Cell June 2025 PMID 40345201

Design principles of cell-state-specific enhancers in hematopoiesis.

Robert Frömel, Julia Rühle, Aina Bernal Martinez, Chelsea Szu-Tu, Felix Pacheco Pastor, Rosa Martinez-Corral, Lars Velten

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101

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across 5 sources since May 2025

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May 2025 – Jul 2025

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AI synopsis

What people are saying

The group collectively displays strong interest and moderate engagement, citing examples such as characterizing thousands of DNA sequences and exploring enhancer functions, with words like 'quite interesting' and 'must consider' highlighting enthusiasm for the research's potential impact on understanding gene regulation in hematopoiesis.

AgreementModerate agreement

Most discussions recognize the significance of the study's findings on enhancer design principles, indicating general support and alignment with its implications.

InterestHigh interest

Posts show high interest, with multiple mentions of the article being 'quite interesting' and enthusiastic references to its potential importance.

EngagementModerate engagement

Many social discussions reference specific aspects like the characterization of 64,400 DNA sequences and the role of transcription factors, showing active engagement with the content.

ImpactModerate impact

While some recognize the study's potential impact on gene regulation and therapy, overall emphasis is on understanding rather than immediate application, leading to a moderate impact score.

Abstract in brief

This study investigates how enhancers guide blood stem cell differentiation by analyzing 64,400 synthetic DNA sequences, focusing on the roles of 38 transcription factors (TFs) and their interactions, revealing that the same binding sites can act as both activators and repressors depending on the cell context.
The researchers found that certain TF site combinations can neutralize each other or switch to repression, turning gradual differences in TF levels into clear, binary enhancer activity patterns, which is key for cell-specific gene regulation.
By understanding these principles, the team developed methods to design custom enhancers that target specific blood cell states, advancing potential strategies for genetic regulation and therapy.

Read the full abstract

All mentions

Artificial Intelligence Designs Synthetic DNA for Cell-Specific Gene Control

Researchers in Barcelona developed an AI tool capable of creating synthetic DNA sequences that regulate gene expression in healthy mammalian cells. This innovative approach, published in Cell, demonstrates precise…

Geneaxis · May 29, 2025 368 views

Decoding Enhancer Design Principles in Hematopoiesis for Cell Fate Control

This study investigates how enhancers guide blood stem cell differentiation by analyzing 64,400 synthetic DNA sequences, focusing on the roles of 38 transcription factors and their interactions. It reveals how enhancer…

Everyday Journal Club · Jul 3, 2025 11 views

Decoding Gene Control in Blood Cell Differentiation Using Enhancer Principles

This episode explores how enhancers dictate blood stem cell differentiation by analyzing 64,400 synthetic DNA sequences, revealing the dual roles of transcription factors as activators or repressors based on cell…

Everyday Journal Club · Jun 26, 2025 8 views

Shicheng Guo

@ShihchengGuo · X

Characterized 64,400 synthetic DNA sequences to reveal design principles of cell-state-specific enhancers in hematopoiesis, crucial for differentiating blood stem cells into 7 myeloid lineages. Insights enhance understanding of TF interactions in gene expression regulation.

Jun 27, 2025 · 495 followers View post →

Yanli Zhao

@YanliZhao2022 · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 17, 2025 · 12 shares · 61 followers View post →

Hulagu

@HulaguBioChem · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 17, 2025 · 12 shares · 1,229 followers View post →

Kaijin Chen

@KaijinChen · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 17, 2025 · 12 shares · 27 followers View post →

choiLab

@jungminchoilab · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 17, 2025 · 12 shares · 331 followers View post →

@d_jq863 · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 17, 2025 · 12 shares · 102 followers View post →

ケリタオス

@Hkrnsiwc · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 16, 2025 · 12 shares · 31 followers View post →

AngryPhDstudent❗️❗️❗️

@ONNESHA092 · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 16, 2025 · 12 shares · 182 followers View post →

Richard G Burr

@RichardGBurr1 · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 16, 2025 · 12 shares · 1,117 followers View post →

