Blood May 2025 PMID 40067117

Clonal hematopoiesis landscape in frequent blood donors.

Darja Karpova, Hector Huerga Encabo, Elisa Donato, Silvia Calderazzo, Michael Scherer, Miriam Llorian-Sopena, Aino-Maija Leppä, Roberto Würth, Patrick Stelmach, Despoina Papazoglou, Alessandra Ferrelli, Steven Ngo, Iuliia Kotova, Sabine Harenkamp, Kai Zimmer

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Mentions

202

Peak: 59 in Mar 2025

across 6 sources since Feb 2025

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1,547,147

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242

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Feb 2025 – Jun 2025

Where it's discussed

News114 articles
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AI synopsis

What people are saying

Multiple discussions mention key findings such as the link between frequent blood donation and beneficial genetic changes in stem cells, with remarks emphasizing phrases like 'linked to lower risk of pre-cancer gene' and 'promotes beneficial mutations'. The use of enthusiastic language and claims about changes in blood cell evolution contribute to a tone of excitement and underscore the perceived importance of the findings.

AgreementModerate agreement

Most discussions reflect a positive view towards the findings of the publication, indicating a general agreement.

InterestHigh interest

A variety of posts express a high level of curiosity surrounding the study and its implications for blood donation.

EngagementHigh engagement

Many participants provide detailed insights into specific aspects of the research, showcasing a strong engagement with the topic.

ImpactHigh impact

Participants frequently highlight the potential significance of the study in informing blood donation practices and health outcomes.

Abstract in brief

The study investigates the effects of frequent blood donation on clonal hematopoiesis (CH) in older male donors with extensive donation histories, finding no overall incidence difference between frequent and sporadic donors.
Detailed analysis revealed distinct mutational patterns in the DNMT3A gene, with functional tests showing that certain variants in frequent donors can promote competitive growth with erythropoietin (EPO) stimulation.
The findings suggest ongoing evolutionary changes in hematopoietic stem cells, highlighting EPO as a factor that may favor specific DNMT3A mutations under conditions of blood loss.

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血液の健康度を高めるには？

やまみー · Mar 23, 2025 9 views

Clonal Hematopoiesis and Genetic Changes in Frequent Blood Donors

This video investigates the effects of frequent blood donation on clonal hematopoiesis (CH) in older male donors. The study highlights distinct mutational patterns in the DNMT3A gene and suggests that erythropoietin…

【ポケモン•えほん•AI】ぎりちー · Mar 21, 2025 9 views

F. Niro Ghadaki

@FNGhadaki · X

Paper: Clonal hematopoiesis landscape in frequent blood donors https://t.co/qF5dpygkFn Giving blood linked to lower risk of pre-cancer gene – @TheCrick team finds genetic changes in #StemCells from frequent #BloodDonors that support production of new, non-cancerous cells. https://t.co/6cYCDL2v3H

Jun 24, 2025 · 2,707 followers View post →

Jim Cavet

@CavetJim · X

RT @TalhaBadarMD: Clonal hematopoiesis landscape in frequent blood donors https://t.co/lkThd0bRe3 Frequent blood donor > 120 lifetime don…

Jun 15, 2025 · 5 shares · 518 followers View post →

arimayo pures kiru

@ArimayoKiru · X

RT @cure_for_kids: #気まぐれ論文共有 https://t.co/8vSVtfI3yT Blood 2025 献血ドナーの献血頻度とクローン性造血の関係を調べています。頻回に献血するドナーはエリスロポエチン（EPO）が高い期間が長いことになりますが、クロー…

Jun 4, 2025 · 5 shares · 7 followers View post →

Toya

@takashtoy · X

Jun 4, 2025 · 5 shares · 357 followers View post →

mocchi

@mocchi_ym · X

Jun 4, 2025 · 5 shares · 211 followers View post →

KATOM

@cure_for_kids · X

Jun 4, 2025 · 24 likes · 5 shares · 1,929 followers View post →

Urja Parekh

@UrjaParekh · X

RT @BloodJournal: CH analysis of a unique and uniform cohort of exclusively healthy individuals exposed to a novel type of selection pressu…

May 28, 2025 · 9 shares · 420 followers View post →

Rabi Hanna

@RabiHannaMD · X

RT @BloodJournal: CH analysis of a unique and uniform cohort of exclusively healthy individuals exposed to a novel type of selection pressu…

May 28, 2025 · 9 shares · 2,547 followers View post →

Mraz Lab

@MrazLab · X

RT @BloodJournal: CH analysis of a unique and uniform cohort of exclusively healthy individuals exposed to a novel type of selection pressu…

