Nat Metab April 2025 PMID 40128612

Reversible reduction in brain myelin content upon marathon running.

Pedro Ramos-Cabrer, Alberto Cabrera-Zubizarreta, Daniel Padro, Mario Matute-González, Alfredo Rodríguez-Antigüedad, Carlos Matute

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AI synopsis

What people are saying

Many posts highlight the intriguing nature of temporary myelin reduction, especially in relation to energy use and neurological health, with words like 'reversible' and 'impact' emphasizing the significance. The tone is curious and analytical, reflecting an interest in how these findings could inform treatments or deepen understanding of brain plasticity in response to physical stress.

AgreementModerate agreement

Most discussions acknowledge the validity of the findings, with some expressing curiosity about potential applications such as treatments for neurological conditions.

InterestHigh interest

The posts show a high level of interest, as discussions revolve around the mechanisms and implications of temporary myelin reduction due to marathon running.

EngagementModerate engagement

The discussions demonstrate active engagement, with users referencing the reversible nature of the changes and possible energy-related functions of myelin.

ImpactModerate impact

The collective tone suggests that this research might influence future studies in neurology and exercise physiology, hinting at moderate potential impact.

Abstract in brief

This study used MRI to examine how marathon running affects brain structure in humans.
The research found that marathon running significantly reduces myelin water fraction in certain brain areas, which is linked to motor coordination and emotional processing, but this reduction is temporary and recovers within two months.
These results indicate that intense exercise can temporarily lower brain myelin content, similar to findings from studies on rodents suggesting myelin serves as an energy reserve during extreme physical activity.

Read the full abstract

All mentions

Effects of Marathon Running on Brain Myelin Content Reversibility

This study used MRI to examine how marathon running affects brain structure in humans. It found that marathon running significantly reduces myelin water fraction in certain brain areas, which is linked to motor…

Cuerpo y Metas · Mar 30, 2025 7,332 views

Effects of Marathon Running on Brain Myelin Content and Function

This MRI study explores how marathon running temporarily reduces brain myelin, impacting motor coordination and emotional processing. Myelin recovers within two months, indicating exercise's reversible influence on…

ThePenguinProf · Apr 16, 2025 1,886 views

Effects of Marathon Running on Brain Myelin Content and Recovery

This video explores how endurance exercise can temporarily reduce brain myelin content, impacting motor and emotional functions, with effects reversing within two months, highlighting the brain's resilience and…

Mario Rubbino · Apr 27, 2025 293 views

Does intense exercise impact cognitive function temporarily?

This episode reviews Darios Triathlon experience, discussing overtraining and its cognitive effects. A recent MRI study shows marathon running temporarily reduces brain myelin, affecting coordination and emotions, but…

Schwellentalk · Apr 13, 2025 38 views

Impact of Marathon Running on Brain Myelin Content: MRI Findings

This study used MRI to examine how marathon running affects brain structure in humans. It found that intense exercise temporarily reduces myelin water fraction in specific brain regions, which recovers within two…

犬も学ぶ雑学 · May 7, 2025 23 views

Neurobiolog Lab

@matutelab.bsky.social · Bluesky

Oct 7, 2025 View post →

José Luis Trejo

@JLTrejo2 · X

RT @MatuteLab: Learning how brain #myelin recovers after #marathon running may help uncovering new #treatments for #multiple #sclerosis See…

Jul 4, 2025 · 2 shares · 2,301 followers View post →

CIBER ISCIII

@CIBER_ISCIII · X

RT @MatuteLab: Learning how brain #myelin recovers after #marathon running may help uncovering new #treatments for #multiple #sclerosis See…

Jul 4, 2025 · 2 shares · 8,184 followers View post →

Neurobiology Lab

@MatuteLab · X

Jul 3, 2025 · 5 likes · 2 shares · 1,213 followers View post →

Patricia González-Rodríguez #SinCienciaNoHayFuturo

@pgonzrodriguez · X

RT @MatuteLab: New evidence on myelin as an energy source and store Reversible reduction in brain myelin content upon marathon running @upv…

Jun 21, 2025 · 12 shares · 17,470 followers View post →

Altamiro Bottino

@BottinoAltamiro · X

Reversible reduction in brain myelin content upon marathon running https://t.co/IP2SYgK1TQ https://t.co/Zq5x9N3GCa

May 16, 2025 · 94 followers View post →

Neurobiology Lab

@MatuteLab · X

RT @NatureJapan: [注目のHL] 神経科学：マラソンランナーは脳内のミエリンの可逆的な変化を経験する https://t.co/osCgQWhwFx Carlos Matuteらの@NatMetabolism #OA #論文 Reversible reducti…

May 1, 2025 · 2 shares · 1,213 followers View post →

SASMA

@SASMA_ZA · X

This week's Editor's Choice!

Apr 30, 2025 · 1,175 followers View post →

Tomoko Aoki

@kumamonhikonyan · X

Apr 30, 2025 · 2 shares · 480 followers View post →

Nature Japan

@NatureJapan · X

Apr 30, 2025 · 3 likes · 2 shares · 90,044 followers View post →

Kevin Vermeer

@kevinvermeer.bsky.social · Bluesky

I'm not David, but links to a similar topic are all over the Internet, so here's a link to the open-access paper "Reversible reduction in brain myelin content upon marathon running" by Ramos-Cabrer ey al: www.nature.com/articles/s42...

