The social discussions overwhelmingly express excitement and hope, citing examples like 'a breakthrough reported in NEJM,' 'moving closer to a cure,' and 'being on the verge of a revolution in treatment.' Words such as 'impressive,' 'amazing,' and 'game changer' demonstrate a tone of optimism and acknowledgment of the research's potential for a profound impact on medical science and patient lives.
AgreementStrong agreement
Most discussions positively emphasize the breakthrough nature of the research, with many expressing hope and optimism about the findings supporting a potential cure for type 1 diabetes.
InterestHigh interest
The social discussions reveal high curiosity and enthusiasm, with phrases like 'game changer,' 'impressive leap,' and 'help is on the way,' indicating strong engagement and interest in the scientific advances.
EngagementHigh engagement
Several posts delve into specific details like CRISPR editing techniques, the absence of immunosuppression, and future prospects, showing deep involvement and reflection on the implications.
ImpactHigh impact
Many comments highlight the significance of this research as a major step toward curing diabetes, suggesting people believe these advancements could revolutionize treatment and have a broad societal impact.
Abstract in brief
The study explores the transplantation of genetically modified allogeneic donor islet cells in a man with type 1 diabetes without using immunosuppressive drugs, addressing the risk of immune rejection.
The cells were edited using CRISPR technology and then implanted into the participant's forearm muscle, demonstrating no immune response after 12 weeks.
Measurements indicated stable insulin secretion, with only minor adverse events occurring that were unrelated to the cell transplant procedure.
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/rBaLoR8ivH
Original https://t.co/fizLOtBJzk
Aug 19, 2025 · 58 likes · 21 shares · 35,493 followersView post →
DN
Dr. Dominic Ng
@DrDominicNg · X
Another big downside is that they utilised donor pancreatic cells (in very rare supply).
Next steps?
1. Higher doses for actual insulin independence
2. Longer follow-up
3. More patients
4. Lab-grown cells instead of donor cells (mass producible)
Link: https://t.co/xC9UV9RtUn
Aug 6, 2025 · 43 likes · 5 shares · 15,178 followersView post →
MX
Medical Xpress
@medical_xpress · X
#Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating functional insulin production and no immune rejection in a first-in-human trial. @nejm https://t.co/BwkIVVKBIS https://t.co/PUGXZ4J8VL
Aug 6, 2025 · 29 likes · 22 shares · 172,968 followersView post →
SG
Shicheng Guo
@shihcheng.bsky.social · Bluesky
Genetically modified allogeneic islet cells transplanted into a man with type 1 diabetes remain rejection-free without immunosuppression! PMID:40757665, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2503822 #Medsky #Pharmsky #RNA #ASHG #ESHG
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/HE274nnYe4 #itsthecells! #helpisontheway!
Aug 7, 2025 · 21 likes · 4 shares · 1,881 followersView post →
This study explores the transplantation of genetically edited allogeneic beta cells using CRISPR technology, allowing immune acceptance without immunosuppressants. The cells remained functional after 12 weeks, showing…
This week features promising treatments for type 1 diabetes showing success in human trials, along with experimental viral infection research. Disappointing events include RFKrayKray's mistakes and misleading claims…
Nov 29, 2025 · 2 shares · 156 followersView post →
AH
Anders Hellström
@AHellstrom_com · X
@Saquib0509 @sciencegirl @grok said: "This claim stems from a real August 2025 NEJM study (doi:10.1056/NEJMoa2503822), the first human trial showing genetically modified allogeneic beta cells evading immune rejection via edits to HLA genes and CD47 overexpression, with no side effects observed at three
Nov 28, 2025 · 2 shares · 353 followersView post →
SU
Stem Cells Research Unit
@ESCR_KFMRC · X
A breakthrough reported in @NEJM: Researchers transplanted CRISPR-edited, insulin-producing β-cells into a type 1 diabetic patient — no immunosuppression, insulin release responsive to glucose, and clean safety profile.
