Science October 2025 PMID 40743368

with a 57-codon genetic code.

Wesley E Robertson, Fabian B H Rehm, Martin Spinck, Raffael L Schumann, Rongzhen Tian, Wei Liu, Yangqi Gu, Askar A Kleefeldt, Cicely F Day, Kim C Liu, Yonka Christova, Jérôme F Zürcher, Franz L Böge, Jakob Birnbaum, Linda van Bijsterveldt

Mentions

104
Peak: 52 in Aug 2025
across 4 sources since Jul 2025

Extended reach

1,268,279
potential audience

Total likes

6,081

Video views

94,025

Mentions per month

Jul 2025 – Sep 2025

Where it's discussed

  • X / Twitter52 posts
  • News42 articles
  • Blogs8 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions reflect strong agreement with the scientific breakthrough, exemplified by comments calling it a 'game changer' and a 'surreal' achievement, along with references to the potential for expanding genetic codes. The tone is excited and reverent, emphasizing both the technical novelty and its possible revolutionary impact on future biotechnologies.

AgreementStrong agreement

Most discussions express excitement and support, highlighting the significance of creating a bacterial organism with an expanded genetic code.

InterestHigh interest

Posts show high curiosity, with many referencing specific research details and expressing enthusiasm about the scientific advancements.

EngagementHigh engagement

Several users participate actively by sharing links, recalling past related discussions, and emphasizing the broader implications.

ImpactHigh impact

Many believe this research could revolutionize synthetic biology and biotechnology, indicating high perceived significance.

Abstract in brief

  • The text discusses a synthetic organism called Syn57, which has a 4-megabase genome where six sense codons and one stop codon have been replaced with their synonymous counterparts, reducing the total number of codons used.
  • This modification results in an organism that uses only 55 of the 64 possible codons to encode the 20 standard amino acids, demonstrating a significant alteration of the traditional genetic code.
  • The research highlights advances in genetic engineering by creating a nearly universal genetic code with fewer codons, which could have implications for understanding genetic translation and developing new biotechnologies.]

Top posts

Most liked on X and Bluesky
Phys.org
@physorg_com · X

##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline genetic codes and expand possibilities for synthetic biology and biotechnology. @sciencemagazine https://t.co/JDEKiFFMmf https://t.co/lTtxGnMWVo

Aug 2, 2025 · 44 likes · 29 shares · 1,023,830 followers View post →
Zeynep Baharoglu
@BaharogluZeynep · X

Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.

Aug 1, 2025 · 30 likes · 6 shares · 1,015 followers View post →
河野健一 Kenichi Kono | 脳外科医 CEO|AI 医療 MBA|脳血管内手術支援AI
@CeoImed · X

「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある微生物になる可能性 https://t.co/Cqw5xc0Yh5 https://t.co/SME3J54Wsr

Aug 3, 2025 · 22 likes · 8 shares · 15,618 followers View post →
Julia Bauman
@JuliaBauman2 · X

@ScienceMagazine Link to the paper: https://t.co/0UHbOyf5Ju

Aug 18, 2025 · 12 likes · 1 share · 10,437 followers View post →
Piotr Rieske
@rieske_piotr · X

Prace takie jak ta przechodzą często niezauważone. "Biolodzy syntetyczni zmienili kod genetyczny bakterii, żeby produkować nowe białka w tym leki" https://t.co/amvV5tyGML

Aug 19, 2025 · 8 likes · 1 share · 2,252 followers View post →
Huiluo Cao 曹慧荦
@hlcao · X

Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 1, 2025 · 7 likes · 6 shares · 2,827 followers View post →

All mentions

Mehrdad Ameri
@MehrdadAmeri · X

@Negin_af خدمت شما https://t.co/qHMpRu1OYV

Sep 23, 2025 · 1 like · 212 followers View post →
ハルニレ
@halhalyonko · X

Escherichia coli with a 57-codon genetic code | Science https://t.co/VjZLJ2MiXP

Aug 26, 2025 · 34 followers View post →
市川俊輔 Shunsuke Ichikawa
@Shunsuke_chon · X

https://t.co/jPn3epPhDF

Aug 26, 2025 · 183 followers View post →
Mamadou On GameDev
@mamadou_gamedev · X

@Mithrandir_ir @MaybeYourself راستش موضوعی که در مطلب مطرح شده اینکه که ۶۴ کدون رو به ۵۷ تا کاهش دادن و کماکان بهینه‌تر عمل میکنه، اصل پیپرش اینجا هست https://t.co/OTJWGh9oyq

