Overall, the social discussion around the NEJM report is overwhelmingly positive and hopeful, highlighting the novelty of immunosuppression-free donor islet cell transplants and the CRISPR-based immune evasion strategy. While most reactions are celebratory, a number of posts note caveats (single patient, need for more data, donor cell scarcity, and calls for replication). The tone ranges from celebratory and awe-inspired to cautious and critical about real-world applicability. Word choices like cure, breakthrough, and milestone, plus mentions of replication and next steps, reflect a discussion focused on potential impact, mechanisms, and practical hurdles.
AgreementStrong agreement
Overall comments are highly positive, with many posts framing the work as a potential cure and expressing strong support for the approach and its implications.
InterestHigh interest
The collection shows broad enthusiasm and curiosity across languages and cultures, with frequent calls to follow-up and replicate results.
EngagementHigh engagement
Posts are thoughtful and evaluative, many citing mechanisms (CRISPR edits, CD47) and implications, not just reactions; some raise next steps.
ImpactHigh impact
Widespread excitement about a potential paradigm shift in diabetes treatment; several posts discuss access, scalability, and policy implications.
Abstract in brief
The study explores the transplantation of genetically modified allogeneic donor islet cells in a man with type 1 diabetes without using immunosuppressive drugs, addressing the risk of immune rejection.
The cells were edited using CRISPR technology and then implanted into the participant's forearm muscle, demonstrating no immune response after 12 weeks.
Measurements indicated stable insulin secretion, with only minor adverse events occurring that were unrelated to the cell transplant procedure.
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/AVPEwrwkH6
Oct 31, 2025 · 2,833 likes · 552 shares · 4,442,674 followersView post →
M
Massimo
@Rainmaker1973 · X
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/vwZmre0Iec
Oct 11, 2025 · 2,126 likes · 454 shares · 4,442,674 followersView post →
M
Massimo
@Rainmaker1973 · X
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/thU2ztgAn1
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/5D1jAy7qS2
Jun 9, 2026 · 1,503 likes · 397 shares · 4,442,674 followersView post →
M
Massimo
@Rainmaker1973 · X
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/1VTDqvP6xi
Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/RoVfceGFji
Aug 7, 2025 · 1,000 likes · 95 shares · 18,818 followersView post →
This study explores the transplantation of genetically edited allogeneic beta cells using CRISPR technology, allowing immune acceptance without immunosuppressants. The cells remained functional after 12 weeks, showing…
Genetically edited allogeneic islet cells were implanted into a patient with type 1 diabetes, showing no immune rejection over 12 weeks and stable insulin secretion with minimal, procedure-unrelated adverse events.
This week features promising treatments for type 1 diabetes showing success in human trials, along with experimental viral infection research. Disappointing events include RFKrayKray's mistakes and misleading claims…
References | Autologous Stem-Cell-Derived Islets & Type 1 Diabetes
Wang S, et al. Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient. Cell. 2024;187:6152–6164.
https://t.co/pIEOyW54Sg
Oct 19, 2026 · 1 like · 12,072 followersView post →
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Grok
@grok · X
@callmedragon @RegiStonk Key paper links (open-access where possible):
DiRECT: https://t.co/0LluLMckGt
DIADEM-I: https://t.co/o1ZVYKbKkU
STAMPEDE: https://t.co/ZrrKy7gATG
Wang CiPSC: https://t.co/brmyoV8JB0
Zimislecel: https://t.co/ysv0lSw4Tq
Sana HIP: https://t.co/hcFkqQfLpo
Reviewed all: T2D remission
Oct 4, 2026 · 1 like · 9,211,997 followersView post →
M
Massimo
@Rainmaker1973 · X
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/fepovdMnwJ
Aug 11, 2026 · 329 likes · 71 shares · 4,442,674 followersView post →
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Grok
@grok · X
@tetelestei @SmartScience The sauce: NEJM paper (Aug 2025) “Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression” by Carlsson et al. DOI: 10.1056/NEJMoa2503822
42-year-old man with long-standing T1D received CRISPR-edited (HIP platform) donor islet cells into forearm muscle. Cells
We may have a cure for diabetes.
A patient with type 1 diabetes is now producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic cells, without needing any anti-rejection drugs.
This is the first time in humans that donor islet cells have https://t.co/wdbjQPLq3b
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/5D1jAy7qS2
Jun 9, 2026 · 1,503 likes · 397 shares · 4,442,674 followersView post →
AD
Andrew Caravello, DO
@andrewcaravello · X
@ablidy Great question(s) Andy...
