference specific mechanisms and future implications, showing thoughtful engagement, although some comments are more about sharing rather than deep analysis.

ImpactHigh impact

Multiple comments underscore the possible revolutionary impact on heart failure treatment and the significant boost in cardiomyocyte regeneration, emphasizing high perceived impact.

Abstract in brief

  • Cardiomyocytes in adult human hearts have a low regeneration rate of about 0.5% per year, raising questions about their role in heart failure recovery.
  • Patients with advanced heart failure showed dramatically reduced cardiomyocyte renewal, with rates significantly lower than healthy individuals, while those with left ventricular assist devices (LVAD) experienced a notable increase in regeneration.
  • These results suggest that the heart retains a potential for regeneration in disease states, which could be harnessed for future therapies.

Top posts

Most liked on X and Bluesky
Hesham Sadek
@heshamasadek · X

Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with our Leducq consortium 6 years ago showing that LVAD responders have a higher rate of new myocytes formation. https://t.co/pjNcPtRyzy

Nov 21, 2024 · 49 likes · 9 shares · 1,634 followers View post →
Circulation
@CircAHA · X

Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjonas @Joseph_Taleb @SJovinge @ThirupuraShank1 @CPKyriakopoulos @mandra @oibergmann https://t.co/U2RQhzLSTo https://t.co/XQrllMZINz

Nov 25, 2024 · 30 likes · 24 shares · 77,755 followers View post →
Olaf Bergmann
@oibergmann · X

Mechanical unloading unlocks latent regenerative potential. Cardiomyocyte renewal is boosted in LVAD responders. Great Leducq collaboration! @FrisenJonas @StavrosDrakos @heshamasadek https://t.co/z64hz23e3l https://t.co/sHetWE2dl5

Nov 21, 2024 · 16 likes · 6 shares · 49 followers View post →
Joseph Taleb
@Joseph_Taleb · X

Thrilled to share our study in Circulation! https://t.co/hmUIrjgnGG Led by @oibergmann, we found a >6-fold boost in cardiac regeneration in LVAD responders vs healthy hearts. Honored to be part of this transformative research. @UofUCV @UCSDCardiology

Nov 21, 2024 · 10 likes · 3 shares · 277 followers View post →
Fabian Rost
@fabianrost84 · X

Turning nuclear fallout into heart-healing insights.

Nov 22, 2024 · 4 likes · 1 share · 157 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically. https://t.co/bSRAkZ7GhS https://t.co/tGW72ZMCor

Nov 26, 2024 · 2 likes · 3,259 followers View post →

All mentions

Hannah
@FloridaWhoaman · X

@dylanschuddinh @wolf_pants @thltd_ It can under very limited circumstances. https://t.co/IHzLZuRCbL

Mar 17, 2025 · 170 followers View post →
Bagamian Scientific Consulting LLC
@NE14science · X

A new study shows that #heart muscle #regeneration occurred in approximately 25% of #LVAD patients. These results open promising new avenues for treating heart failure, which causes 14% of annual deaths in the US. https://t.co/Qj3TBbOdVc https://t.co/gxDCTRWtY5

Feb 14, 2025 · 16 followers View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Cardiomyocyte regeneration in heart failure is minimal, but significantly boosts with left ventricular assist device therapy, showcasing therapeutic potential. by Derks W, Rode J (...) Bergmann O et 23 al. in Circulation https://t.co/oO6Z3F1nkA #MedX #MedResearch

Jan 30, 2025 · 98 followers View post →
Niccolo Bonini
@BoniniNiccolo · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Jan 24, 2025 · 24 shares · 114 followers View post →
Alberto Aimo
@AlbertoAimo90 · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Jan 24, 2025 · 24 shares · 2,084 followers View post →
McMaster Heart Function Education
@MacHeartFailure · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Jan 24, 2025 · 24 shares · 514 followers View post →
Misako TOKI
@misako_desu · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Jan 24, 2025 · 24 shares · 957 followers View post →
Satoshi Miyashita, MD | 宮下 智
@satoshiboston · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Jan 23, 2025 · 24 shares · 1,994 followers View post →
Ryan Williams, MD
@RyanJWilliamsMD · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Dec 22, 2024 · 24 shares · 112 followers View post →
UArizona Sarver Heart Center
@UAZHeart · X

