Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @ScienceMagazine! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: https://t.co/T7rfR8uK8M https://t.co/hGFpvlPb53
De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.
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Dec 2024 – Sep 2025Where it's discussed
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AI synopsis
What people are saying
The discussions highlight various aspects of the article, such as the innovative design platform and its potential for personalized immunotherapy. For example, phrases like 'rapid design of protein binders' and 'custom proteins in weeks rather than years' indicate excitement about the advancements being made. The enthusiasm is further illustrated by comments about the need for broader efforts to address cancer, with words like 'reprogram immune cells' and 'game changer' enhancing the tone of urgency and optimism.
The general tone of the discussions shows recognition of the significance of the study, with many participants expressing support for the findings and implications.
There is a high level of curiosity surrounding the research, particularly regarding the use of AI in designing cancer treatments.
While many discussions summarize the findings, a few delve deeper into the methodologies and potential applications of the research.
Participants express a belief that this research could greatly influence cancer treatment approaches moving forward.
Abstract in brief
- The study focuses on how CD8 T cells identify antigens inside cells, crucial for fighting infections and cancer, and addresses the challenges of identifying T cell receptors (TCRs) from patients.
- A new design platform called "minibinder" (miBd) uses advanced generative models and in silico methods to create targeted binders for cancer-associated peptides, enhancing specificity and predictability.
- The researchers successfully developed a high-affinity binder for the NY-ESO-1 peptide, which not only killed melanoma cells but also showed promise in targeting other neoantigens for precision immunotherapy.
Top posts
Most liked on X and BlueskyWe really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/A4koTBKK2p
De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex (pMHC) https://t.co/mkUxTAE4de
An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially accelerating personalized immunotherapy development from years to weeks. @sciencemagazine https://t.co/5Bh4Yoc27o https://t.co/jyISvWWNnI
Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: doi.org/10.1126/scie...
https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
All mentions
Advancements in T Cell Immunotherapy for Cancer Treatment
This video discusses how CD8 T cells identify antigens within cells, a key process in combatting infections and cancer. The study highlights a design platform, "minibinder," that creates specific binders for…
Enhancing T-Cell Precision in Cancer Treatment with AI Innovations
Discover how AI is revolutionizing cancer treatment by enhancing T-cells. This video explores a new design platform called 'minibinder' that creates targeted binders, improving T-cell-mediated cytotoxicity against…
RT @Nick_HTLC: Hey @Aubrai_, what if we integrate AI-designed de novo pMHC binders (like those in the 2025 Science study, DOI: 10.1126/scie…
Hey @Aubrai_, what if we integrate AI-designed de novo pMHC binders (like those in the 2025 Science study, DOI: 10.1126/science.adv0422) with nanoparticle-delivered mRNA vaccines and pulsed senolytics to engineer precision T-cell responses against patient-specific neoantigens in https://t.co/8CYgIliQz9
AI-designed cancer fighters in weeks, not years A new platform from DTU designs tumor-targeting proteins in just 4–6 weeks, using AI and virtual safety checks. Faster, safer, and fit for personalized immunotherapy. Read more: https://t.co/HokSkOQMqN #AIinBiotech #Immunotherapy https://t.co/W9HVuHTKks
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/iu1DzORuhh
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
Misiles moleculares contra células cancerosas https://t.co/6AbEDA8o53 Más información: De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity towards cancer cells https://t.co/kf8Y0q4udM
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @chayito09: Fuentes: https://t.co/Aql9Knui1o https://t.co/f37kb6gZIu
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @aratama0315: https://t.co/QLVLBvDGfu
Fuentes: https://t.co/Aql9Knui1o https://t.co/f37kb6gZIu
https://t.co/QLVLBvDGfu
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…
RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
https://t.co/vVJIXbY1Pn
We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/A4koTBKK2p
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
RT @GreenwoodNathan: You can read related work here! https://t.co/ECsk4o0OMA https://t.co/IVlaEHFFFw
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells - New StudyScience, Volume 389, Issue 6758, Page 380-385, July 2025. Summary I cannot provide a summary without access to the content of the specified issue of Sci... https://t.co/CTjRcaWDwy
RT @4quaOf: De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells https://t.co/3jdPL9MoYX https://t.co/…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells https://t.co/3jdPL9MoYX https://t.co/B0Z2PxMUXI https://t.co/0NoImkkmaf
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells www.science.org/doi/10.1126/...
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex (pMHC)
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @4quaOf:
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
RT @ilyassahinMD: *https://t.co/rP3J6s9cp5
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/gyj47gswLk
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
*https://t.co/rP3J6s9cp5
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
You can read related work here! https://t.co/ECsk4o0OMA https://t.co/IVlaEHFFFw
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
“De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells.”
“De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells.” https://t.co/tDwZX4R26L
https://t.co/MPtMf1Zbyg
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells pubmed.ncbi.nlm.nih.gov/40705893/ #cryoEM
More AI for science… De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/7oGVPooAuu
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
Scientists from the Technical University of Denmark just developed an AI platform that designs custom proteins in weeks rather than years, enabling immune (T) cells to target and destroy cancer cells https://t.co/mdxr0qIrsj #artificalintelligence #Technology #Innovation #Tech
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…
RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groun…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @KrisHaurum: Huge thanks to the incredible team, especially Tim, Sine, Beatrice Scapolo, Darian Wolff, and @moonii1020 !
RT @Dr_Singularity: paper https://t.co/l0CeRaWDVb
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/5kiaH1bi8j
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex (pMHC) https://t.co/mkUxTAE4de
De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex https://t.co/gZi3297vWR
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
paper https://t.co/l0CeRaWDVb
RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
@TimothyPJenkins et al developed a TCR mimic specific to the NY-ESO-1 peptide bound to HLA-A*02, referred to as a minibinder https://t.co/BWWftQP5Ad https://t.co/kEudOsoQIU
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…
An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially accelerating personalized immunotherapy development from years to weeks. @sciencemagazine https://t.co/5Bh4Yoc27o https://t.co/jyISvWWNnI
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells https://t.co/rMnGDUNNLF
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
To my rare readers who think doctors have cured cancer but are just hiding it to make $$$, please read this article. The fact it is way over your head shows geniuses are working feverishly to cure cancer. https://t.co/X91v2uMFQB
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
Huge thanks to the incredible team, especially Tim, Sine, Beatrice Scapolo, Darian Wolff, and @moonii1020 !
https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…
RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…
How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@ScienceMagazine @DTUtweet "De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells" • Researchers developed a rapid de novo https://t.co/gZsqWgMsA0
Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: doi.org/10.1126/scie...
Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @ScienceMagazine! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: https://t.co/T7rfR8uK8M https://t.co/hGFpvlPb53
De novo designed pMHC binders facilitate T cell induced killing of cancer cells This paper describes a novel platform for designing minibinders (miBds) targeting cancer-associated pMHC complexes using generative AI. The miBds were designed, screened in silico and validated in vitro, ...
De novo designed pMHC binders facilitate T cell induced killing of cancer cells https://www.biorxiv.org/content/10.1101/2024.11.27.624796v1
De novo designed pMHC binders facilitate T cell induced killing of cancer cells https://www.biorxiv.org/content/10.1101/2024.11.27.624796v1