Sci Adv March 2025 PMID 40085710

Senolytic treatment for low back pain.

Matthew Mannarino, Hosni Cherif, Saber Ghazizadeh, Oliver Wu Martinez, Kai Sheng, Elsa Cousineau, Seunghwan Lee, Magali Millecamps, Chan Gao, Alice Gilbert, Cedric Peirs, Reza Sharif Naeini, Jean A Ouellet, Laura S Stone, Lisbet Haglund

Mentions

92
Peak: 31 in Mar 2025
across 7 sources since Jan 2024

Extended reach

1,616,608
potential audience

Total likes

248

Video views

3,380

Mentions per month

Jan 2024 – Oct 2025

Where it's discussed

  • X / Twitter42 posts
  • News33 articles
  • Blogs8 articles
  • Bluesky3 posts
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

Several posts praise the research, emphasizing its innovative approach to treating low back pain by removing senescent cells, with words like 'potential,' 'excited,' and 'thrilled' conveying enthusiasm and high regard. The tone across posts is generally optimistic and anticipatory, while the context of referencing the publication indicates a shared interest in the transformative possibilities of senolytic therapies.

AgreementStrong agreement

Most discussions strongly support the potential of senolytics as a promising treatment for low back pain, indicated by phrases like 'excited to see,' 'potential,' and 'thrilled to share,' showing optimism about the research.

InterestHigh interest

Overall, there is high curiosity and relevance, with many posts highlighting the significance of the findings and the groundbreaking nature of targeting senescent cells, evidenced by terms like 'game changer' and 'exciting research.'

EngagementModerate engagement

While many discuss the implications and summarize the research, few posts delve into detailed mechanisms or critique the study, suggesting moderate but genuine engagement.

ImpactModerate impact

The discussions reflect a perception that this research could have meaningful clinical impacts, though some posts primarily celebrate the novelty rather than concrete applications, leading to a moderate impact perception.

Abstract in brief

  • Senescent cells accumulate due to aging and stress, causing inflammation that contributes to age-related issues like low back pain (LBP).
  • Senolytics, specifically -vanillin and RG-7112, can eliminate these senescent cells and reduce their harmful secretions in human intervertebral discs.
  • In mouse studies, these treatments showed significant reductions in LBP, improved intervertebral disc health, and lower pain marker expression in the spinal cord, suggesting their potential as new treatments for LBP and related disorders.

Top posts

Most liked on X and Bluesky
Eric Topol
@EricTopol · X

The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. @ScienceAdvances https://t.co/1GMhhoc99x https://t.co/PsStWO2u2Z

Mar 14, 2025 · 123 likes · 24 shares · 679,132 followers View post →
Agingdoc
@agingdoc1 · X

Senolytic treatment for low back pain https://t.co/qOw6jVyo4n

Mar 21, 2025 · 21 likes · 3 shares · 41,754 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS

Apr 23, 2025 · 12 likes · 4 shares · 505,819 followers View post →
Waggoner Lab
@LabWaggoner · X

Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord @ScienceAdvances @MattMannarino @HaglundLisbet https://t.co/mcCYAG5WnD https://t.co/qTDXs8oK2n

Mar 14, 2025 · 9 likes · 1 share · 11,452 followers View post →
Science Advances
@ScienceAdvances · X

Senolytic drugs, which target zombie cells that accumulate from aging and cellular stress, reduced degeneration in the spine and pain signaling in the spinal cords of mice. @mcgillu @HaglundLisbet https://t.co/iwJ2I9ftn9 https://t.co/Z3SJ5JkztI

Mar 18, 2025 · 4 likes · 1 share · 66,365 followers View post →
UMN Dept. of Anesthesiology
@UMNanes · X

Dr. Laura Stone's latest work in Science Advances suggests senolytics o-vanillin & RG-7112 reduce low back pain by clearing senescent cells, lowering inflammation, and improving spine health. ➡️ https://t.co/3VAahAfKA2 https://t.co/VjXFWhZMZB

