Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers.

Jin Gyun Lee, Joseph Petraccione, Katherine A Trese, Alex C Hughes, Taylor R Ausec, Maren Salzmann-Sullivan, Lih-Jen Su, Matthew T Kim, Sangchul Roh, Andrew P Goodwin, Frances Xiuyan Feng, Thomas W Flaig, C Wyatt Shields

September 2025 Adv Mater

Synopsis of Social media discussions

The overall tone combines supportive remarks, as seen in comments like 'Huge congrats' and mentions of the gecko-inspired mechanism, with an appreciation of the research's practical implications. The emphasis on biodegradability and targeted therapy signals recognition of its innovative potential and significance for future cancer treatments.

A
Agreement
 Moderate agreement

Most discussions express support or approval, highlighting the innovative nature and potential of the research.

I
Interest
 Moderate level of interest

Posts show moderate curiosity, with some emphasizing the gecko-inspired design and targeted drug delivery.

E
Engagement
 Moderate level of engagement

Comments include congratulations and references to the treatment approach, indicating active recognition but limited deep analysis.

I
Impact
 Moderate level of impact

Discussions suggest acknowledgment of the research's significance for bladder cancer treatment, reflecting a positive perception of its potential impact.

Social Mentions

YouTube

2 Videos

Twitter

13 Posts

Blogs

5 Articles

News

14 Articles

Metrics

Video Views

57

Total Likes

33

Extended Reach

1,198,867

Social Features

34

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Gecko-Inspired Adhesive Technology for Improved Cancer Therapy

Gecko-Inspired Adhesive Technology for Improved Cancer Therapy

Scientists develop a new material inspired by gecko toes that could help chemotherapy drugs cling to tumors, enabling less frequent, more effective treatment with fewer side effects. The research focuses on bladder cancer and innovative drug delivery methods.

KUNC

August 13, 2025

42 views

Innovative Gecko-Inspired Cancer Therapy for Enhanced Tumor Targeting

Innovative Gecko-Inspired Cancer Therapy for Enhanced Tumor Targeting

Scientists at the University of Colorado Boulder developed a new therapy inspired by gecko adhesion, using soft dendritic particles embedded in hydrogel to stick to bladder cancer cells, enabling sustained drug delivery and improved treatment effectiveness.

KUNC

October 24, 2025

15 views

  • Greg A Jackson
    @GregAJackson1 (Twitter)

    Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/Y2IKvwSCLW
    view full post

    August 5, 2025

  • HealthyBuilds
    @JamesSw70043542 (Twitter)

    Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/XXW2rCIqaN
    view full post

    August 4, 2025

  • HealthyBuilds
    @HealthyBuilds (Twitter)

    Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/iqYos7qUz8
    view full post

    August 4, 2025

  • Wyatt Shields
    @WyattShieldsIV (Twitter)

    RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…
    view full post

    July 21, 2025

    9

  • Theo-the-cat & Sybee
    @TheoLeChat (Twitter)

    RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…
    view full post

    July 21, 2025

    9

  • Chris Evans
    @chessmoderna (Twitter)

    RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…
    view full post

    July 21, 2025

    9

  • Chris Simms
    @BaltimoreCard (Twitter)

    RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…
    view full post

    July 21, 2025

    9

  • Leti Vargas
    @s_Orbital (Twitter)

    RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…
    view full post

    July 21, 2025

    9

  • Phys.org
    @physorg_com (Twitter)

    RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…
    view full post

    July 21, 2025

    9

  • Medical Xpress
    @medical_xpress (Twitter)

    A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment with fewer side effects and the potential for improved patient outcomes. @advmater https://t.co/EBsa4bKSBV https://t.co/rW17bh4EYm
    view full post

    July 21, 2025

    22

    9

  • Courtney
    @bailey_etal (Twitter)

    RT @WyattShieldsIV: Huge congrats Jin and co-authors
    view full post

    July 7, 2025

    2

  • Arkodip Mandal
    @arkodipm23 (Twitter)

    RT @WyattShieldsIV: Huge congrats Jin and co-authors
    view full post

    July 7, 2025

    2

  • Wyatt Shields
    @WyattShieldsIV (Twitter)

    Huge congrats Jin and co-authors
    view full post

    July 7, 2025

    11

    2

Abstract Synopsis

  • The study introduces a straightforward method to create soft dendritic particles (SDPs) made from biodegradable materials like PLGA and chitosan, which can stick to bladder cancer cells and deliver chemotherapy drugs over several days.
  • These SDPs are embedded in an alginate hydrogel for precise, sustained application and show improved drug retention, effectiveness, and immune response in mouse models of bladder cancer.
  • The approach mimics gecko feet's adhesion mechanism, providing a simple, cost-effective way to enhance drug delivery in epithelial cancers with minimal toxicity.]