The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. @ScienceAdvances https://t.co/1GMhhoc99x https://t.co/PsStWO2u2Z
Senolytic treatment for low back pain.
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Jan 2024 – Oct 2025Where it's discussed
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X / Twitter42 posts
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News33 articles
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Blogs8 articles
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Bluesky3 posts
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YouTube2 videos
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What people are saying
Several posts praise the research, emphasizing its innovative approach to treating low back pain by removing senescent cells, with words like 'potential,' 'excited,' and 'thrilled' conveying enthusiasm and high regard. The tone across posts is generally optimistic and anticipatory, while the context of referencing the publication indicates a shared interest in the transformative possibilities of senolytic therapies.
Most discussions strongly support the potential of senolytics as a promising treatment for low back pain, indicated by phrases like 'excited to see,' 'potential,' and 'thrilled to share,' showing optimism about the research.
Overall, there is high curiosity and relevance, with many posts highlighting the significance of the findings and the groundbreaking nature of targeting senescent cells, evidenced by terms like 'game changer' and 'exciting research.'
While many discuss the implications and summarize the research, few posts delve into detailed mechanisms or critique the study, suggesting moderate but genuine engagement.
The discussions reflect a perception that this research could have meaningful clinical impacts, though some posts primarily celebrate the novelty rather than concrete applications, leading to a moderate impact perception.
Abstract in brief
- Senescent cells accumulate due to aging and stress, causing inflammation that contributes to age-related issues like low back pain (LBP).
- Senolytics, specifically -vanillin and RG-7112, can eliminate these senescent cells and reduce their harmful secretions in human intervertebral discs.
- In mouse studies, these treatments showed significant reductions in LBP, improved intervertebral disc health, and lower pain marker expression in the spinal cord, suggesting their potential as new treatments for LBP and related disorders.
Top posts
Most liked on X and BlueskySenolytic treatment for low back pain https://t.co/qOw6jVyo4n
“Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS
Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord @ScienceAdvances @MattMannarino @HaglundLisbet https://t.co/mcCYAG5WnD https://t.co/qTDXs8oK2n
Senolytic drugs, which target zombie cells that accumulate from aging and cellular stress, reduced degeneration in the spine and pain signaling in the spinal cords of mice. @mcgillu @HaglundLisbet https://t.co/iwJ2I9ftn9 https://t.co/Z3SJ5JkztI
Dr. Laura Stone's latest work in Science Advances suggests senolytics o-vanillin & RG-7112 reduce low back pain by clearing senescent cells, lowering inflammation, and improving spine health. ➡️ https://t.co/3VAahAfKA2 https://t.co/VjXFWhZMZB
All mentions
Senolytic Therapies for Age-Related Low Back Pain
Senescent cells accumulate with age and stress, promoting inflammation linked to low back pain. Treatments with senolytics like -vanillin and RG-7112 reduce these cells and improve disc health, showing promise as…
Review of March 2025 Longevity Studies
This video reviews significant longevity studies from March, highlighting how low-frequency ultrasound can reverse cellular senescence, thereby increasing mouse lifespan. It also covers innovative methods for reducing…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
Dr. Laura Stone's latest work in Science Advances suggests senolytics o-vanillin & RG-7112 reduce low back pain by clearing senescent cells, lowering inflammation, and improving spine health. ➡️ https://t.co/3VAahAfKA2 https://t.co/VjXFWhZMZB
https://t.co/D8hnKs2QNS Senescence will be the buzzword that inflammation was for the last decade. Excited to see where this research leads
RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS
RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS
RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS
RT @NeuroscienceNew: “Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS
“Senolytic treatment for low back pain” by Lisbet Haglund et al. Science Advances https://t.co/x5Kvrv5rHS
Check out this #PapersoftheWeek #EditorsPick from @MattMannarino and @ScienceAdvances about the use of drugs that selectively target and remove senescent cells, such as o-vanillin and RG-7112, as treatment for low back pain https://t.co/ntFBBxea5H #PRF https://t.co/bt9Xqbngfh
RT @agingdoc1: Senolytic treatment for low back pain https://t.co/qOw6jVyo4n
RT @agingdoc1: Senolytic treatment for low back pain https://t.co/qOw6jVyo4n
RT @agingdoc1: Senolytic treatment for low back pain https://t.co/qOw6jVyo4n
Senolytic treatment for low back pain https://t.co/qOw6jVyo4n
RT @pokrath: มีการทดลอง (ในหนู) ใช้ยา 2 ชนิดยับยั้ง degenerative change ของ lumbar spine ได้ sparc-/- หนูดัดแปลงพันธุกรรม wt หนูปกติ HO ยา…
มีการทดลอง (ในหนู) ใช้ยา 2 ชนิดยับยั้ง degenerative change ของ lumbar spine ได้ sparc-/- หนูดัดแปลงพันธุกรรม wt หนูปกติ HO ยาชนิดที่ 1 (high dose) HR ยาชนิดที่ 2 (high dose) HO+HR ให้สองชนิด ใกล้จะไม่ต้องปวดหลังแล้วสิมนุษย์ https://t.co/VjxFCl4Wvw https://t.co/1k9E1BSYnw
Senolytic drugs, which target zombie cells that accumulate from aging and cellular stress, reduced degeneration in the spine and pain signaling in the spinal cords of mice. @mcgillu @HaglundLisbet https://t.co/iwJ2I9ftn9 https://t.co/Z3SJ5JkztI
We’re thrilled to share our new paper, "Senolytic Treatment for Low Back Pain," published on March 14, 2025, in Science Advances!
Senolytic treatment for low back pain Science Advances https://t.co/kdjxuf96Vm
Senolytic treatment for low back pain Science Advances www.science.org/doi/10.1126/...
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord @ScienceAdvances @MattMannarino @HaglundLisbet https://t.co/mcCYAG5WnD https://t.co/qTDXs8oK2n
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
RT @EricTopol: The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in…
The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. @ScienceAdvances https://t.co/1GMhhoc99x https://t.co/PsStWO2u2Z
Senolytic Treatment for Low Back Pain. https://www.biorxiv.org/content/10.1101/2024.01.15.575738v1
Senolytic Treatment for Low Back Pain. https://www.biorxiv.org/content/10.1101/2024.01.15.575738v1
Senolytic Treatment for Low Back Pain. https://t.co/OnwtlMYLP6 #biorxiv_cellbio
Senolytic Treatment for Low Back Pain. https://t.co/JU48KkT5jU #bioRxiv