Sci Adv December 2024 PMID 39661679

Deep and dynamic metabolic and structural imaging in living tissues.

Kunzan Liu, Honghao Cao, Kasey Shashaty, Li-Yu Yu, Sarah Spitz, Francesca Michela Pramotton, Zhengpeng Wan, Ellen L Kan, Erin N Tevonian, Manuel Levy, Eva Lendaro, Roger D Kamm, Linda G Griffith, Fan Wang, Tong Qiu

Mentions

38
Peak: 14 in Dec 2024
across 6 sources since Apr 2024

Extended reach

99,428
potential audience

Total likes

32

Video views

86

Mentions per month

Apr 2024 – Jul 2025

Where it's discussed

  • News17 articles
  • X / Twitter13 posts
  • Bluesky2 posts
  • YouTube2 videos
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reveal excitement about the technical breakthroughs, exemplified by phrases like 'awesome collaboration' and 'deeper and noninvasive imaging,' which emphasize both technical achievement and potential biological applications. The tone is mainly positive, highlighting the importance of extending imaging depths for studying living tissues, reinforcing the recognition of this work as a promising advancement in biomedical imaging.

AgreementModerate agreement

Most discussions express strong support and enthusiasm for the research findings, emphasizing the innovation and potential impact.

InterestHigh interest

Participants show high interest, often highlighting the technical advancements and applications in biomedical research.

EngagementModerate engagement

Several posts reference specific methods, collaborations, and implications, indicating a moderate level of engagement.

ImpactModerate impact

Comments suggest the research could significantly influence future biomedical imaging techniques, though some focus remains on its ongoing development.

Abstract in brief

  • The text discusses a new imaging technique that uses three-photon excitation at 1100 nm to visualize cellular activities in living tissues more than twice as deep as traditional methods, extending the imaging depth from 300 micrometers to over 700 micrometers.
  • This is achieved by utilizing multimode fiber-based high peak power pulses, which enhance imaging resolution and speed, allowing for faster observation of cellular behaviors such as immune cell activities in thicker tissue samples.
  • The advancements hold significant potential for broad applications in biomedical research, particularly in areas like cancer, immune responses, and tissue engineering, by enabling detailed imaging of living tissues at greater depths.

Top posts

Most liked on X and Bluesky
Sixian You
@sixian_you · X

Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome collaboration with @LindaGGriffith1 Fan Wang @rdkamm https://t.co/naChhFA9QG https://t.co/4o8maJXgVK

Dec 11, 2024 · 25 likes · 4 shares · 615 followers View post →
Freddy T. Nguyen, MD, PhD
@freddytn · X

Paper "Deep and dynamic metabolic and structural imaging in living tissues" at @ScienceAdvances "imaging depth for NAD(P)H can be extended to more than 700 μm in living engineered human multicellular microtissues" @MIT #photonics #optics #medicine https://t.co/bkBlvrG4Rp

Dec 17, 2024 · 3 likes · 2,446 followers View post →
Rubia
@rubiapedone.bsky.social · Bluesky

Loved this! Deep and dynamic metabolic and structural imaging in living tissues | Science Advances www.science.org/doi/10.1126/...

Feb 11, 2025 · 2 likes View post →
Science Advances
@ScienceAdvances · X

New research explains a method for extending the depth for simultaneous label-free autofluorescence and multiharmonic to 700 nanometers in human tissues. https://t.co/r9WxR6I6AQ https://t.co/xwh9qkK9qj

Dec 17, 2024 · 1 like · 66,161 followers View post →
MIT Dept of BE
@MITdeptofBE · X

"Deep and dynamic metabolic and structural imaging in living tissues" https://t.co/77zZECz3JF @sixian_you @kamm_lab @LindaGGriffith1 https://t.co/YzF5KsNECg

Dec 11, 2024 · 1 like · 9,287 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @sixian_you: Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome…

Dec 11, 2024 · 4 shares · 14,322 followers View post →

All mentions

Rubia
@rubiapedone.bsky.social · Bluesky

Loved this! Deep and dynamic metabolic and structural imaging in living tissues | Science Advances www.science.org/doi/10.1126/...

Feb 11, 2025 · 2 likes View post →
Science Advances
@ScienceAdvances · X

New research explains a method for extending the depth for simultaneous label-free autofluorescence and multiharmonic to 700 nanometers in human tissues. https://t.co/r9WxR6I6AQ https://t.co/xwh9qkK9qj

Dec 17, 2024 · 1 like · 66,161 followers View post →
Freddy T. Nguyen, MD, PhD
@freddytn · X

Paper "Deep and dynamic metabolic and structural imaging in living tissues" at @ScienceAdvances "imaging depth for NAD(P)H can be extended to more than 700 μm in living engineered human multicellular microtissues" @MIT #photonics #optics #medicine https://t.co/bkBlvrG4Rp

Dec 17, 2024 · 3 likes · 2,446 followers View post →
Carlos R. Ferreira
@carlosrof · X

Deep and dynamic metabolic and structural imaging in living tissues | Science Advances https://t.co/PggKEDxrGH

Dec 14, 2024 · 804 followers View post →
Gabriel Falcão G. DeMoura
@gabrielfalcao · X

https://t.co/TuDa3HJsfV

Dec 13, 2024 · 654 followers View post →
Ordo Fraterna Fibonacci
@ordofibonacci.bsky.social · Bluesky

Deep and dynamic metabolic and structural imaging in living tissues Science Advances www.science.org/doi/10.1126/...

Dec 12, 2024 View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Deep and dynamic metabolic and structural imaging in living tissues Science Advances https://t.co/dn0PVmnldC

Dec 12, 2024 · 2,569 followers View post →
Harikumar
@Harie1897 · X

https://t.co/CIrci2d6VE

Dec 11, 2024 · 420 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @sixian_you: Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome…

Dec 11, 2024 · 4 shares · 14,322 followers View post →
Pengfei Song
@SongLabDuke · X

RT @sixian_you: Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome…

Dec 11, 2024 · 4 shares · 1,159 followers View post →
Honghao Cao
@Honghao_Cao · X

RT @sixian_you: Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome…

Dec 11, 2024 · 4 shares · 9 followers View post →
MIT Dept of BE
@MITdeptofBE · X

"Deep and dynamic metabolic and structural imaging in living tissues" https://t.co/77zZECz3JF @sixian_you @kamm_lab @LindaGGriffith1 https://t.co/YzF5KsNECg

Dec 11, 2024 · 1 like · 9,287 followers View post →
Michael Birnbaum
@MEBirnbaum · X

RT @sixian_you: Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome…

Dec 11, 2024 · 4 shares · 814 followers View post →
Sixian You
@sixian_you · X

Deeper and noninvasive metabolic imaging powered by multimode fiber sources by Kunzan Liu, Tong Qiu, Honghao Cao. Awesome collaboration with @LindaGGriffith1 Fan Wang @rdkamm https://t.co/naChhFA9QG https://t.co/4o8maJXgVK

Dec 11, 2024 · 25 likes · 4 shares · 615 followers View post →
Biological Physics Papers
@ENWV · X

Deep and Dynamic Metabolic and Structural Imaging in Living Tissues. https://t.co/QAZ6nptqBR

Apr 19, 2024 · 43 followers View post →