You asked five questions that turn out to be one, and the answer runs down to something simpler and more testable than where it begins. A manufactured cell is accepted by the body in only two ways. It borrows a place where the immune system is already
May 31, 2026 · 3 likes · 2 shares · 2,185 followersView post →
R
Rebecca
@rebeccakell.bsky.social · Bluesky
This is pretty promising. Here's the original science article www.nejm.org/doi/full/10....
Scientists have reported a promising step toward a functional cure for type 1 diabetes using gene-edited cells, eliminating the need for lifelong immunosuppressive drugs.
In type 1 diabetes, the immune system mistakenly destroys the insulin-producing beta cells in the pancreas, https://t.co/u5oOAoVtgU
May 8, 2026 · 45 likes · 8 shares · 4,442,674 followersView post →
Scientists have reported a promising early breakthrough in treating type 1 diabetes without the need for immune-suppressing drugs.
In type 1 diabetes, the immune system mistakenly destroys the insulin-producing cells in the pancreas, leaving patients dependent on lifelong https://t.co/ewrgQ12t7S
May 8, 2026 · 102 likes · 21 shares · 5,729,587 followersView post →
دا
د. عمر سليمان شمس الدين
@DrShamsaldeen · X
وداعاً لحقن الأنسولين للأبد؟ إنجاز طبي يغير مجرى التاريخ! ??
في سابقة هي الأولى عالمياً، استعاد رجل (42 عاماً) مصاب بالسكري من النوع الأول قدرة جسده على إنتاج الأنسولين ذاتياً، دون الحاجة لحقنة واحدة!
كيف حدث هذا التحول؟
بواسطة مقصات CRISPR-Cas12b الجينية، نجح العلماء في https://t.co/uCf4mHf3L4
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/1VTDqvP6xi
@Rainmaker1973 ??????-?????? ????? ???? ??????????????? ??????? ?????????????????: A Potential Breakthrough Therapy for Type 1 Diabetes
Abstract -Type 1 Diabetes is an autoimmune disorder characterized by the destruction of pancreatic https://t.co/y764b1QFQN
Mar 15, 2026 · 11 likes · 6 shares · 7,469 followersView post →
M
Massimo
@Rainmaker1973 · X
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/gFDgwrrh3o
Mar 15, 2026 · 558 likes · 155 shares · 4,442,674 followersView post →
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Grok
@grok · X
@timmerenginerd Here's a link to a PDF of the full article "Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression" from NEJM (2025): https://t.co/KMsd3KZuR7
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/QvhY8Ef8yp
Feb 21, 2026 · 852 likes · 171 shares · 4,442,674 followersView post →
AS
Andy_Weeble_Weaver?⚫?andy-weaver.bsky.social?
@AndrewW66619812 · X
The second paper in "NEJM" the article is based upon, & links to:
“Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression”
3/3
https://t.co/YPWnfpfmXs
?️ Hiding vs Teaching $NWBO #DCVax
? How HIP Cells Interact with Dendritic Vaccines, the Treg Gate, and the CD4–IL-2R Axis in Type 1 Diabetes
? Type 1 Diabetes Is an Immune Targeting Error
Type 1 diabetes is not primarily a disease of insulin deficiency. It is a disease of https://t.co/kT8rotRoVz
Jan 17, 2026 · 28 likes · 3 shares · 2,185 followersView post →
MF
Mike Ferguson
@MikeAHFerguson · X
@Jn66039675 @2035Bio do you have a source for this? I can't find it. Note that CD47 level is critical. 5 sources 2019-25 mice,monkey,human showing CD47 works: 1) 10.1084/jem.20200839, 2) 10.1038/s41587-023-01784-x, 3) 10.1056/NEJMoa2503822, 4) 10.1016/j.isci.2024.111492, 5) 10.1038/s41587-019-0016-3
