PubHawk
April 2025 PMID 40215311

Confirmation of Breslow's hypothesis: A carbene stable in liquid water.

Varun Tej Raviprolu, Aaron Gregory, Isaac Banda, Scott G McArthur, Sarah E McArthur, William A Goddard, Charles B Musgrave, Vincent Lavallo

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Mentions

66
Peak: 25 in Apr 2025
across 6 sources since Apr 2025

Extended reach

1,080,996
potential audience

Total likes

121

Video views

297

Mentions per month

Apr 2025 – Sep 2025

Where it's discussed

  • X / Twitter27 posts
  • News27 articles
  • Blogs5 articles
  • Bluesky3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions collectively reflect widespread excitement, with phrases like 'nice one!' and mentions of the 67-year-old theory being confirmed. The tone is celebratory and emphasizes the potential for greener, more efficient chemical processes, demonstrating a high level of interest and perceived significance in the scientific community.

AgreementStrong agreement

Most discussions express enthusiasm and support for the confirmation of Breslow's hypothesis, emphasizing its significance in chemistry.

InterestHigh interest

The topic appears highly engaging for the community, with many posts highlighting the importance and implications of the discovery.

EngagementModerate engagement

Several posts show active engagement by sharing enthusiasm, such as 'nice one!', indicating genuine interest and recognition of the breakthrough.

ImpactHigh impact

Participants believe that confirming the existence of stable carbenes in water could have broad implications, especially for green chemistry and pharmaceutical development.

Abstract in brief

  • The text discusses Breslow's 1958 hypothesis that vitamin B (thiamine) produces transient carbenes in water, which help enzymes catalyze reactions, challenging the idea that carbenes can't exist in water.
  • Although indirect evidence like labeling experiments supported this idea, no direct spectroscopic proof was available until now.
  • The study presents the synthesis and detailed spectroscopic analysis of a carbene that is stable in water, providing clear evidence that carbenes can exist in aqueous environments, confirming Breslow's early hypothesis.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Phys.org
@physorg_com · X

#A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for greener, more efficient pharmaceutical production. @UCRiverside @ScienceAdvances https://t.co/FobgcSsNna https://t.co/ysiclxZXNc

Apr 21, 2025 · 59 likes · 20 shares · 1,024,114 followers View post →
Taichi Koike
@SiAdamas · X

nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 51 likes · 10 shares · 636 followers View post →
Abhik Ghosh
@abhikghosh · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/prFa7VtbTp

May 26, 2025 · 2 likes · 2,253 followers View post →
Arumugam Jayaraman
@AruJayaram6 · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/W32HnjQpRy

Apr 14, 2025 · 2 likes · 135 followers View post →
Dr. Rick Pescatore
@Rick_Pescatore · X

@edwin_leap Fascinating stuff: https://t.co/qkuljaa3Jz.

Jul 7, 2025 · 1 like · 36,721 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water Science Advances https://t.co/r45DAmPPGn

Apr 15, 2025 · 1 like · 2,569 followers View post →

All mentions

Altamiro Bottino
@BottinoAltamiro · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water https://t.co/qekMjCMXBK https://t.co/h90pg0vIdo

Sep 15, 2025 · 93 followers View post →
Dr. Rick Pescatore
@Rick_Pescatore · X

@edwin_leap Fascinating stuff: https://t.co/qkuljaa3Jz.

Jul 7, 2025 · 1 like · 36,721 followers View post →
Abhik Ghosh
@abhikghosh · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/prFa7VtbTp

May 26, 2025 · 2 likes · 2,253 followers View post →
M1Κ4_3L
@M1K4_3L · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/HCFIZ2GMuP

May 7, 2025 · 2,341 followers View post →
StereoMatch
@stereomatch2 · X

Paper: https://t.co/zTMfE5mZtw Confirmation of Breslow’s hypothesis: A carbene stable in liquid water 11 April 2025

May 6, 2025 · 766 followers View post →
Robert Olney
@boretrol · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/3i8m7fevQF

