Nat Neurosci May 2025 PMID 40087396

Endothelial TDP-43 depletion disrupts core blood-brain barrier pathways in neurodegeneration.

Omar M F Omar, Amy L Kimble, Ashok Cheemala, Jordan D Tyburski, Swati Pandey, Qian Wu, Bo Reese, Evan R Jellison, Bing Hao, Yunfeng Li, Riqiang Yan, Patrick A Murphy

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Many discussions reference the core findings of the study, emphasizing the correlation between TDP-43 depletion and changes in the blood-brain barrier. Phrases like 'crucial findings' and 'transformative insights' highlight the participants' excitement about the research's potential implications for conditions like Alzheimer's and ALS. The tone is predominantly positive, indicating a strong collective interest in the subject and recognizing the importance of the study in advancing understanding of neurodegeneration.

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The majority of discussions show strong support for the findings of the publication, indicating a consensus among participants.

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There is a high level of curiosity concerning the mechanisms outlined in the research, reflecting its relevance to ongoing studies.

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Users frequently express the belief that this study may significantly influence future research on neurodegenerative diseases.

Abstract in brief

Endothelial cells (ECs) are crucial for maintaining the blood-brain barrier, which often breaks down in neurodegenerative diseases.
Researchers used a unique method to analyze nuclei from postmortem human brain samples of 92 donors to uncover changes in ECs, indicating specific alterations in Alzheimer's, ALS, and frontotemporal degeneration.
The study found that the loss of a protein called TDP43 in ECs correlates with detrimental changes in gene expression, suggesting that TDP43 depletion may play a significant role in the deterioration of the blood-brain barrier in these disorders.

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Endothelial TDP43 Depletion and Blood-Brain Barrier Dysfunction

Join Michael and Amber on the Health Headliner Podcast as they discuss groundbreaking research revealing how endothelial TDP43 depletion contributes to blood-brain barrier dysfunction in Alzheimer's, ALS, and…

Health Headliner Podcast · Mar 18, 2025 27 views

P53 and Senescent Cells: Key Players in Chronic Inflammation

In this episode of the Health Headliner Podcast, hosts Michael and Amber explore how the tumor suppressor protein p53 collaborates with senescent cells to combat chronic inflammation. Discover potential therapeutic…

Health Headliner Podcast · Mar 19, 2025 11 views

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AD, ALS and FTD, exhibit a unique transcriptional signature. Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration www.nature.com/articles/s41...

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RT @MariAngelesMoro: Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration | Nature Neuroscience htt…

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration | Nature Neuroscience https://t.co/jdj8pLCExW

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@healingfromlc Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration https://t.co/cMRmJRHY1d Phosphorylated TDP43 Immunostain, Technical Component Only https://t.co/97faIPvvzL

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration https://t.co/FehLbFSzKh

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RT @thmonk_pf: 神経変性疾患におけるBBB障害にはTDP-43の枯渇が関与する Alzheimer病/ALS/FTLDなどの神経変性疾患において、毛細血管内皮細胞の核内TDP-43蛋白減少がNF-κB転写活性の異常亢進とWnt/β-catinine信号経路の抑制…

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration https://t.co/L6ss6imjrl via @medical_xpress

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration | Nature Neuroscience https://t.co/Gm3Wx51WsL

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RT @LukensJohnR: Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration @NatureNeuro https://t.co/IP…

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RT @LukensJohnR: Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration @NatureNeuro https://t.co/IP…

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Abraham Alahmad, PhD

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration www.nature.com/articles/s41...

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Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration @NatureNeuro https://t.co/IPN9N5qhJs

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Endothelial TDP-43 depletion disrupts core blood-brain barrier pathways in neurodegeneration.

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Endothelial TDP43 Depletion and Blood-Brain Barrier Dysfunction

P53 and Senescent Cells: Key Players in Chronic Inflammation