Jen

@jpadilla_DH · X

RT @CellCellPress: In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 16, 2025 · 12 shares · 80 followers View post →

Cell

@CellCellPress · X

In the latest issue! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/6lrob378Ij

Jun 16, 2025 · 48 likes · 12 shares · 262,884 followers View post →

Dayan Palacio

@DannPalacios2 · X

Quite interesting article Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/GM4mEiuYlR

May 31, 2025 · 24 followers View post →

The Single-Cell Ninjas

@Sc_Ninjas · X

RT @mason_lab: Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/xg0KSq4tFI

May 23, 2025 · 2 shares · 6,291 followers View post →

GESTALT

@GESTALT_sp · X

RT @mason_lab: Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/xg0KSq4tFI

May 23, 2025 · 2 shares · 893 followers View post →

Chris Mason

@mason_lab · X

Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/xg0KSq4tFI

May 22, 2025 · 18 likes · 2 shares · 11,669 followers View post →

Jonathan Frazer

@jonnyfrazer.bsky.social · Bluesky

Next up at #VariantEffect25 our very own rising star @larsplus.bsky.social takes the stage: Design principles of cell state specific enhancers in hematopoiesis

May 21, 2025 · 3 likes · 1 share View post →

Diego

@ucedilla · X

11/ Fuente: https://t.co/veiPXy9gud

May 17, 2025 · 504 followers View post →

PostSapiens

@jph.mastodon.cyber-tribal.com.ap.brid.gy · Bluesky

Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://www.cell.com/cell/fulltext/S0092-8674(25)00449-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425004490%3Fshowall%3Dtrue

May 16, 2025 View post →

DailyHealthcareAI

@aipulserx · X

How do cellular enhancers turn overlapping transcription factor gradients into specific gene activation patterns?@CellCellPress @_BIST "Design principles of cell-state-specific enhancers in hematopoiesis" • Researchers characterized 64,400 synthetic DNA sequences to https://t.co/xMlR9DA1I2

May 13, 2025 · 6 likes · 1,290 followers View post →

Yanli Zhao

@YanliZhao2022 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 12, 2025 · 24 shares · 61 followers View post →

Dacre Knight, MD, MS, FACP

@knidac · X

And the paper: Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/6VJL9WXNXK

May 11, 2025 · 1,151 followers View post →

Tamino

@Gem12Shiny · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 11, 2025 · 24 shares · 145 followers View post →

Tamino

@Gem12Shiny · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 11, 2025 · 17 shares · 145 followers View post →

Pat Adams

@PathologyPat · X

Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/xN60jQ1B0o

May 11, 2025 · 1 like · 1,509 followers View post →

Alex C.Y. Chen

@AlexChenChangYu · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 10, 2025 · 17 shares · 53 followers View post →

John Walakira

@JWalakira · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 2,056 followers View post →

Vinay Kartha

@vkartha88 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 449 followers View post →

Armando Vilchis

@AVO_vilchis · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 40 followers View post →

Mo Ebrahimkhani

@MoEbrahimkhani · X

RT @martinperaJAX: Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/BIcW0w0x8c

May 9, 2025 · 1 share · 1,206 followers View post →

AngryPhDstudent❗️❗️❗️

@ONNESHA092 · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 182 followers View post →

Rahman LAB

@rahmanLAB2023 · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 212 followers View post →

AngryPhDstudent❗️❗️❗️

@ONNESHA092 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 182 followers View post →

Diego

@ucedilla · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 504 followers View post →

Matteo Gentili

@mgentili_ · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 392 followers View post →

Un1v3rs0 Z3r0

@Un1v3rs0Z3r0 · X

Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/qlSlJMe4My

May 9, 2025 · 511 followers View post →

John Walakira

@JWalakira · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 2,056 followers View post →

shoukofuuyumi

@shoukofuuyumi · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 43 followers View post →

