Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to detect all stages of PDAC with better performance than the clinical biomarker CA 19-9." www.science.org/doi/10.1126/...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay.
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Feb 2025 – Sep 2025Where it's discussed
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X / Twitter106 posts
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News77 articles
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Bluesky11 posts
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Blogs6 articles
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YouTube4 videos
AI synopsis
What people are saying
The discussions reflect strong support and excitement for the assay, using words like 'promising', 'impressive', and 'could significantly enhance survival rates', which indicate high interest in its clinical impact. Posts cite specific figures like '85% sensitivity' and mention the assay's ability to detect all stages of pancreatic cancer, demonstrating in-depth engagement with the research's potential benefits and technical advancements.
Most discussions recognize the study's promising results, highlighting high sensitivity and specificity, indicating general support.
The posts show a high level of curiosity and enthusiasm about early detection methods for pancreatic cancer.
Several discussions delve into the technical details of the nanosensor assay, showing deep engagement with the research methodology and implications.
Many emphasize the potential for this assay to improve early diagnosis and survival rates, underscoring its significant clinical impact.
Abstract in brief
- The study introduces a new noninvasive blood test called PACMANN that can detect pancreatic ductal adenocarcinoma (PDAC) by measuring protease activity in the blood, which is higher in cancer patients, allowing for earlier diagnosis.
- They identified a specific peptide probe sensitive to enzymes (MMPs) that can differentiate PDAC patients from healthy controls with about 79% accuracy, and the test’s signal decreases after tumor removal, indicating it tracks tumor presence.
- The PACMANN assay, especially when combined with traditional markers like CA 19-9, achieved high sensitivity and specificity (up to 85% and 96%) in detecting early-stage PDAC and can distinguish between cancer and non-cancer pancreatic diseases, offering a promising tool for early diagnosis.]
Top posts
Most liked on X and Bluesky1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הקשור לסרטן. מטופלים מאובחנים לעיתים קרובות בשלבים מתקדמים כאשר אפשרויות הטיפול מוגבלות. חוקרים פיתחו https://t.co/1fX9O8UiHA https://t.co/UOlq5f5O9k
A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #TreatmentOptions. This advancement could significantly enhance survival rates. @sciencetm https://t.co/XosIBIQ2Pa https://t.co/fM47ZLKbTM
A new liquid biopsy assay named PAC-MANN detects protease activity in blood samples to distinguish #PancreaticCancer with promising sensitivity and specificity for early-stage tumors in a clinical study. @fischerjm @OHSUKnight https://t.co/ArBRtEqb6z https://t.co/OcSw9p0Lfg
A new liquid biopsy assay named PAC-MANN detects protease activity in blood samples to distinguish #PancreaticCancer with promising sensitivity and specificity for early-stage tumors in a clinical study. @fischerjm @OHSUKnight https://t.co/ArBRtEqb6z https://t.co/NK2oBMQD25
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to detect all stages of PDAC with better performance than the clinical biomarker CA 19-9." https://t.co/B40LHMtSdy https://t.co/zBRcYtyLJH
All mentions
Advances in Early Detection of Pancreatic Cancer Using Nanosensor Blood Test
This briefing covers recent developments in healthy longevity, including a novel blood test for early pancreatic cancer detection that measures protease activity, achieving high accuracy and offering promising prospects…
Advances in Noninvasive Blood Test for Early Pancreatic Cancer Detection
This video covers recent scientific developments including a noninvasive blood test called PACMANN that detects pancreatic cancer by measuring protease activity. The test shows high accuracy for early diagnosis and…
Analyzing Ancient Egyptian Mummies: Odor Profiles and Preservation Techniques
Ancient Egyptian mummification aimed to preserve bodies for the afterlife through a complex embalming process using various substances. The study examines mummies in the Egyptian Museum, analyzing odors to understand…
Innovative Blood Test for Early Pancreatic Cancer Detection
This video explores a new noninvasive blood test called PACMANN, which detects pancreatic cancer by measuring protease activity, enabling earlier diagnosis and improved treatment prospects.
