PubHawk
Cell March 2025 PMID 39889695

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment.

Atreyo Pal, Mark A Noble, Matheo Morales, Richik Pal, Marybeth Baumgartner, Je Won Yang, Kristina M Yim, Severin Uebbing, James P Noonan

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Mentions

58
Peak: 23 in Mar 2025
across 3 sources since Jun 2024

Extended reach

858,966
potential audience

Total likes

197

Video views

96

Mentions per month

Jun 2024 – Sep 2025

Where it's discussed

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AI synopsis

What people are saying

The collective discussions express strong interest in the research's role in uncovering the genetic basis of human brain evolution, with words like 'more work' and 'genetic changes' showing curiosity about implications. Many posts share links and praise the publication, while others highlight its relevance using terms like 'precise genetic changes' and 'brain development,' reflecting a recognition of its potential impact on future research in neurogenetics.

AgreementModerate agreement

Most discussions highlight the significance of understanding brain development in humans versus chimpanzees, indicating general support for the research's importance.

InterestHigh interest

The frequent use of phrases like 'more work needed' and emphasizing the 'genetic changes' shows high curiosity about the implications of the findings.

EngagementModerate engagement

Posts reference specific concepts like the 'interactome' and 'neurodevelopment,' suggesting a moderate depth of engagement, though many are summaries or shares.

ImpactModerate impact

Several discussions mention how this research could influence future studies or understanding of human evolution, indicating perceived moderate impact.

Abstract in brief

  • This study identifies 2,963 conserved gene targets of 1,590 human accelerated regions (HARs) in neural stem cells of humans and chimpanzees, linking these regions to neurodevelopmental functions.
  • The research finds that HAR targets are primarily involved in brain development and are differentially expressed between species, especially in cell types like outer radial glia related to cortical expansion.
  • The findings suggest HARs influence human brain evolution mainly by modifying ancestral gene functions shared with chimpanzees rather than gaining entirely new targets, aiding future studies on HAR roles in brain development.
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Cell
@CellCellPress · X

In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/f7KhhTxHkK

Mar 21, 2025 · 50 likes · 13 shares · 263,609 followers View post →
Cell
@CellCellPress · X

Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/4sDPSujVvc

Jun 21, 2025 · 40 likes · 6 shares · 263,609 followers View post →
Juhyun Kim
@juhyunk_ · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/21xDnP0jhi #journals #feedly

Mar 21, 2025 · 34 likes · 6 shares · 1,401 followers View post →
Juhyun Kim
@juhyunk_ · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/R9qDAAb2Gi

Jan 30, 2025 · 23 likes · 3 shares · 1,401 followers View post →
Cell
@CellCellPress · X

In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/rCdA7XdUGq

Jul 14, 2025 · 22 likes · 5 shares · 263,609 followers View post →
TNia
@Dr_Tnia · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment: Cell https://t.co/Zu9UD7aRZo

Mar 20, 2025 · 7 likes · 1 share · 3,885 followers View post →

All mentions

The Role of DNA in Human Brain Evolution

What makes the human brain differ from primates? A 2025 study reveals the impact of Human Accelerated Regions (HARs) on neuron growth and brain wiring. These tiny DNA segments play a crucial role in learning and memory…

Crediblyweekly · Sep 21, 2025 96 views
Geneva Grace
@Geneva___Grace · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Aug 9, 2025 · 5 shares · 101 followers View post →
qicy
@qicy11 · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Jul 14, 2025 · 5 shares · 379 followers View post →
Hulagu
@HulaguBioChem · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Jul 14, 2025 · 5 shares · 1,280 followers View post →
Daniel Thomson
@djthomson · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Jul 14, 2025 · 5 shares · 2,076 followers View post →
Pranav Adithya
@PranavAdithya10 · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Jul 14, 2025 · 5 shares · 197 followers View post →
Cell
@CellCellPress · X

In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/rCdA7XdUGq

Jul 14, 2025 · 22 likes · 5 shares · 263,609 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/vq79XChT5a https://t.co/5M1KbP8VtF

Jun 24, 2025 · 93 followers View post →
Abstream
@abstreamme · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment #science #publication #research #publications https://t.co/4cTGrqviPE

Jun 23, 2025 · 786 followers View post →
Hulagu
@HulaguBioChem · X

RT @CellCellPress: Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurod…

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Vladimir Martínez-Álvarez
@vladiberto · X

RT @CellCellPress: Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurod…

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Un1v3rs0 Z3r0
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Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/2boiFmz8uF

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Alejandro De Los Angeles, DPhil, MPH
@delosangeles520 · X

RT @CellCellPress: Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurod…

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LAMA
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RT @CellCellPress: Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurod…

