Neuron October 2025 PMID 40834861

Microglia regulate neuronal activity via structural remodeling of astrocytes.

Ning Gu, Olena Makashova, Celeste Laporte, Chris Qilongyue Chen, Banruo Li, Pierre-Marie Chevillard, Graham Lean, Jieyi Yang, Calvin Wong, Jonathan Fan, Behrang Sharif, Susana Puche Saud, Misha Hubacek, Katrina Y Choe, Margaret M McCarthy

Mentions

163
Peak: 90 in Aug 2025
across 8 sources since Feb 2025

Extended reach

355,375
potential audience

Total likes

361

Video views

1,736

Mentions per month

Feb 2025 – Nov 2025

Where it's discussed

  • X / Twitter93 posts
  • News20 articles
  • LinkedIn18 posts
  • Instagram14 posts
  • Facebook7 posts
  • Bluesky6 posts
  • YouTube3 videos
  • Blogs2 articles

AI synopsis

What people are saying

Overall, the discussions demonstrate high enthusiasm and support, with posts praising the visual reconstructions and highlighting the potential for this research to impact understanding of hypertension and neuronal health, using words like 'beautiful,' 'crucial,' and phrases indicating potential paradigm shifts.

AgreementStrong agreement

Most discussions show strong support and acknowledgment of the significance of the research, emphasizing the potential broad implications.

InterestHigh interest

The posts reflect high curiosity, with many highlighting the innovative aspects of microglia's role in neuronal activity and sharing enthusiasm.

EngagementHigh engagement

Several posts include detailed references to visual content, summaries, and implications, demonstrating deep involvement.

ImpactHigh impact

The discussions suggest that the findings are viewed as potentially revolutionary, impacting future research and treatment approaches.

Abstract in brief

  • Neuron-glia interactions are crucial for managing synaptic transmission and neuronal excitability, with astrocyte structural changes tied to various conditions.
  • A high-salt diet in rats leads to microglial accumulation that causes the pruning of astrocytic processes surrounding vasopressin neurons, affecting synaptic function.
  • Inhibiting this microglial activity can reduce increased neuronal activity and related health issues due to the high-salt intake.

Top posts

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Neuron
@NeuroCellPress · X

Online now: Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/EcEoFCmtUJ https://t.co/Ts4n87av1K

Aug 19, 2025 · 228 likes · 71 shares · 146,836 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Microglia regulate neuronal activity via structural remodeling of astrocytes: Neuron https://t.co/Mri6IPJkdr

Aug 19, 2025 · 30 likes · 6 shares · 4,735 followers View post →
Nat Rev Neurology
@NatRevNeurol · X

Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/QXcIZMX6o0

Aug 21, 2025 · 17 likes · 5 shares · 46,399 followers View post →
bioRxiv Neuroscience
@biorxiv-neursci.bsky.social · Bluesky

Microglia regulate neuronal activity via structural remodeling of astrocytes https://www.biorxiv.org/content/10.1101/2025.02.18.638874v1

Feb 19, 2025 · 13 likes · 2 shares View post →
Bertoglio lab (FMC/UFSC)
@bertogliolab · X

Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/wWSE4QRdGd

Aug 19, 2025 · 9 likes · 3 shares · 1,703 followers View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/ipReRHwxL3 #biorxiv_neursci

Feb 19, 2025 · 8 likes · 1 share · 59,790 followers View post →

All mentions

Walter Suárez Carmona
@a_fisiolog57853 · X

De confirmarse este mecanismo en humanos podría suponer un cambio en el enfoque de la hipertensión asociada a la sal. ¡¡¡A leer, zagales!!! https://t.co/tDGhYafGrL

Oct 30, 2025 · 4,194 followers View post →
Nuno Luciano
@nunoluciano · X

Microglia regulate neuronal activity via structural remodeling of astrocytes #astrocytes #microglia #structural #plasticity #neuronal #excitability #synaptic #transmission https://t.co/HfhMpRgopQ

Oct 25, 2025 · 478 followers View post →
Rodrigo Acosta-Luna
@Voyxger_2 · X

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Sep 23, 2025 · 71 shares · 2 followers View post →
Biomedical Picture of the Day BPoD
@BPoD_s · X

RT @Masha_P_K: @BPoD_s @mcgillu @NeuroCellPress @rooph This beautiful video showing a 3D reconstruction of a “hungry” microglia was generat…

Sep 20, 2025 · 1 share · 3,790 followers View post →
Masha Prager-Khoutorsky
@Masha_P_K · X

@BPoD_s @mcgillu @NeuroCellPress @rooph This beautiful video showing a 3D reconstruction of a “hungry” microglia was generated by @LaporteCeleste - co-author on the paper: https://t.co/p0WYYiaGXK

Sep 20, 2025 · 4 likes · 1 share · 949 followers View post →
Yuki Hattori
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@guardian_xcu · X

➡️ Die Studienzusammenfassung von Forschenden der McGill University, Montréal, Québec,

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Hideto Takekida
@HidetoTakekida · X

塩分での高血圧になるの真因は脳の炎症? https://t.co/hbCNVyrnx3 Microglia regulate neuronal activity via structural remodeling of astrocytes: Neuron この論文では高血圧を引き起こす新たな要因を分析しており、それがなんと脳の炎症だということが示されています。

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Kelvin R.
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Microglia regulate neuronal activity via structural remodeling of astrocytes: Neuron https://t.co/ylpWH6xYXQ

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Life Science Journal Content
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Rosaura Brisuela @roswitta.bsky.social
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えぬゆ
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Nature Reviews Neurology
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Microglia regulate neuronal activity via structural remodeling of astrocytes www.sciencedirect.com/science/arti...

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Nat Rev Neurology
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Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/QXcIZMX6o0

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Researching the Brain
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arvie 아비, PhD
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Viet Van Dang
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Pain & itch research group@富山大学・薬学部・応用薬理学研究室
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Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/uC3GnXdQv5

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Pluchino lab - Regenerative Neuroimmunology
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Microglia regulate neuronal activity via structural remodeling of astrocytes: Neuron www.cell.com/neuron/abstr...

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Pluchino lab - Regenerative Neuroimmunology
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Microglia regulate neuronal activity via structural remodeling of astrocytes: Neuron https://t.co/Mri6IPJkdr

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Bertoglio lab (FMC/UFSC)
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Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/wWSE4QRdGd

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Microglia regulate neuronal activity via structural remodeling of astrocytes https://www.biorxiv.org/content/10.1101/2025.02.18.638874v1

Feb 19, 2025 · 13 likes · 2 shares View post →
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Microglia regulate neuronal activity via structural remodeling of astrocytes https://t.co/ipReRHwxL3 #biorxiv_neursci

Feb 19, 2025 · 8 likes · 1 share · 59,790 followers View post →
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