New research co-authored by Sarver Heart Center Director, Hesham Sadek, MD, PhD, reveals that 25% of artificial heart patients regenerate heart muscle after a heart attack. These findings could transform heart failure treatment. Learn more: https://t.co/R3myX9N9un #HeartResearch

Dec 20, 2024 · 2 likes · 1 share · 1,626 followers View post →
Institute of Pharmacology and Toxicology, UMG
@pharmaumg · X

RT @oibergmann: Mechanical unloading unlocks latent regenerative potential. Cardiomyocyte renewal is boosted in LVAD responders. Great Ledu…

Dec 20, 2024 · 6 shares · 270 followers View post →
キャニック・ブラベル の 健康天寿™︎リテラシー
@iCannich_jp · X

なんと ”終末期心不全患者で左心室サポートデバイス療法(Left Ventricular Assist Device, LVAD)を受けている患者は、健康な心臓と比較して心筋細胞の再生が6倍以上増加しました 成人の心臓の心筋細胞は、年間再生率が≈0.5%で再生能力を示す“ https://t.co/gxNY0zybmZ 年間3%に及ぶ回復力⁉️

Dec 15, 2024 · 314 followers View post →
Jinrong Hu
@HJRBio · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Dec 1, 2024 · 24 shares · 449 followers View post →
Thirupura Shankar
@ThirupuraShank1 · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 29, 2024 · 24 shares · 79 followers View post →
Endo Fellow
@endo_fellow · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 29, 2024 · 24 shares · 32 followers View post →
Francesco Dellagrazia
@_radikalek · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 26, 2024 · 24 shares · 1,607 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 26, 2024 · 24 shares · 2,447 followers View post →
はっか@ICU×循内×心エコー×心リハ
@Super_hakka31 · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 26, 2024 · 24 shares · 595 followers View post →
Felix Rausch
@felix_mller · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 26, 2024 · 24 shares · 149 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically. https://t.co/bSRAkZ7GhS https://t.co/tGW72ZMCor

Nov 26, 2024 · 2 likes · 3,259 followers View post →
Ivan Netuka
@netuka_ivan · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 26, 2024 · 24 shares · 323 followers View post →
Junedh M. Amrute
@junedh_amrute · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 475 followers View post →
Shinya Goto
@sgoto4 · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 322 followers View post →
Circulation 日本版
@Circulation_nih · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 352 followers View post →
Christos P. Kyriakopoulos
@CPKyriakopoulos · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 395 followers View post →
Joseph Taleb
@Joseph_Taleb · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 277 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 573 followers View post →
Bowen Wang
@NU_JEANSS · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 274 followers View post →
Sherry-Ann Brown, MD, PhD, FACC, FAHA
@drbrowncares · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 7,755 followers View post →
Christin Franke
@ChristinFranke2 · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 102 followers View post →
Tim Kambič
@TimKambic · X

RT @CircAHA: Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjona…

Nov 25, 2024 · 24 shares · 234 followers View post →
Circulation
@CircAHA · X

Patients with LVAD demonstrate substantial cardiomyocyte regeneration, highlighting a potential therapeutic avenue @frisenjonas @Joseph_Taleb @SJovinge @ThirupuraShank1 @CPKyriakopoulos @mandra @oibergmann https://t.co/U2RQhzLSTo https://t.co/XQrllMZINz

Nov 25, 2024 · 30 likes · 24 shares · 77,755 followers View post →
Cardiology Papers
@Cardiology_P · X

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease https://t.co/N31pzPcF7W

Nov 24, 2024 · 60 followers View post →
Center for Genomic Medicine
@UtahCGM · X

New Pub Alert from @UtahCGM! A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease https://t.co/kDkueezAXx

Nov 22, 2024 · 297 followers View post →
Nadia Mercader
@nmercaderh · X

RT @heshamasadek: Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with o…

Nov 22, 2024 · 9 shares · 1,153 followers View post →
Matt Stroud Lab
@stroudlab.bsky.social · Bluesky

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease www.ahajournals.org/doi/epdf/10....

