Sci Adv April 2025 PMID 40238873

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport.

Sergey Bukhdruker, Ivan Gushchin, Vitaly Shevchenko, Kirill Kovalev, Vitaly Polovinkin, Fedor Tsybrov, Roman Astashkin, Alexey Alekseev, Anatoly Mikhaylov, Siarhei Bukhalovich, Dmitry Bratanov, Yury Ryzhykau, Daria Kuklina, Nicolas Caramello, Tatyana Rokitskaya

Mentions

21
Peak: 16 in Apr 2025
across 5 sources since Apr 2025

Extended reach

75,730
potential audience

Total likes

86

Video views

5,163

Mentions per month

Apr 2025 – Aug 2025

Where it's discussed

  • X / Twitter13 posts
  • Bluesky3 posts
  • News2 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone demonstrates strong interest and support for the detailed structural insights, exemplified by comments such as 'this is the level of detail we aim for' and expressions of congratulations, which indicate recognition of its scientific importance. The use of technical terms and references to methods suggest that the discussions involve a deep engagement with the research's implications.

AgreementModerate agreement

Most discussions show enthusiastic support and recognition for the importance of the structural findings, especially with phrases like 'congratulations' and 'finally read about it,' indicating agreement with the significance of the research.

InterestHigh interest

Several posts highlight the detailed nature of the structural data and the aim to deepen understanding, reflecting high interest in the scientific content.

EngagementModerate engagement

Posts reference specific methods like X-ray crystallography and discuss the process behind the research, suggesting a meaningful level of engagement.

ImpactModerate impact

The discussions imply that this research could inform future studies in bacterial proton pumps and bio-molecular mechanisms, showing a moderate potential impact.

Abstract in brief

  • Bacterial proton pumps called proteorhodopsins (PRs) are unique light-driven membrane proteins found in marine bacteria, differing significantly from similar proteins in archaea and eukaryotes.
  • To better understand how PRs transfer protons and how they compare to nonbacterial pumps, high-resolution structures of these proteins in their functional states are essential.
  • This study presents atomic-resolution structures of a marine PR, MAR, especially in the complex late O intermediate state, revealing critical features for light-driven proton pumping, such as long hydrogen-bonded pathways, short hydrogen bonds for proton storage, and the role of the retinal Schiff base as the main proton donor and acceptor.

Top posts

Most liked on X and Bluesky
INOUE lab. (ISSP, Univ. Tokyo)
@LabInoue · X

High-resolution atomic structures of the late intermediate states of proteorhodopsin (MAR) by Prof. Gordeliy and his team! Congratulations!✨ https://t.co/SA6uvtjTJY @ScienceAdvances #OpenAccess https://t.co/eqMKS80eNe

Apr 18, 2025 · 10 likes · 1 share · 946 followers View post →
Cameron Thrash
@jcamthrash · X

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh

Apr 18, 2025 · 9 likes · 2 shares · 17,421 followers View post →
Tominaga K. (tomiken)
@pacyc1841 · X

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://t.co/rPnrlkiq6G

Apr 16, 2025 · 9 likes · 1 share · 860 followers View post →
Kirill Kovalev
@kirkovalev94 · X

Also is worth reposting once again, as this is the level of details we aim at with X-ray crystallography. You can finally read about it in https://t.co/ek8xGDr5Dt from @bukhdruker and colleagues https://t.co/CmAnkJk9eS

Apr 17, 2025 · 8 likes · 255 followers View post →
SciencesNetwork
@SciencesNetwork · X

#GWAS: https://t.co/4w0GYSJjgy https://t.co/r7wxLzU0VC https://t.co/LnP8i1s6GP https://t.co/SazcIRP261 https://t.co/JUc6Qn3cQB https://t.co/cTuiXN41sf https://t.co/HXPKBPw8V7

Apr 17, 2025 · 3 likes · 1 share · 345 followers View post →
Cameron Thrash
@jcamthrash.bsky.social · Bluesky

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport www.science.org/doi/full/10.... #jcampubs

