Aging Cell April 2025 PMID 39853804

Comprehensive evaluation of lifespan-extending molecules in C. elegans.

Grace B Phelps, Jonas Morin, Carla Pinto, Lucas Schoenfeldt, Sebastien Guilmot, Alejandro Ocampo, Kevin Perez

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Mentions

Peak: 15 in Jan 2025

across 3 sources since Jun 2024

Extended reach

259,391

potential audience

Total likes

127

Video views

479

Mentions per month

Jun 2024 – Oct 2025

Where it's discussed

X / Twitter32 posts
Bluesky3 posts
YouTube2 videos

AI synopsis

What people are saying

The overall discussions exhibit strong interest and moderate engagement, as evidenced by comments referencing the study’s scope, novel findings, and cross-species effects. Words like 'comprehensive,' 'profound implications,' and 'most effective molecules' convey a positive tone, highlighting the perceived importance and potential impact of the research in advancing aging and lifespan extension studies.

AgreementModerate agreement

Most discussions support the significance of the study, with some highlighting its thoroughness and potential implications, such as references to the study being 'most comprehensive' and 'showing effects across species.'

InterestHigh interest

Posts show high curiosity, especially noting the evaluation of new molecules, effects in different organisms, and potential for transforming lifespan research, indicated by terms like 'interesting,' 'profound implications,' and 'comprehensive study.'

EngagementModerate engagement

Several posts mention details about the study's scope, methods, and its broader significance, demonstrating moderate depth of engagement; comments about combining molecules and cross-species effects suggest thoughtful analysis.

ImpactModerate impact

The discussions reflect recognition of the study's potential impact on aging research, with phrases like 'profound implications' and 'demonstrating conserved effects,' suggesting they see this as a meaningful contribution to understanding lifespan extensi

Abstract in brief

The study evaluated 16 molecules previously reported to extend lifespan in the nematode Celegans, testing their effects under different diets and starting treatment ages to determine their consistency and potential mechanisms.
Results confirmed that many of these compounds significantly extend lifespan, with some showing additive effects when combined, and demonstrated that some also extend lifespan in fruit flies, indicating conserved aging pathways.
The research also identified new potential lifespan-extending compounds by screening a broader set of molecules, helping to clarify which treatments are effective and how they might work across species.]

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All mentions

Impactful Longevity Studies: A January 2025 Review

This video reviews the most significant longevity studies from January 2025, focusing on reversing cell senescence and the role of free radicals in lifespan extension. Explore findings on youthful stem cells in aged…

Canadian Longevity Association · Feb 23, 2025 404 views

Evaluating Lifespan-Extending Molecules in Model Organisms

This study reviews the most comprehensive analysis of lifespan-extending molecules in C. elegans, exploring the effects of various compounds, combinations, and their impact on other species like fruit flies. It provides…

Canadian Longevity Association · Feb 20, 2025 75 views

Surojit Sural

@surojitsural.bsky.social · Bluesky

Comprehensive evaluation of lifespan-extending molecules in C. elegans. Some of these compounds also extend lifespan in Drosophila melanogaster, demonstrating a conserved effect across species. onlinelibrary.wiley.com/doi/10.1111/...

Oct 14, 2025 · 1 like View post →

Surojit Sural

@surojitsural · X

RT @agingdoc1: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/9PjPgG5Djx

Oct 14, 2025 · 2 shares · 882 followers View post →

Agingdoc

@agingdoc1 · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/5ie1QMLOek

Apr 27, 2025 · 2 likes · 41,755 followers View post →

BioChemCalc

@BioChemCalc · X

RT @OcampoLab: Comprehensive evaluation of lifespan‐extending molecules in C. elegans

Apr 20, 2025 · 3 shares · 54 followers View post →

Agingdoc

@agingdoc1 · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/5ie1QMLOek

Feb 25, 2025 · 3 likes · 41,755 followers View post →

Chris Linnell

@ChrisPollyanna1 · X

RT @canlongevity: Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen l…

Feb 23, 2025 · 1 share · 703 followers View post →

Canadian Longevity Association

@canlongevity · X

Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can also increase lifespan; 1/2 https://t.co/g3U8OX5tZG

Feb 23, 2025 · 1 share · 121 followers View post →

Chris Linnell

@ChrisPollyanna1 · X

RT @canlongevity: Longevity Snapshot 4 - Reviewing the most comprehensive study on life-extending molecules in the roundworm c.elegans, sho…

Feb 20, 2025 · 1 share · 703 followers View post →

Canadian Longevity Association

@canlongevity · X

2/2 ... their effects on fruit flies, as well as discovering new life-extending molecules. It has some profound implications for interpreting previous lifespan studies. Study Reviewed: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/6k0Ljs1Ruq