Nov 22, 2024 · 1 like View post →
Ahmad A. Cluntun
@molecularpepsi · X

RT @Joseph_Taleb: Thrilled to share our study in Circulation! https://t.co/hmUIrjgnGG Led by @oibergmann, we found a >6-fold boost in cardi…

Nov 22, 2024 · 3 shares · 808 followers View post →
The Dobreva Lab
@DobrevaLab · X

RT @heshamasadek: Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with o…

Nov 22, 2024 · 9 shares · 388 followers View post →
Professor Erwin Loh
@erwinloh · X

Researchers found that a damaged #heart's ability to #generate new #muscle cells is up to six times greater than that of a healthy heart. But the mechanism behind the effect is still unknown and there isn’t yet any hypothesis to explain it. https://t.co/Q6gsBL5fKZ https://t.co/Ly9gxFQph9

Nov 22, 2024 · 6,987 followers View post →
Hallou Lab
@Hallou_Lab · X

RT @fabianrost84: Turning nuclear fallout into heart-healing insights.

Nov 22, 2024 · 1 share · 927 followers View post →
Fabian Rost
@fabianrost84 · X

Turning nuclear fallout into heart-healing insights.

Nov 22, 2024 · 4 likes · 1 share · 157 followers View post →
Karolinska Institutet
@karolinskainst · X

Link to publication: https://t.co/rOYRHVJbIj

Nov 22, 2024 · 40,645 followers View post →
UC San Diego Cardiology
@UCSDCardiology · X

RT @Joseph_Taleb: Thrilled to share our study in Circulation! https://t.co/hmUIrjgnGG Led by @oibergmann, we found a >6-fold boost in cardi…

Nov 22, 2024 · 3 shares · 814 followers View post →
Carles Díez
@diez_carles · X

RT @heshamasadek: Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with o…

Nov 22, 2024 · 9 shares · 763 followers View post →
Christos P. Kyriakopoulos
@CPKyriakopoulos · X

RT @oibergmann: Mechanical unloading unlocks latent regenerative potential. Cardiomyocyte renewal is boosted in LVAD responders. Great Ledu…

Nov 22, 2024 · 6 shares · 395 followers View post →
Christos P. Kyriakopoulos
@CPKyriakopoulos · X

RT @heshamasadek: Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with o…

Nov 22, 2024 · 9 shares · 395 followers View post →
Joseph Taleb
@Joseph_Taleb · X

Thrilled to share our study in Circulation! https://t.co/hmUIrjgnGG Led by @oibergmann, we found a >6-fold boost in cardiac regeneration in LVAD responders vs healthy hearts. Honored to be part of this transformative research. @UofUCV @UCSDCardiology

Nov 21, 2024 · 10 likes · 3 shares · 277 followers View post →
Stavros George Drakos
@StavrosDrakos · X

RT @oibergmann: Mechanical unloading unlocks latent regenerative potential. Cardiomyocyte renewal is boosted in LVAD responders. Great Ledu…

Nov 21, 2024 · 6 shares · 4,056 followers View post →
Vikram Prasad
@prasad_vik · X

RT @heshamasadek: Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with o…

Nov 21, 2024 · 9 shares · 144 followers View post →
Hesham Sadek
@heshamasadek · X

RT @oibergmann: Mechanical unloading unlocks latent regenerative potential. Cardiomyocyte renewal is boosted in LVAD responders. Great Ledu…

Nov 21, 2024 · 6 shares · 1,634 followers View post →
Olaf Bergmann
@oibergmann · X

Mechanical unloading unlocks latent regenerative potential. Cardiomyocyte renewal is boosted in LVAD responders. Great Leducq collaboration! @FrisenJonas @StavrosDrakos @heshamasadek https://t.co/z64hz23e3l https://t.co/sHetWE2dl5

Nov 21, 2024 · 16 likes · 6 shares · 49 followers View post →
Hesham Sadek
@heshamasadek · X

Excited to share the latest collaboration spearheaded by @oibergmann @FrisenJonas @StavrosDrakos this work started with our Leducq consortium 6 years ago showing that LVAD responders have a higher rate of new myocytes formation. https://t.co/pjNcPtRyzy

Nov 21, 2024 · 49 likes · 9 shares · 1,634 followers View post →
UofU3i
@UofU3i · X

New 3i Investigator Article Alert!! A latent cardiomyocyte regeneration potential in human heart disease https://t.co/LluZ5snNUd

Oct 20, 2023 · 1,183 followers View post →
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Comer más flavonoles, antioxidantes presentes en muchas ...
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The human heart is one of the most remarkable organs in the body ...
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... revolutionizing heart disease treatment. https://doi.org/10.1161/CIRCULATIONAHA.123.067156. more. View 1 comment. June 28 · iamashok_12. •.

