Diabetes Care December 2025 PMID 40249765

Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes.

John B Buse, Steven E Kahn, Vanita R Aroda, Richard J Auchus, Timothy Bailey, Irina Bancos, Robert S Busch, Elena A Christofides, Ralph A DeFronzo, Bradley Eilerman, James W Findling, Vivian Fonseca, Oksana Hamidi, Yehuda Handelsman, Harold J Miller

Mentions

65
Peak: 24 in Apr 2025
across 6 sources since Sep 2024

Extended reach

188,538
potential audience

Total likes

109

Video views

423

Mentions per month

Sep 2024 – Aug 2025

Where it's discussed

  • X / Twitter41 posts
  • News15 articles
  • Facebook3 posts
  • Bluesky2 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions frequently emphasize the notable prevalence of hypercortisolism in difficult-to-control type 2 diabetes, citing figures like 'about one-quarter' or '24%.' The tone and language, such as 'massive help,' 'crazy implications,' and 'groundbreaking findings,' reflect excitement and the perceived importance of this research for future clinical and market developments.

AgreementModerate agreement

Most discussions acknowledge the significance of the finding that about 25% of individuals with difficult-to-control type 2 diabetes have hypercortisolism, supporting the original interpretation.

InterestHigh interest

Posts expressed high interest, highlighting the study's implications for understanding and treating challenging diabetes cases.

EngagementHigh engagement

Many discussions reference specific aspects such as the prevalence rate and the potential influence on clinical practices, indicating deep engagement.

ImpactModerate impact

The findings are perceived as impactful, suggesting that identifying hypercortisolism could alter management strategies and improve outcomes.

Abstract in brief

  • The study examined the prevalence of hypercortisolism as a possible reason for poor glucose control in individuals with type 2 diabetes who were already on multiple medications.
  • About 23.8% of participants exhibited hypercortisolism, with higher rates seen in those with cardiac issues or on several blood pressure medications.
  • Various factors, including certain diabetes medications, age, BMI, and ethnicity, were linked to an increased likelihood of having hypercortisolism.

Top posts

Most liked on X and Bluesky
Daniel J Drucker
@DanielJDrucker · X

Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals with inadequately controlled type 2 #diabetes despite multiple medications https://t.co/QfhDggf9P9 @DiabeteCareADA s https://t.co/cR9FFiMuBc

Apr 19, 2025 · 25 likes · 8 shares · 34,074 followers View post →
Diabetes Care, a research journal of the ADA
@DiabetesCareADA · X

CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 diabetes despite multiple medications. @ADA_Pubs Read Here ➡️ https://t.co/Y7FYozf8uh https://t.co/H8AellHhui

May 14, 2025 · 21 likes · 8 shares · 3,138 followers View post →
Cristina Tejera
@cristinatejerap · X

Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 19, 2025 · 20 likes · 15 shares · 11,456 followers View post →
Michael Weintraub, MD
@MWeintraubMD · X

The prevalence of difficult to control type 2 diabetes patients with hypercortisolism is surprisingly high at 24%, as reported in the CATALYST trial. https://t.co/ingoKgWz9N Looking forward to seeing the full paper of the impact of medical treatment of hypercortisolism on https://t.co/aH7u93SioP https://t.co/khjBb5bLeZ

May 13, 2025 · 20 likes · 4 shares · 4,481 followers View post →
Emory Global Diabetes Research Center
@egdrc · X

New study in Diabetes Care co-authored by EGDRC's Dr. Guillermo Umpierrez finds ~24% of people with difficult-to-control type 2 diabetes may have hypercortisolism—potentially contributing to poor glycemic control despite multiple meds. https://t.co/4FtVhWy1GT https://t.co/IPLkV81YuO

Apr 22, 2025 · 7 likes · 3 shares · 556 followers View post →
STITCHES Medicine - the Best of Medical Research
@medicine.stitches.today · Bluesky

Hypercortisolism affects one-quarter of patients with difficult-to-control type 2 diabetes, complicating their glycemic management despite medication use. by Buse JB, Kahn SE (...) Einhorn D et 23 al. in Diabetes Care #MedSky

Apr 27, 2025 · 3 likes · 2 shares View post →

All mentions

BalaBio Research
@BalaBioResearch · X

@plainyogurt21 This is massive help thank you, I was looking into it because Corcept seems to be trying to sell their drug in this population and this distinction massively changes the market size. These readouts have crazy implications. https://t.co/m39GkyLySb https://t.co/bQIrRTPga1

Aug 18, 2025 · 914 followers View post →
HCPLive
@HCPLiveNews · X

Learn more about the prevalence of hypercortisolism in difficult-to-control type 2 diabetes and the historic CATALYST trial. https://t.co/t6A8XS8mtp https://t.co/xZaXDFmdOD

Jun 30, 2025 · 1 like · 7,532 followers View post →
HCPLive
@HCPLiveNews · X

Learn more about the prevalence of hypercortisolism in difficult-to-control type 2 #diabetes and the historic CATALYST trial. View more: https://t.co/4ngFnk078W https://t.co/xAXdjq2EbB

Jun 30, 2025 · 2 likes · 7,532 followers View post →
HCPLive
@hcplivenews.bsky.social · Bluesky

Learn more about the prevalence of hypercortisolism in difficult-to-control type 2 diabetes and the historic CATALYST trial. www.hcplive.com/view/diabete...