Apr 30, 2025 · 3 likes · 1,368 followers View post →

All mentions

S. Davis Share
@Davis_Sharing · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Oct 18, 2025 · 24 shares · 601 followers View post →
Clara Dawn Ellington
@temple_bblythe · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Aug 9, 2025 · 24 shares · 128 followers View post →
UMN Dept. of Anesthesiology
@UMNanes · X

Dr. Laura Stone's latest work in Science Advances suggests senolytics o-vanillin & RG-7112 reduce low back pain by clearing senescent cells, lowering inflammation, and improving spine health. ➡️ https://t.co/3VAahAfKA2 https://t.co/VjXFWhZMZB

Apr 30, 2025 · 3 likes · 1,368 followers View post →
Jeffrey J. Wiegers, M.D.
@JeffWiegers · X

https://t.co/D8hnKs2QNS Senescence will be the buzzword that inflammation was for the last decade. Excited to see where this research leads

Apr 24, 2025 · 54 followers View post →
PulsePilot
@Pulse1Pilot · X

RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS

Apr 23, 2025 · 4 shares · 5,641 followers View post →
Rami EdgeLord
@KhouryHopes · X

RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS

Apr 23, 2025 · 4 shares · 34 followers View post →
Mari Carmen Porres
@LaPorres · X

RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS

Apr 23, 2025 · 4 shares · 10,669 followers View post →
Timmie Pollock, Ph.D.
@equexcellence · X

RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS

Apr 23, 2025 · 4 shares · 2,255 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS

Apr 23, 2025 · 12 likes · 4 shares · 505,819 followers View post →
Pain Research Forum
@PainResForum · X

Check out this #PapersoftheWeek #EditorsPick from @MattMannarino and @ScienceAdvances about the use of drugs that selectively target and remove senescent cells, such as o-vanillin and RG-7112, as treatment for low back pain https://t.co/ntFBBxea5H #PRF https://t.co/bt9Xqbngfh

Apr 4, 2025 · 1 like · 15,364 followers View post →
EJ
@EJuliachs · X

RT @agingdoc1: Senolytic treatment for low back pain https://t.co/qOw6jVyo4n

Mar 22, 2025 · 3 shares · 374 followers View post →
Alexander Morgan
@alex_biolit · X

RT @agingdoc1: Senolytic treatment for low back pain https://t.co/qOw6jVyo4n

Mar 22, 2025 · 3 shares · 21 followers View post →
Well Done
@welldone00 · X

RT @agingdoc1: Senolytic treatment for low back pain https://t.co/qOw6jVyo4n

Mar 21, 2025 · 3 shares · 1,059 followers View post →
Agingdoc
@agingdoc1 · X

Senolytic treatment for low back pain https://t.co/qOw6jVyo4n

Mar 21, 2025 · 21 likes · 3 shares · 41,754 followers View post →
แฮร่แง่ม
@khawnom · X

RT @pokrath: มีการทดลอง (ในหนู) ใช้ยา 2 ชนิดยับยั้ง degenerative change ของ lumbar spine ได้ sparc-/- หนูดัดแปลงพันธุกรรม wt หนูปกติ HO ยา…

Mar 21, 2025 · 2 shares · 11 followers View post →
Pokrath Hansasuta
@pokrath · X

มีการทดลอง (ในหนู) ใช้ยา 2 ชนิดยับยั้ง degenerative change ของ lumbar spine ได้ sparc-/- หนูดัดแปลงพันธุกรรม wt หนูปกติ HO ยาชนิดที่ 1 (high dose) HR ยาชนิดที่ 2 (high dose) HO+HR ให้สองชนิด ใกล้จะไม่ต้องปวดหลังแล้วสิมนุษย์ https://t.co/VjxFCl4Wvw https://t.co/1k9E1BSYnw

Mar 21, 2025 · 2 likes · 2 shares · 94,530 followers View post →
Science Advances
@ScienceAdvances · X

Senolytic drugs, which target zombie cells that accumulate from aging and cellular stress, reduced degeneration in the spine and pain signaling in the spinal cords of mice. @mcgillu @HaglundLisbet https://t.co/iwJ2I9ftn9 https://t.co/Z3SJ5JkztI

Mar 18, 2025 · 4 likes · 1 share · 66,365 followers View post →
Hosni Cherif, Dr
@HosniCherifDr1 · X

We’re thrilled to share our new paper, "Senolytic Treatment for Low Back Pain," published on March 14, 2025, in Science Advances!

