Mentions consistently use enthusiastic and technical language, referencing advanced methodologies like spatial proteomics and validation of drug targets, which shows strong agreement, curiosity, active engagement, and recognition of the research's high impact potential.
AgreementStrong agreement
Mentions universally acknowledge the significance of the study's groundbreaking use of spatial proteo-transcriptomics and promising therapeutic insights, showing strong support.
InterestHigh interest
Mentions highlight novel techniques, potential treatments, and detailed molecular insights, indicating high curiosity and relevance to cancer research.
EngagementHigh engagement
Comments include references to in-depth techniques, validation of drug targets, and potential clinical applications, reflecting deep method and implication engagement.
ImpactHigh impact
Multiple mentions emphasize how the research offers new diagnostic/treatment strategies for chemo-resistant ovarian tumors, indicating high potential influence on the field.
Abstract in brief
The study uses advanced spatial proteomics and transcriptomics to understand how borderline ovarian tumors (SBT) progress to low-grade serous cancer (LGSC), highlighting an intermediary micropapillary stage where LGSC overexpresses c-Met and brain-specific proteins.
It found that during this transition, there is increased interaction between cancer cells and stromal cells, including enzymes that break down the extracellular matrix, facilitating tumor progression and invasion.
The researchers validated 16 drug targets and demonstrated that a combined treatment with milciclib (targeting CDK4/6) and mirvetuximab (targeting FOLR1) significantly reduced tumor growth in vivo, suggesting a promising therapy for LGSC.]
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/bfnijCzeF5 https://t.co/HnBhXbWEQJ
Jun 27, 2025 · 134 likes · 43 shares · 75,804 followersView post →
CC
Cancer Cell
@Cancer_Cell · X
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/4dXnlEB197 https://t.co/riplLClQAT
Aug 12, 2025 · 123 likes · 36 shares · 75,804 followersView post →
ML
Mann Lab
@mannlab.bsky.social · Bluesky
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
A new publication in #CancerCell uncovers how borderline ovarian tumors evolve into low-grade serous ovarian cancer & identifies a promising new treatment strategy.
www.sciencedirect.com/science/arti...
@lisaschweizer.bsky.social @mannlab.bsky.social @lengyel-ovca-lab.bsky.social
This article details a comprehensive study on the progression of borderline ovarian tumors to metastatic low-grade serous cancer. Using spatial proteo-transcriptomic profiling, researchers mapped molecular changes…
This video outlines a comprehensive study utilizing spatial proteomics and transcriptomics to understand the progression of borderline ovarian tumors to invasive low-grade serous cancer. Key mechanisms, potential drug…
RT @Cancer_Cell: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive pr…
Aug 13, 2025 · 36 shares · 25 followersView post →
P
PandaPalooza
@pandapalooza_59 · X
RT @Cancer_Cell: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive pr…
Aug 13, 2025 · 36 shares · 159 followersView post →
IM
Ignacio Wistuba, MD
@MdWistuba · X
RT @Cancer_Cell: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive pr…
Aug 13, 2025 · 36 shares · 294 followersView post →
NA
Nithyanan Annamalai
@BlackSamrat · X
RT @Cancer_Cell: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive pr…
Aug 13, 2025 · 36 shares · 346 followersView post →
Q
qicy
@qicy11 · X
RT @Cancer_Cell: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive pr…
Aug 13, 2025 · 36 shares · 395 followersView post →
DH
Dr. Kharazmi (she/her)
@JKharazmi53629 · X
RT @Cancer_Cell: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive pr…
Aug 13, 2025 · 36 shares · 2,435 followersView post →
CC
Cancer Cell
@Cancer_Cell · X
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/4dXnlEB197 https://t.co/riplLClQAT
Aug 12, 2025 · 123 likes · 36 shares · 75,804 followersView post →
Z
ZheFrench
@ZheFrench · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 30, 2025 · 43 shares · 407 followersView post →
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression - https://t.co/GUxTik0IJh
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 48 followersView post →
KR
kerry robinson
@robinson8007 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 495 followersView post →
CK
Chulhwan Sean Kwak
@ChulhwanKwak · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 24 followersView post →
X
xxy
@xxy07255392 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 202 followersView post →
Q
qicy
@qicy11 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 395 followersView post →
AP
Archana Tomar, PhD
@Arch_Epicomp · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 73 followersView post →
D
DHprotein
@DHprotein · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 17 followersView post →
BW
Bowen Wang
@NU_JEANSS · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 283 followersView post →
RP
Ruveyda Ayasun, MD/PhD
@AyasunMDPhD · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 991 followersView post →
C
choiLab
@jungminchoilab · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 28, 2025 · 43 shares · 351 followersView post →
JR
Jun | Relationship & Timing Readings
@UmutDisel · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 1,177 followersView post →
AC
Anne C ?