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Cell - a Cell Press journal
@cp-cell.bsky.social · Bluesky

Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment

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qicy
@qicy11 · X

RT @CellCellPress: Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurod…

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Cell
@CellCellPress · X

Now online! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/4sDPSujVvc

Jun 21, 2025 · 40 likes · 6 shares · 263,609 followers View post →
HealthSci.AI
@HealthSci_AI · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

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Timothy En Haw Chan
@timothykoala · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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John Mariani
@JohnMariani · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

Mar 22, 2025 · 6 shares · 289 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

Mar 22, 2025 · 6 shares · 10,816 followers View post →
Sudripta Das
@DasSudript19120 · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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Szu Shuo Lee
@ShuoSzu · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/UJuinGxlWz

Mar 22, 2025 · 2,070 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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Suiliang Xia
@YanYang80603102 · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

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Manoj Mayogi Mishra
@mayogisense · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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qicy
@qicy11 · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

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Jen
@jpadilla_DH · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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choiLab
@jungminchoilab · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Mar 21, 2025 · 13 shares · 336 followers View post →
Juhyun Kim
@juhyunk_ · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Mar 21, 2025 · 13 shares · 1,401 followers View post →
Juhyun Kim
@juhyunk_ · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/21xDnP0jhi #journals #feedly

Mar 21, 2025 · 34 likes · 6 shares · 1,401 followers View post →
Atreyo Pal
@atreyop · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

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dorukcan özköse
@drkcnnckrd · X

RT @CellCellPress: In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanze…

Mar 21, 2025 · 13 shares · 605 followers View post →
Cell
@CellCellPress · X

In the latest issue! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/f7KhhTxHkK

Mar 21, 2025 · 50 likes · 13 shares · 263,609 followers View post →
Deepanshu Soota
@DeepanshuSoota · X

RT @Dr_Tnia: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment: Cell ht…

Mar 20, 2025 · 1 share · 88 followers View post →
TNia
@Dr_Tnia · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment: Cell https://t.co/Zu9UD7aRZo

Mar 20, 2025 · 7 likes · 1 share · 3,885 followers View post →
MU-Peter Shimon
@mu-peter.bsky.social · Bluesky

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment

Mar 20, 2025 · 6 likes · 1 share View post →
RRID Robot
@rridrobot.bsky.social · Bluesky

RRID:CVCL_1G34 was used by the authors of the Cell paper "Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment". RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #ReproducibleResearch

Feb 16, 2025 · 1 like View post →
by a relatively small number of
@3_5_11x · X

ヒト脳の進化は HARs による遺伝子制御の変化で起こった

Feb 8, 2025 · 107 followers View post →
Un1v3rs0 Z3r0
@Un1v3rs0Z3r0 · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/A6Iv1LUSTd

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Sushmita Roy
@sroyyors.bsky.social · Bluesky

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment: Cell www.cell.com/cell/fulltex...

Feb 2, 2025 · 2 likes View post →
Sushmita Roy @sroyyors.bsky.social,genomic.social
@sroyyors · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment: Cell https://t.co/wCTqwSCQ1z

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Bradley Davidson
@bradleydavidson.bsky.social · Bluesky

More work getting at the precise genetic changes that resulted in human-specific cognition… how our minds came to be! Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment: Cell www.cell.com/cell/fulltex...

Jan 31, 2025 · 5 likes View post →
Carme Zaragoza
@CarmeZaragoza · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

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Hassan El-Amin
@hassanel_amin · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

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qicy
@qicy11 · X

RT @juhyunk_: Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https:/…

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Waggoner Lab
@LabWaggoner · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/zg5JouAK1X @CellCellPress @atreyop @NoonanLab https://t.co/ysK54wrblp

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Waggoner Lab
@labwaggoner.bsky.social · Bluesky

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment www.cell.com/cell/fulltex... @cellcellpress.bsky.social @atreyop.bsky.social @noonanlab.bsky.social

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Juhyun Kim
@juhyunk_ · X

Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment https://t.co/R9qDAAb2Gi

Jan 30, 2025 · 23 likes · 3 shares · 1,401 followers View post →
Atreyo Pal
@atreyop · X

RT @cedricboeckx: 2.“Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment”…

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cedric boeckx
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2.“Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment” https://t.co/4nEmtrVT6G

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Atreyo Pal
@atreyop · X

RT @biorxiv_genomic: Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment…

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bioRxiv Genomics
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Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment https://www.biorxiv.org/content/10.1101/2024.06.25.600691v1

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bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment https://www.biorxiv.org/content/10.1101/2024.06.25.600691v1

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bioRxiv Genomics
@biorxiv_genomic · X

Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment https://t.co/7oR7kLlios #biorxiv_genomic

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