May 28, 2025 · 9 shares · 515 followers View post →

Blood Journals Portfolio

@BloodPortfolio · X

May 28, 2025 · 29 likes · 9 shares · 53,534 followers View post →

Orlando Palma-Moreno MD

@plasmablasto · X

RT @TalhaBadarMD: Clonal hematopoiesis landscape in frequent blood donors https://t.co/lkThd0bRe3 Frequent blood donor > 120 lifetime don…

May 23, 2025 · 5 shares · 4,290 followers View post →

Ruth Wangondu MD PhD

@Wang_Rwang · X

RT @TalhaBadarMD: Clonal hematopoiesis landscape in frequent blood donors https://t.co/lkThd0bRe3 Frequent blood donor > 120 lifetime don…

May 22, 2025 · 5 shares · 1,060 followers View post →

Andrew J Wilson

@WilsonAndrewDr · X

RT @TalhaBadarMD: Clonal hematopoiesis landscape in frequent blood donors https://t.co/lkThd0bRe3 Frequent blood donor > 120 lifetime don…

May 22, 2025 · 5 shares · 1,885 followers View post →

Talha Badar

@TalhaBadarMD · X

May 22, 2025 · 25 likes · 5 shares · 3,936 followers View post →

Tom Watkins

@tbkwatkins · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Apr 6, 2025 · 17 shares · 1,184 followers View post →

Dr. Abdullah Aljedai

@Dr_Aljedai · X

Clonal Hematopoiesis Landscape in Frequent Blood Donors | Blood | American Society of Hematology https://t.co/Sf4GhEOlrv

Apr 4, 2025 · 3 likes · 948 followers View post →

HumbleMan☂️

@MarshawnTL · X

@microsamonomics @NathanielGivens I am unbothered, moisturized, in my lane levels of calm, sammy. If you actually read the screenshot of the opinion piece you could have easily found this. But keep riding that high horse

Apr 4, 2025 · 1,496 followers View post →

виробник коробок

@H_K_Y2022 · X

RT @MDPHD_mouchoi: この研究は男性高齢者、献血経験「100回超」「10回未満」を比較し、「100回超で明らかに多かった変異」を調べているが、回数で確率は上がっても変異の発生に閾値などがあるわけではないと思う論文リンク（適当なキーワードでググるといろんな言語…

Mar 30, 2025 · 2 shares · 401 followers View post →

真理波

@MDPHD_mouchoi · X

Mar 30, 2025 · 10 likes · 2 shares · 2,900 followers View post →

Ben Greenfield

@bengreenfield · X

...supporting the production of new, non-cancerous cells without increasing cancer risk, as reported in the journal Blood: https://t.co/hpmR3tLyN6

Mar 26, 2025 · 4 likes · 94,892 followers View post →

藤井　恒

@my_flute · X

RT @SARUMATA_MD_PhD: @my_flute ただし、その記事が書かれた根拠となる論文中では、その記事の方向性のようなことは全然記載されていません。 https://t.co/FvdsJCT74Y

Mar 25, 2025 · 1 share · 3,234 followers View post →

さるまた♋️血液内科SoundropsⅡ名古屋/大阪

@SARUMATA_MD_PhD · X

@my_flute ただし、その記事が書かれた根拠となる論文中では、その記事の方向性のようなことは全然記載されていません。 https://t.co/FvdsJCT74Y

Mar 25, 2025 · 2 likes · 1 share · 879 followers View post →

God's Autumn Enjoyer

@GPT_Neanderthal · X

This too now Link to study: https://t.co/DnqPMbw9Or https://t.co/XUwk2sUToi https://t.co/NqvLuPj8G3

Mar 23, 2025 · 5 likes · 2,311 followers View post →

Important thing

@Citrinell · X

https://t.co/3DArw7QILh https://t.co/nXpa1WzPjO

Mar 22, 2025 · 39 followers View post →

يوسف عبدالله الخرب

@yousef071113 · X

RT @a_altofily: تبرعك المتكرر بالدم قد يحميك من السرطان! دراسة حديثة كشفت أن المتبرعين على المدى الطويل لديهم طفرات جينية تقلل خطر الإصابة…

Mar 20, 2025 · 2 shares · 666 followers View post →

Stem Cells Research Unit

@ESCR_KFMRC · X

Mar 20, 2025 · 2 shares · 502 followers View post →

Dr. Abdullah Alzahrani | د. عبدالله

@a_altofily · X

تبرعك المتكرر بالدم قد يحميك من السرطان! دراسة حديثة كشفت أن المتبرعين على المدى الطويل لديهم طفرات جينية تقلل خطر الإصابة بسرطانات الدم، تحفز التبرعات تجدد الخلايا الجذعية بطريقة صحية، تبرعك بالدم لا ينقذ الآخرين فقط، بل قد يفيد صحتك أيضاً! https://t.co/hRuqncI9CS

Mar 20, 2025 · 5 likes · 2 shares · 2,633 followers View post →

Miguel A.