Feb 20, 2025 · 121 followers View post →

Canadian Longevity Association

@canlongevity · X

Longevity Snapshot 4 - Reviewing the most comprehensive study on life-extending molecules in the roundworm c.elegans, showing how numerous variables can effect the outcome. This study also explored the results of combining the most effective molecules, 1/2 https://t.co/GqaPM3ZDmn

Feb 20, 2025 · 1 share · 121 followers View post →

Morgan Lee

@morgant_think · X

RT @agingdoc1: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/9PjPgG5Djx

Feb 13, 2025 · 2 shares · 21 followers View post →

Agingdoc

@agingdoc1 · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/9PjPgG5Djx

Feb 13, 2025 · 4 likes · 2 shares · 41,755 followers View post →

Chris Linnell

@ChrisPollyanna1 · X

2/2 ... some of these compounds also extend lifespan in" flies, "demonstrating a conserved effect across species", and "identified novel lifespan-extending compounds" in worms. Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/QTpR8ArpoW

Feb 4, 2025 · 2 likes · 703 followers View post →

priya joseph

@ayirpelle · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 25, 2025 · 9 shares · 4,944 followers View post →

Matias Hartman

@HartmanMatias_ · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 25, 2025 · 9 shares · 572 followers View post →

LEX

@shalindachaos99 · X

RT @OcampoLab: Comprehensive evaluation of lifespan‐extending molecules in C. elegans

Jan 25, 2025 · 3 shares · 339 followers View post →

ComputingCell

@trendycomputing · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 25, 2025 · 9 shares · 150 followers View post →

nike

@wot_mikey · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 25, 2025 · 9 shares · 476 followers View post →

Charlotte

@Charlotte_c0n · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 25, 2025 · 9 shares · 7 followers View post →

Diablo Habanero Chocolate

@HabaneroDiabloC · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 24, 2025 · 9 shares · 373 followers View post →

João Pedro de Magalhães

@jpsenescence · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 24, 2025 · 9 shares · 18,260 followers View post →

Hao Yin

@HaoYin20 · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 24, 2025 · 9 shares · 12,325 followers View post →

Lucas Schoenfeldt

@schlucas_ · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 24, 2025 · 9 shares · 76 followers View post →

Aging Science News

@AgingBiology · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/HpBpDAxtWM

Jan 24, 2025 · 48 likes · 9 shares · 30,642 followers View post →

AlfredoPietracatella

@alfredopietraca · X

RT @OcampoLab: Comprehensive evaluation of lifespan‐extending molecules in C. elegans

Jan 24, 2025 · 3 shares · 244 followers View post →

Ocampo Lab

@OcampoLab · X

Comprehensive evaluation of lifespan‐extending molecules in C. elegans

Jan 24, 2025 · 2 likes · 3 shares · 2,878 followers View post →

MakeAmericaAgeless

@AgelessMAGA · X

RT @kgiperez: Two new papers from our group published in @AgingCell today

Jan 24, 2025 · 1 share · 140 followers View post →

Kevin Perez

@kgiperez · X

Two new papers from our group published in @AgingCell today

Jan 24, 2025 · 35 likes · 1 share · 569 followers View post →

Ellen Siobhan Mitchell PhD

@siobhanmitchell · X

Interesting study which evaluates which combinations of molecules may extend #lifespan Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/6UevOl8zgv

Sep 16, 2024 · 695 followers View post →

john morley

@drjohnmorley · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/Mw4GS0sh9Q

Jul 18, 2024 · 8,313 followers View post →

João Pedro de Magalhães

@jpsenescence · X

RT @AgingBiology: Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/C3BwMj2nke

Jul 18, 2024 · 1 share · 18,260 followers View post →

Aging Science News

@AgingBiology · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/C3BwMj2nke

Jul 18, 2024 · 8 likes · 1 share · 30,642 followers View post →

bioRxiv Pharmacology and Toxicology

@biorxiv-pharma.bsky.social · Bluesky

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://www.biorxiv.org/content/10.1101/2024.06.24.600458v1

Jun 28, 2024 View post →

bioRxivpreprint

@biorxivpreprint.bsky.social · Bluesky

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://www.biorxiv.org/content/10.1101/2024.06.24.600458v1

Jun 28, 2024 View post →

biorxiv_pharma

@biorxiv_pharma · X

Comprehensive evaluation of lifespan-extending molecules in C. elegans https://t.co/0662H7U7bg #biorxiv_pharma

Jun 28, 2024 · 82 followers View post →

Comprehensive evaluation of lifespan-extending molecules in C. elegans.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Impactful Longevity Studies: A January 2025 Review

Evaluating Lifespan-Extending Molecules in Model Organisms