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Cell June 2025 PMID 40359942

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice.

Anna C Geraghty, Lehi Acosta-Alvarez, Maria C Rotiroti, Selena Dutton, Michael R O'Dea, Wonju Kim, Vrunda Trivedi, Rebecca Mancusi, Kiarash Shamardani, Karen Malacon, Pamelyn J Woo, Naiara Martinez-Velez, Theresa Pham, Noemi N Reche-Ley, Gabriel Otubu

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Mentions

117
Peak: 61 in May 2025
across 6 sources since May 2024

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1,169,047
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Total likes

199

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99

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May 2024 – Aug 2025

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AI synopsis

What people are saying

Overall, the conversations reflect strong agreement and high interest, with many posts emphasizing the study's potential to transform treatment strategies by mentioning elements like microglial activity and white matter damage. The tone and choice of technical language demonstrate active engagement and recognition of the research's broader significance.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some explicitly supporting its findings, suggesting a general consensus on its importance.

InterestHigh interest

The posts demonstrate high curiosity, frequently highlighting the novelty of the findings and emphasizing the potential implications for future therapies.

EngagementHigh engagement

Several discussions reference specific mechanisms, such as microglial reactivity and neuroinflammation, indicating deep engagement and analysis of the research details.

ImpactHigh impact

The posts imply that the study could substantially influence future clinical approaches and understanding of cognitive side effects related to immunotherapy, signaling a high perceived impact.

Abstract in brief

  • Immunotherapy, specifically CAR T cell therapy, has shown promise in treating various cancers but may lead to cognitive dysfunction and persistent immune responses in the central nervous system (CNS).
  • Researchers found that this therapy caused changes in brain cells that disrupted crucial processes for cognitive function, like neurogenesis and white matter health.
  • In experiments with mice and human data, strategies to reduce microglial activity helped improve cognitive performance, highlighting potential treatments for managing cognitive side effects of immunotherapy.
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Cell
@CellCellPress · X

Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

May 12, 2025 · 64 likes · 21 shares · 262,809 followers View post →
Cell
@CellCellPress · X

In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

Jun 16, 2025 · 49 likes · 15 shares · 262,809 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuroinflammation leading to dysregulation of oligodendroglial cells and impaired cognition https://t.co/N4gW3ftVBs

May 12, 2025 · 21 likes · 6 shares · 4,736 followers View post →
Ming "Tommy" Tang
@tangming2005 · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/9AOL8o3mAg https://t.co/wcHkRFmJIl

Jun 21, 2025 · 15 likes · 3 shares · 40,852 followers View post →
Christoph Bammer
@CBammerMD · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Are there also implications for ME/CFS? via @cstroeckw https://t.co/HmgMmCVeWL

May 13, 2025 · 11 likes · 1 share · 1,328 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/yMBUF0Ej7L

May 12, 2025 · 9 likes · 2 shares · 18,060 followers View post →

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Sandra kate
@sshanmugamgens1 · X

RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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Signal Transduction and Targeted Therapy (STTT)
@sigtrans_sttt · X

#STTT highlight Geraghty, A. C. et al. Immunotherapy-related cognitive impairment after CAR T cell therapy in mice. Cell 188, 3238–3258.e25 (2025): Gabriel, K., Kobold, S. Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy..

Jul 21, 2025 · 1 like · 463 followers View post →
Fadi Hassan
@OnePatientFH · X

RT @tangming2005: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/9AOL8o3mAg https://t.co/wcHkRFmJ…

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Sefa
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RT @tangming2005: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/9AOL8o3mAg https://t.co/wcHkRFmJ…

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@Vic_Bioinfo · X

RT @tangming2005: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/9AOL8o3mAg https://t.co/wcHkRFmJ…

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Ming Tommy Tang
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Immunotherapy-related cognitive impairment after CAR T cell therapy in mice www.cell.com/cell/fullte...

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Ming "Tommy" Tang
@tangming2005 · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/9AOL8o3mAg https://t.co/wcHkRFmJIl

Jun 21, 2025 · 15 likes · 3 shares · 40,852 followers View post →
おくさん/OKUSUN
@Astella6174 · X

CAR-Tによる認知機能障害の神経メカニズム https://t.co/BFES1D0E8R CNS・非CNS腫瘍モデルでCAR-T治療後、神経炎症により認知機能が障害されているらしい。MΦの反応性亢進→オリゴ細胞恒常性破綻→海馬神経新生障害の連鎖という流れで、MΦ除去やCCR3阻害で制御できることも示されている https://t.co/rxaZD9E3K4

Jun 18, 2025 · 1,185 followers View post →
Hpr Kunchai
@HprKunchai · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Hulagu
@HulaguBioChem · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

Jun 17, 2025 · 15 shares · 1,232 followers View post →
Nithyanan Annamalai
@BlackSamrat · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Químics de Catalunya
@quimics · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Yehuda M. Danino
@DaninoYehuda · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/Te7fncQ3t6

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Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Kyle Dyson
@Kyle_Dyson · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Eric
@ericsophia12 · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

Jun 16, 2025 · 15 shares · 95 followers View post →
Agathokakological
@aaish_muhammad · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Namphungo
@Waterbee_19 · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Alejandro De Los Angeles, DPhil, MPH
@delosangeles520 · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Richard G Burr
@RichardGBurr1 · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

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Alejandro García Núñez
@AleGarNu81 · X

RT @CellCellPress: In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

Jun 16, 2025 · 15 shares · 115 followers View post →
Cell
@CellCellPress · X

In the latest issue! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/2pWhq5M0Hu

Jun 16, 2025 · 49 likes · 15 shares · 262,809 followers View post →
María A. Moro
@MariAngelesMoro · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/YBiVjBJyjE

Jun 13, 2025 · 4 likes · 1,036 followers View post →
旅人 tabito
@tabibito250 · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/XOELlvYZwT

May 27, 2025 · 2 likes · 1,073 followers View post →
Javi Ibarrondo
@jibarrondo.bsky.social · Bluesky

CAR T cell therapy induces white matter microglial reactivity and neuroinflammation Microglial depletion or CCR3 blockade rescues cellular and cognitive dysfunction Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell www.cell.com/cell/fulltex...

