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Nat Biotechnol May 2025 PMID 40140559

Induced proximity at the cell surface.

Nicholas A Till, Muthukumar Ramanathan, Carolyn R Bertozzi

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68
Peak: 45 in Mar 2025
across 4 sources since Mar 2025

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747,266
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Mar 2025 – Jun 2025

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AI synopsis

What people are saying

The collective discussions show strong support and interest in the article, with posts calling it a 'powerful engineering strategy' and noting its potential for applications like targeted protein degradation and signaling regulation. The tone and choice of words reflect optimism about its future impact in both basic science and translational medicine, though engagement remains moderate with few in-depth analyses.

AgreementModerate agreement

Most discussions express strong support and appreciation for the significance of the research, highlighting phrases like 'advance the manipulation of responses' and 'powerful engineering strategy.'

InterestHigh interest

The posts demonstrate high curiosity about emerging technologies and applications, with mentions of targeted degradation, receptor inhibition, and signaling activation.

EngagementModerate engagement

Some discussions reference specific scientists and publications, suggesting active engagement, though overall responses are somewhat surface-level.

ImpactModerate impact

The posts imply that this research could have notable effects in biotechnology and medicine, emphasized by words like 'diverse applications' and 'powerful strategy.'

Abstract in brief

  • Molecular proximity is key in biology, influencing both normal and disease-related biochemical processes at the cell surface by regulating how proteins interact with each other.
  • Induced proximity refers to a molecular engineering technique where bifunctional molecules are created to bring two proteins together, leading to specific biological effects that can be harnessed for therapeutic applications.
  • This Review highlights the application of induced proximity in areas like targeted protein degradation, receptor inhibition, and activating intracellular signaling, suggesting a promising future for this approach in both basic research and practical medical uses.
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Nature Biotechnology
@NatureBiotech · X

Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 155 likes · 43 shares · 318,398 followers View post →
Nature Biotechnology
@NatureBiotech · X

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses https://t.co/6cyiXnxHgy https://t.co/gdoN3HcmOy

May 21, 2025 · 78 likes · 16 shares · 318,398 followers View post →
Nature Biotechnology
@natbiotech.nature.com · Bluesky

Induced proximity at the cell surface - @carolynbertozzi.bskyverified.social @stanfordchemistry.bsky.social go.nature.com/4c9hu6M

Mar 26, 2025 · 32 likes · 8 shares View post →
Nature Biotechnology
@natbiotech.nature.com · Bluesky

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses go.nature.com/4c9hu6M rdcu.be/em3WN

May 21, 2025 · 21 likes · 4 shares View post →
Iris
@irismarchal.bsky.social · Bluesky

Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @naturebiotech.bsky.social www.nature.com/articles/s41...

Mar 26, 2025 · 7 likes · 1 share View post →
Ram Vishwakarma
@R_A_Vishwakarma · X

Induced proximity at the cell surface for diverse applications, such as targeted protein degradation, receptor inhibition and activating intracellular signaling cascades. Modulation of surface in basic and translational science | Carolyn Bertozzi https://t.co/4hPhQaxAaK

Mar 28, 2025 · 5 likes · 1 share · 895 followers View post →

All mentions

Man_of_caliber
@Manofcaliber4 · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

Jun 14, 2025 · 16 shares · 5 followers View post →
Kylie
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RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 30, 2025 · 16 shares · 388 followers View post →
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@CuriouzMonkey · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 23, 2025 · 16 shares · 40 followers View post →
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@pandapalooza_59 · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 142 followers View post →
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RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 1,735 followers View post →
Sila Sopran
@SilaSoprancis · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 134 followers View post →
Yiming Zhou
@Yiming_Zhou_PhD · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 72 followers View post →
Paul Geeleher
@PGeeleher · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 652 followers View post →
Narkhyun Bae
@ghostbnh · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 523 followers View post →
A Better Innovation
@ABetterInnovat1 · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 22, 2025 · 16 shares · 50,784 followers View post →
Ahmed Ezat
@AhmedAdelEzat · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 21, 2025 · 16 shares · 86 followers View post →
priya joseph
@ayirpelle · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 21, 2025 · 16 shares · 4,897 followers View post →
Ryuta Koyama
@ryuta_koyama · X

Induced proximity at the cell surface | Nature Biotechnology https://t.co/d8h3b0753G

May 21, 2025 · 1 like · 381 followers View post →
Alfred C. Chin
@alfredcchin · X

RT @NatureBiotech: Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses…

May 21, 2025 · 16 shares · 414 followers View post →
Nature Biotechnology
@NatureBiotech · X

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses https://t.co/6cyiXnxHgy https://t.co/gdoN3HcmOy

May 21, 2025 · 78 likes · 16 shares · 318,398 followers View post →
Nature Biotechnology
@natbiotech.nature.com · Bluesky