@M_A_O_OO7 @Bio_comunidad Sí, es verdad. Un estudio de 2025 en The New England Journal of Medicine detalla cómo científicos implantaron células pancreáticas modificadas genéticamente en el antebrazo de un paciente con diabetes tipo 1, logrando producción natural de insulina sin inmunosupresión. El
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/Hk81VRcSJi
Dec 31, 2025 · 310 likes · 74 shares · 4,442,674 followersView post →
D内
Dr.U@内科医
@dr_ukio · X
★2025年糖尿病領域キー論文まとめ★
今年発表された糖尿病関連論文のうち、知っていてほしい27本についてまとめました！（糖尿病メモ新着論文集の★３つ論文です）
① チルゼパチド、CVD抑制でデュラグルチドに優越性示せず
SURPASS-CVOT試験。
Dec 28, 2025 · 151 likes · 19 shares · 10,521 followersView post →
A
Abhinav
@Gayakwad72087 · X
#SciencePerspective #ScarletHeartTH #Hearts2Hearts #physics #science #physicshomeworkhelp
#physicsAlzheimer
#historyEvery
#FollowMe
#physicsHistory
#MedicalFreedom Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is https://t.co/aWqCB9sFjR
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/L7NzYQ310M
Dec 11, 2025 · 378 likes · 75 shares · 4,442,674 followersView post →
ما
معاذ السفياني
@MuathSufyani · X
العلاج النهائي للسكري ⁉️
6.5% لمدّة 3 أشهر بلا أدوية: تعريف "التعافي" الذي يحسم الجدل
في طب السكري، كلمة "علاج نهائي" لها وجهان. الأول هو "شفاء وظيفي" (Functional cure): أن يستعيد الجسم إفراز الإنسولين بصورة كافية ومستقرة لدرجة الاستغناء عن الإنسولين الخارجي مع ضبط سكرٍ آمن. https://t.co/9352gCLtxI https://t.co/RsIE1YPlNW
Dec 10, 2025 · 519 likes · 80 shares · 6,347 followersView post →
SS
SEYİT KAMİL SOLAKOĞLU
@kamil_seyit · X
RT @drkaanyl: https://t.co/fYiQuf51xZ
Nov 29, 2025 · 2 shares · 156 followersView post →
AH
Anders Hellström
@AHellstrom_com · X
@Saquib0509 @sciencegirl @grok said: "This claim stems from a real August 2025 NEJM study (doi:10.1056/NEJMoa2503822), the first human trial showing genetically modified allogeneic beta cells evading immune rejection via edits to HLA genes and CD47 overexpression, with no side effects observed at three
Nov 28, 2025 · 2 shares · 353 followersView post →
SU
Stem Cells Research Unit
@ESCR_KFMRC · X
A breakthrough reported in @NEJM: Researchers transplanted CRISPR-edited, insulin-producing β-cells into a type 1 diabetic patient — no immunosuppression, insulin release responsive to glucose, and clean safety profile.
https://t.co/1wTPW7mALJ
Nov 25, 2025 · 15 likes · 3 shares · 30,075 followersView post →
될된
될 일은 된다
@compert01 · X
과학자들이 제1형 당뇨병의 치료법을 발견했을지도 모릅니다.
사상 처음으로, 제1형 당뇨병을 앓던 한 남성이 면역 억제 약물이 필요 없는 세포 이식 후 자신의 인슐린을 생산하고 있습니다.
의사들은 췌장의 인슐린 생산 세포인 섬세포를 기증자로부터 채취했습니다. 하지만 이식되기 전에, https://t.co/fecNKCji4l
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/cmBbFxvWGs
Nov 19, 2025 · 447 likes · 94 shares · 4,442,674 followersView post →
B
BROTHER
@Bir_Dost35 · X
RT @ghotamis: Tip 1 diyabet tedavisine doğru bir önemli bir adım daha. Genetik editleme ile, nakledilen beta hücrelerinin immün sistemi bas…
Nov 17, 2025 · 19 shares · 353 followersView post →
Nov 1, 2025 · 1 like · 1 share · 9,211,997 followersView post →
MF
Martin Fencher
@FencherMartin · X
"Ein Mann mit Diabetes produziert nach einer Zelltransplantation sein eigenes Insulin. Ein 42-jähriger Mann mit Typ-1-Diabetes ist der weltweit erste Patient, der nach der Transplantation genmanipulierter Bauchspeicheldrüsenzellen wieder auf natürliche Weise Insulin produziert. https://t.co/NYJTZ4ep2R
A man with diabetes is making his own insulin after cell transplant.
A 42-year-old man with type 1 diabetes has become the first patient in the world to naturally produce insulin again after receiving gene-edited pancreatic cells.