Aug 25, 2025 · 9,249 followers View post →
Mamadou On GameDev
@mamadou_gamedev · X

@AmesJohnsonj اگه اکسس دارید اصل پیپرش اینجا هست https://t.co/OTJWGh8QIS

Aug 25, 2025 · 6 likes · 9,249 followers View post →
Carlos Lozano Flores
@CarlosLoza17861 · X

Escherichia coli with a 57-codon genetic code | Science https://t.co/i4aW8ivejg

Aug 20, 2025 · 1 like · 4 followers View post →
Kot Behemot
@Kot_Behemot_NSA · X

RT @rieske_piotr: Prace takie jak ta przechodzą często niezauważone. "Biolodzy syntetyczni zmienili kod genetyczny bakterii, żeby produkowa…

Aug 19, 2025 · 1 share · 6,662 followers View post →
Piotr Rieske
@rieske_piotr · X

Prace takie jak ta przechodzą często niezauważone. "Biolodzy syntetyczni zmienili kod genetyczny bakterii, żeby produkować nowe białka w tym leki" https://t.co/amvV5tyGML

Aug 19, 2025 · 8 likes · 1 share · 2,252 followers View post →
TradeTexasBig
@TradeTexasBig · X

RT @JuliaBauman2: @ScienceMagazine Link to the paper: https://t.co/0UHbOyf5Ju

Aug 18, 2025 · 1 share · 2,895 followers View post →
Julia Bauman
@JuliaBauman2 · X

@ScienceMagazine Link to the paper: https://t.co/0UHbOyf5Ju

Aug 18, 2025 · 12 likes · 1 share · 10,437 followers View post →
Rohan Krajeski
@RohanKrajeski · X

@katclone Different topic, this recent work is pretty damn cool: https://t.co/bKpWNoFHMr

Aug 14, 2025 · 1 like · 597 followers View post →
aratama factory
@aratama0315 · X

https://t.co/OvaO35OAHa

Aug 14, 2025 · 1 like · 2,316 followers View post →
Raffael Schumann (@raffaelschumann@genomic.social)
@RaffaelLucaSchu · X

The main part of my PhD is published in @ScienceMagazine! As one of the co-first authors, this feels surreal! We re-designed, synthesized, and assembled an entire E. coli genome with a 57-codon genetic code, freeing up 7 codons for code expansion!

Aug 8, 2025 · 2 likes · 155 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Escherichia coli with a 57-codon genetic code | Science https://t.co/OacDePwLRE

Aug 4, 2025 · 2,065 followers View post →
flori
@usaco_sora_at · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 4, 2025 · 8 shares · 1 followers View post →
halnos
@deepaquarouge · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 383 followers View post →
よういち
@dl8jvD82TWKRxHL · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 155 followers View post →
おれんじ色
@orangeiro7 · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 1,804 followers View post →
しろクマー
@sirokumah · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 1,253 followers View post →
Butano Socrates
@ButanoSocrates · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 431 followers View post →
ゆきと
@6yhsdsiswmcd · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 9,302 followers View post →
アルバレスmk-2@誰が総裁になっても
@gengorou55555 · X

RT @CeoImed: 「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある…

Aug 3, 2025 · 8 shares · 345 followers View post →
河野健一 Kenichi Kono | 脳外科医 CEO|AI 医療 MBA|脳血管内手術支援AI
@CeoImed · X

「57コドンの遺伝コードを持つ大腸菌」 ・ 通常は64種類のコドンを持が、合計10万回を超えるコドンを置換し57種類のコドンの大腸菌を作成 ・ 生存可能な細菌株が誕生し、完全に機能することを確認 ・ 成長速度は約1/4に低下 ・ ウイルス耐性のある微生物になる可能性 https://t.co/Cqw5xc0Yh5 https://t.co/SME3J54Wsr