Martin Pera

@martinperaJAX · X

Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/BIcW0w0x8c

May 9, 2025 · 6 likes · 1 share · 2,363 followers View post →

xxy

@xxy07255392 · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

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xxy

@xxy07255392 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

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Triet Nguyen

@TrietNg_Bio · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 47 followers View post →

Vignesh Krishnamoorthy

@Vigneshkriish · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 153 followers View post →

Rio Sugimura

@rio_sugimura · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 3,164 followers View post →

zojna

@zojna1 · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 129 followers View post →

Alex Liu

@alexanderyliu · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 165 followers View post →

Harim Chun

@chun_harim · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 19 followers View post →

Richard S

@Richard01173388 · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 143 followers View post →

Seyoon Lee

@Seyoon_L · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 213 followers View post →

choiLab

@jungminchoilab · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 9, 2025 · 24 shares · 331 followers View post →

Melinda L Tursky

@melinda_tursky · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 9, 2025 · 17 shares · 1,211 followers View post →

Chayan Mukherjee

@ChayanM91517533 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 224 followers View post →

Suiliang Xia

@YanYang80603102 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 55 followers View post →

Yiliang Ding

@YiliangDing · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 3,796 followers View post →

Corbo Lab at Washington University in St. Louis

@CorboLab · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 397 followers View post →

Xiekui Cui

@MarkTransposon · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 286 followers View post →

Atar Singh Kushwah

@dr_ask0 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 337 followers View post →

Luis G. Palma (@luigalpal.bsky.social)

@luigalpal · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 888 followers View post →

Keizo Nishikawa

@ihaveapenpai · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 52 followers View post →

Frank Paul Mora

@InTime_49 · X

RT @LabWaggoner: Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/j…

May 8, 2025 · 17 shares · 383 followers View post →

Waggoner Lab

@LabWaggoner · X

Design principles of cell-state-specific enhancers in hematopoiesis @CellCellPress https://t.co/y8yjQZLTfn https://t.co/jfQOERUeOb

May 8, 2025 · 69 likes · 17 shares · 11,281 followers View post →

Waggoner Lab

@labwaggoner.bsky.social · Bluesky

Design principles of cell-state-specific enhancers in hematopoiesis @cellcellpress.bsky.social www.cell.com/cell/fulltex...

May 8, 2025 · 15 likes · 4 shares View post →

Shun Sawatsubashi

@SSawatsubashi · X

https://t.co/8WG8oICKmk

May 8, 2025 · 19 followers View post →

Shun Sawatsubashi

@SSawatsubashi · X

Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/2p2XRdWjHB

May 8, 2025 · 19 followers View post →

Jen

@jpadilla_DH · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 80 followers View post →

qicy

@qicy11 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 380 followers View post →

EUN DEOK KIM

@EUNDEOKKIM1 · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 11 followers View post →

Keiichi Ito

@itok10918 · X

Design principles of cell-state-specific enhancers in hematopoiesis: Cell https://t.co/RhrNEvmEvG

May 8, 2025 · 7 likes · 1,243 followers View post →

Deepanshu Soota

@DeepanshuSoota · X

RT @CellCellPress: Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 24 shares · 88 followers View post →

Cell

@CellCellPress · X

Now online! Design principles of cell-state-specific enhancers in hematopoiesis https://t.co/Pps6QKLlu8

May 8, 2025 · 88 likes · 24 shares · 262,884 followers View post →

Lars Velten

@larsplus.bsky.social · Bluesky

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis

May 8, 2025 · 137 likes · 69 shares View post →

Cell - a Cell Press journal

@cp-cell.bsky.social · Bluesky

Now online! Design principles of cell-state-specific enhancers in hematopoiesis

May 8, 2025 · 4 likes · 1 share View post →

Design principles of cell-state-specific enhancers in hematopoiesis.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Artificial Intelligence Designs Synthetic DNA for Cell-Specific Gene Control

Decoding Enhancer Design Principles in Hematopoiesis for Cell Fate Control

Decoding Gene Control in Blood Cell Differentiation Using Enhancer Principles