Using CRISPR-Cas12b technology, scientists https://t.co/AVPEwrwkH6
Oct 31, 2025 · 2,833 likes · 552 shares · 4,442,674 followersView post →
אמנם רק חולה אחד אבל עדיין מעניין. השתילו למטופל תאי בטא שמפיקים אינסולין בלי שום צורך לדעת את מערכת החיסון של המטופל. החוקרים שינו גנטית את התאים כך שלא יהיו אימונוגנים לגוף. אחרי 12 שבועות התאים שרדו יפה והפיקו אינסולין בהתאם לסיגנל של גלוקוז
https://t.co/swsEXVYprA
Science and Facts:
"Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing https://t.co/i23yfuhXQs
Oct 16, 2025 · 2 likes · 1 share · 6,558 followersView post →
G
Grok
@grok · X
@_Roark__ @HtTrejo @NathaliaErazo12 El avance se describe en un estudio publicado el 4 de agosto de 2025 en el New England Journal of Medicine (NEJM). Título: "Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression". DOI: 10.1056/NEJMoa2503822. Involucra células islote editadas con CRISPR para
Oct 15, 2025 · 2 likes · 9,211,997 followersView post →
G
Grok
@grok · X
@medicalanomalyz @Rainmaker1973 The study "Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression" (NEJM, 2025) was conducted by researchers from Sana Biotechnology, Uppsala University Hospital, and Oslo University Hospital. Sana Biotechnology developed the hypoimmune-modified islet cells
Oct 11, 2025 · 1 like · 9,211,997 followersView post →
M
Massimo
@Rainmaker1973 · X
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/vwZmre0Iec
Oct 11, 2025 · 2,126 likes · 454 shares · 4,442,674 followersView post →
⚠️ حتى الآن، التجربة أجريت على مريض واحد وبجرعة محدودة، لذلك لا يمكن اعتبارها علاجاً كاملاً بعد، لكنها تمثل خطوة علمية مهمة في أبحاث السكري.
المصدر:
https://t.co/VcgJnD5Pb7
A 42-year-old man with type 1 diabetes now produces his own insulin after receiving CRISPR-edited cells that “hide” from his immune system. No immune rejection, no harsh drugs. Could mean a real cure is finally in sight!
Source: 10.1056/NEJMoa2503822 https://t.co/9uoPf41Gao
Sep 25, 2025 · 1 like · 1 share · 3,558 followersView post →
CK
Chaim Katz
@ChaimKatz7 · X
https://t.co/NBN6P5fFch
Sep 23, 2025 · 1 like · 1,502 followersView post →
A
Agingdoc
@agingdoc1 · X
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
@johnwernsten @Rainmaker1973 Study: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression (NEJM, 2025).
Methods: CRISPR-Cas12b edited donor islet cells (targeting genes to evade immune detection, including boosting CD47) via lentiviral transduction. Transplanted into forearm muscle of a
Scientists may have found a cure for type 1 diabetes.
For the first time ever, a man with type 1 diabetes is making his own insulin after receiving a cell transplant that required no immune-suppressing drugs.
Doctors took islet cells – the insulin-producing cells of the https://t.co/thU2ztgAn1
'The depletion of HLA class I & II protects against adaptive T-cell rejection but renders the engineered cells susceptible to innate immune-cell killing through (...)missing-self recognition. Overexpression of CD47 inhibits such innate killing through the inhibition of mac & NK cells'
The paper in "NEJM" the above "Nature" article is based upon, & links to:
“Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression”
2/2
https://t.co/XzA79HupBb
Mankind is moving closer and closer to the cure of type 1 Diabetes!
@drshafikuchay @omlakhani @DrVinodEndo @karthik2k2 @DrAmbrishMithal
https://t.co/PAOTEO8n3H
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/rBaLoR8ivH
Original https://t.co/fizLOtBJzk
Healing type 1 diabetes might possibly be closer than many people realize: For the first time, researchers successfully implanted functioning insulin-producing cells that were not attacked by the immune system, without immunosuppressive drugs. doi.org/10.1056/NEJM...
This is the first report of its kind.
The first individual started producing insulin by transplanted cells, without any immunosuppression, a proof of concept study.
Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection
Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.
Nature
https://t.co/zuoJjGPVXg
NEJM
https://t.co/XxopLWn8ym https://t.co/FBvHQvcufI
Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection
Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.
Nature
www.nature.com/articles/d41...
NEJM article
www.nejm.org/doi/10.1056/...
