October 2025 PMID 40855190

Pig-to-human lung xenotransplantation into a brain-dead recipient.

Jianxing He, Jiang Shi, Chao Yang, Guilin Peng, Chunrong Ju, Yi Zhao, Hui Liu, Ping He, Xiaoqing Liu, Zuopeng Zhang, Chuanbao Chen, Dengke Pan, Zifeng Yang, Wenda Guang, Hongtao Li

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Mentions

303

Peak: 51 in Aug 2025

across 6 sources since Aug 2025

Extended reach

1,067,165

potential audience

Total likes

157

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Mentions per month

Aug 2025 – Sep 2025

Where it's discussed

News231 articles
X / Twitter49 posts
Blogs15 articles
Bluesky3 posts
Facebook3 posts
YouTube2 videos

AI synopsis

What people are saying

In the collective discussions, several posts highlight key elements of the research, such as the mention of a pig lung maintaining functionality for 216 hours without hyperacute rejection. Others express excitement, using terms like 'impressive effort' and underlining the implications of such advancements, contributing to a tone of optimism and hope for the future of organ transplantation.

AgreementModerate agreement

There is a general consensus among the discussions that the publication represents a significant breakthrough in xenotransplantation.

InterestHigh interest

Participants show a high level of curiosity, often referencing the details of the study and its implications.

EngagementModerate engagement

While some posts are surface-level mentions, a number of them delve into specific scientific details, indicating moderate engagement.

ImpactHigh impact

Many participants believe that this research could have a substantial effect on future organ transplantation practices.

Abstract in brief

The first successful transplant of genetically engineered pig lungs into a human was performed on a 39-year-old brain-dead male, raising important questions about immune response and organ rejection in xenotransplantation.
The lung from a six-gene-edited pig functioned well for 216 hours post-transplant without hyperacute rejection or infection, although it experienced severe edema and antibody-mediated rejection later on.
Immunosuppression protocols were used to manage the recipient's immune response, highlighting the ongoing challenges of organ rejection and infection before xenotransplantation can become a standard clinical practice.

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All mentions

Successful Pig Lung Transplant: A Breakthrough in Xenotransplantation

A groundbreaking achievement in xenotransplantation occurred with the first successful transplant of a genetically engineered pig lung into a brain-dead recipient. The lung functioned for 216 hours without hyperacute…

MasterMedFacts · Aug 28, 2025 18 views

Successful Pig-to-Human Lung Xenotransplantation Insights

This episode explores the groundbreaking possibilities of pig organ donation to humans, focusing on the first successful transplant of genetically engineered pig lungs into a brain-dead recipient. Key challenges of…

Swinentist · Aug 29, 2025 0 views

Mario Alberto Macías Duvignau

@mario190598 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Sep 8, 2025 · 24 shares · 186 followers View post →

竹内康正 ❤️ Yasumasa Takeuchi

@zephyorg · X

RT @NatureJapan: Jianxing He、芳川豊史氏らの@NatureMedicine #論文 Pig-to-human lung xenotransplantation into a brain-dead recipient https://t.co/Lx…

Sep 4, 2025 · 3 shares · 6,310 followers View post →

Nature Japan

@NatureJapan · X

Sep 3, 2025 · 4 likes · 3 shares · 90,265 followers View post →

Sino

@SinoReddit · X

#Pig-to-#human #lung #xenotransplantation into a brain-dead recipient: The lung #xenograft maintained viability and functionality over the course of the 216 hours of the monitoring period, without signs of hyperacute rejection or infection https://t.co/xlczDtgTq1

Aug 31, 2025 · 2,149 followers View post →

Life Science Journal Content

@lsn_jc · X

Pig-to-human lung xenotransplantation into a brain-dead recipient #science #publication #research #journal https://t.co/qCacwfDSFs

Aug 30, 2025 · 265 followers View post →

ListenToTheEpsteinVictims

@jos1463.bsky.social · Bluesky

Impressive effort. 6 genes edited Pig-to-human lung xenotransplantation into a brain-dead recipient. www.nature.com/articles/s41...