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Do we have any test which has more than 76% sensitivity with low cost...can be used as a regular screening tool? Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/ckgmi3X576
RT @Aiims1742: Impressive early phase study on a promising biomarker assay for #PancreaticCancer in @ScienceTM Early detection of pancreat…
RT @Aiims1742: Impressive early phase study on a promising biomarker assay for #PancreaticCancer in @ScienceTM Early detection of pancreat…
RT @Aiims1742: Impressive early phase study on a promising biomarker assay for #PancreaticCancer in @ScienceTM Early detection of pancreat…
Impressive early phase study on a promising biomarker assay for #PancreaticCancer in @ScienceTM Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay https://t.co/8h6zfbc1Gg 85% sensitive for Stage 1 cancers at 96% specificity is great.
RT @Breast_ARMYteam: 膵臓がんが早期発見できる新規の血液検査を開発
RT @Breast_ARMYteam: 膵臓がんが早期発見できる新規の血液検査を開発
膵臓がんが早期発見できる新規の血液検査を開発
Une équipe de recherche a mis au point un test sanguin permettant la détection du cancer du pancréas à un stade précoce.
A recent study reported that a blood test to detect early-stage #pancreaticcancer achieved 98% specificity & 73% sensitivity! The test could accurately distinguish pancreatic ductal adenocarcinoma from other non-cancer pancreatic conditions. Learn more ⬇️ https://t.co/gRz6b42ESH https://t.co/g4jdJyA9GP
Early detection of #pancreatic #cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/O4NpPUdIoG
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine
I can't find OHSU or this lab on X, but really hoping to connect with the team. The world needs a pancreatic cancer blood screen to be commercialized. https://t.co/PpsbBqE9DS
RT @SoyPatriSenent:
RT @SoyPatriSenent:
RT @SoyPatriSenent:
RT @SoyPatriSenent:
A new liquid biopsy assay named PAC-MANN detects protease activity in blood samples to distinguish #PancreaticCancer with promising sensitivity and specificity for early-stage tumors in a clinical study. @fischerjm @OHSUKnight https://t.co/ArBRtEqb6z https://t.co/NK2oBMQD25
New nanosensor assay shows promise for early pancreatic cancer detection by Montoya Mira JL, Quentel A (...) Fischer JM et 12 al. in Sci Transl Med #Surgery #SurgSky #GeneralSurgery #MedSky
New nanosensor assay shows promise for early pancreatic cancer detection by Montoya Mira JL, Quentel A (...) Fischer JM et 12 al. in Sci Transl Med
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/2iWkplPMiL
Test auf Pankreaskarzinom mit hoher Sensitivität. #onkologie Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/P0eDioljzN
Pancreatic cancer, one of the deadliest cancers, can be detected early with just a small blood test by nanosensor, according to a study by Mira et al. published in Science Translational Medicine. #pancreaticcancer #nanosensor #PAC-MANN-1 https://t.co/4o95jgrqez https://t.co/CGI7lMxcsQ
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine www.science.org/doi/10.1126/...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/tZjGTF7mLt
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay - goo.gl/alerts/JWvkRA #GoogleAlerts
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay - https://t.co/AXqsSSDmPF #GoogleAlerts
Detection of #PancreaticCancer from protease activity in blood. Potential utility in monitoring therapy and early detection. https://t.co/MpJfzWKyQs
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Pancreatic Cancer - Detection by Blood Test (5 of 5) #health #fitness #wellness Researchers recently developed a noninvasive early detection assay for pancreatic cancer based on serum protease activity (called PAC-MANN-1). (Sci Transl Med 2025. doi: 10.1126/scitranslmed.adq3110)
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/XtOqKllgmC The problem is will early detection by such an assay theoretically just measure lead time and length time bias and ultimately
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/IveUsR0cHV
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @Dr_ElvinaA:
RT @Dr_ElvinaA:
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay www.science.org/doi/10.1126/... "The PAC-MANN assay combined with the clinical biomarker CA 19-9 was 85% sensitive for detection of stage I PDAC with 96% specificity."