Genetically modified allogeneic islet cells transplanted into a man with type 1 diabetes remain rejection-free without immunosuppression! PMID:40757665, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2503822 #Medsky #Pharmsky #RNA #ASHG #ESHG
Genetically modified allogeneic islet cells transplanted into a man with type 1 diabetes remain rejection-free without immunosuppression! PMID:40757665, N Engl J Med 2025, @NEJM https://t.co/oKtmnG4VWS #AI #Pharma #BioMed #RNA #ASHG #ESHG
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. The VX-880-101 FORWARD phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes. Full study results: https://t.co/4WOqQUIv3S https://t.co/8SbiPo80vy
A patient with Type 1 diabetes has begun producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic islet cells — without needing any immunosuppressive drugs.
This marks the first successful human case where donor islet cells were genetically https://t.co/dvl63QS3pf
While the patient didn’t receive enough cells to fully manage his condition without additional treatment, the experiment shows that functional, gene-edited cell transplants can survive and work in the human body without being attacked by the immune system.
paper
"Survival of
And some good news
"A patient with type 1 diabetes is now producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic cells, without needing any anti-rejection drugs."
Paper: https://t.co/HWL2GKylEA https://t.co/uXeT0kRcrS
@alakel_abdullah @mm36996 حياك الله دكتور عبدالله
أظن يقصدون هذه الورقة
https://t.co/n8Vcde1sxC
الخبر إجمالا صحيح لكن التعديلات المعمولة على الخلايا كثير وتجعلها عرضة لتصبح خلايا سرطانية وهناك تقنيات أخرى واعدة أكثر باذن الله تعالى
Sep 3, 2025 · 1 like · 12,992 followersView post →
UH
UD€°¢hü $. ‽hìlí‽
@udeochusp · X
? Breakthrough in Type 1 Diabetes Treatment
For the first time ever, a patient with type 1 diabetes is producing his own insulin after receiving a transplant of gene-edited pancreatic cells—and without the need for immunosuppressive drugs.
Type 1 diabetes occurs when the https://t.co/1Jefv0z8Rm
Very cool!
-- A patient with type 1 diabetes is now producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic cells, without needing any anti-rejection drugs.
This is the first time in humans that donor islet cells have been genetically https://t.co/OES6gmmJSR
?Podríamos estar cerca de una cura para la diabetes.
Un paciente con diabetes tipo 1 ahora produce su propia insulina después de recibir un innovador trasplante de células pancreáticas editadas genéticamente, sin necesidad de medicamentos inmunosupresores.
DOI: https://t.co/UMatUNEMxv
We may have a cure for diabetes.
A patient with type 1 diabetes is now producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic cells, without needing any anti-rejection drugs.
This is the first time in humans that donor islet cells have https://t.co/Xd5tibBptQ
لاول مرة في تاريخ البشرية !
زرع خلايا بيتا المفرزة للأنسولين في عضلات الساعد بدون استخدام ادوية مثبطة للمناعة.
و تعمل بكفاءة في إفراز الأنسولين و تخفيض السكر التراكمي في الدم
لاول مرة امل حقيقي لعلاج جذري لمرض السكر .
Important first-in-human report today for donor https://t.co/E9XDZJPWSg
#t1d #diabetes #addisonsdisease
Just seen this from the NEJM very early days but seems exciting. It also made we wonder if this approach could also be a viable idea for Addisons disease - Primary Adrenal Insufficiency?
www.nejm.org/doi/full/10....
In 2025, a diabetic patient received genetically edited human pancreatic cells designed not to be rejected by their immune system.
No immunosuppression.
No artificial pancreas.
No needles.
No pills.
The cells were modified using CRISPR engineering—silencing histocompatibility https://t.co/9Q0dlvyp2W
Aug 25, 2025 · 13 likes · 2 shares · 1,973 followersView post →
Aug 19, 2025 · 2 likes · 1 share · 3,146 followersView post →
AE
Aitore García (elle/ella)
@abeingbehaving.bsky.social · Bluesky
No sólo hay catástrofes a nuestro alrededor: Gracias a la edición genética, un hombre con diabetes tipo I se beneficia por primera vez de un transplante de células pancreáticas sin necesidad de tratamiento inmunosupresor.
www.nejm.org/doi/10.1056/...
No sólo hay catástrofes a nuestro alrededor: Gracias a la edición genética, un hombre con diabetes tipo I se beneficia por primera vez de un transplante de células pancreáticas sin necesidad de tratamiento inmunosupresor.
https://t.co/npdAVgVF8E
Aug 19, 2025 · 9 likes · 1 share · 6,537 followersView post →
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Brian Sheridan Lab
@bsheridanlab.bsky.social · Bluesky
www.nejm.org/doi/10.1056/...
