July 2025 PMID 40632570

Thalamic CGRP neurons define a spinothalamic pathway for affective pain.

Sukjae J Kang, Shijia Liu, Jong-Hyun Kim, Dong-Il Kim, Tae Gyu Oh, Jiahang Peng, Mao Ye, Kuo-Fen Lee, Ronald M Evans, Martyn Goulding, Sung Han

Mentions

53
Peak: 27 in Jul 2025
across 5 sources since Jul 2025

Extended reach

1,913,166
potential audience

Total likes

2,885

Video views

21,948

Mentions per month

Jul 2025 – Oct 2025

Where it's discussed

  • X / Twitter29 posts
  • News16 articles
  • Blogs5 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

Several posts highlight the groundbreaking nature of identifying a distinct neural circuit for affective pain, emphasizing words like 'revealed,' 'link,' and 'new targets.' The tone conveys excitement and anticipation about how this research might influence future pain therapies and understanding of emotional suffering, demonstrating high engagement and perceived importance.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some explicitly supporting its implications for understanding pain mechanisms, as seen in comments about the 'neural circuits linking physical pain to emotional suffering' and the call fo

InterestHigh interest

The posts demonstrate high curiosity, frequently asking questions about potential advances or implications, such as 'What advances do you think may arise?' and emphasizing the novelty of the findings.

EngagementModerate engagement

Several discussions reference specific neural pathways, brain regions, and potential applications, showing deeper analytical interest, like mentions of 'relaying pain signals to the amygdala' and 'targets for treating conditions like migraine and PTSD.'

ImpactHigh impact

The posts reflect a perception of high impact, with some describing the research as a 'game changer' or noting its potential for formulating new treatments for emotionally-focused chronic pain conditions, suggesting strong perceived influence on future re

Top posts

Most liked on X and Bluesky
Sung Han
@iamhans · X

New paper out in @PNASNews. Thalamic CGRP neurons form a spinothalamic pain pathway relaying pain signal to the amygdala & insular, but not sensory cortex to encode the affective dimension of pain. Huge congrats to first author @SJ_J_Kang_24 & coauthors. https://t.co/1GENFL7tX1

Jul 9, 2025 · 92 likes · 14 shares · 1,129 followers View post →
Medical Xpress
@medical_xpress · X

#A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and potential new targets for treating conditions like migraine and PTSD. @salkinstitute @PNASNews https://t.co/VPRrMfa4M6 https://t.co/wZzieyzuFU

Jul 9, 2025 · 20 likes · 15 shares · 173,158 followers View post →
Rosario in Paris ᥫ᭡
@chayito09 · X

Fuente: https://t.co/AH4UXLZG85 Artículo original https://t.co/tfXuM8tl5I

Aug 15, 2025 · 13 likes · 1 share · 75,546 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Thalamic CGRP neurons define spinothalamic pathway for affective pain” by Sung Han et al. PNAS https://t.co/VtTKyMe62N

Jul 10, 2025 · 10 likes · 2 shares · 505,817 followers View post →
Pain Research Forum
@PainResForum · X

What advances do you think may arise from the revelation of a distinct neural circuit involving CGRP neurons in the subparafascicular nucleus, published by Kang et al. in @PNASNews? https://t.co/Iul5Jhe837 #PRF #EditorsPick https://t.co/PedLZ08Ul4

Jul 25, 2025 · 4 likes · 2 shares · 15,364 followers View post →
VGranados
@VinicioGranados · X

https://t.co/1c60vwE36q

Jul 19, 2025 · 4 likes · 1 share · 309 followers View post →

All mentions

Gabriel Bendinelli
@GabrielBendine5 · X

https://t.co/TsYBp6q9fv

Oct 2, 2025 · 422 followers View post →
ferminacevesd
@ferminacevesd · X

RT @chayito09: Fuente: https://t.co/AH4UXLZG85 Artículo original https://t.co/tfXuM8tl5I

Aug 15, 2025 · 1 share · 2,695 followers View post →
Rosario in Paris ᥫ᭡
@chayito09 · X

Fuente: https://t.co/AH4UXLZG85 Artículo original https://t.co/tfXuM8tl5I

Aug 15, 2025 · 13 likes · 1 share · 75,546 followers View post →
Luigi F. Iannone
@Luigi_Ian_ · X

RT @PainResForum: What advances do you think may arise from the revelation of a distinct neural circuit involving CGRP neurons in the subpa…

Jul 25, 2025 · 2 shares · 82 followers View post →
Victoria E. Abraira
@VAbraira · X

RT @PainResForum: What advances do you think may arise from the revelation of a distinct neural circuit involving CGRP neurons in the subpa…

Jul 25, 2025 · 2 shares · 2,807 followers View post →
Pain Research Forum
@PainResForum · X

What advances do you think may arise from the revelation of a distinct neural circuit involving CGRP neurons in the subparafascicular nucleus, published by Kang et al. in @PNASNews? https://t.co/Iul5Jhe837 #PRF #EditorsPick https://t.co/PedLZ08Ul4

Jul 25, 2025 · 4 likes · 2 shares · 15,364 followers View post →
Australian Pain Soc
@AusPainSoc · X

RT @IASPpain: What advances do you think may arise from the revelation of a distinct neural circuit involving CGRP neurons in the subparafa…

Jul 24, 2025 · 1 share · 4,764 followers View post →
IASP
@IASPpain · X

What advances do you think may arise from the revelation of a distinct neural circuit involving CGRP neurons in the subparafascicular nucleus, published by Kang et al. in @PNASNews? https://t.co/Px4AP1Q8Uy #PRF #EditorsPick https://t.co/oiW5LnW2VR

Jul 23, 2025 · 3 likes · 1 share · 22,732 followers View post →
Yarim De la Luz-Cuellar
@atarii_cuellar · X

RT @VinicioGranados: https://t.co/1c60vwE36q

Jul 19, 2025 · 1 share · 199 followers View post →
Dr Andrea Furlan
@andreafurlan.bsky.social · Bluesky

We can’t deny it: there is emotional pain. We need better treatments that address the emotional and motivational components of pain. Thalamic CGRP neurons define a spinothalamic pathway for affective pain www.pnas.org/doi/10.1073/...