https://t.co/1wTPW7mALJ
אמנם רק חולה אחד אבל עדיין מעניין. השתילו למטופל תאי בטא שמפיקים אינסולין בלי שום צורך לדעת את מערכת החיסון של המטופל. החוקרים שינו גנטית את התאים כך שלא יהיו אימונוגנים לגוף. אחרי 12 שבועות התאים שרדו יפה והפיקו אינסולין בהתאם לסיגנל של גלוקוז
https://t.co/swsEXVYprA
@_Roark__ @HtTrejo @NathaliaErazo12 El avance se describe en un estudio publicado el 4 de agosto de 2025 en el New England Journal of Medicine (NEJM). Título: "Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression". DOI: 10.1056/NEJMoa2503822. Involucra células islote editadas con CRISPR para
Oct 15, 2025 · 2 likes · 6,718,084 followersView post →
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Grok
@grok · X
@medicalanomalyz @Rainmaker1973 The study "Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression" (NEJM, 2025) was conducted by researchers from Sana Biotechnology, Uppsala University Hospital, and Oslo University Hospital. Sana Biotechnology developed the hypoimmune-modified islet cells
Oct 11, 2025 · 1 like · 6,718,084 followersView post →
⚠️ حتى الآن، التجربة أجريت على مريض واحد وبجرعة محدودة، لذلك لا يمكن اعتبارها علاجاً كاملاً بعد، لكنها تمثل خطوة علمية مهمة في أبحاث السكري.
المصدر:
https://t.co/VcgJnD5Pb7
A 42-year-old man with type 1 diabetes now produces his own insulin after receiving CRISPR-edited cells that “hide” from his immune system. No immune rejection, no harsh drugs. Could mean a real cure is finally in sight!
Source: 10.1056/NEJMoa2503822 https://t.co/9uoPf41Gao
Sep 25, 2025 · 1 like · 1 share · 3,527 followersView post →
CK
Chaim Katz
@ChaimKatz7 · X
https://t.co/NBN6P5fFch
Sep 23, 2025 · 1 like · 1,502 followersView post →
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Agingdoc
@agingdoc1 · X
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
@johnwernsten @Rainmaker1973 Study: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression (NEJM, 2025).
Methods: CRISPR-Cas12b edited donor islet cells (targeting genes to evade immune detection, including boosting CD47) via lentiviral transduction. Transplanted into forearm muscle of a
The paper in "NEJM" the above "Nature" article is based upon, & links to:
“Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression”
2/2
https://t.co/XzA79HupBb
Mankind is moving closer and closer to the cure of type 1 Diabetes!
@drshafikuchay @omlakhani @DrVinodEndo @karthik2k2 @DrAmbrishMithal
https://t.co/PAOTEO8n3H
A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: https://t.co/rBaLoR8ivH
Original https://t.co/fizLOtBJzk
This is the first report of its kind.
The first individual started producing insulin by transplanted cells, without any immunosuppression, a proof of concept study.
Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection
Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.
Nature
https://t.co/zuoJjGPVXg
NEJM
https://t.co/XxopLWn8ym https://t.co/FBvHQvcufI
Genetically modified allogeneic islet cells transplanted into a man with type 1 diabetes remain rejection-free without immunosuppression! PMID:40757665, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2503822 #Medsky #Pharmsky #RNA #ASHG #ESHG
Genetically modified allogeneic islet cells transplanted into a man with type 1 diabetes remain rejection-free without immunosuppression! PMID:40757665, N Engl J Med 2025, @NEJM https://t.co/oKtmnG4VWS #AI #Pharma #BioMed #RNA #ASHG #ESHG
And some good news
"A patient with type 1 diabetes is now producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic cells, without needing any anti-rejection drugs."
