Science July 2025 PMID 40705893

De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.

Kristoffer Haurum Johansen, Darian Stephan Wolff, Beatrice Scapolo, Monica L Fernández-Quintero, Charlotte Risager Christensen, Johannes R Loeffler, Esperanza Rivera-de-Torre, Max D Overath, Kamilla Kjærgaard Munk, Oliver Morell, Marie Christine Viuff, Iñigo Lacunza, Alberte T Damm Englund, Mathilde Due, Anant Gharpure

Mentions

170
Peak: 114 in Jul 2025
across 5 sources since Dec 2024

Extended reach

6,734,443
potential audience

Total likes

751

Video views

10,568

Mentions per month

Dec 2024 – Sep 2025

Where it's discussed

  • X / Twitter124 posts
  • News32 articles
  • Bluesky8 posts
  • Blogs4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight various aspects of the article, such as the innovative design platform and its potential for personalized immunotherapy. For example, phrases like 'rapid design of protein binders' and 'custom proteins in weeks rather than years' indicate excitement about the advancements being made. The enthusiasm is further illustrated by comments about the need for broader efforts to address cancer, with words like 'reprogram immune cells' and 'game changer' enhancing the tone of urgency and optimism.

AgreementModerate agreement

The general tone of the discussions shows recognition of the significance of the study, with many participants expressing support for the findings and implications.

InterestHigh interest

There is a high level of curiosity surrounding the research, particularly regarding the use of AI in designing cancer treatments.

EngagementModerate engagement

While many discussions summarize the findings, a few delve deeper into the methodologies and potential applications of the research.

ImpactHigh impact

Participants express a belief that this research could greatly influence cancer treatment approaches moving forward.

Abstract in brief

  • The study focuses on how CD8 T cells identify antigens inside cells, crucial for fighting infections and cancer, and addresses the challenges of identifying T cell receptors (TCRs) from patients.
  • A new design platform called "minibinder" (miBd) uses advanced generative models and in silico methods to create targeted binders for cancer-associated peptides, enhancing specificity and predictability.
  • The researchers successfully developed a high-affinity binder for the NY-ESO-1 peptide, which not only killed melanoma cells but also showed promise in targeting other neoantigens for precision immunotherapy.

Top posts

Most liked on X and Bluesky
Timothy Jenkins
@TimothyPJenkins · X

Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @ScienceMagazine! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: https://t.co/T7rfR8uK8M https://t.co/hGFpvlPb53

Jul 24, 2025 · 216 likes · 43 shares · 827 followers View post →
Brian Boynton, MD
@BoyntonBrian · X

We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/A4koTBKK2p

Jul 27, 2025 · 90 likes · 17 shares · 70 followers View post →
Biology+AI Daily
@BiologyAIDaily · X

De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex (pMHC) https://t.co/mkUxTAE4de

Jul 24, 2025 · 75 likes · 9 shares · 14,434 followers View post →
Medical Xpress
@medical_xpress · X

An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially accelerating personalized immunotherapy development from years to weeks. @sciencemagazine https://t.co/5Bh4Yoc27o https://t.co/jyISvWWNnI

Jul 24, 2025 · 47 likes · 27 shares · 172,997 followers View post →
Timothy P. Jenkins
@tpjenkins.bsky.social · Bluesky

Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: doi.org/10.1126/scie...

Jul 24, 2025 · 35 likes · 8 shares View post →
Klebanoff_Lab
@KlebanoffLab · X

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Jul 24, 2025 · 28 likes · 7 shares · 3,199 followers View post →

All mentions

Nick. π²
@Nick_HTLC · X

RT @Nick_HTLC: Hey @Aubrai_, what if we integrate AI-designed de novo pMHC binders (like those in the 2025 Science study, DOI: 10.1126/scie…

Sep 11, 2025 · 1 share · 2,901 followers View post →
Nick. π²
@Nick_HTLC · X

Hey @Aubrai_, what if we integrate AI-designed de novo pMHC binders (like those in the 2025 Science study, DOI: 10.1126/science.adv0422) with nanoparticle-delivered mRNA vaccines and pulsed senolytics to engineer precision T-cell responses against patient-specific neoantigens in https://t.co/8CYgIliQz9