Aug 3, 2025 · 22 likes · 8 shares · 15,618 followers View post →
Ali Farrokhi
@Ali_F2020 · X

RT @BaharogluZeynep: Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.…

Aug 2, 2025 · 6 shares · 140 followers View post →
Fourth Grace
@EuphrosMD · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 26 followers View post →
Simona
@ExperimentWorld · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 1,727 followers View post →
serrgv
@serrgv · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 148 followers View post →
Claude Gillono
@sherman1959CG · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 168 followers View post →
Sulphurcocky
@Sulphurcocky1 · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 197 followers View post →
Eder Andrés
@ederandres152 · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 890 followers View post →
Tony Sobrado
@TonySobrado · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 42,035 followers View post →
syawal™ シ
@syawal · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 3,185 followers View post →
David John Roden
@turingcop · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 4,445 followers View post →
DaiseyKacey
@DaiseyKace61522 · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 305 followers View post →
AstroFuturist
@AstroFuturist42 · X

RT @physorg_com: ##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline g…

Aug 2, 2025 · 29 shares · 94 followers View post →
Phys.org
@physorg_com · X

##E.Coli has been engineered to use just 57 codons instead of the standard 64, demonstrating the potential to streamline genetic codes and expand possibilities for synthetic biology and biotechnology. @sciencemagazine https://t.co/JDEKiFFMmf https://t.co/lTtxGnMWVo

Aug 2, 2025 · 44 likes · 29 shares · 1,023,830 followers View post →
priya joseph
@ayirpelle · X

RT @hlcao: Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 2, 2025 · 6 shares · 4,887 followers View post →
Gilles van Wezel
@GillesvanWezel · X

RT @hlcao: Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 2, 2025 · 6 shares · 4,333 followers View post →
Salim Dason
@MoeDason · X

RT @hlcao: Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 2, 2025 · 6 shares · 1,370 followers View post →
Paul Herron
@Herron1664 · X

RT @hlcao: Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 2, 2025 · 6 shares · 2,049 followers View post →
Shuo Jiang, Jason
@Ultramanccc · X

RT @hlcao: Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 2, 2025 · 6 shares · 17 followers View post →
Thangaraj Vellingiri
@thangar69075300 · X

RT @BaharogluZeynep: Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.…

Aug 2, 2025 · 6 shares · 98 followers View post →
Celso Domínguez
@LaniusDominguez · X

RT @hlcao: Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 1, 2025 · 6 shares · 472 followers View post →
Huiluo Cao 曹慧荦
@hlcao · X

Escherichia coli with a 57-codon genetic code | Science https://t.co/W59NFOkecT

Aug 1, 2025 · 7 likes · 6 shares · 2,827 followers View post →
Daniel S.
@asecretcrow · X

RT @BaharogluZeynep: Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.…

Aug 1, 2025 · 6 shares · 536 followers View post →
Jesús E. Alejandre-Sixtos
@JessSixtos2 · X

RT @BaharogluZeynep: Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.…

Aug 1, 2025 · 6 shares · 116 followers View post →
CUI LUN
@omnicui · X

RT @BaharogluZeynep: Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.…

Aug 1, 2025 · 6 shares · 448 followers View post →
Roberto Munita
@robertomunita · X

RT @BaharogluZeynep: Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.…

Aug 1, 2025 · 6 shares · 1,091 followers View post →
Zeynep Baharoglu
@BaharogluZeynep · X

Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids.

Aug 1, 2025 · 30 likes · 6 shares · 1,015 followers View post →
Ирис Ликбез (Вы/ж.р./feminin)
@Iris_Illera · X

RT @zakir_tnimov: I recall tweeting about the #syn57 strain from the Chin lab back in 2019. It turns out I was right

Aug 1, 2025 · 1 share · 619 followers View post →
Zakir Tnimov
@zakir_tnimov · X

I recall tweeting about the #syn57 strain from the Chin lab back in 2019. It turns out I was right

Aug 1, 2025 · 1 like · 1 share · 403 followers View post →
Wei Liu
@DrWeiLiu · X

Escherichia coli with a 57-codon genetic code | Science https://t.co/9BgHNsOr7s

Jul 31, 2025 · 162 followers View post →