May 22, 2025 · 2 likes · 2 shares View post →
HealthyBuilds
@HealthyBuilds · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/SI9lpJYi70

May 19, 2025 · 193 followers View post →
HealthyBuilds
@JamesSw70043542 · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/Xe4nEm5tEL

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Uijin Kim
@uijin311 · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/lBb5zjofaA

May 19, 2025 · 57 followers View post →
dhuv.io
@DhuviKarthikey1 · X

(05/12/2025) Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/by5XzVLdL2

May 18, 2025 · 1 like · 454 followers View post →
Cecilia
@jycp42 · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/Jc3GJ34cLI

May 17, 2025 · 34 followers View post →
@Neuro_AI
@NeuroAI_Nexus · X

Here is original cell paper: https://t.co/mxonmiAY87

May 16, 2025 · 2 likes · 4,734 followers View post →
Anna Miller
@Anna1985Ki · X

RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

May 15, 2025 · 21 shares · 167 followers View post →
な bot
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[Cell] Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/rlikA3c6M7

May 14, 2025 · 26 followers View post →
moonp
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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moonp
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

May 14, 2025 · 21 shares · 6 followers View post →
Yoshihisa Okazaki
@XX62 · X

『Immunotherapy-related cognitive impairment after CAR T cell therapy in mice』 Cell　May 12, 2025 ミクログリア活性化と神経炎症が白質で確認 オリゴデンドログリアと神経新生が影響を受け 記憶・注意力などに悪影響 ヒトの脳組織解析でも同様の細胞反応あり https://t.co/Ge9Q0IWaXV

May 13, 2025 · 1 like · 2,282 followers View post →
José M. Valdés, MD
@dr_jmvaldes · X

RT @NeuroscienceNew: “Immunotherapy-related cognitive impairment after CAR T cell therapy in mice” by Michelle Monje et al. Cell https://t…

May 13, 2025 · 2 shares · 144 followers View post →
Joanna Teglund
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RT @NeuroscienceNew: “Immunotherapy-related cognitive impairment after CAR T cell therapy in mice” by Michelle Monje et al. Cell https://t…

May 13, 2025 · 2 shares · 8,529 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Immunotherapy-related cognitive impairment after CAR T cell therapy in mice” by Michelle Monje et al. Cell https://t.co/Tem0LG5cSi

May 13, 2025 · 4 likes · 2 shares · 505,190 followers View post →
Kelvin R.
@Kelvin_ramlo · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/IJXehj7wNt

May 13, 2025 · 103 followers View post →
ShorterLab
@ShorterLab · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/aP3Fu1pqbt

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Mingqi Dong
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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xxy
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/KvTI5eVZHD

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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Cell https://t.co/ohUwYqxB5y

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kNr
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @weldeiry: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/yMBUF0Ej7L

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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @CBammerMD: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Are there also implications for ME/CFS? via @cs…

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Namphungo
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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Christoph Bammer
@CBammerMD · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice: Are there also implications for ME/CFS? via @cstroeckw https://t.co/HmgMmCVeWL

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Emre Kocakavuk, MD, PhD
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

May 12, 2025 · 21 shares · 937 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/9In71BMg26

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よちむん
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SNZK
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RT @Pluchinolab: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuro…

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AngryPhDstudent❗️❗️❗️
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @weldeiry: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/yMBUF0Ej7L

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Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry.bsky.social · Bluesky

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice www.cell.com/cell/fulltex...

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Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/yMBUF0Ej7L

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Lara M
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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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RT @CellCellPress: Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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Cell
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Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/sLuss8I4vB

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José María Cabrera
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RT @Pluchinolab: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuro…

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şule terzili
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RT @Pluchinolab: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuro…

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Giovanni Di Liberto
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RT @Pluchinolab: Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuro…

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Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice | white matter microglial reactivity and neuroinflammation leading to dysregulation of oligodendroglial cells and impaired cognition https://t.co/N4gW3ftVBs

May 12, 2025 · 21 likes · 6 shares · 4,736 followers View post →
Roman Sankowski
@rsankowski.bsky.social · Bluesky

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice www.cell.com/cell/fulltex...

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Cell - a Cell Press journal
@cp-cell.bsky.social · Bluesky

Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

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bxv_neurosci
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Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://t.co/oEMnyTDZh9 https://t.co/yRkCJPbqHw

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bioRxiv Neuroscience
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Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://www.biorxiv.org/content/10.1101/2024.05.14.594163v1

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bioRxivpreprint
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Immunotherapy-related cognitive impairment after CAR T cell therapy in mice https://www.biorxiv.org/content/10.1101/2024.05.14.594163v1

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