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @ScienceTM: A new liquid biopsy assay named PAC-MANN detects protease activity in blood samples to distinguish #PancreaticCancer with pr…
A new liquid biopsy assay named PAC-MANN detects protease activity in blood samples to distinguish #PancreaticCancer with promising sensitivity and specificity for early-stage tumors in a clinical study. @fischerjm @OHSUKnight https://t.co/ArBRtEqb6z https://t.co/OcSw9p0Lfg
RT @BatyaCohen1: 1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הק…
RT @SciencNews: Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to…
糖鎖抗原CA 19-9のみでは難しかった膵臓がん早期検出に向けて。少量の末梢血から腫瘍で増加したプロテアーゼ活性を検出する方法“PAC-MANN-1”の開発。 Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay https://t.co/9j4f96uStZ
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/39UTniemyJ
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @AndrewW66619812: The paper in "Science Translational Medicine" the above "Nature" article is based upon, & links to: “Early detection…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay www.science.org/doi/10.1126/...
The paper in "Science Translational Medicine" the above "Nature" article is based upon, & links to: “Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay” 2/2 https://t.co/nKQw8nyDkj
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay - https://t.co/6BMw6AiuD6 #GoogleAlerts
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay - goo.gl/alerts/Bi4HJJ #GoogleAlerts
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @BatyaCohen1: 1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הק…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @weldeiry: Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay https://t.co/IZbNpY6gAX
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @BatyaCohen1: 1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הק…
RT @BatyaCohen1: 1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הק…
RT @BatyaCohen1: 1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הק…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @BatyaCohen1: 1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הק…
1/5 פיתוח מציל חיים, בדיקת דם פשוטה לגילוי סרטן הלבלב! אדנוקרצינומה של צינור הלבלב (PDAC) היא בין הסיבות העיקריות למוות הקשור לסרטן. מטופלים מאובחנים לעיתים קרובות בשלבים מתקדמים כאשר אפשרויות הטיפול מוגבלות. חוקרים פיתחו https://t.co/1fX9O8UiHA https://t.co/UOlq5f5O9k
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay https://t.co/ULAYLe62wI
RT @RaieBekele: A protease-activated nanosensor blood test enables early detection of pancreatic cancer. | Science Translational Medicine h…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
A protease-activated nanosensor blood test enables early detection of pancreatic cancer. | Science Translational Medicine https://t.co/OUrUfIT7SX
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine www.science.org/doi/10.1126/... #PancreaticCancer
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/zwQ7vrrbBH
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay www.science.org/doi/10.1126/...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay https://t.co/IZbNpY6gAX
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @SciencNews: Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to…
RT @SciencNews: Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to…
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to detect all stages of PDAC with better performance than the clinical biomarker CA 19-9." https://t.co/B40LHMtSdy https://t.co/zBRcYtyLJH
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to detect all stages of PDAC with better performance than the clinical biomarker CA 19-9." www.science.org/doi/10.1126/...
A rapid, noninvasive assay based on a fluorescently labeled protease-sensitive peptide coupled to a magnetic nanosensor to detect protease activity from a small sample of blood. | Science TM https://t.co/wx7wlybZ2x
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine www.science.org/doi/10.1126/...
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay | Science Translational Medicine https://t.co/fmfJvQYso8
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
RT @medical_xpress: A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #Tre…
A novel blood test, PAC-MANN, detects #PancreaticCancer with 85% accuracy, offering earlier diagnosis and improved #TreatmentOptions. This advancement could significantly enhance survival rates. @sciencetm https://t.co/XosIBIQ2Pa https://t.co/fM47ZLKbTM
RT @EricTopol: A different kind of Pac-Man! An innovative, rapid nanosensor assay to help diagnose early pancreatic cancer in people at hi…
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