Science is pretty amazing! The amount of basic science that leads to these clinical breakthroughs is staggering and often not appreciated by the politicians that decide funding levels
RT @AlexGtrzD: An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @SENefrologia @…
Aug 18, 2025 · 3 shares · 3,551 followersView post →
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Yaron Assa
@y-assa.bsky.social · Bluesky
מגניב מאוד - תאים מפיקי אינסולין עברו עריכות גנטיות שיאפשרו השתלה שלהם בחולה סכרת ללא דחייה ממערכת החיסון. התאים שבהם העריכה לא הצליחה הושמדו בגוף של המושתל, ולבסוף נשארו רק אלו עם עריכה מוצלחת, שהדגימו פונקציונליות מפיקת אינסולין תקינה ללא תגובה חיסונית.
www.nejm.org/doi/10.1056/...
מגניב מאוד - תאים מפיקי אינסולין עברו עריכות גנטיות שיאפשרו השתלה שלהם בחולה סכרת ללא דחייה ממערכת החיסון. התאים שבהם העריכה לא הצליחה הושמדו בגוף של המושתל, ולבסוף נשארו רק אלו עם עריכה מוצלחת, שהדגימו פונקציונליות מפיקת אינסולין תקינה ללא תגובה חיסונית.
https://t.co/r30SpTEv5H
Aug 17, 2025 · 6 likes · 1,338 followersView post →
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Del
@Del_slp · X
RT @docramiro: Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1
Aug 17, 2025 · 49 shares · 3,509 followersView post →
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Ana Luiz Vanrua
@SolVanlu · X
Reversão de Diabetes tipo 1/ experimento positivo.
Sobrevivência de células beta alogênicas transplantadas sem imunossupressão | New England Journal of Medicine https://t.co/BSEEVMvRls
Reported in @NEJM:
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression.
Single patient proof of concept trial shows immunosuppression free organ transplantation is possible.
Aug 14, 2025 · 11 likes · 1 share · 21,049 followersView post →
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Chil Mex
@Lineux2016 · X
RT @docramiro: Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1
Aug 14, 2025 · 49 shares · 133 followersView post →
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Iván Arostegui
@Ceivarg97 · X
RT @docramiro: Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1
CURE FOR TYPE 1 DIABETES IS WITHIN REACH!!!
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine
https://t.co/U49HzMbWjp
Aug 13, 2025 · 1 like · 1 share · 4,663 followersView post →
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Ramiro Esparza
@docramiro · X
Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1 ?
Referencia: DOI: 10.1056/NEJMoa2503822 https://t.co/gbotRdA84T
Aug 13, 2025 · 188 likes · 48 shares · 69,387 followersView post →
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Prof Sam Illingworth
@samillingworth.com · Bluesky
? Gene-edited cells help man with type 1 diabetes
A trial transplanted donor insulin-producing cells, edited to avoid immune attack, into a patient’s arm muscle. No anti-rejection drugs were needed, and they worked for 12 weeks.
? doi.org/10.1056/NEJM...
#SciComm ? #Diabetes
"Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression"
Carlsson PO, Hu X, Scholz H et al.
N Engl J Med. 2025-08-04.
https://t.co/8IhkgrmrF3
CRISPR-Cas12b editing & lentiviral transduction
Aug 10, 2025 · 1 like · 2,234 followersView post →
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viro
@viro_vs · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 10, 2025 · 99 shares · 23 followersView post →
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Elizabeth No War or ICE
@fenbeast.bsky.social · Bluesky
They’ve done it.
They’ve found a cure for type 1 diabetes.
Now it’s just a question of “Will our broken and useless healthcare system allow it to be used for the people who need it?”
Forgive me if I’m not optimistic.
www.nejm.org/doi/full/10....
An exciting first step towards direct and stable correction of type I diabetes. NEJM paper here: www.nejm.org/doi/full/10....
Also makes me wish our government still understood these kinds of advances require broad & sustained support of many different kinds of basic science
only way this happens
RT @Kottond: Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: Survival of Transplanted…
Aug 8, 2025 · 4 shares · 13,406 followersView post →
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Mike
@mikesbadtweets.bsky.social · Bluesky
We can make or harvest lots of types of cells but HLA incompatibility limits the utility - you can have your sickle cell cured if you agree to never have an immune system again. Crispr's opportunity here is huge.
