Trends Mol Med September 2025 PMID 39966070

Gene therapies for neurogenetic disorders.

Orrin Devinsky, Jeff Coller, Rebecca Ahrens-Nicklas, X Shawn Liu, Nadav Ahituv, Beverly L Davidson, Kathie M Bishop, Yael Weiss, Ana Mingorance

Mentions

25
Peak: 14 in Feb 2025
across 5 sources since Feb 2025

Extended reach

35,374
potential audience

Total likes

57

Video views

213

Mentions per month

Feb 2025 – Nov 2025

Where it's discussed

  • X / Twitter15 posts
  • Bluesky3 posts
  • YouTube3 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

The posts show high engagement and interest, with phrases like 'so fun to write' and mentions of 'transformative potential,' highlighting excitement. Supportive comments about the review and focus on patient foundations reflect agreement, whereas the moderate impact score suggests discussions center on ongoing research rather than immediate clinical breakthroughs.

AgreementModerate agreement

Most posts express support and enthusiasm for the review, indicating agreement with its significance.

InterestHigh interest

Posts demonstrate high interest through mentions of new developments, podcasts, and discussions around gene therapies.

EngagementHigh engagement

Users actively engage by sharing links, discussing patient involvement, and emphasizing the importance of research foundations.

ImpactModerate impact

While the enthusiasm is clear, the actual perceived impact on clinical practice appears moderate, as most focus on research and awareness.

Abstract in brief

  • Gene therapies for neurogenetic disorders target genetic mutations causing over 1700 different diseases, but delivery challenges like the blood-brain barrier and neuron postmitotic nature make treatment difficult.
  • Since the approval of nusinersen in 2016, advancements have included new delivery methods such as BBB-crossing capsids, viral-like proteins, and lipid nanoparticles, as well as innovative therapeutic strategies like gene editing, RNA-based therapies, and epigenetics.
  • Patient-led organizations have played a crucial role in speeding up research and trial readiness, helping shape the development of new treatment options and shaping the future of gene therapy for neurogenetic disorders.]

Top posts

Most liked on X and Bluesky
Ana Mingorance
@CNSdrughunter · X

This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMolecMed We talk a lot about patient-led research foundations and clinical trial readiness because it matters a lot to us

Feb 17, 2025 · 30 likes · 9 shares · 3,311 followers View post →
Ana Mingorance
@cnsdrughunter.bsky.social · Bluesky

Check out our "Gene therapies for neurogenetic disorders" review at @cp-trendsmolecmed.bsky.social So fun to write! We talk a lot about #RareDisease patient foundations and clinical trial readiness because it matters a lot to us

Feb 17, 2025 · 15 likes · 6 shares View post →
Dennis Lal
@LalDennis · X

Episode 9 of our AI podcast series: Gene Therapies for Neurogenetic Disorders The AI podcast covers the new review from @epilepsia , @CNSdrughunter & team on gene therapies for neurogenetic disorders. AI Podcasts in Spanish, German and English: https://t.co/JuItWjNa3W https://t.co/wi5S3rAGKb

Feb 18, 2025 · 4 likes · 3,307 followers View post →
Cell Press
@cellpress.bsky.social · Bluesky

"Gene therapies for neurogenetic disorders" http://dlvr.it/TPHWjf Orrin Devinsky, @cnsdrughunter.bsky.social & colleagues @cp-trendsmolecmed.bsly.social #SfN2025

Nov 15, 2025 · 4 likes · 1 share View post →
Trends in Molecular Medicine
@TrendsMolecMed · X

ONLINE NOW: Gene therapies for neurogenetic disorders https://t.co/Brr6AeMyKr https://t.co/5VsAEMWrtu

Feb 18, 2025 · 1 like · 2 shares · 5,589 followers View post →
Ángel Aledo-Serrano
@AledoNeuro · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Mar 2, 2025 · 9 shares · 6,742 followers View post →

