Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations.

Giulia Ferraretti, Aina Rill, Paolo Abondio, Kyra Smith, Claudia Ojeda-Granados, Sara De Fanti, Marta Alberti, Massimo Izzi, Phurba T Sherpa, Paolo Cocco, Massimiliano Tiriticco, Marco Di Marcello, Agnese Dezi, Guido Alberto Gnecchi-Ruscone, Luca Natali

March 2025 Commun Biol

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Convergent Evolution in High-Altitude Humans Enhances Blood Flow Adaptations

Convergent Evolution in High-Altitude Humans Enhances Blood Flow Adaptations

Study info reveals that high-altitude Andean and Himalayan populations developed similar genetic adaptations in blood perfusion, showcasing convergent evolution driven by low oxygen environments.

Crediblyweekly

September 18, 2025

833 views

  • Tizio Incognito
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    Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations https://t.co/5zzYz8dj0X
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    Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations www.nature.com/articles/s42...
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    Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations: Communications Biology, Published online: 06 March 2025; doi:10.1038/s42003-025-07813-6Combination of selection scans and gene… https://t.co/ji93B9CBq3 https://t.co/V5nwH2QmZG
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Abstract Synopsis

  • The study explores how high-altitude Andean and Himalayan populations have developed similar complex traits, specifically in angiogenesis (blood vessel formation), due to natural selection.
  • Using advanced genomic methods, researchers found evidence of widespread selective pressures on genes involved in blood vessel growth, which are similar in both populations despite differences at individual genes.
  • The findings support the idea that convergent evolution occurs at the pathway level, driven by long-term exposure to low oxygen environments, leading to enhanced blood flow adaptations in high-altitude humans.]