Cell Signal March 2025 PMID 39848456

AP2A1 modulates cell states between senescence and rejuvenation.

Pirawan Chantachotikul, Shiyou Liu, Kana Furukawa, Shinji Deguchi

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The group's discussions reflect enthusiasm and recognition of the research's potential, as many posts mention interest in future applications, with phrases like 'want to read more' and 'big implications.' The tone and word choices indicate a positive outlook on the findings' impact and relevance for understanding aging and cell rejuvenation.

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Abstract in brief

AP2A1 is a protein that becomes more active in senescent cells, helping to maintain their large size by reorganizing stress fibers and aiding cell adhesion.
Reducing AP2A1 levels can reverse signs of aging in cells, while increasing it can accelerate the aging process, showing its key role in cell senescence and rejuvenation.
The study suggests that senescent cells use a specialized mechanism involving AP2A1 and integrin 1 to stabilize their size and adhesion, unlike younger cells that rely on less efficient random diffusion.

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Role of AP2A1 in Cellular Aging and Rejuvenation Mechanisms

Researchers from Osaka University have identified AP2A1 as a key regulator in cell aging, offering potential avenues for anti-aging treatments. The study highlights how manipulating AP2A1 levels influences cell size…

Science News · Mar 6, 2025 309 views

AP2A1's Role in Cell Senescence and Rejuvenation Mechanisms

The function of organisms gradually declines due to accumulation of senescent cells, leading to age-related diseases. AP2A1 is a potential marker involved in regulating cell aging and rejuvenation, playing a key role in…

Update Forschung · Jul 15, 2025 80 views

AKL Therapeutics

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RT @NeuroscienceNew: “AP2A1 modulates cell states between senescence and rejuvenation” by Pirawan Chantachotikul et al. Cellular Signaling…

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RT @NeuroscienceNew: “AP2A1 modulates cell states between senescence and rejuvenation” by Pirawan Chantachotikul et al. Cellular Signaling…

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System

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RT @AgingBiology: AP2A1 modulates cell states between senescence and rejuvenation https://t.co/xnnGxSzXvv

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Peng CHEN

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RT @AgingBiology: AP2A1 modulates cell states between senescence and rejuvenation https://t.co/xnnGxSzXvv

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RT @NeuroscienceNew: “AP2A1 modulates cell states between senescence and rejuvenation” by Pirawan Chantachotikul et al. Cellular Signaling…

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【公式】大阪大学基礎工学部/大学院基礎工学研究科

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細胞老化と若返りを制御する新たな分子メカニズムを発見―抗老化技術の開発につながる可能性― JP：https://t.co/ZAMI4T8FOy EN：https://t.co/2ebaKqCYGT https://t.co/1pYa89Vtap

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TheKnightofEvening

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Neuroscience News

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“AP2A1 modulates cell states between senescence and rejuvenation” by Pirawan Chantachotikul et al. Cellular Signaling https://t.co/Sj6UoIpilX

Feb 19, 2025 · 11 likes · 4 shares · 507,240 followers View post →

ForensicPsyMD

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Feb 19, 2025 · 363 followers View post →

HeartStopper61

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@lgj170 Научная работа "AP2A1 modulates cell states between senescence and rejuvenation" была опубликована в журнале Cellular Signalling. Авторы работы: Пираван Чантачотикул, С. Лю, К. Фурукава и С. Дегучи. Статья была опубликована в 2025 году, и её DOI: 10.1016/j.cellsig.2025.111616

Feb 18, 2025 · 1 like · 411 followers View post →

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AP2A1 modulates cell states between senescence and rejuvenation.

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Role of AP2A1 in Cellular Aging and Rejuvenation Mechanisms

AP2A1's Role in Cell Senescence and Rejuvenation Mechanisms