Jul 19, 2025 · 1 like View post →
VGranados
@VinicioGranados · X

https://t.co/1c60vwE36q

Jul 19, 2025 · 4 likes · 1 share · 309 followers View post →
Andrea D. Furlan MD PhD PM&R
@adfurlan · X

We can’t deny it: there is emotional pain. We need better treatments that address the emotional and motivational components of pain. Thalamic CGRP neurons define a spinothalamic pathway for affective pain | PNAS https://t.co/nrRuRaCJKY

Jul 19, 2025 · 2 likes · 6,643 followers View post →
Dr. Dominic Ng
@DrDominicNg · X

@drjonathanchung https://t.co/LElDiALeFv Oh yeah I must have forgot to do it - here you go

Jul 13, 2025 · 1 like · 12,717 followers View post →
Robert West, PhD ✝️
@westr · X

How a hidden brain circuit fuels fibromyalgia, migraines, and PTSD https://t.co/OXOspDQjDe Thalamic CGRP neurons define a spinothalamic pathway for affective pain https://t.co/dP2agOgIeH

Jul 13, 2025 · 3 likes · 19,314 followers View post →
Professor Erwin Loh
@erwinloh · X

Source: https://t.co/r8jdeH6bFt

Jul 13, 2025 · 9,415 followers View post →
Ingentium
@Ingentium_Inc · X

Thalamic CGRP neurons define a spinothalamic pathway for affective pain. https://t.co/z9UGitEMCx https://t.co/OsVLi3V0R7

Jul 11, 2025 · 108 followers View post →
な bot
@NeuroNNNNN_bot · X

[PNAS] Thalamic CGRP neurons define a spinothalamic pathway for affective pain https://t.co/MiL29xT80H

Jul 10, 2025 · 26 followers View post →
Unknown
@TradWifeRN · X

RT @NeuroscienceNew: “Thalamic CGRP neurons define spinothalamic pathway for affective pain” by Sung Han et al. PNAS https://t.co/VtTKyMe6…

Jul 10, 2025 · 2 shares · 374 followers View post →
Whisper Truth
@Elroi311 · X

RT @NeuroscienceNew: “Thalamic CGRP neurons define spinothalamic pathway for affective pain” by Sung Han et al. PNAS https://t.co/VtTKyMe6…

Jul 10, 2025 · 2 shares · 374 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Thalamic CGRP neurons define spinothalamic pathway for affective pain” by Sung Han et al. PNAS https://t.co/VtTKyMe62N

Jul 10, 2025 · 10 likes · 2 shares · 505,817 followers View post →
Rebecca Seal
@lab_seal · X

RT @iamhans: New paper out in @PNASNews. Thalamic CGRP neurons form a spinothalamic pain pathway relaying pain signal to the amygdala & ins…

Jul 9, 2025 · 14 shares · 898 followers View post →
Errant Thoughts
@ErrantThoughts · X

RT @medical_xpress: #A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and po…

Jul 9, 2025 · 15 shares · 281 followers View post →
⚡️GREG_CORDER⚡️
@FlyBottleEscape · X

RT @iamhans: New paper out in @PNASNews. Thalamic CGRP neurons form a spinothalamic pain pathway relaying pain signal to the amygdala & ins…

Jul 9, 2025 · 14 shares · 3,655 followers View post →
Michael Krashes
@michael_krashes · X

RT @iamhans: New paper out in @PNASNews. Thalamic CGRP neurons form a spinothalamic pain pathway relaying pain signal to the amygdala & ins…

Jul 9, 2025 · 14 shares · 2,190 followers View post →
Sung Han
@iamhans · X

New paper out in @PNASNews. Thalamic CGRP neurons form a spinothalamic pain pathway relaying pain signal to the amygdala & insular, but not sensory cortex to encode the affective dimension of pain. Huge congrats to first author @SJ_J_Kang_24 & coauthors. https://t.co/1GENFL7tX1

Jul 9, 2025 · 92 likes · 14 shares · 1,129 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @medical_xpress: #A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and po…

Jul 9, 2025 · 15 shares · 2,820 followers View post →
human-ish
@CANALI3N · X

RT @medical_xpress: #A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and po…

Jul 9, 2025 · 15 shares · 1,620 followers View post →
MCAS, PTSD and ME
@FatigueMe92484 · X

RT @medical_xpress: #A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and po…

Jul 9, 2025 · 15 shares · 1,189 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: #A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and po…

Jul 9, 2025 · 15 shares · 1,024,242 followers View post →
Medical Xpress
@medical_xpress · X

#A newly identified #BrainCircuit links physical pain to emotional suffering, offering insight into chronic pain and potential new targets for treating conditions like migraine and PTSD. @salkinstitute @PNASNews https://t.co/VPRrMfa4M6 https://t.co/wZzieyzuFU

Jul 9, 2025 · 20 likes · 15 shares · 173,158 followers View post →