Apr 25, 2025 · 1 like · 1,672 followers View post →
HN
@hnws.bsky.social · Bluesky

Confirmation of Breslow's hypothesis: A carbene stable in liquid water L: https://www.science.org/doi/10.1126/sciadv.adr9681 C: https://news.ycombinator.com/item?id=43764805 posted on 2025.04.22 at 14:11:22 (c=1, p=14)

Apr 23, 2025 View post →
Andrew
@cevaboyz · X

Confirmation of Breslow's hypothesis: A carbene stable in liquid water https://t.co/cZtlTLPaU6 2

Apr 23, 2025 · 139 followers View post →
Hacker News Top 100 Bot (Unofficial)
@hn100.bsky.social · Bluesky

Confirmation of Breslow's hypothesis: A carbene stable in liquid water Discussion

Apr 23, 2025 View post →
Yaroslav Borodkin
@BorodkinYar · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 22, 2025 · 10 shares · 130 followers View post →
Wenyang Hong
@HWenyang · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 22, 2025 · 10 shares · 78 followers View post →
Guy-Stone, MD, MPH
@MPH_Stone · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 22, 2025 · 10 shares · 583 followers View post →
Dr Anthony Martin
@AMAinsight · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/VINc6VCVkp

Apr 22, 2025 · 912 followers View post →
Subhajit Chakraborty
@schlenkchemist · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 22, 2025 · 10 shares · 507 followers View post →
Hayoung Song
@HSong_chem · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 10 shares · 416 followers View post →
Jacsol Joc
@jacsoljoc · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 10 shares · 973 followers View post →
Sakabe, M.
@MSakabe51 · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 10 shares · 425 followers View post →
Maxleung
@Leungtszfai3 · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 10 shares · 239 followers View post →
Roland Roesler
@RolandRoesler · X

RT @SiAdamas: nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 10 shares · 1,610 followers View post →
Taichi Koike
@SiAdamas · X

nice one! https://t.co/viYf4tpgK6

Apr 21, 2025 · 51 likes · 10 shares · 636 followers View post →
serrgv
@serrgv · X

RT @physorg_com: #A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for…

Apr 21, 2025 · 20 shares · 147 followers View post →
Shapley Fürskyn
@shiva137 · X

RT @physorg_com: #A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for…

Apr 21, 2025 · 20 shares · 219 followers View post →
Nirmata
@En_formare · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water • Science Advances https://t.co/JwQ8UJbrMq https://t.co/5Ixx5h2CMP

Apr 21, 2025 · 1 like · 442 followers View post →
Fernando Jimenez Motte
@stockfjm · X

RT @physorg_com: #A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for…

Apr 21, 2025 · 20 shares · 1,433 followers View post →
Autistic interpretation
@P87951Proxiss · X

RT @physorg_com: #A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for…

Apr 21, 2025 · 20 shares · 358 followers View post →
Yasemin Ersun-Hallsb
@ENVHandSR · X

RT @physorg_com: #A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for…

Apr 21, 2025 · 20 shares · 348 followers View post →
Phys.org
@physorg_com · X

#A 67-year-old theory about vitamin B1 is confirmed as chemists stabilize a reactive #Carbene in water, paving the way for greener, more efficient pharmaceutical production. @UCRiverside @ScienceAdvances https://t.co/FobgcSsNna https://t.co/ysiclxZXNc

Apr 21, 2025 · 59 likes · 20 shares · 1,024,114 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water Science Advances https://t.co/r45DAmPPGn

Apr 15, 2025 · 1 like · 2,569 followers View post →
Ordo Fraterna Fibonacci
@ordofibonacci.bsky.social · Bluesky

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water Science Advances www.science.org/doi/10.1126/...

Apr 15, 2025 View post →
Arumugam Jayaraman
@AruJayaram6 · X

Confirmation of Breslow’s hypothesis: A carbene stable in liquid water | Science Advances https://t.co/W32HnjQpRy

Apr 14, 2025 · 2 likes · 135 followers View post →