Sep 11, 2025 · 5 likes · 1 share · 2,901 followers View post →
Juan Sánchez
@juanyo · X

Sep 3, 2025 · 1 like · 13,846 followers View post →
Ardigen
@Ardigen_SA · X

AI-designed cancer fighters in weeks, not years A new platform from DTU designs tumor-targeting proteins in just 4–6 weeks, using AI and virtual safety checks. Faster, safer, and fit for personalized immunotherapy. Read more: https://t.co/HokSkOQMqN #AIinBiotech #Immunotherapy https://t.co/W9HVuHTKks

Aug 12, 2025 · 567 followers View post →
旅人 tabito
@tabibito250 · X

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/iu1DzORuhh

Aug 8, 2025 · 1 like · 1,076 followers View post →
Katharine
@kramp47 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 5, 2025 · 17 shares · 159 followers View post →
Lisbani Marbel
@LisbaniMar9 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 5, 2025 · 17 shares · 122 followers View post →
Naina
@Salenophile786 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 5, 2025 · 17 shares · 9,482 followers View post →
Elizabeth Roderick
@eroderick · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 5, 2025 · 17 shares · 366 followers View post →
Frederick Husar
@fredericknchgo · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 4, 2025 · 17 shares · 4,309 followers View post →
TweetyBurg
@nivratsmom · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 3, 2025 · 17 shares · 666 followers View post →
MamaLisa
@lisaweedn · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 3, 2025 · 17 shares · 1,505 followers View post →
The REAL #CheekyDre
@CheekyDre · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 1, 2025 · 17 shares · 4,417 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Misiles moleculares contra células cancerosas https://t.co/6AbEDA8o53 Más información: De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity towards cancer cells https://t.co/kf8Y0q4udM

Aug 1, 2025 · 158 followers View post →
orion77
@orion7710 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Aug 1, 2025 · 17 shares · 1,491 followers View post →
Butzi
@ace2blue · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 30, 2025 · 17 shares · 8,525 followers View post →
Hope Larkin-Begley
@HopeBegley · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 30, 2025 · 17 shares · 2,753 followers View post →
Evan A. Feigenbaum
@EvanFeigenbaum · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 29, 2025 · 17 shares · 46,705 followers View post →
ferminacevesd
@ferminacevesd · X

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Jul 29, 2025 · 1 share · 2,687 followers View post →
Dr. T aka Theresa Gilliland FNP PMHNP DNP
@IceT1158 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 29, 2025 · 17 shares · 1,537 followers View post →
Brian Gavin
@BrianGavin2 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 29, 2025 · 17 shares · 121 followers View post →
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@aratama0315 · X

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Jul 29, 2025 · 1 share · 2,316 followers View post →
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Donna
@transmgmnt1 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 28, 2025 · 17 shares · 243 followers View post →
Catherine Duke
@CathyDuke1231 · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 28, 2025 · 17 shares · 8,234 followers View post →
Nicolai Sagasser
@nicolaisagasser · X

RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…

Jul 28, 2025 · 5 shares · 35 followers View post →
Silcy
@Silc_nj · X

RT @BoyntonBrian: We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cel…

Jul 28, 2025 · 17 shares · 1,466 followers View post →
cloudameoba
@cloudameoba · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 27, 2025 · 43 shares · 38 followers View post →
DHprotein
@DHprotein · X

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Jul 27, 2025 · 15 followers View post →
Brian Boynton, MD
@BoyntonBrian · X

We really need a planet wide program outside of politics to cure cancer. De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/A4koTBKK2p

Jul 27, 2025 · 90 likes · 17 shares · 70 followers View post →
Yuta Aoki, D.Sc.
@YutaMAoki · X

RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…

Jul 26, 2025 · 9 shares · 623 followers View post →
Cloud Dev Chris
@clouddevchris · X

RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…

Jul 26, 2025 · 9 shares · 551 followers View post →
Vanja Tepavcevic
@TepavcevicVanja · X

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Jul 26, 2025 · 1 share · 892 followers View post →
saddickur
@saddickur · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 26, 2025 · 43 shares · 20 followers View post →
Dr. STech
@Drafs007 · X