Paper: https://t.co/HWL2GKylEA https://t.co/uXeT0kRcrS
@alakel_abdullah @mm36996 حياك الله دكتور عبدالله
أظن يقصدون هذه الورقة
https://t.co/n8Vcde1sxC
الخبر إجمالا صحيح لكن التعديلات المعمولة على الخلايا كثير وتجعلها عرضة لتصبح خلايا سرطانية وهناك تقنيات أخرى واعدة أكثر باذن الله تعالى
Sep 3, 2025 · 1 like · 12,992 followersView post →
Aug 19, 2025 · 2 likes · 1 share · 2,790 followersView post →
AP
Aitore García (any/all pronouns)
@abeingbehaving · X
No sólo hay catástrofes a nuestro alrededor: Gracias a la edición genética, un hombre con diabetes tipo I se beneficia por primera vez de un transplante de células pancreáticas sin necesidad de tratamiento inmunosupresor.
https://t.co/npdAVgVF8E
Aug 19, 2025 · 9 likes · 1 share · 6,537 followersView post →
S
SETrasplante
@SETrasplante · X
RT @AlexGtrzD: An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @SENefrologia @…
Aug 18, 2025 · 3 shares · 3,551 followersView post →
YA
Yaron Assa
@yassa · X
מגניב מאוד - תאים מפיקי אינסולין עברו עריכות גנטיות שיאפשרו השתלה שלהם בחולה סכרת ללא דחייה ממערכת החיסון. התאים שבהם העריכה לא הצליחה הושמדו בגוף של המושתל, ולבסוף נשארו רק אלו עם עריכה מוצלחת, שהדגימו פונקציונליות מפיקת אינסולין תקינה ללא תגובה חיסונית.
https://t.co/r30SpTEv5H
Aug 17, 2025 · 6 likes · 1,338 followersView post →
D
Del
@Del_slp · X
RT @docramiro: Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1
Aug 17, 2025 · 49 shares · 3,509 followersView post →
AV
Ana Luiz Vanrua
@SolVanlu · X
Reversão de Diabetes tipo 1/ experimento positivo.
Sobrevivência de células beta alogênicas transplantadas sem imunossupressão | New England Journal of Medicine https://t.co/BSEEVMvRls
Reported in @NEJM:
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression.
Single patient proof of concept trial shows immunosuppression free organ transplantation is possible.
Aug 14, 2025 · 11 likes · 1 share · 15,276 followersView post →
CM
Chil Mex
@Lineux2016 · X
RT @docramiro: Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1
Aug 14, 2025 · 49 shares · 133 followersView post →
IA
Iván Arostegui
@Ceivarg97 · X
RT @docramiro: Trasplante de islotes pancreáticos sin inmunosupresores en paciente con diabetes tipo 1
CURE FOR TYPE 1 DIABETES IS WITHIN REACH!!!
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine
https://t.co/U49HzMbWjp
Aug 13, 2025 · 1 like · 1 share · 3,644 followersView post →
CS
CRISP_SCIENCE
@ScienceCrisp · X
"Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression"
Carlsson PO, Hu X, Scholz H et al.
N Engl J Med. 2025-08-04.
https://t.co/8IhkgrmrF3
CRISPR-Cas12b editing & lentiviral transduction
Aug 10, 2025 · 1 like · 1,930 followersView post →
V
viro
@viro_vs · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 10, 2025 · 99 shares · 23 followersView post →
YP
You Make Me Sick! Podcast
@makemesickpod · X
RT @Kottond: Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: Survival of Transplanted…
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 8, 2025 · 99 shares · 1,714 followersView post →
JB
Juanita Bre
@rinaalvarezoz · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 508 followersView post →
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NervoznaMama
@NervoznaMama · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 166 followersView post →
ND
Nobles Duck
@cakana81 · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 2,767 followersView post →
DK
Darrell Kotton
@kottond.bsky.social · Bluesky
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....
Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine https://t.co/HE274nnYe4 #itsthecells! #helpisontheway!
Aug 7, 2025 · 21 likes · 4 shares · 1,881 followersView post →
DB
Daniel Balos
@daniel_balos · X
RT @slobadoktor: Budućnost na pragu. Za neku godinu tip 1 dijabetes ce biti izlečiva bolest. Survival of Transplanted Allogeneic Beta Cells…
Aug 7, 2025 · 99 shares · 2,909 followersView post →
RT @DrDominicNg: Another big downside is that they utilised donor pancreatic cells (in very rare supply).
