Nat Cell Biol June 2025 PMID 40467769

Extracellular exosomal RNAs are glyco-modified.

Sunny Sharma, Xinfu Jiao, Jun Yang, Kelvin Y Kwan, Megerditch Kiledjian

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Peak: 13 in Jun 2025

across 3 sources since Dec 2024

Extended reach

37,651

potential audience

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Mentions per month

Dec 2024 – Nov 2025

Where it's discussed

X / Twitter10 posts
YouTube5 videos
Bluesky4 posts

AI synopsis

What people are saying

The discussions emphasize the groundbreaking nature of discovering glyco-modified RNAs within exosomes, with words like 'revealing,' 'potential,' and 'significance' highlighting enthusiasm and perceived importance. Participants reference the stability of glycoRNAs and their role in intercellular communication to illustrate the study's implications for diagnostics and therapeutics, reflecting both scientific curiosity and optimism about future applications.

AgreementStrong agreement

Most discussions highlight the novelty and potential significance of glycoRNAs found in exosomes, indicating strong support for the findings.

InterestHigh interest

The posts show high curiosity about the stability and communication roles of glycoRNAs, suggesting a keen interest in implications for disease research and therapy.

EngagementModerate engagement

Several discussions delve into the technical aspects, such as glycan transfer and RNase resistance, demonstrating moderate in-depth engagement.

ImpactHigh impact

The consensus reflects recognition of the study's potential to advance diagnostics and RNA-based treatments, indicating high perceived impact.

Abstract in brief

This study investigates glycoRNAs, a newly discovered class of glycosylated small noncoding RNAs, which are resistant to RNases and mainly found within exosomes, suggesting their role in intercellular communication.
The research demonstrates that inhibiting exosome formation causes an accumulation of glycoRNAs inside cells, while blocking glycan transfer to proteins reduces their incorporation into exosomes, indicating a link between protein and RNA glycosylation in exosome cargo sorting.
Overall, the findings highlight the potential functional importance of glycosylation in directing RNAs into exosomes, offering new insights for developments in diagnostics and RNA-based therapies.]

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All mentions

Glycosylation of Cellular RNA and Its Role in Exosome Communication

RNA glycosylation is a posttranslational modification associated with exosomal RNAs, which are resistant to RNases and involved in intercellular communication. The study highlights the importance of glycosylation in RNA…

Informative · Jun 6, 2025 17 views

GlycoRNA Biosynthesis in Exosomes and Implications for Intercellular Communication

This study investigates glycoRNAs, a newly discovered class of glycosylated small noncoding RNAs found within exosomes, suggesting their role in intercellular communication. It highlights the importance of glycosylation…

Informative · Jun 8, 2025 14 views

GlycoRNAs and Exosomes: Insights into Intercellular RNA Transfer

This video explores glycoRNAs, a novel class of glycosylated small noncoding RNAs found mainly in exosomes, highlighting their potential role in intercellular communication and insights into RNA-based diagnostics and…

Informative · Jun 9, 2025 9 views

GlycoRNAs in Exosomes: Implications for Intercellular Communication

GlycoRNAs are a newly discovered class of glycosylated small noncoding RNAs mainly found within exosomes, suggesting roles in intercellular communication. This study explores their glycosylation, resistance to RNases…

Informative · Jun 7, 2025 9 views

GlycoRNAs and OST in Exosomal RNA Glycosylation Dynamics

This video explores glycoRNAs, a class of glycosylated small noncoding RNAs protected from RNases and found mainly in exosomes, highlighting their role in intercellular communication and RNA sorting through…

Informative · Jun 10, 2025 9 views

Rene Sugar

@renesugar · X

@tessfalor @OtrPat @BhupeshPrusty Extracellular exosomal RNAs are glyco-modified https://t.co/lIRR2rTKYE https://t.co/8rg8gERdMY

Nov 9, 2025 · 3,986 followers View post →

Shicheng Guo

@shihcheng.bsky.social · Bluesky

Discover: glycosylated RNAs resist RNases, enhancing stability. Metabolic labelling unveils non-coding glycoRNAs.

Jul 19, 2025 · 10 likes View post →

Shicheng Guo

@ShihchengGuo · X

Discover: glycosylated RNAs resist RNases, enhancing stability. Metabolic labelling unveils non-coding glycoRNAs.

Jul 19, 2025 · 1 like · 494 followers View post →

Rene Sugar

@renesugar · X

RT @ExosomeRNA: Scientists at @RutgersU found that #exosomes carry stable #glycoRNAs, revealing a new layer of #RNA communication with pote…

Jun 6, 2025 · 2 shares · 3,952 followers View post →

Ahmed Ibrahim

@TheIbrahimLab · X

RT @ExosomeRNA: Scientists at @RutgersU found that #exosomes carry stable #glycoRNAs, revealing a new layer of #RNA communication with pote…

Jun 6, 2025 · 2 shares · 604 followers View post →

Exosome RNA

@ExosomeRNA · X

Scientists at @RutgersU found that #exosomes carry stable #glycoRNAs, revealing a new layer of #RNA communication with potential for disease research and RNA-based treatments. https://t.co/Vz9wpzCiWM

Jun 6, 2025 · 4 likes · 2 shares · 3,385 followers View post →

Leo Liu

@leonardliu88 · X

Extracellular exosomal RNAs are glyco-modified | Nature Cell Biology https://t.co/2YBE40PMUC

Jun 5, 2025 · 1 like · 233 followers View post →

ShorterLab

@ShorterLab · X

Extracellular exosomal RNAs are glyco-modified: https://t.co/dIQ8v1SinC

Jun 5, 2025 · 12 likes · 12,021 followers View post →

Bahnisikha Barman, Ph.D. (she/her)

@bahnisikha_b · X

RT @Pluchinolab: Extracellular exosomal RNAs are glyco-modified https://t.co/fGx7CJXXVO

Jun 5, 2025 · 1 share · 527 followers View post →

Pluchino lab - Regenerative Neuroimmunology

@pluchinolab.bsky.social · Bluesky

Extracellular exosomal RNAs are glyco-modified www.nature.com/articles/s41...

Jun 5, 2025 View post →

Pluchino lab - Regenerative Neuroimmunology

@Pluchinolab · X

Extracellular exosomal RNAs are glyco-modified https://t.co/fGx7CJXXVO

Jun 5, 2025 · 3 likes · 1 share · 4,737 followers View post →

bioRxiv Cell Biology

@biorxiv-cellbio.bsky.social · Bluesky

Extracellular Exosomal RNAs are Glyco-Modified https://www.biorxiv.org/content/10.1101/2024.12.17.628987v1

Dec 18, 2024 View post →

bioRxivpreprint

@biorxivpreprint.bsky.social · Bluesky