Adv Mater September 2025 PMID 40611758

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers.

Jin Gyun Lee, Joseph Petraccione, Katherine A Trese, Alex C Hughes, Taylor R Ausec, Maren Salzmann-Sullivan, Lih-Jen Su, Matthew T Kim, Sangchul Roh, Andrew P Goodwin, Frances Xiuyan Feng, Thomas W Flaig, C Wyatt Shields

Mentions

34
Peak: 10 in Jul 2025
across 4 sources since Jul 2025

Extended reach

1,198,867
potential audience

Total likes

33

Video views

57

Mentions per month

Jul 2025 – Oct 2025

Where it's discussed

  • News14 articles
  • X / Twitter13 posts
  • Blogs5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone combines supportive remarks, as seen in comments like 'Huge congrats' and mentions of the gecko-inspired mechanism, with an appreciation of the research's practical implications. The emphasis on biodegradability and targeted therapy signals recognition of its innovative potential and significance for future cancer treatments.

AgreementModerate agreement

Most discussions express support or approval, highlighting the innovative nature and potential of the research.

InterestModerate interest

Posts show moderate curiosity, with some emphasizing the gecko-inspired design and targeted drug delivery.

EngagementModerate engagement

Comments include congratulations and references to the treatment approach, indicating active recognition but limited deep analysis.

ImpactModerate impact

Discussions suggest acknowledgment of the research's significance for bladder cancer treatment, reflecting a positive perception of its potential impact.

Abstract in brief

  • The study introduces a straightforward method to create soft dendritic particles (SDPs) made from biodegradable materials like PLGA and chitosan, which can stick to bladder cancer cells and deliver chemotherapy drugs over several days.
  • These SDPs are embedded in an alginate hydrogel for precise, sustained application and show improved drug retention, effectiveness, and immune response in mouse models of bladder cancer.
  • The approach mimics gecko feet's adhesion mechanism, providing a simple, cost-effective way to enhance drug delivery in epithelial cancers with minimal toxicity.]

Top posts

Most liked on X and Bluesky
Medical Xpress
@medical_xpress · X

A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment with fewer side effects and the potential for improved patient outcomes. @advmater https://t.co/EBsa4bKSBV https://t.co/rW17bh4EYm

Jul 21, 2025 · 22 likes · 9 shares · 173,238 followers View post →
Wyatt Shields
@WyattShieldsIV · X

Huge congrats Jin and co-authors

Jul 7, 2025 · 11 likes · 2 shares · 1,105 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 1,020,412 followers View post →
Leti Vargas
@s_Orbital · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 1,231 followers View post →
Wyatt Shields
@WyattShieldsIV · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 1,105 followers View post →
Greg A Jackson
@GregAJackson1 · X

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/Y2IKvwSCLW

Aug 5, 2025 · 544 followers View post →

All mentions

Greg A Jackson
@GregAJackson1 · X

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/Y2IKvwSCLW

Aug 5, 2025 · 544 followers View post →
HealthyBuilds
@JamesSw70043542 · X

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/XXW2rCIqaN

Aug 4, 2025 · 15 followers View post →
HealthyBuilds
@HealthyBuilds · X

Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers https://t.co/iqYos7qUz8

Aug 4, 2025 · 201 followers View post →
Wyatt Shields
@WyattShieldsIV · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 1,105 followers View post →
Theo-the-cat & Sybee
@TheoLeChat · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 527 followers View post →
Chris Evans
@chessmoderna · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 20 followers View post →
Chris Simms
@BaltimoreCard · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 50 followers View post →
Leti Vargas
@s_Orbital · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 1,231 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment wit…

Jul 21, 2025 · 9 shares · 1,020,412 followers View post →
Medical Xpress
@medical_xpress · X

A gecko-inspired biodegradable material delivers chemotherapy drugs directly to tumors, offering targeted treatment with fewer side effects and the potential for improved patient outcomes. @advmater https://t.co/EBsa4bKSBV https://t.co/rW17bh4EYm

Jul 21, 2025 · 22 likes · 9 shares · 173,238 followers View post →
Courtney
@bailey_etal · X

RT @WyattShieldsIV: Huge congrats Jin and co-authors

Jul 7, 2025 · 2 shares · 40 followers View post →
Arkodip Mandal
@arkodipm23 · X

RT @WyattShieldsIV: Huge congrats Jin and co-authors

Jul 7, 2025 · 2 shares · 184 followers View post →
Wyatt Shields
@WyattShieldsIV · X

Huge congrats Jin and co-authors

Jul 7, 2025 · 11 likes · 2 shares · 1,105 followers View post →