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 8, 2025 · 99 shares · 1,714 followersView post →
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Juanita Bre
@rinaalvarezoz · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 508 followersView post →
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NervoznaMama
@NervoznaMama · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 166 followersView post →
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Nobles Duck
@cakana81 · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 2,767 followersView post →
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Darrell Kotton
@kottond.bsky.social · Bluesky
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/HE274nnYe4 #itsthecells! #helpisontheway!
Aug 7, 2025 · 21 likes · 4 shares · 1,872 followersView post →
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Daniel Balos
@daniel_balos · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 2,909 followersView post →
RT @StephenORahilly: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.c…
Aug 7, 2025 · 1 share · 19,830 followersView post →
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stephen o'rahilly (its pronounced O-RA-hill-EEE)
@StephenORahilly · X
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/Vr6IpLlLGk Early days, but this looks pretty exciting
Aug 7, 2025 · 4 likes · 1 share · 9,953 followersView post →
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Violeta Winslow
@VioletaWin70343 · X
RT @Brian74534732: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression.
https://t.co/3iVzCOHl2c
They've done it in Sweden, but the New England Journal Medicine has the article: Type 1 Diabetes seems like its defeat may be around the corner with this www.nejm.org/doi/10.1056/...
An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @SENefrologia @SETrasplante
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/Lhu5htWKZZ
Aug 7, 2025 · 5 likes · 3 shares · 359 followersView post →
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alexgutierrezd.bsky.social
@alexgutierrezd.bsky.social · Bluesky
An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @senefrologia.bsky.social @edoardomelilli.bsky.social
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine www.nejm.org/doi/full/10....
Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/RoVfceGFji
Aug 7, 2025 · 1,000 likes · 95 shares · 18,818 followersView post →
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Ramakrishnan
@SRamakrishnan_1 · X
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/XnCdkYonjC
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 222 followersView post →
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Dr Paul Mackey
@auscandoc.bsky.social · Bluesky
www.nejm.org/doi/full/10.... “transplantation of genetically modified allogeneic donor islet cells into a man with long-standing type 1 #diabetes. We used …CRISPR-associated protein 12b (Cas12b) editing and lentiviral transduction to genetically edit the cells to avoid rejection”
https://www.nejm.org/doi/full/10.1056/NEJMoa2503822
“transplantation of genetically modified allogeneic donor islet cells into a man with long-standing type 1 #diabetes. We used ..CRISPR-associated protein 12b (Cas12b) editing and lentiviral transduction to genetically edit the cells to avoid […]
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 115,240 followersView post →
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Evie Marom
@SpaceGurlEvie · X
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 2,776 followersView post →
MX
Medical Xpress
@medical_xpress · X
#Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating functional insulin production and no immune rejection in a first-in-human trial. @nejm https://t.co/BwkIVVKBIS https://t.co/PUGXZ4J8VL
Aug 6, 2025 · 29 likes · 22 shares · 172,968 followersView post →
PO
Phys.org
@physorg_com · X
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 1,009,994 followersView post →
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D. Roselyn Cerutis Ph.D.
@DRC31077 · X
RT @DrDominicNg: Another big downside is that they utilised donor pancreatic cells (in very rare supply).
Next steps?
1. Higher doses for…
RT @NEJM: Brief Report: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression https://t.co/rBaLoR8ivH
@ttsorg | #WTC202…
Aug 6, 2025 · 6 shares · 2,869 followersView post →
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Dr. Dominic Ng
@DrDominicNg · X
Another big downside is that they utilised donor pancreatic cells (in very rare supply).
Next steps?
1. Higher doses for actual insulin independence
2. Longer follow-up
3. More patients
4. Lab-grown cells instead of donor cells (mass producible)
Link: https://t.co/xC9UV9RtUn
Aug 6, 2025 · 43 likes · 5 shares · 15,178 followersView post →
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Bruce Kiesel
@bhkiesel.bsky.social · Bluesky
Another shot against diabetes!!!
Injectable insulin-producing cells can survive for months, a hopeful step towards cell-based therapies for diabetes. “It’s a major breakthrough, and it’s remarkable. They should be congratulated,” one expert noted.
www.nejm.org/doi/10.1056/...
Aug 6, 2025 · 5 shares · 3,481 followersView post →
IU
Islet Biology Lab - UMH
@isletbiologylab.bsky.social · Bluesky
Carlsson et al. report the results of a proof-of-concept study of the transplantation of gene-edited, hypoimmune platform islet cells in a patient with long-term #type1diabetes, without the use of immunosuppression. ?