@AsimovIsaac1919 · X

Este hallazgo (https://t.co/f89TvGProB) sugiere que la donación regular de sangre podría estar asociada con un menor riesgo de desarrollar ciertos tipos de cáncer hematológico.

Mar 18, 2025 · 7,844 followers View post →

はげひげ（菊仙人）

@96hage · X

献血は自身の血液も健康にするようです。 https://t.co/8CVxeG7gNC

Mar 17, 2025 · 9 likes · 5,766 followers View post →

yayafa.bsky.social

@yayafa.bsky.social · Bluesky

よく献血している人は血液のがんになりにくいかもしれない – GIGAZINE https://www.yayafa.com/2233817/ 輸血や血液製剤のために必要な血液は、基本的に善意のボランティアによる無償の献血でまかなわれています。献血は多くの人々の命を救うことができる意義のある活動であり、新たな研究では「よく献血をする人は血液がんのリスクが低いかもしれない」という結果も示されました。 Clonal Hematopoiesis Landscape in Frequent Blood Donors | Blood | American Society of …

Mar 17, 2025 · 1 like View post →

멍멍몽

@TesalHolic3515 · X

RT @yepiny471: 최근 발표된 연구에 따르면, 정기적인 헌혈자들의 혈액 줄기세포에서 흥미로운 유전적 적응이 발견되었습니다. 정기 헌혈자에게 더 많이 발견되는 DNMT3A 돌연변이가 건강한 혈액 세포 재생을 촉진하고, 백혈병 위험을 증가시…

Mar 16, 2025 · 1 share · 465 followers View post →

yepiny

@yepiny471 · X

최근 발표된 연구에 따르면, 정기적인 헌혈자들의 혈액 줄기세포에서 흥미로운 유전적 적응이 발견되었습니다. 정기 헌혈자에게 더 많이 발견되는 DNMT3A 돌연변이가 건강한 혈액 세포 재생을 촉진하고, 백혈병 위험을 증가시키지 않으면서 혈액 세포 생성을 개선합니다. https://t.co/X1nYAs7KCI

Mar 16, 2025 · 7 likes · 1 share · 1,513 followers View post →

Agingdoc

@agingdoc1 · X

Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/fCaNwcbHGK

Mar 16, 2025 · 4 likes · 41,391 followers View post →

The Biomics

@TheBiomics · X

RT @TheBiomics: Men who had given blood more than 100 times in their life were more likely to have blood cells carrying certain beneficial…

Mar 15, 2025 · 1 share · 434 followers View post →

Mostafa Faisal

@MostafaFaisal14 · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 14, 2025 · 17 shares · 1,053 followers View post →

Patrick Stelmach

@pstelmach_md · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 14, 2025 · 17 shares · 25 followers View post →

The Biomics

@TheBiomics · X

Men who had given blood more than 100 times in their life were more likely to have blood cells carrying certain beneficial mutations, suggesting that donating blood promotes the growth of these cells. Source- Clonal Hematopoiesis Landscape in Frequent Blood Donors. PMID: https://t.co/scQh40Tj8Q

Mar 13, 2025 · 1 share · 434 followers View post →

Stem Cells Australia

@StemCellsAus · X

RT @AusStemCell: ‘Giving blood linked to lower risk of pre-cancer gene’ – Francis Crick Institute team finds 'genetic changes in stem cell…

Mar 13, 2025 · 2 shares · 4,554 followers View post →

Darja Karpova

@DarjaK1 · X

RT @AusStemCell: ‘Giving blood linked to lower risk of pre-cancer gene’ – Francis Crick Institute team finds 'genetic changes in stem cell…

Mar 13, 2025 · 2 shares · 69 followers View post →

Darja Karpova

@DarjaK1 · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 13, 2025 · 17 shares · 69 followers View post →

Rhys Morgan

@RhysMorganLab · X

Link to original article in @BloodJournal below: https://t.co/Tob8dCYtV5

Mar 13, 2025 · 1,205 followers View post →

Errant Thoughts

@ErrantThoughts · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 270 followers View post →

Nathalia Le Hen

@NathaliaLeHen · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 2,753 followers View post →