Aug 28, 2025 View post →

RR BaligaMD, Professor & Cardiologist

@RRBaligaMD · X

Dr Baliga’s Podkast for the Curious Doc

Aug 28, 2025 · 4 likes · 1,408 followers View post →

Dr. Mich

@michelamaury · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 216 followers View post →

910bb

@taka910bb · X

RT @carpe_diem0820: Pig-to-human lung xenotransplantation into a brain-dead recipient 脳死ヒトへのブタ肺異種移植中国の研究チームは、6遺伝子改変ブタの左肺を39歳の脳死男性に移植した。…

Aug 27, 2025 · 3 shares · 1,205 followers View post →

Chinedu Stephen Mathias Ekweremadu III

@ChineduEkw · X

RT @NatureAsia: [Highlight] Gene-edited pig lung functions in human for 9 days Pig-to-human lung xenotransplantation into a brain-dead reci…

Aug 27, 2025 · 7 shares · 633 followers View post →

Aaron Gonzalez

@EngAaronG · X

RT @NatureAsia: [Highlight] Gene-edited pig lung functions in human for 9 days Pig-to-human lung xenotransplantation into a brain-dead reci…

Aug 27, 2025 · 7 shares · 31 followers View post →

Ryan Chen

@chessandai · X

RT @NatureAsia: [Highlight] Gene-edited pig lung functions in human for 9 days Pig-to-human lung xenotransplantation into a brain-dead reci…

Aug 27, 2025 · 7 shares · 8 followers View post →

DGG

@DGG7334 · X

RT @NatureAsia: [Highlight] Gene-edited pig lung functions in human for 9 days Pig-to-human lung xenotransplantation into a brain-dead reci…

Aug 27, 2025 · 7 shares · 113 followers View post →

Manuel Villegas

@M3xico3nl4b4nC4 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 1,044 followers View post →

Felipe Coiro

@CoiroFelipe · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 509 followers View post →

KanzakiS

@nchdaks · X

RT @NatureAsia: [Highlight] Gene-edited pig lung functions in human for 9 days Pig-to-human lung xenotransplantation into a brain-dead reci…

Aug 27, 2025 · 7 shares · 675 followers View post →

Nature Medicine

@NatureMedicine · X

RT @NatureAsia: [Highlight] Gene-edited pig lung functions in human for 9 days Pig-to-human lung xenotransplantation into a brain-dead reci…

Aug 27, 2025 · 7 shares · 351,869 followers View post →

Jaime Baíza Montoya

@JaimeBaiza · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 74 followers View post →

Reinaldo Burgos ®

@Reburgoslapalma · X

RT @_jdevos_: Pig-to-human lung xenotransplantation into a brain-dead recipient. In Nature Medicine. But still a long way to go before clin…

Aug 27, 2025 · 2 shares · 484 followers View post →

フルチン中年男性

@otakutokkai · X

Aug 27, 2025 · 3 shares · 1,650 followers View post →

チル

@arigatou0815 · X

RT @NatureJapan: [注目のHL]医療研究：遺伝子編集された豚の肺が人間の体内で9日間機能した https://t.co/NR5KW6TcL8 Jianxing He、芳川豊史氏らの@NatureMedicine #論文 Pig-to-human lung xe…

Aug 27, 2025 · 2 shares · 253 followers View post →

Nature Japan

@NatureJapan · X

Aug 27, 2025 · 9 likes · 2 shares · 90,265 followers View post →

avalon1982

@avalon1982 · X

Aug 27, 2025 · 3 shares · 2,443 followers View post →

Mugen UJIIE (氏家無限)

@carpe_diem0820 · X

Aug 27, 2025 · 5 likes · 3 shares · 12,385 followers View post →

UrquideZ G Migde

@IdaliaGutz · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 183 followers View post →

baron rojo

@Alfredo35855092 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 12 followers View post →