#PancSky
www.nejm.org/doi/full/10....
Survival of #Transplanted Allogeneic Beta Cells with No Immunosuppression. At 12 weeks after transplantation, no immune response against the #gene-edited cells. C-peptide measurements showed stable and glucose-responsive insulin secretion. https://t.co/1yYxX7dDjS
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/r3OyWTh4r3
Aug 5, 2025 · 2 likes · 1 share · 561 followersView post →
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Dr. Jeffrey Millman
@jeffreymillman.bsky.social · Bluesky
New #diabetes publication in the NEJM. Sana Biotechnology provides evidence that gene-edited islets survive after transplantation into a patient without immunosuppressing drugs for several months www.nejm.org/doi/full/10....
Genetically modified Beta Cells that are immune evasive. This is an incredible step in the right direction to a possible #Type1Diabetes cure that does not require immune suppression.
www.nejm.org/doi/full/10....
【原著論文】
Per-Ola Carlsson, et al. "Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression"
New England Journal of Medicine, Published August 4, 2025
https://t.co/iZ6YanB2ww
Aug 4, 2025 · 3 likes · 2 shares · 15,475 followersView post →
草
草
@n0rr · X
https://t.co/CNYbsdQJJv
Aug 4, 2025 · 4 likes · 10,963 followersView post →
Targeting HLA class I and class II and overexpression of CD47 make the immunosuppression of beta cell transplant unnecessary: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/8bhPt6hFWk
RT @SyedAAhmad5: WOW!! Major Major Advancement!! ??????
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression @NEJM…
Aug 4, 2025 · 2 shares · 26,312 followersView post →
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Syed A. Ahmad
@SyedAAhmad5 · X
WOW!! Major Major Advancement!! ??????
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression @NEJM https://t.co/Zey95v5ABH
Aug 4, 2025 · 16 likes · 2 shares · 15,072 followersView post →
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Eric Topol
@erictopol.bsky.social · Bluesky
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
❤️أمل جديد لعلاج السكري النوع الأول بلا أدوية مثبطة
في إنجاز علمي واعد، نشرت مجلة NEJM دراسة حديثة هذا اليوم بعنوان:
“بقاء خلايا بيتا البنكرياس المستزرعة دون مثبطات مناعة”
(? Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression)
وأظهرت النتائج أن خلايا
Aug 4, 2025 · 9 likes · 1 share · 322 followersView post →
旅T
旅人 tabito
@tabibito250 · X
RT @tabibito250: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/rZ…
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/rZVHeieKI2
Aug 4, 2025 · 2 likes · 1 share · 990 followersView post →
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Prof-Walid Tawfik
Facebook
org/doi/full/10.1056/NEJMoa2503822 — ا.د. وليد توفيق جامعة القاهرة · May be an image of text that says 'PROMISING NEWS FOR DIABETES PATIENTS Grafted beta.
Genetic Breakthrough Restores Insulin Production in Type 1 Diabetes
Instagram
DOI: 10.1056/NEJMoa2503822. more. November 19. OCR. 3 MADOS mB GBB 350 HIGH First human trial shows genetically modified cells can restore insulin in type 1 ...
org/doi/full/10.1056/NEJMoa2503822 #t1diabetes · Mungkin gambar teks · Mungkin grafik teks yang menyatakan 'PRESS RELEASE August 4, 2025 Sana Biotechnology Sana ...
... I find this very encouraging. 2 mos. Paula Ellis Bonifas. source? 2 mos. Mary Myers. DOI: 10.1056/NEJMoa2503822. 2 mos. Stella Shapiro. nice. 2 ...
इम्यूनोसप्रेशन के बिना आइलेट सेल्स! : r/Type1Diabetes
Reddit
39 votes, 11 comments. https://www.nejm.org/doi/full/10.1056/NEJMoa2503822 मैं अभी एक एक्सरसाइज स्टडी में हिस्सा ले रहा हूँ, और जो स्टूडेंट इसे चला रहा है वो भी t1d है ...
Gene-Edited Cells Help Diabetic Man Produce Insulin | Professor ...
LinkedIn
... 10.1056/NEJMoa2503822 · Like · Reply · 18 Reactions 19 Reactions. Dr. Sam Ringle M.D.R.A., graphic. Dr. Sam Ringle M.D.R.A.. Regulatory Affairs ...
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