Abelus

@abelusmx · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 380 followers View post →

toros

@1985ivriz · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 163 followers View post →

Sanjay Patel, MD

@SanjayPatelMD · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 1,943 followers View post →

Almansour

@malmansour81 · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 209 followers View post →

JDanner

@JDanner28 · X

RT @humanOS_me: Blood donation may do more than just help others — it could reshape your own stem cell evolution, pushing it toward a lower…

Mar 12, 2025 · 1 share · 261 followers View post →

AA&MDSIF

@aamdsif · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 4,404 followers View post →

Jose Sandoval S, MD FACP

@HemSandoval · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 1,320 followers View post →

Orlando Palma-Moreno MD

@plasmablasto · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 4,290 followers View post →

Seth Corey, MD MPH

@sethcorey · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 1,129 followers View post →

Ezzard Charles Burdette

@ezzardcb · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 13 followers View post →

humanOS.me

@humanOS_me · X

Blood donation may do more than just help others — it could reshape your own stem cell evolution, pushing it toward a lower-risk pathway. Could this be yet another reason to donate blood? Study: 10.1182/blood.2024027999 https://t.co/ky9o0DEMbJ

Mar 12, 2025 · 2 likes · 1 share · 9,663 followers View post →

Urja Parekh

@UrjaParekh · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 420 followers View post →

Shih-Bo Huang

@ShihboHuang · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 99 followers View post →

Una

@jbtsiiMD · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 161 followers View post →

Abhinav Mathur

@AbhinavMathur92 · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 35 followers View post →

NP AGARWAL世界一フォローを目指しますAiming best in world.

@np_grwl · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 1,785 followers View post →

Nour A. Haidar

@nourhaidar4 · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 862 followers View post →

Dr. Chokri Ben Lamine

@abouabdrahman0 · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 2,076 followers View post →

Weisse Rose

@Z0KPiyAPUz8Mt4c · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 639 followers View post →

老人くん Rohjinkun

@rodinkun.bsky.social · Bluesky

Darja Karpova et al., Clonal Hematopoiesis Landscape in Frequent Blood Donors.

Mar 12, 2025 View post →

Carmelo Gurnari

@CarmeloGurnari · X

RT @AshKishtagari: Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 17 shares · 3,287 followers View post →

Stem Cell Foundation

@AusStemCell · X

‘Giving blood linked to lower risk of pre-cancer gene’ – Francis Crick Institute team finds 'genetic changes in stem cells from frequent blood donors that support production of new, non-cancerous cells'. @TheCrick @DKFZ [Paper: https://t.co/ScTMAuZmCn] https://t.co/Mi1nD23omC

Mar 12, 2025 · 3 likes · 2 shares · 14,870 followers View post →

Andromache Tziamou

@MaggieTziamou · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 12, 2025 · 20 shares · 2,821 followers View post →

Ashwin Kishtagari, MD

@AshKishtagari · X

Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j https://t.co/wfFuaugEIH

Mar 12, 2025 · 60 likes · 17 shares · 1,959 followers View post →

Ashwin Kishtagari, MD

@AshKishtagari · X

Clonal Hematopoiesis Landscape in Frequent Blood Donors https://t.co/tpL7KROo3j

Mar 12, 2025 · 1,959 followers View post →

Luis Alberto Luengo

@luengo1958 · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 11, 2025 · 20 shares · 17,518 followers View post →

rigved

@RigvedN · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 11, 2025 · 20 shares · 242 followers View post →

serrgv

@serrgv · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 11, 2025 · 20 shares · 148 followers View post →

EquateAll

@Equateall · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 11, 2025 · 20 shares · 7,397 followers View post →

Phys.org

@physorg_com · X

RT @medical_xpress: Regular #BloodDonation may promote beneficial #GeneticChanges in #BloodStemCells, supporting new cell production withou…

Mar 11, 2025 · 20 shares · 1,024,000 followers View post →

Medical Xpress

@medical_xpress · X

Mar 11, 2025 · 37 likes · 20 shares · 173,038 followers View post →

ESH (Haematology)

@ESHaematology · X

Beautifully presented configuration of the clonal hematopoiesis landscape in frequent blood donors by Dr. Darja Karpova. #ESHMICRO2025 #ESHCONFERENCES #EPO #DNMT3A https://t.co/h9LncEm6Nr

Feb 17, 2025 · 9 likes · 1 share · 14,808 followers View post →

Clonal hematopoiesis landscape in frequent blood donors.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

血液の健康度を高めるには？

Clonal Hematopoiesis and Genetic Changes in Frequent Blood Donors