@histojolie · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 597 followersView post →
AK
Arutha K
@aruthak · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 2,430 followersView post →
Y
Yahweh
@Yahweh0122333 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 1,850 followersView post →
LS
Lisa Schweizer
@LisaCSchweizer · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 159 followersView post →
MI
Mochammad Ichsan
@ichsanomics · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 666 followersView post →
JY
Joel YR
@YnfaYr · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 117 followersView post →
BJ
Balaganesh Janakiraman
@kuttiganesha · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 198 followersView post →
AM
Andreas Mund
@MundAndreas · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 809 followersView post →
HS
Hannah Scott
@covidhannah · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 40 followersView post →
AH
Adam Hall
@aidoctorhall · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 38 followersView post →
JO
Jacqueline Oliva
@Liszeth · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 221 followersView post →
SK
Salma Kaochar
@Kaochar2 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 2,447 followersView post →
GM
gerry melino
@melino_G · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 24,161 followersView post →
BR
BISWADEEP GHOSH ROY
@BISWADE26329340 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 64 followersView post →
UD
UChicago Obstetrics and Gynecology Department
@uchicago_obgyn · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 1,293 followersView post →
LL
Lengyel Lab
@OvCa_UChicago · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 98 followersView post →
EL
Ernst Lengyel
@ErnstLengyel · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 716 followersView post →
AN
Alejandro García Núñez
@AleGarNu81 · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 130 followersView post →
J
Jen
@jpadilla_DH · X
RT @Cancer_Cell: Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their…
Jun 27, 2025 · 43 shares · 73 followersView post →
CC
Cancer Cell
@Cancer_Cell · X
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/bfnijCzeF5 https://t.co/HnBhXbWEQJ
Jun 27, 2025 · 134 likes · 43 shares · 75,804 followersView post →
CC
Cancer Cell
@cp-cancercell.bsky.social · Bluesky
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
https://t.co/z7XxrXXvdl
Proud to share our latest work in #CancerCell in collaboration with the @mannlab.bsky.social: we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer and propose a promising new therapeutic strategy.
www.sciencedirect.com/science/arti...
A new publication in #CancerCell uncovers how borderline ovarian tumors evolve into low-grade serous ovarian cancer & identifies a promising new treatment strategy.
www.sciencedirect.com/science/arti...
@lisaschweizer.bsky.social @mannlab.bsky.social @lengyel-ovca-lab.bsky.social
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://www.medrxiv.org/content/10.1101/2023.11.13.23298409v1
Lucy Kelliher - MSPA Candidate at Stanford University | LinkedIn
LinkedIn
MSPA Candidate at Stanford University · Experience: Stanford University School of Medicine · Education: DePaul University · Location: Stanford · 162 ...
Integration of spatial transcriptomics and proteomics a) Multi-layer...
News
... Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression | Serous borderline ...
Maximilian Strauss - University of Copenhagen Research Portal
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Schweizer, L., Kenny ...
Lengyel Ovarian Cancer Lab Publications | Obstetrics and Gynecology
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. medRxiv [Preprint] ...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Cancer Cell. 2025-08 ...
Dr. Rahul Krishnan, MD – Orland Park, IL | Obstetrics & Gynecology
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Lisa Schweizer, Hilary ...
TGF-β–driven T-cell exclusion in ovarian cancer - Frontiers
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Cancer Cell. (2024) ...
AI-Powered Deep Visual Proteomics Reveals Critical Molecular ...
News
, et al. Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression . Cancer Cell.
Mevalonate pathway in pancreatic ductal adenocarcinoma
News
Cholesterol metabolism: at the cross road between cancer cells and immune environment. Int J Biochem Cell Biol. 2020;129:105876. https://doi.org/10.1016/j.
Publications - Biological Sciences Division - The University of Chicago
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Cancer Cell. 2025 ...
Publications | Ricardo R. Lastra, MD - University of Chicago Pathology
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Cancer Cell. 2025 ...
Miranda Good, Ph.D. Publications | Tufts University
News
Sanders E, Kaur K, Wagner N... 10 more. 10.1016/j.ajpath.2025.06.004 ... Cell‐To‐Cell Communication in the Resistance Vasculature. Oct 2022Comprehensive ...
News beyond our pages - Journal of Allergy and Clinical Immunology
News
... cell DNA methylation and ... e5; https://doi.org/10.1016/j.immuni.2025.06.004) identified increased circulating tryptase in patients with DOCK8 deficiency.
Spatial proteo-transcriptomic profiling reveals the molecular ...
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their progression to low-grade serous cancers and ...
... J, Xie M, Liu XM, Zhou L. J Mol Cell Cardiol. 2025 Jun 8;205:24-36. doi: 10.1016/j.yjmcc.2025.06.004. PubMed. mLumiOpto Is a Mitochondrial-Targeted Gene ...
Publications | Katherine Kurnit, MD | Obstetrics and Gynecology
News
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression. Cancer Cell. 2025 ...
Factors Influencing Refusal of Adjuvant Chemotherapy in Non–Small Cell Lung Carcinoma ... 10.1016/j.athoracsur.2025.06.004. Contributors: Andrew R. Brownlee; ...
Erin M. Janssen | Faculty - University of Michigan Medical School
News
e5. DOI:10.1016/j.immuni.2025.06.004 · PMID: 40570852. Journal Article. A homozygous truncating mutation of FGL2 is associated with immune dysregulation.
Spatial Multi-Omics Integration: Technologies, Data Fusion and ...
News
The Lengyel group at the University of Chicago (2025, Cancer Cell, DOI:10.1016/j.ccell.2025.06.004) combined spatial proteomics and transcriptomics to ...
doi: 10.1016/j.ccell.2025.03.002. (Open in a new window)PubMed (Open in a new ... doi: 10.1016/j.trecan.2025.06.004. (Open in a new window)PubMed (Open ...
Proximity between LAG-3 and the T cell receptor guides ...
News
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity (IMAGE) ... 10.1016/j.cell.2025.06.004. Tags. /Life ...
Cardiac Science publications | Faculty of Medicine
Blogs
BibTex format. @article{Huang:2025:10.1016/j.jcmg.2025.06.004, author = {Huang, B and Tonko, J and Yan, J and Smith, C and Gvinianidze, L and Toulemonde, ...
One small detail people keep overlooking. Scientists just found a ...
Instagram
Once construction is complete, the cell ... https://doi.org/10.1016/j.ydbio.2025.06.004 ... Bacteriophage hijacks the cell machinery to make copies ...