Jun 30, 2025 View post →
Rafa Mayoral.
@anchoa78 · X

RT @DanielJDrucker: Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals wit…

May 15, 2025 · 8 shares · 163 followers View post →
ADA Professional Publications
@ADA_Pubs · X

RT @DiabetesCareADA: CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 dia…

May 15, 2025 · 8 shares · 10,583 followers View post →
endocatracha
@endocatracha · X

RT @DiabetesCareADA: CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 dia…

May 14, 2025 · 8 shares · 2,045 followers View post →
Naeem ul Hassan
@naeemulhassan_ · X

RT @DiabetesCareADA: CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 dia…

May 14, 2025 · 8 shares · 349 followers View post →
fausto heredia z.
@drfherediaz · X

RT @DiabetesCareADA: CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 dia…

May 14, 2025 · 8 shares · 4,351 followers View post →
Dr. Nazifa Kadery, PharmD, RPh
@dose_of_naz · X

RT @MWeintraubMD: The prevalence of difficult to control type 2 diabetes patients with hypercortisolism is surprisingly high at 24%, as rep…

May 14, 2025 · 4 shares · 259 followers View post →
luis Rodriguez
@luisRod60597844 · X

RT @MWeintraubMD: The prevalence of difficult to control type 2 diabetes patients with hypercortisolism is surprisingly high at 24%, as rep…

May 14, 2025 · 4 shares · 23 followers View post →
Edith WK Chow
@EWKChow · X

RT @DiabetesCareADA: CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 dia…

May 14, 2025 · 8 shares · 19 followers View post →
Rodolfo J. Galindo MD
@RodolfoJGalindo · X

RT @DiabetesCareADA: CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 dia…

May 14, 2025 · 8 shares · 1,101 followers View post →
Diabetes Care, a research journal of the ADA
@DiabetesCareADA · X

CATALYST study finds hypercortisolism in approximately one quarter of individuals with difficult-to-control type 2 diabetes despite multiple medications. @ADA_Pubs Read Here ➡️ https://t.co/Y7FYozf8uh https://t.co/H8AellHhui

May 14, 2025 · 21 likes · 8 shares · 3,138 followers View post →
Justin Cikomola
@CCikomola · X

RT @MWeintraubMD: The prevalence of difficult to control type 2 diabetes patients with hypercortisolism is surprisingly high at 24%, as rep…

May 14, 2025 · 4 shares · 3,762 followers View post →
JG FNP-BC
@soonergise · X

RT @MWeintraubMD: The prevalence of difficult to control type 2 diabetes patients with hypercortisolism is surprisingly high at 24%, as rep…

May 13, 2025 · 4 shares · 250 followers View post →
Michael Weintraub, MD
@MWeintraubMD · X

The prevalence of difficult to control type 2 diabetes patients with hypercortisolism is surprisingly high at 24%, as reported in the CATALYST trial. https://t.co/ingoKgWz9N Looking forward to seeing the full paper of the impact of medical treatment of hypercortisolism on https://t.co/aH7u93SioP https://t.co/khjBb5bLeZ

May 13, 2025 · 20 likes · 4 shares · 4,481 followers View post →
STITCHES Medicine - the Best of Medical Research
@medicine.stitches.today · Bluesky

Hypercortisolism affects one-quarter of patients with difficult-to-control type 2 diabetes, complicating their glycemic management despite medication use. by Buse JB, Kahn SE (...) Einhorn D et 23 al. in Diabetes Care #MedSky

Apr 27, 2025 · 3 likes · 2 shares View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Hypercortisolism affects one-quarter of patients with difficult-to-control type 2 diabetes, complicating their glycemic management despite medication use. by Buse JB, Kahn SE (...) Einhorn D et 23 al. in Diabetes Care https://t.co/m0JwHOcIkp #MedX #MedResearch

Apr 27, 2025 · 82 followers View post →
Cory Johnston
@CoryJohnst60605 · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 27, 2025 · 15 shares View post →
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@BuckleySop24157 · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 27, 2025 · 15 shares · 1 followers View post →
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@DHart47405 · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 25, 2025 · 15 shares View post →
Nicole Wodderspoon
@NWodderspoaco · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 24, 2025 · 15 shares · 1 followers View post →
Timothy Cole
@TimothyCol66199 · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 24, 2025 · 15 shares · 2 followers View post →
Headlands Research
@HeadlandsRsrch · X

