PubHawk
October 2025 PMID 40816292

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer.

Juan C Osorio, David A Knorr, Polina Weitzenfeld, Lucas Blanchard, Ning Yao, Maria Baez, Carlo Sevilla, Meghan DiLillo, Jahan Rahman, Ved P Sharma, Jacqueline Bromberg, Michael A Postow, Charlotte Ariyan, Mark E Robson, Jeffrey V Ravetch

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Mentions

124
Peak: 30 in Aug 2025
across 5 sources since Aug 2025

Extended reach

101,454
potential audience

Total likes

116

Video views

96

Mentions per month

Aug 2025 – Sep 2025

Where it's discussed

  • News88 articles
  • X / Twitter28 posts
  • Blogs4 articles
  • Bluesky2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions highlight promising results such as tumor regression and immune activation, using words like 'systemic immunity' and 'formation of immune structures,' which convey optimism and curiosity. The tone varies from cautious support to admiration of its potential, reflecting a balanced perception of its significance and the need for further research.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some posts highlighting its promising findings, such as complete remissions and immune activation, indicating cautious support.

InterestHigh interest

The discussions demonstrate high curiosity, especially around the clinical implications and immune mechanisms, as diverse posts emphasize key results and potential breakthroughs.

EngagementModerate engagement

Participants reference specific aspects like the formation of tertiary lymphoid structures and immune responses, showing moderate to deep engagement with the detailed scientific content.

ImpactModerate impact

While some posts emphasize the potential transformative impact on metastatic cancer treatment, others view it as preliminary, assigning a moderate impact due to early-phase findings.

Abstract in brief

  • The study investigates the safety and effectiveness of an experimental treatment called 2141-V11, an anti-CD40 antibody, in patients with metastatic cancer.
  • It found that the treatment was well tolerated by patients, with no serious side effects, and resulted in tumor reduction in half of the patients, including complete remission in two cases.
  • The therapy appears to enhance immune responses by promoting the formation of specialized immune structures and activating T cells, leading to both localized and systemic antitumor effects.
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Top posts

Most liked on X and Bluesky
Cancer Cell
@Cancer_Cell · X

Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer https://t.co/L6CEbCfuyo https://t.co/lZKa2oyHsc

Aug 18, 2025 · 91 likes · 21 shares · 72,195 followers View post →
Waggoner Lab
@LabWaggoner · X

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer @Cancer_Cell @juanosoriomd https://t.co/ZyrpTooyD2 https://t.co/DN3GOSish1

Aug 14, 2025 · 12 likes · 11,300 followers View post →
Diego A. Díaz-García
@diegoadiazg · X

Aug 31, 2025 · 3 likes · 1 share · 1,644 followers View post →
Waggoner Lab
@labwaggoner.bsky.social · Bluesky

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer @cp-cancercell.bsky.social @juanosoriomd.bsky.social www.cell.com/cancer-cell/...

Aug 14, 2025 · 3 likes · 1 share View post →
Cancer Care PubMed
@OncologyPubMed · X

#Cancer_Cell Phase 1 trial (n=12) of intratumoral Fc-optimized CD40 agonistic antibody (2141-V11) in metastatic cancer showed 2 CRs (melanoma, breast) and tumor regression with systemic CD8(+) T cell activation and TLS formation. PMID:40816292 https://t.co/Df51gvDCMb

Aug 17, 2025 · 1 like · 36 followers View post →
Raheel Shfiea
@DaaniPooh · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 6,150 followers View post →

All mentions

Sadaf Mughal
@sadaf_mugh · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Sep 10, 2025 · 21 shares · 42 followers View post →
Lawrence Bennett
@LawrieBrain · X

RT @diegoadiazg:

Sep 1, 2025 · 1 share · 54 followers View post →
Diego A. Díaz-García
@diegoadiazg · X

Aug 31, 2025 · 3 likes · 1 share · 1,644 followers View post →
Diego A. Díaz-García
@diegoadiazg · X

Aug 31, 2025 · 1,644 followers View post →
Peter_BB
@peter_bb87312 · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 26, 2025 · 21 shares · 5 followers View post →
rajivk-substack
@RajivkSubstack · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 20, 2025 · 21 shares · 19 followers View post →
Maryada Sharma
@sharma_maryada · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 20, 2025 · 21 shares · 356 followers View post →
Anqi Gao
@anqigao · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 324 followers View post →
Joao Fogacci
@FogacciJoao · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 724 followers View post →
PPBI
@PPBIOConsWW · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 715 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 1,319 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 182 followers View post →
Being chakravarthy
@beingchakravrty · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 329 followers View post →
SomeoneSomewhere
@Someone68423357 · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 98 followers View post →
Omar Shabana
@omarimmunity · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 44 followers View post →
Inmunología Animal vs Virología Animal
@AlesandroSherry · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 360 followers View post →
Cancer Cell
@cp-cancercell.bsky.social · Bluesky

Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

Aug 19, 2025 View post →
xxy
@xxy07255392 · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 265 followers View post →
Dieter
@Wuhle · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 475 followers View post →
Timothy Chao
@timchao_mdphd · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 304 followers View post →
Karen Sullivan
@BiotechLeadKS · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 49 followers View post →
L_TK
@LTK81872901 · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 118 followers View post →
Raheel Shfiea
@DaaniPooh · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 19, 2025 · 21 shares · 6,150 followers View post →
Ignacio Wistuba, MD
@MdWistuba · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 18, 2025 · 21 shares · 205 followers View post →
Juan C Osorio MD
@juanosoriomd · X

RT @Cancer_Cell: Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immu…

Aug 18, 2025 · 21 shares · 1,208 followers View post →
Cancer Cell
@Cancer_Cell · X

Online Now: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer https://t.co/L6CEbCfuyo https://t.co/lZKa2oyHsc

Aug 18, 2025 · 91 likes · 21 shares · 72,195 followers View post →
Life Science Journal Content
@lsn_jc · X

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer #science #publication #research #journal https://t.co/OHngu7vMm1

Aug 18, 2025 · 265 followers View post →
Cancer Care PubMed
@OncologyPubMed · X

#Cancer_Cell Phase 1 trial (n=12) of intratumoral Fc-optimized CD40 agonistic antibody (2141-V11) in metastatic cancer showed 2 CRs (melanoma, breast) and tumor regression with systemic CD8(+) T cell activation and TLS formation. PMID:40816292 https://t.co/Df51gvDCMb

Aug 17, 2025 · 1 like · 36 followers View post →
Waggoner Lab
@LabWaggoner · X

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer @Cancer_Cell @juanosoriomd https://t.co/ZyrpTooyD2 https://t.co/DN3GOSish1

Aug 14, 2025 · 12 likes · 11,300 followers View post →
Waggoner Lab
@labwaggoner.bsky.social · Bluesky

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer @cp-cancercell.bsky.social @juanosoriomd.bsky.social www.cell.com/cancer-cell/...

Aug 14, 2025 · 3 likes · 1 share View post →