Cancer Cell August 2025 PMID 40578359

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression.

Lisa Schweizer, Hilary A Kenny, Rahul Krishnan, Lucy Kelliher, Agnes J Bilecz, Janna Heide, Leonhard Donle, Aasa Shimizu, Andreas Metousis, Rachelle Mendoza, Thierry M Nordmann, Sarah Rauch, Sabrina Richter, Yan Li, Florian A Rosenberger

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Mentions

185
Peak: 45 in Jun 2025
across 8 sources since Nov 2023

Extended reach

233,062
potential audience

Total likes

294

Video views

6

Mentions per month

Nov 2023 – Oct 2026

Where it's discussed

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AI synopsis

What people are saying

Mentions consistently use enthusiastic and technical language, referencing advanced methodologies like spatial proteomics and validation of drug targets, which shows strong agreement, curiosity, active engagement, and recognition of the research's high impact potential.

AgreementStrong agreement

Mentions universally acknowledge the significance of the study's groundbreaking use of spatial proteo-transcriptomics and promising therapeutic insights, showing strong support.

InterestHigh interest

Mentions highlight novel techniques, potential treatments, and detailed molecular insights, indicating high curiosity and relevance to cancer research.

EngagementHigh engagement

Comments include references to in-depth techniques, validation of drug targets, and potential clinical applications, reflecting deep method and implication engagement.

ImpactHigh impact

Multiple mentions emphasize how the research offers new diagnostic/treatment strategies for chemo-resistant ovarian tumors, indicating high potential influence on the field.

Abstract in brief

  • The study uses advanced spatial proteomics and transcriptomics to understand how borderline ovarian tumors (SBT) progress to low-grade serous cancer (LGSC), highlighting an intermediary micropapillary stage where LGSC overexpresses c-Met and brain-specific proteins.
  • It found that during this transition, there is increased interaction between cancer cells and stromal cells, including enzymes that break down the extracellular matrix, facilitating tumor progression and invasion.
  • The researchers validated 16 drug targets and demonstrated that a combined treatment with milciclib (targeting CDK4/6) and mirvetuximab (targeting FOLR1) significantly reduced tumor growth in vivo, suggesting a promising therapy for LGSC.]

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Cancer Cell
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Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/bfnijCzeF5 https://t.co/HnBhXbWEQJ

Jun 27, 2025 · 134 likes · 43 shares · 75,804 followers View post →
Cancer Cell
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Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/4dXnlEB197 https://t.co/riplLClQAT

Aug 12, 2025 · 123 likes · 36 shares · 75,804 followers View post →
Mann Lab
@mannlab.bsky.social · Bluesky

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. www.cell.com/cancer-cell/...

Jun 26, 2025 · 23 likes · 13 shares View post →
Cancer Cell
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Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression

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uchicagoobgyn.bsky.social
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A new publication in ‪‪#CancerCell uncovers how borderline ovarian tumors evolve into low-grade serous ovarian cancer & identifies a promising new treatment strategy.‬‬ www.sciencedirect.com/science/arti... @lisaschweizer.bsky.social @mannlab.bsky.social @lengyel-ovca-lab.bsky.social

Jun 26, 2025 · 2 likes View post →

All mentions

Joel YR
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Cancer Cell
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Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/4dXnlEB197 https://t.co/riplLClQAT

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Taner
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Lisa Schweizer
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Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/bfnijCzeF5 https://t.co/HnBhXbWEQJ

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Ernst Lengyel
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Proud to share our latest work in ‪#CancerCell‬ in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy. ‬‬ www.sciencedirect.com/science/arti...

Jun 26, 2025 · 1 like · 3 shares View post →
uchicagoobgyn.bsky.social
@uchicagoobgyn.bsky.social · Bluesky

A new publication in ‪‪#CancerCell uncovers how borderline ovarian tumors evolve into low-grade serous ovarian cancer & identifies a promising new treatment strategy.‬‬ www.sciencedirect.com/science/arti... @lisaschweizer.bsky.social @mannlab.bsky.social @lengyel-ovca-lab.bsky.social

Jun 26, 2025 · 2 likes View post →
Mann Lab
@mannlab.bsky.social · Bluesky

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. www.cell.com/cancer-cell/...

Jun 26, 2025 · 23 likes · 13 shares View post →
medRxivpreprint
@medrxivpreprint.bsky.social · Bluesky

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://www.medrxiv.org/content/10.1101/2023.11.13.23298409v1

Nov 14, 2023 View post →
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