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Dr. Andre Terzic, MD, PhD, a pioneer in stem cell therapy, focuses ...
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Interesting Engineering | Vanderbilt University Medical Center has ...
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How Cardiac Fibroblasts Repair Heart Tissue Following a Heart ...
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In an inspiring discovery, researchers found strong evidence that ...
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We always knew we had courage—who knew Utahns had this much ...
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A new study from the University of Arizona reveals that men are ...
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Have a Heart | The Future of Heart Surgery: Less Cutting, More ...
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Perfusion Fact of the Day The bubble oxygenator was a ...
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This is the world's smallest pacemaker. It's smaller than rice and ...
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Scientists have developed a revolutionary wireless, rice-sized ...
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A new injection could stop heart failure before it starts and heal ...
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In a groundbreaking surgery, a team of Chinese doctors has ...
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BREAKING NEWS: This rice-sized pacemaker has no wires and ...
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INFARCTUS : Et si le cœur pouvait se réparer tout seul ? | santé log
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Source: Circulation 21 Nov, 2024 DOI: 10.1161/CIRCULATIONAHA.123.067156 A latent cardiomyocyte regeneration potential in human heart disease.

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El mecanismo oculto del corazón para 'autorrepararse' según una ...
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Estudio publicado en Circulation y consultado on line en https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.067156 el 5 de diciembre de ...

Jan 23, 2025 View →
There is strong cardiomyocyte regenerative potential in advanced ...
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Jan 12, 2025 View →
Herzregeneration kann durch mechanische Unterstützung angeregt ...
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... 10.1161/CIRCULATIONAHA.123.067156). Diese Erkenntnisse könnten den Studienautoren helfen, in künftigen translationalen Untersuchungen ...

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Se trata de nueva estrategia, que podría integrarse fácilmente en los ...
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Kalp kendi kendini iyileştirebilir mi? Yeni bir çalışma diyor ki, evet ...
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Can the heart heal itself? New study says it can: An international ...
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Dec 22, 2024 View →
Study says the heart can heal itself
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A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease. Circulation, 2024; DOI: 10.1161/CIRCULATIONAHA.123.067156. Picks for you.

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A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease. Circulation. doi.org/10.1161/circulationaha.123.067156. Currently rated ...

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Can the heart heal itself? New study says it can | EurekAlert!
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10.1161/CIRCULATIONAHA.123.067156. Method of Research. Randomized controlled/clinical trial. Subject of Research. Human tissue samples. Article ...

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Can the heart heal itself? New study says it can | ScienceDaily
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A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease. Circulation, 2024; DOI: 10.1161/CIRCULATIONAHA.123.067156. Cite This Page:.

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Mechanische Herzunterstützung fördert Regeneration von ...
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DOI: 10.1161/CIRCULATIONAHA.123.067156. Bilder. Die Abbildung zeigt isolierte humane Herzmuskelzellen (rot) mit einem oder zwei Zellkernen ...

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Circulation, 2024 DOI: 10.1161/CIRCULATIONAHA.123.067156. Cite This Page: MLA; APA; Chicago. Karolinska Institutet. "The human heart may have ...

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The human heart may have a hidden ability to repair itself | EurekAlert!
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... 10.1161/CIRCULATIONAHA.123.067156. Journal. Circulation. DOI. 10.1161/CIRCULATIONAHA.123.067156. Method of Research. Experimental study. Subject ...

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Study suggests a key to kick-start the heart's own repair mechanism
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doi.org/10.1161/CIRCULATIONAHA.123.067156. Currently rated 4.5 by 2 people. Posted in: Medical Science News | Medical Research News | Medical ...

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El tema de experimentación animal ha estado bajo el lente desde el ...
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