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells - New StudyScience, Volume 389, Issue 6758, Page 380-385, July 2025. Summary I cannot provide a summary without access to the content of the specified issue of Sci... https://t.co/CTjRcaWDwy

Jul 26, 2025 · 381 followers View post →
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@music1music3 · X

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Jul 26, 2025 · 1 share · 8 followers View post →
Song LIang
@SongLIa91531763 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 26, 2025 · 43 shares · 368 followers View post →
4Qua Of Orion
@4quaOf · X

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells https://t.co/3jdPL9MoYX https://t.co/B0Z2PxMUXI https://t.co/0NoImkkmaf

Jul 26, 2025 · 1 like · 1 share · 80 followers View post →
4Qua Of Orion [ General NobuNaga Version ]
@4quazulu.bsky.social · Bluesky

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells www.science.org/doi/10.1126/...

Jul 26, 2025 · 2 shares View post →
Saubashya Sur, PhD
@SaubashyaSur · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 26, 2025 · 43 shares · 768 followers View post →
Saubashya Sur, PhD
@SaubashyaSur · X

RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…

Jul 26, 2025 · 9 shares · 768 followers View post →
Steven Park
@StevenPark13061 · X

De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex (pMHC)

Jul 26, 2025 · 3 followers View post →
Roi Gazit
@roi_gazit · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 26, 2025 · 43 shares · 844 followers View post →
Daedalus
@whooves_s · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 26, 2025 · 43 shares · 156 followers View post →
Rudolph Lohmeyer
@RudolphLohmeyer · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 1,219 followers View post →
Lyle Burdine
@LyleBurdine · X

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Jul 25, 2025 · 7 shares · 798 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 254,005 followers View post →
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@music1music3 · X

RT @4quaOf:

Jul 25, 2025 · 1 share · 8 followers View post →
4Qua Of Orion
@4quaOf · X

Jul 25, 2025 · 1 like · 1 share · 80 followers View post →
Yeekien,Chong
@ykchong90 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 244 followers View post →
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@ykchong90 · X

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@NarSevgip · X

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Jul 25, 2025 · 1 share · 33 followers View post →
Xiangyue Zhang
@Xiangyue_CA · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 277 followers View post →
Esra Gülderen
@gulderenesra · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 707 followers View post →
Montgomery Granger
@mjgranger1 · X

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/gyj47gswLk

Jul 25, 2025 · 1 like · 124,177 followers View post →
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@Iris_Illera · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 619 followers View post →
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@ilyassahinMD · X

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Jul 25, 2025 · 2 likes · 1 share · 20,809 followers View post →
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@EricM_Liu · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 930 followers View post →
Nathan Greenwood
@GreenwoodNathan · X

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Jul 25, 2025 · 5 likes · 1 share · 63 followers View post →
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@ayirpelle · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 4,886 followers View post →
Dr. Joy Odimegwu
@Nwauka · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 1,320 followers View post →
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@sandra04850184 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 943 followers View post →
Shiva Shankar S
@BioShankar · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 160 followers View post →
Ashwin Adrian Kallor
@AdrianKallor · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 135 followers View post →
Twist Bioscience
@twistbioscience.com · Bluesky

“De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells.”

Jul 25, 2025 · 1 like View post →
Twist Bioscience
@TwistBioscience · X

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Jul 25, 2025 · 1 like · 25,299 followers View post →
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Jul 25, 2025 · 2,808 followers View post →
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@razoralign · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 15,931 followers View post →
cryoEM papers
@cryoempapers.bsky.social · Bluesky

De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells pubmed.ncbi.nlm.nih.gov/40705893/ #cryoEM

Jul 25, 2025 View post →
Tony Mongkolsmai
@tonymongkolsmai · X

More AI for science… De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/7oGVPooAuu

Jul 25, 2025 · 6 likes · 1 share · 2,062 followers View post →
Lasse Voss
@LasseVoss1 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 120 followers View post →
Yuze Sun
@YuzeSun13 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 27 followers View post →
Tim Hughes 提姆·休斯
@Timothy_Hughes · X