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses go.nature.com/4c9hu6M rdcu.be/em3WN

May 21, 2025 · 21 likes · 4 shares View post →
PPBI
@PPBIOConsWW · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Apr 20, 2025 · 43 shares · 714 followers View post →
Grace Pruksarojanakul
@gracedpst · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 31, 2025 · 43 shares · 247 followers View post →
Anil Katare
@AnilKatare16518 · X

RT @R_A_Vishwakarma: Induced proximity at the cell surface for diverse applications, such as targeted protein degradation, receptor inhibit…

Mar 29, 2025 · 1 share · 4 followers View post →
Alex Chudnovskiy
@ChudnovskiyLab · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 28, 2025 · 43 shares · 829 followers View post →
Madhura Mohole
@MadhuraMohole · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 28, 2025 · 43 shares · 153 followers View post →
Ram Vishwakarma
@R_A_Vishwakarma · X

Induced proximity at the cell surface for diverse applications, such as targeted protein degradation, receptor inhibition and activating intracellular signaling cascades. Modulation of surface in basic and translational science | Carolyn Bertozzi https://t.co/4hPhQaxAaK

Mar 28, 2025 · 5 likes · 1 share · 895 followers View post →
Leonardo Viana
@leonardopviana · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 28, 2025 · 43 shares · 886 followers View post →
Antonio Cembellin Prieto
@A_Cembellin_Pri · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 428 followers View post →
Dear DNR
@OBrien4sheriff · X

Induced proximity at the cell surface Source: Nature https://t.co/puhO4kq7W7 Shared via the Google App

Mar 27, 2025 · 241 followers View post →
priya joseph
@ayirpelle · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 4,897 followers View post →
Christopher Richards
@ChrisVirology · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 32 followers View post →
Xing Wang Research Group
@XingWangGroup · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 362 followers View post →
Nhung Truong
@mynhungtruong · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 9 followers View post →
花鳥風月
@kachofugetsujp · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 1,622 followers View post →
John Janetzko
@jjanetzko · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 3,242 followers View post →
Shiva Shankar S
@BioShankar · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 160 followers View post →
Fourth Grace
@EuphrosMD · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 38 followers View post →
Dirk H. Siepe
@dhsiepe · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 33 followers View post →
Solomon Oguche
@Soloattah · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 104 followers View post →
adeliebiology
@adeliebiology · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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Mochammad Ichsan
@ichsanomics · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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Koshi Kinoshita
@bruinwhitered · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 74 followers View post →
Samer Alhawa
@SamAlhawaBio · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 4 followers View post →
Avash Das, MBBS, PhD
@avash22 · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 1,015 followers View post →
Aaron Novikoff
@AaronNovikoff · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 437 followers View post →
Protein-Degraders
@ProtDegraders · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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Onu Anda
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RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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Alexander Wittenberg
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RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 27, 2025 · 43 shares · 189 followers View post →
Kyle Dyson
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RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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PandaPalooza
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RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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John Mariani
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RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 288 followers View post →
Paul Geeleher
@PGeeleher · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 652 followers View post →
nike
@wot_mikey · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 465 followers View post →
Jen
@jpadilla_DH · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 80 followers View post →
Ferroproteina
@Ferroproteina · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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Ryan Lu
@RyanLu_CRP · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

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Scott C Blanchard
@TheBlanchardLab · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 2,242 followers View post →
Guido van Mierlo
@GuidoMierlo · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 282 followers View post →
Ramakrishnan
@ramki17071993 · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 341 followers View post →
Palmarine128
@Palmarine128 · X

RT @NatureBiotech: Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 43 shares · 15,030 followers View post →
Nature Biotechnology
@natbiotech.nature.com · Bluesky

Induced proximity at the cell surface - @carolynbertozzi.bskyverified.social @stanfordchemistry.bsky.social go.nature.com/4c9hu6M

Mar 26, 2025 · 32 likes · 8 shares View post →
Nature Biotechnology
@NatureBiotech · X

Induced proximity at the cell surface - @CarolynBertozzi https://t.co/tgtdWuTzqp https://t.co/wQBGggxSTG

Mar 26, 2025 · 155 likes · 43 shares · 318,398 followers View post →
Ah-Ram Kim
@ahramkim1128 · X

Induced proximity at the cell surface https://t.co/5Q8kBKAk5U

Mar 26, 2025 · 1 like · 282 followers View post →
Iris Marchal
@iris_march_ · X

Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @NatureBiotech https://t.co/b7doi5gN8w

Mar 26, 2025 · 2 likes · 63 followers View post →
Iris
@irismarchal.bsky.social · Bluesky

Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in @naturebiotech.bsky.social www.nature.com/articles/s41...

Mar 26, 2025 · 7 likes · 1 share View post →