Proteorhodopsin insights into the molecular mechanism of vectorial proton transport.

Sergey Bukhdruker, Ivan Gushchin, Vitaly Shevchenko, Kirill Kovalev, Vitaly Polovinkin, Fedor Tsybrov, Roman Astashkin, Alexey Alekseev, Anatoly Mikhaylov, Siarhei Bukhalovich, Dmitry Bratanov, Yury Ryzhykau, Daria Kuklina, Nicolas Caramello, Tatyana Rokitskaya

April 2025 Sci Adv

Synopsis of Social media discussions

The overall tone demonstrates strong interest and support for the detailed structural insights, exemplified by comments such as 'this is the level of detail we aim for' and expressions of congratulations, which indicate recognition of its scientific importance. The use of technical terms and references to methods suggest that the discussions involve a deep engagement with the research's implications.

A
Agreement
 Moderate agreement

Most discussions show enthusiastic support and recognition for the importance of the structural findings, especially with phrases like 'congratulations' and 'finally read about it,' indicating agreement with the significance of the research.

I
Interest
 High level of interest

Several posts highlight the detailed nature of the structural data and the aim to deepen understanding, reflecting high interest in the scientific content.

E
Engagement
 Moderate level of engagement

Posts reference specific methods like X-ray crystallography and discuss the process behind the research, suggesting a meaningful level of engagement.

I
Impact
 Moderate level of impact

The discussions imply that this research could inform future studies in bacterial proton pumps and bio-molecular mechanisms, showing a moderate potential impact.

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13 Posts

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75,730

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Posts referencing the article

Understanding Proteorhodopsins and Proton Transport Mechanisms

Understanding Proteorhodopsins and Proton Transport Mechanisms

Proteorhodopsins are bacterial light-driven proton pumps vital for marine bacteria. This study presents atomic-resolution structures revealing how these proteins transfer protons through specific pathways and the role of retinal Schiff base in the process.

Ascending Prism

August 23, 2025

5,163 views

  • Toyota_Group_Komaba
    @KomaToug (Twitter)

    RT @LabInoue: High-resolution atomic structures of the late intermediate states of proteorhodopsin (MAR) by Prof. Gordeliy and his team! Co…
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    April 19, 2025

    1

  • SciencesNetwork
    @SciencesNetwork (Twitter)

    Proteorhodopsin insights into the molecular mechanism of vectorial proton transport. https://t.co/SazcIRP261
    view full post

    April 19, 2025

  • INOUE lab. (ISSP, Univ. Tokyo)
    @LabInoue (Twitter)

    High-resolution atomic structures of the late intermediate states of proteorhodopsin (MAR) by Prof. Gordeliy and his team! Congratulations!✨ https://t.co/SA6uvtjTJY @ScienceAdvances #OpenAccess https://t.co/eqMKS80eNe
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    April 18, 2025

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  • Isabel Ferrera
    @IsabelFerreraC (Twitter)

    RT @jcamthrash: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh
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    April 18, 2025

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  • Dr. Geo (Michel Geovanni Santiago-Martínez, PhD)
    @GeoSantiagoM (Twitter)

    RT @jcamthrash: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh
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    April 18, 2025

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  • Cameron Thrash
    @jcamthrash.bsky.social (Bluesky)

    Proteorhodopsin insights into the molecular mechanism of vectorial proton transport www.science.org/doi/full/10.... #jcampubs
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    April 18, 2025

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  • Cameron Thrash
    @jcamthrash (Twitter)

    Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh
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    April 18, 2025

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  • Vincent Zimmerman
    @zimmermanv66.bsky.social (Bluesky)

    Proteorhodopsin insights into the molecular mechanism of vectorial proton transport Source: Science | AAAS search.app/J61BZ Shared via the Google App
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    April 17, 2025

  • Kirill Kovalev
    @kirkovalev94 (Twitter)

    Also is worth reposting once again, as this is the level of details we aim at with X-ray crystallography. You can finally read about it in https://t.co/ek8xGDr5Dt from @bukhdruker and colleagues https://t.co/CmAnkJk9eS
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    April 17, 2025

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  • Dmitrii Zabelskii
    @dzabelskii (Twitter)

    RT @bukhdruker: The scientific process can be compared to the relay of the Olympic flame. I was glad to receive it from @ivangushchin. Find…
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    April 17, 2025

    1

  • Sergey Bukhdruker
    @bukhdruker (Twitter)

    The scientific process can be compared to the relay of the Olympic flame. I was glad to receive it from @ivangushchin. Find out why studying proteorhodopsin took 10 years in our new article: https://t.co/OqfF90Phnx. Spoiler: inside you'll find some brilliant structural data.
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    April 17, 2025

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  • @gen0m1cs
    @gen0m1cs (Twitter)

    RT @SciencesNetwork: #GWAS: https://t.co/4w0GYSJjgy https://t.co/r7wxLzU0VC https://t.co/LnP8i1s6GP https://t.co/SazcIRP261 https://t.co/JU…
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    April 17, 2025

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  • SciencesNetwork
    @SciencesNetwork (Twitter)

    #GWAS: https://t.co/4w0GYSJjgy https://t.co/r7wxLzU0VC https://t.co/LnP8i1s6GP https://t.co/SazcIRP261 https://t.co/JUc6Qn3cQB https://t.co/cTuiXN41sf https://t.co/HXPKBPw8V7
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    April 17, 2025

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  • サクセスリバーコーテシーinエイトプリンス
    @rei_nari (Twitter)

    RT @pacyc1841: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://t.co/rPnrlkiq…
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    April 16, 2025

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  • Tominaga K. (tomiken)
    @pacyc1841 (Twitter)

    Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://t.co/rPnrlkiq6G
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    April 16, 2025

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  • Tominaga K. (tomiken)
    @pacyc184.bsky.social (Bluesky)

    Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://www.science.org/doi/10.1126/sciadv.adu5303
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    April 16, 2025

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Abstract Synopsis

  • Bacterial proton pumps called proteorhodopsins (PRs) are unique light-driven membrane proteins found in marine bacteria, differing significantly from similar proteins in archaea and eukaryotes.
  • To better understand how PRs transfer protons and how they compare to nonbacterial pumps, high-resolution structures of these proteins in their functional states are essential.
  • This study presents atomic-resolution structures of a marine PR, MAR, especially in the complex late O intermediate state, revealing critical features for light-driven proton pumping, such as long hydrogen-bonded pathways, short hydrogen bonds for proton storage, and the role of the retinal Schiff base as the main proton donor and acceptor.