Apr 18, 2025 · 3 likes View post →

All mentions

Toyota_Group_Komaba
@KomaToug · X

RT @LabInoue: High-resolution atomic structures of the late intermediate states of proteorhodopsin (MAR) by Prof. Gordeliy and his team! Co…

Apr 19, 2025 · 1 share · 667 followers View post →
SciencesNetwork
@SciencesNetwork · X

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport. https://t.co/SazcIRP261

Apr 19, 2025 · 345 followers View post →
INOUE lab. (ISSP, Univ. Tokyo)
@LabInoue · X

High-resolution atomic structures of the late intermediate states of proteorhodopsin (MAR) by Prof. Gordeliy and his team! Congratulations!✨ https://t.co/SA6uvtjTJY @ScienceAdvances #OpenAccess https://t.co/eqMKS80eNe

Apr 18, 2025 · 10 likes · 1 share · 946 followers View post →
Isabel Ferrera
@IsabelFerreraC · X

RT @jcamthrash: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh

Apr 18, 2025 · 2 shares · 1,551 followers View post →
Dr. Geo (Michel Geovanni Santiago-Martínez, PhD)
@GeoSantiagoM · X

RT @jcamthrash: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh

Apr 18, 2025 · 2 shares · 5,509 followers View post →
Cameron Thrash
@jcamthrash.bsky.social · Bluesky

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport www.science.org/doi/full/10.... #jcampubs

Apr 18, 2025 · 3 likes View post →
Cameron Thrash
@jcamthrash · X

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport https://t.co/sqkETldoIh

Apr 18, 2025 · 9 likes · 2 shares · 17,421 followers View post →
Vincent Zimmerman
@zimmermanv66.bsky.social · Bluesky

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport Source: Science | AAAS search.app/J61BZ Shared via the Google App

Apr 17, 2025 View post →
Kirill Kovalev
@kirkovalev94 · X

Also is worth reposting once again, as this is the level of details we aim at with X-ray crystallography. You can finally read about it in https://t.co/ek8xGDr5Dt from @bukhdruker and colleagues https://t.co/CmAnkJk9eS

Apr 17, 2025 · 8 likes · 255 followers View post →
Dmitrii Zabelskii
@dzabelskii · X

RT @bukhdruker: The scientific process can be compared to the relay of the Olympic flame. I was glad to receive it from @ivangushchin. Find…

Apr 17, 2025 · 1 share · 80 followers View post →
Sergey Bukhdruker
@bukhdruker · X

The scientific process can be compared to the relay of the Olympic flame. I was glad to receive it from @ivangushchin. Find out why studying proteorhodopsin took 10 years in our new article: https://t.co/OqfF90Phnx. Spoiler: inside you'll find some brilliant structural data.

Apr 17, 2025 · 2 likes · 1 share · 16 followers View post →
@gen0m1cs
@gen0m1cs · X

RT @SciencesNetwork: #GWAS: https://t.co/4w0GYSJjgy https://t.co/r7wxLzU0VC https://t.co/LnP8i1s6GP https://t.co/SazcIRP261 https://t.co/JU…

Apr 17, 2025 · 1 share · 28,586 followers View post →
SciencesNetwork
@SciencesNetwork · X

#GWAS: https://t.co/4w0GYSJjgy https://t.co/r7wxLzU0VC https://t.co/LnP8i1s6GP https://t.co/SazcIRP261 https://t.co/JUc6Qn3cQB https://t.co/cTuiXN41sf https://t.co/HXPKBPw8V7

Apr 17, 2025 · 3 likes · 1 share · 345 followers View post →
サクセスリバーコーテシーinエイトプリンス
@rei_nari · X

RT @pacyc1841: Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://t.co/rPnrlkiq…

Apr 16, 2025 · 1 share · 13,956 followers View post →
Tominaga K. (tomiken)
@pacyc1841 · X

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://t.co/rPnrlkiq6G

Apr 16, 2025 · 9 likes · 1 share · 860 followers View post →
Tominaga K. (tomiken)
@pacyc184.bsky.social · Bluesky

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport | Science Advances https://www.science.org/doi/10.1126/sciadv.adu5303

Apr 16, 2025 · 1 like · 1 share View post →