Next steps?
1. Higher doses for…
Aug 7, 2025 · 5 shares · 1,996 followersView post →
AS
alexgutierrezd.bsky.social
@alexgutierrezd.bsky.social · Bluesky
An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @senefrologia.bsky.social @edoardomelilli.bsky.social
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine www.nejm.org/doi/full/10....
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 222 followersView post →
A
Auscandoc
@auscandoc.med-mastodon.com.ap.brid.gy · Bluesky
https://www.nejm.org/doi/full/10.1056/NEJMoa2503822
“transplantation of genetically modified allogeneic donor islet cells into a man with long-standing type 1 #diabetes. We used ..CRISPR-associated protein 12b (Cas12b) editing and lentiviral transduction to genetically edit the cells to avoid […]
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 115,240 followersView post →
EM
Evie Marom
@SpaceGurlEvie · X
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 2,776 followersView post →
PO
Phys.org
@physorg_com · X
RT @medical_xpress: #Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating fu…
Aug 6, 2025 · 22 shares · 1,009,994 followersView post →
MX
Medical Xpress
@medical_xpress · X
#Gene-edited islet cells survived 12 weeks in a person with type 1 diabetes without immunosuppression, demonstrating functional insulin production and no immune rejection in a first-in-human trial. @nejm https://t.co/BwkIVVKBIS https://t.co/PUGXZ4J8VL
Aug 6, 2025 · 29 likes · 22 shares · 172,968 followersView post →
DD
D. Roselyn Cerutis Ph.D.
@DRC31077 · X
RT @DrDominicNg: Another big downside is that they utilised donor pancreatic cells (in very rare supply).
Next steps?
1. Higher doses for…
Another big downside is that they utilised donor pancreatic cells (in very rare supply).
Next steps?
1. Higher doses for actual insulin independence
2. Longer follow-up
3. More patients
4. Lab-grown cells instead of donor cells (mass producible)
Link: https://t.co/xC9UV9RtUn
Aug 6, 2025 · 43 likes · 5 shares · 15,178 followersView post →
N
NDロドスタ乗り
@BlackBird_P964 · X
RT @EARL_med_tw:
Aug 6, 2025 · 5 shares · 3,481 followersView post →
う
うるる☘️
@ulu_ululu · X
RT @EARL_med_tw:
Aug 6, 2025 · 5 shares · 1,656 followersView post →
org/doi/full/10.1056/NEJMoa2503822 — ا.د. وليد توفيق جامعة القاهرة · May be an image of text that says 'PROMISING NEWS FOR DIABETES PATIENTS Grafted beta.
Genetic Breakthrough Restores Insulin Production in Type 1 Diabetes
Instagram
DOI: 10.1056/NEJMoa2503822. more. November 19. OCR. 3 MADOS mB GBB 350 HIGH First human trial shows genetically modified cells can restore insulin in type 1 ...
org/doi/full/10.1056/NEJMoa2503822 #t1diabetes · Mungkin gambar teks · Mungkin grafik teks yang menyatakan 'PRESS RELEASE August 4, 2025 Sana Biotechnology Sana ...
... I find this very encouraging. 2 mos. Paula Ellis Bonifas. source? 2 mos. Mary Myers. DOI: 10.1056/NEJMoa2503822. 2 mos. Stella Shapiro. nice. 2 ...
इम्यूनोसप्रेशन के बिना आइलेट सेल्स! : r/Type1Diabetes
Reddit
39 votes, 11 comments. https://www.nejm.org/doi/full/10.1056/NEJMoa2503822 मैं अभी एक एक्सरसाइज स्टडी में हिस्सा ले रहा हूँ, और जो स्टूडेंट इसे चला रहा है वो भी t1d है ...
Gene-Edited Cells Help Diabetic Man Produce Insulin | Professor ...
LinkedIn
... 10.1056/NEJMoa2503822 · Like · Reply · 18 Reactions 19 Reactions. Dr. Sam Ringle M.D.R.A., graphic. Dr. Sam Ringle M.D.R.A.. Regulatory Affairs ...
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