All mentions

Cell Press
@cellpress.bsky.social · Bluesky

"Gene therapies for neurogenetic disorders" http://dlvr.it/TPHWjf Orrin Devinsky, @cnsdrughunter.bsky.social & colleagues @cp-trendsmolecmed.bsly.social #SfN2025

Nov 15, 2025 · 4 likes · 1 share View post →
Almansour
@malmansour81 · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Mar 3, 2025 · 9 shares · 207 followers View post →
Benjamin Tan
@DrBenjaminTan · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Mar 3, 2025 · 9 shares · 571 followers View post →
Neuropediatrics®
@PedNeurol · X

Gene therapies for neurogenetic disorders https://t.co/W61atlpHvn

Mar 3, 2025 · 287 followers View post →
ong beng hooi
@ongbenghooi1 · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Mar 2, 2025 · 9 shares · 534 followers View post →
Alina Ivaniuk
@AlinaIvaniuk · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Mar 2, 2025 · 9 shares · 357 followers View post →
Ángel Aledo-Serrano
@AledoNeuro · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Mar 2, 2025 · 9 shares · 6,742 followers View post →
Trends in Molecular Medicine
@TrendsMolecMed · X

RT @TrendsMolecMed: ONLINE NOW: Gene therapies for neurogenetic disorders https://t.co/Brr6AeMyKr https://t.co/5VsAEMWrtu

Feb 19, 2025 · 2 shares · 5,589 followers View post →
Dennis Lal
@LalDennis · X

Episode 9 of our AI podcast series: Gene Therapies for Neurogenetic Disorders The AI podcast covers the new review from @epilepsia , @CNSdrughunter & team on gene therapies for neurogenetic disorders. AI Podcasts in Spanish, German and English: https://t.co/JuItWjNa3W https://t.co/wi5S3rAGKb

Feb 18, 2025 · 4 likes · 3,307 followers View post →
Trends in Molecular Medicine
@TrendsMolecMed · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Feb 18, 2025 · 9 shares · 5,589 followers View post →
備忘録
@bibourokuabc · X

RT @TrendsMolecMed: ONLINE NOW: Gene therapies for neurogenetic disorders https://t.co/Brr6AeMyKr https://t.co/5VsAEMWrtu

Feb 18, 2025 · 2 shares · 229 followers View post →
Trends in Molecular Medicine
@TrendsMolecMed · X

ONLINE NOW: Gene therapies for neurogenetic disorders https://t.co/Brr6AeMyKr https://t.co/5VsAEMWrtu

Feb 18, 2025 · 1 like · 2 shares · 5,589 followers View post →
cernais
@cernais_AI · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Feb 18, 2025 · 9 shares · 5 followers View post →
Nixa Sedes, MD
@nixassedes.bsky.social · Bluesky

Gene therapies for neurogenetic disorders www.sciencedirect.com/science/arti...

Feb 17, 2025 View post →
Andres Jimenez-Gomez MD
@dretico · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Feb 17, 2025 · 9 shares · 941 followers View post →
Asociación Síndrome de Phelan McDermid España
@PhelanMcDermid · X

RT @CNSdrughunter: This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMole…

Feb 17, 2025 · 9 shares · 1,698 followers View post →
Ana Mingorance
@cnsdrughunter.bsky.social · Bluesky

Check out our "Gene therapies for neurogenetic disorders" review at @cp-trendsmolecmed.bsky.social So fun to write! We talk a lot about #RareDisease patient foundations and clinical trial readiness because it matters a lot to us

Feb 17, 2025 · 15 likes · 6 shares View post →
Ana Mingorance
@CNSdrughunter · X

This was such a great review to write! Check out our "Gene therapies for neurogenetic disorders" review at @TrendsMolecMed We talk a lot about patient-led research foundations and clinical trial readiness because it matters a lot to us

Feb 17, 2025 · 30 likes · 9 shares · 3,311 followers View post →