Apr 29, 2025 · 1 like · 1 share View post →

Hugo Almarza Salazar

@HugoAlmarza · X

RT @ShorterLab: Reversible reduction in brain myelin content upon marathon running: https://t.co/H0tnE8Z0Vq

Apr 28, 2025 · 3 shares · 6,821 followers View post →

Michitaka Suzuki

@MichitakaSuzuk1 · X

RT @ShorterLab: Reversible reduction in brain myelin content upon marathon running: https://t.co/H0tnE8Z0Vq

Apr 28, 2025 · 3 shares · 20 followers View post →

Daniel S.

@asecretcrow · X

RT @ShorterLab: Reversible reduction in brain myelin content upon marathon running: https://t.co/H0tnE8Z0Vq

Apr 27, 2025 · 3 shares · 537 followers View post →

ShorterLab

@ShorterLab · X

Reversible reduction in brain myelin content upon marathon running: https://t.co/H0tnE8Z0Vq

Apr 27, 2025 · 22 likes · 3 shares · 12,021 followers View post →

Adam Rochussen

@AdamRochussen · X

Very intriguing and tricky-to-interpret @NatMetabolism paper from a few weeks ago: https://t.co/pUhfBI8VAM The takeaway is that running a marathon reduces myelin in specific parts of the brain, but this recovers after 2 months. Sounds alarming!

Apr 20, 2025 · 2 likes · 347 followers View post →

Altamiro Bottino

@BottinoAltamiro · X

Qual o preço de estratégias erradas na gestão da energia estocada e mobilizada nos treinos e competições? Observem a longa janela de transitoriedade. Reversible reduction in brain myelin content upon marathon running https://t.co/IP2SYgK1TQ https://t.co/tyrgo0CAhB

Apr 17, 2025 · 94 followers View post →

Hiroshi Yamaguchi

@HYamaguchi · X

Reversible reduction in brain myelin content upon marathon running | Nature Metabolism https://t.co/iZAQzHCtOa

Apr 7, 2025 · 17,932 followers View post →

HYamaguchi

@hyamaguchi.bsky.social · Bluesky

Reversible reduction in brain myelin content upon marathon running | Nature Metabolism https://www.nature.com/articles/s42255-025-01244-7

Apr 7, 2025 View post →

無職Ph.D.のいまい

@1126Imaitk · X

マラソン後は一時的にミエリンが減る (Nat Metab) マラソンランナー10人の

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Nature Metabolism

@natmetabolism.nature.com · Bluesky

ICYMI: Reversible reduction in brain myelin content upon marathon running

Mar 31, 2025 · 1 like View post →

Mind Your Science!

@MindYourSci · X

RT @nick_krontiris: Reversible reduction in brain myelin content upon marathon running (open access) https://t.co/NyERyXB4Im

Mar 30, 2025 · 1 share · 133 followers View post →

Nick Krontiris

@nick_krontiris · X

Reversible reduction in brain myelin content upon marathon running (open access) https://t.co/NyERyXB4Im

Mar 29, 2025 · 1 like · 1 share · 18,966 followers View post →

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salvasapedraza.bsky.social

@salvasapedraza.bsky.social · Bluesky

Ramos-Cabrer, P., Cabrera-Zubizarreta, A., Padro, D. et al. Reversible reduction in brain myelin content upon marathon running. Nat Metab (2025). doi.org/10.1038/s422...

Mar 26, 2025 View post →

Salvador Pedraza

@salvasapedraza · X

Ramos-Cabrer, P., Cabrera-Zubizarreta, A., Padro, D. et al. Reversible reduction in brain myelin content upon marathon running. Nat Metab (2025). https://t.co/fdrRltTZ8T https://t.co/GeFl0rttkJ

Mar 26, 2025 · 6,524 followers View post →

thmonk

@thmonk_pf · X

RT @thmonk_pf: Myelin脂質が過酷な代謝条件下ではgliaのenergy貯蔵として機能する可能性マラソン走行後に運動調節/感覚感情統合に関わる脳領域で髄鞘水分画(髄鞘含有量の指標)が最大28%減少することを発見この減少は一時的であり、2ヶ月以内に完全に回…

Mar 25, 2025 · 3 shares · 1,633 followers View post →

Brain and Sleep Research Laboratory

@bsrlaboratory.bsky.social · Bluesky

Reversible reduction in brain myelin content upon marathon running www.nature.com/articles/s42...

Mar 25, 2025 View post →

LPJ Lab - Neuroimmunometabolism

@lpjlab.org · Bluesky

Reversible reduction in #brain #myelin content upon marathon #running www.nature.com/articles/s42...

Mar 25, 2025 · 3 likes View post →

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Climate, Ecology, War & More by Dr. Glen Barry, BigEarthData.ai

@bigearthdata.bsky.social · Bluesky

Reversible reduction in brain myelin content upon marathon running ->Nature | More info from EcoSearch

Mar 25, 2025 View post →

Reversible reduction in brain myelin content upon marathon running.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Effects of Marathon Running on Brain Myelin Content Reversibility

Effects of Marathon Running on Brain Myelin Content and Function

Effects of Marathon Running on Brain Myelin Content and Recovery

Does intense exercise impact cognitive function temporarily?

Impact of Marathon Running on Brain Myelin Content: MRI Findings