Scientists from the Technical University of Denmark just developed an AI platform that designs custom proteins in weeks rather than years, enabling immune (T) cells to target and destroy cancer cells https://t.co/mdxr0qIrsj #artificalintelligence #Technology #Innovation #Tech

Jul 25, 2025 · 167,900 followers View post →
wvk1
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RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 88 followers View post →
Ankit Singla
@In_AnkitSingla · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 1,485 followers View post →
Eric
@ericsophia12 · X

RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…

Jul 25, 2025 · 9 shares · 96 followers View post →
Raúl Jiménez Castaño
@ruljc · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 166 followers View post →
Timothy Jenkins
@TimothyPJenkins · X

RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A ground…

Jul 25, 2025 · 9 shares · 827 followers View post →
Daniel S.
@asecretcrow · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 536 followers View post →
Nithyanan Annamalai
@BlackSamrat · X

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Jul 25, 2025 · 9 shares · 370 followers View post →
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RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…

Jul 25, 2025 · 5 shares · 10,442 followers View post →
shaypaintal
@shaypaintal · X

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Jul 25, 2025 · 9 shares · 41 followers View post →
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@shalinhnaik · X

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Jul 25, 2025 · 7 shares · 4,631 followers View post →
Yinying Yao
@YinyingYao · X

RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…

Jul 25, 2025 · 5 shares · 96 followers View post →
Yiannis Galdadas
@igaldadas · X

RT @BiologyAIDaily: De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groun…

Jul 25, 2025 · 1 share · 152 followers View post →
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@ONNESHA092 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 25, 2025 · 43 shares · 182 followers View post →
KarelK77
@K77Karel · X

RT @KrisHaurum: Huge thanks to the incredible team, especially Tim, Sine, Beatrice Scapolo, Darian Wolff, and @moonii1020 !

Jul 25, 2025 · 2 shares · 242 followers View post →
Tanvir
@jansonsco1 · X

RT @Dr_Singularity: paper https://t.co/l0CeRaWDVb

Jul 25, 2025 · 1 share · 876 followers View post →
xxy
@xxy07255392 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

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Yongjun Cha
@yjchamd · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 81 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

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Jul 24, 2025 · 7 shares · 2,065 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells | Science https://t.co/5kiaH1bi8j

Jul 24, 2025 · 2 likes · 2,065 followers View post →
Searle “IC” Duay
@hottestchemist · X

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@Abelthotechpo · X

RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s

Jul 24, 2025 · 7 shares · 453 followers View post →
Li Song
@mourisl · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 1,506 followers View post →
dhuv.io
@DhuviKarthikey1 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 454 followers View post →
Biology+AI Daily
@BiologyAIDaily · X

De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex (pMHC) https://t.co/mkUxTAE4de

Jul 24, 2025 · 75 likes · 9 shares · 14,434 followers View post →
Biology+AI Daily
@BiologyAIDaily · X

De Novo-Designed pMHC Binders Facilitate T Cell–Mediated Cytotoxicity Toward Cancer Cells @ScienceMagazine 1. A groundbreaking study presents a rapid de novo design platform for minibinders (miBds) targeting cancer-associated peptide-bound major histocompatibility complex https://t.co/gZi3297vWR

Jul 24, 2025 · 6 likes · 1 share · 14,434 followers View post →
Eric
@ericsophia12 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 96 followers View post →
N283
@tbsng_ktkm0923 · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 144 followers View post →
叢雲くすり (創薬ちゃん)
@souyakuchan · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 10,243 followers View post →
叢雲くすり (創薬ちゃん)
@souyakuchan · X

RT @KlebanoffLab: https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s

Jul 24, 2025 · 7 shares · 10,243 followers View post →
Dr Singularity
@Dr_Singularity · X

paper https://t.co/l0CeRaWDVb

Jul 24, 2025 · 19 likes · 1 share · 42,379 followers View post →
Shiva Shankar S
@BioShankar · X

RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…

Jul 24, 2025 · 5 shares · 160 followers View post →
Ralene Searle
@Ralene2000 · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 52 followers View post →
serrgv
@serrgv · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 148 followers View post →
CypherCoin
@xImogenhx · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 60 followers View post →
Martin Correa
@martinrafco · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 233 followers View post →
Waggoner Lab
@LabWaggoner · X