In this new study, about one in four people with poorly controlled type 2 diabetes were found to have high cortisol levels, which may be linked to their high blood sugar. Dr. Timothy Bailey co-authored the research.   https://t.co/EoeZju9mOp   #DiabetesResearch #HeadlandsResearch https://t.co/ScJSSXafC2

Apr 24, 2025 · 117 followers View post →
Jordan Jacobs
@JordanJaco26889 · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 23, 2025 · 15 shares View post →
Pierre-Henri Ducluzeau
@PHDucluzeau · X

RT @DanielJDrucker: Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals wit…

Apr 23, 2025 · 8 shares · 121 followers View post →
UNC School of Medicine
@UNC_SOM · X

Study reveals hypercortisolism identified in 24 percent of patients with difficult-to-control type 2 diabetes. John Buse, MD, PhD, director of UNC’s Diabetes Care Center, is lead author. https://t.co/vGhLlK0HRN

Apr 23, 2025 · 8,724 followers View post →
Rodolfo J. Galindo MD
@RodolfoJGalindo · X

RT @egdrc: New study in Diabetes Care co-authored by EGDRC's Dr. Guillermo Umpierrez finds ~24% of people with difficult-to-control type 2…

Apr 22, 2025 · 3 shares · 1,101 followers View post →
Georgia Center for Diabetes Translation Research
@GCDTR · X

RT @egdrc: New study in Diabetes Care co-authored by EGDRC's Dr. Guillermo Umpierrez finds ~24% of people with difficult-to-control type 2…

Apr 22, 2025 · 3 shares · 266 followers View post →
Emory Global Diabetes Research Center
@egdrc · X

New study in Diabetes Care co-authored by EGDRC's Dr. Guillermo Umpierrez finds ~24% of people with difficult-to-control type 2 diabetes may have hypercortisolism—potentially contributing to poor glycemic control despite multiple meds. https://t.co/4FtVhWy1GT https://t.co/IPLkV81YuO

Apr 22, 2025 · 7 likes · 3 shares · 556 followers View post →
Dennis Lawson
@LawsonDenn76090 · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 22, 2025 · 15 shares View post →
ADA Professional Publications
@ADA_Pubs · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 22, 2025 · 15 shares · 10,583 followers View post →
Diabetes Care, a research journal of the ADA
@DiabetesCareADA · X

RT @cristinatejerap: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 21, 2025 · 15 shares · 3,138 followers View post →
Farmacia Madrid AP
@FarmaMadridAP · X

(ADA) Prevalencia del hipercortisolismo en la diabetes tipo 2 de difícil control. El hipercortisolismo se asoció con hiperglucemia enuna cuarta parte de las personas con diabetes tipo 2 inadecuadamente controlada a pesar de tomar múltiples medicamentos https://t.co/25dfKGebKG

Apr 21, 2025 · 2 likes · 8,349 followers View post →
Mind Your Science!
@MindYourSci · X

RT @DanielJDrucker: Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals wit…

Apr 20, 2025 · 8 shares · 133 followers View post →
drtpalanichamy palanichamy
@drtpalanichamy · X

Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/XaUsup0YBe

Apr 20, 2025 · 4 followers View post →
Diana
@PharmphoodTM · X

RT @DanielJDrucker: Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals wit…

Apr 19, 2025 · 8 shares · 556 followers View post →
Lou
@Lourdesflog · X

RT @DanielJDrucker: Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals wit…

Apr 19, 2025 · 8 shares · 2,260 followers View post →
Daniel J Drucker
@DanielJDrucker · X

Clinical pearls #T2D Hypercortisolism was associated with hyperglycemia in approximately one-quarter of individuals with inadequately controlled type 2 #diabetes despite multiple medications https://t.co/QfhDggf9P9 @DiabeteCareADA s https://t.co/cR9FFiMuBc

Apr 19, 2025 · 25 likes · 8 shares · 34,074 followers View post →
Cristina Tejera
@cristinatejerap · X

Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes https://t.co/2SC9yRv6wN @DiabetesCareADA

Apr 19, 2025 · 20 likes · 15 shares · 11,456 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @ADA_DiabetesPro: Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes—Investigators share groundbreaking findings fro…

Sep 3, 2024 · 1 share · 32,540 followers View post →
American Diabetes Association - DiabetesPro
@ADA_DiabetesPro · X

Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes—Investigators share groundbreaking findings from CATALYST study during a late-breaking session at the 84th #ADASciSessions. Read a recap at ADA Meeting News: https://t.co/hY9qbzQf3o https://t.co/Kot85e5A1U

Sep 3, 2024 · 1 like · 1 share · 26,975 followers View post →