Mar 17, 2025 · 43 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Senolytic treatment for low back pain Science Advances https://t.co/kdjxuf96Vm

Mar 17, 2025 · 2,568 followers View post →
Ordo Fraterna Fibonacci
@ordofibonacci.bsky.social · Bluesky

Senolytic treatment for low back pain Science Advances www.science.org/doi/10.1126/...

Mar 17, 2025 View post →
Shameela Kehkashan
@shameelake21941 · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 17, 2025 · 24 shares · 638 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 16, 2025 · 24 shares · 190 followers View post →
priya joseph
@ayirpelle · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 15, 2025 · 24 shares · 4,946 followers View post →
Rajani Desai
@bikecancermd · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 15, 2025 · 24 shares · 75 followers View post →
Eric
@ericsophia12 · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 15, 2025 · 24 shares · 94 followers View post →
Libert Nicolas
@dr_Libert_N · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 15, 2025 · 24 shares · 54 followers View post →
Elena Sáiz
@ElenaSaiz63 · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 15, 2025 · 24 shares · 6,422 followers View post →
Waggoner Lab
@LabWaggoner · X

Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord @ScienceAdvances @MattMannarino @HaglundLisbet https://t.co/mcCYAG5WnD https://t.co/qTDXs8oK2n

Mar 14, 2025 · 9 likes · 1 share · 11,452 followers View post →
Raj Sreedhar, MD
@RajSreedhar3 · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 133 followers View post →
Sarah
@SarahMya2000 · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 1,732 followers View post →
Eldon Edwards
@eldonredwards · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 2,607 followers View post →
José Ríos
@jose1rt · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 524 followers View post →
alberto brogi
@albertobrogi · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 176 followers View post →
Niraj
@uscaero · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 248 followers View post →
Maryem Ismael
@mismaela · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 219 followers View post →
Couch Potato : )
@syaberujyagaimo · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 383 followers View post →
josepalau.70@gmail.com
@JMpalauDuarte · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 1,110 followers View post →
Dr Murphy WeightLoss
@TakeWeightOffMD · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 6,813 followers View post →
Arcadiy Ivanov
@IAmArcIvanov · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 679 followers View post →
Clotilde I.
@Cloclozazaprive · X

RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…

Mar 14, 2025 · 24 shares · 802 followers View post →
Eric Topol
@EricTopol · X

The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. @ScienceAdvances https://t.co/1GMhhoc99x https://t.co/PsStWO2u2Z

Mar 14, 2025 · 123 likes · 24 shares · 679,132 followers View post →
bioRxiv Cell Biology
@biorxiv-cellbio.bsky.social · Bluesky

Senolytic Treatment for Low Back Pain. https://www.biorxiv.org/content/10.1101/2024.01.15.575738v1

Jan 16, 2024 View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Senolytic Treatment for Low Back Pain. https://www.biorxiv.org/content/10.1101/2024.01.15.575738v1

Jan 16, 2024 View post →
bioRxiv Cell Biology
@biorxiv_cellbio · X

Senolytic Treatment for Low Back Pain. https://t.co/OnwtlMYLP6 #biorxiv_cellbio

Jan 16, 2024 · 7,673 followers View post →
bioRxiv
@biorxivpreprint · X

Senolytic Treatment for Low Back Pain. https://t.co/JU48KkT5jU #bioRxiv

Jan 16, 2024 · 1 like · 137,337 followers View post →