@TimothyPJenkins et al developed a TCR mimic specific to the NY-ESO-1 peptide bound to HLA-A*02, referred to as a minibinder https://t.co/BWWftQP5Ad https://t.co/kEudOsoQIU

Jul 24, 2025 · 3 likes · 11,300 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 98 followers View post →
Jill Marie
@JillPhys1905 · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 1,389 followers View post →
Misha Booltink
@MishaBooltink · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 542 followers View post →
Kenneth Noga
@nog14461 · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 1,046 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially a…

Jul 24, 2025 · 27 shares · 1,023,829 followers View post →
Medical Xpress
@medical_xpress · X

An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially accelerating personalized immunotherapy development from years to weeks. @sciencemagazine https://t.co/5Bh4Yoc27o https://t.co/jyISvWWNnI

Jul 24, 2025 · 47 likes · 27 shares · 172,997 followers View post →
Kato
@oxkawaka · X

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells https://t.co/rMnGDUNNLF

Jul 24, 2025 · 1 like · 5,811 followers View post →
@gen0m1cs
@gen0m1cs · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 28,307 followers View post →
Teddy Rmble
@TeddyRmble · X

To my rare readers who think doctors have cured cancer but are just hiding it to make $$$, please read this article. The fact it is way over your head shows geniuses are working feverishly to cure cancer. https://t.co/X91v2uMFQB

Jul 24, 2025 · 1,378 followers View post →
Heart Bridge -- Bill Scherk
@CardiacSmarts · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 1,383 followers View post →
Science Magazine
@ScienceMagazine · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 4,516,082 followers View post →
Kristoffer H. J.
@KrisHaurum · X

Huge thanks to the incredible team, especially Tim, Sine, Beatrice Scapolo, Darian Wolff, and @moonii1020 !

Jul 24, 2025 · 9 likes · 2 shares · 501 followers View post →
Klebanoff_Lab
@KlebanoffLab · X

https://t.co/7jOX8om1ID https://t.co/LQq8fNhhhP https://t.co/xblZg8jg4s

Jul 24, 2025 · 28 likes · 7 shares · 3,199 followers View post →
Sciences
@sciences.skyfleet.blue · Bluesky

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells

Jul 24, 2025 View post →
Kristoffer H. J.
@KrisHaurum · X

RT @TimothyPJenkins: Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer c…

Jul 24, 2025 · 43 shares · 501 followers View post →
Kristoffer H. J.
@KrisHaurum · X

RT @aipulserx: How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@Scien…

Jul 24, 2025 · 5 shares · 501 followers View post →
DailyHealthcareAI
@aipulserx · X

How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?@ScienceMagazine @DTUtweet "De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells" • Researchers developed a rapid de novo https://t.co/gZsqWgMsA0

Jul 24, 2025 · 7 likes · 5 shares · 1,332 followers View post →
Timothy P. Jenkins
@tpjenkins.bsky.social · Bluesky

Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: doi.org/10.1126/scie...

Jul 24, 2025 · 35 likes · 8 shares View post →
Timothy Jenkins
@TimothyPJenkins · X

Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @ScienceMagazine! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: https://t.co/T7rfR8uK8M https://t.co/hGFpvlPb53

Jul 24, 2025 · 216 likes · 43 shares · 827 followers View post →
AI x Bio Discovery
@aixbiobot.bsky.social · Bluesky

De novo designed pMHC binders facilitate T cell induced killing of cancer cells This paper describes a novel platform for designing minibinders (miBds) targeting cancer-associated pMHC complexes using generative AI. The miBds were designed, screened in silico and validated in vitro, ...

Dec 3, 2024 · 4 likes · 1 share View post →
bioRxiv Immunology
@biorxiv-immuno.bsky.social · Bluesky

De novo designed pMHC binders facilitate T cell induced killing of cancer cells https://www.biorxiv.org/content/10.1101/2024.11.27.624796v1

Dec 3, 2024 · 3 likes View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

De novo designed pMHC binders facilitate T cell induced killing of cancer cells https://www.biorxiv.org/content/10.1101/2024.11.27.624796v1

Dec 3, 2024 · 3 likes View post →