Alejandro Macias

@doctormacias · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 413,104 followers View post →

Cactus

@Cactus4418 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 27, 2025 · 24 shares · 170 followers View post →

Caesar De Melniboné

@CesarDMelnibone · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 123 followers View post →

Nature Asia-Pacific

@NatureAsia · X

Aug 26, 2025 · 8 likes · 7 shares · 3,328 followers View post →

Alicia Ayala

@alichela · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 94 followers View post →

Mega

@LilianaMega1 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 2,428 followers View post →

CRISP_SCIENCE

@ScienceCrisp · X

“Pig-to-human lung xenotransplantation into a brain-dead recipient” He J [..] Xu X. Nat Med. 2025-08-25. https://t.co/vbtKHsQk6y CRISPR-Cas9 KO 3 genes (GGTA1, B4GALNT2 & CMAH); insertion of 3 human genes (CD55, CD46 & TBM)

Aug 26, 2025 · 1,916 followers View post →

Francisco.

@Hornytorrinco__ · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 330 followers View post →

Fernando P. R.

@chirifercho · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 118 followers View post →

Sr. Diógenes

@ElSrDiogenes · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 401 followers View post →

Juan Carlos

@au640 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 180 followers View post →

Rafael E. Aguirre Q.

@drlitoaguirre1 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 3,080 followers View post →

Aresk

@arezka81 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 515 followers View post →

Tincho

@_mavib · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 470 followers View post →

Nurse Senior

@RoxioYarin · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 831 followers View post →

Luis González Torres

@LuisGonzle5510 · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 1,120 followers View post →

Claudia

@kalisacosta · X

RT @docramiro: Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 24 shares · 95 followers View post →

Ramiro Esparza

@docramiro · X

Xenotrasplante de pulmón de cerdo a humano

Aug 26, 2025 · 122 likes · 24 shares · 68,297 followers View post →

Honnet C

@HonnetC · X

RT @_jdevos_: Pig-to-human lung xenotransplantation into a brain-dead recipient. In Nature Medicine. But still a long way to go before clin…

Aug 26, 2025 · 2 shares · 44 followers View post →

John De Vos

@_jdevos_ · X

Pig-to-human lung xenotransplantation into a brain-dead recipient. In Nature Medicine. But still a long way to go before clinical applications. https://t.co/O5yll59TKA

Aug 26, 2025 · 1 like · 2 shares · 1,411 followers View post →

John De Vos

@jdevos.bsky.social · Bluesky

Pig-to-human lung xenotransplantation into a brain-dead recipient. In Nature Medicine. But still a long way to go before clinical applications. buff.ly/V3SAqv2

Aug 26, 2025 · 2 likes · 2 shares View post →

Abstream

@abstreamme · X

Pig-to-human lung xenotransplantation into a brain-dead recipient #science #publication #research #publications https://t.co/7F5Tn1QfOm

Aug 26, 2025 · 787 followers View post →

Collet Liz | ⚖️

@LizCollet · X

Mindestens einem halben Dutzend Menschen wurden bereits genetisch veränderte Schweineorgane in den USA und China übertragen; Herz, Leber, Niere und nun auch Lunge. Pig-to-human lung xenotransplantation into a brain-dead recipient: https://t.co/ZqGvTer2Tx

Aug 26, 2025 · 1,100 followers View post →

WinAlly

@WinAlly_com · X

NATURE / Pig-to-human lung #xenotransplantation into a brain-dead recipient #Ksenotransplantasyonda https://t.co/u3DAzpkGRC

Aug 26, 2025 · 1,024 followers View post →

Xosé M Fernández

@xosegb.bsky.social · Bluesky

Pig-to-human lung #xenotransplantation into a brain-dead recipient www.nature.com/articles/s41...

Aug 26, 2025 View post →

猫被り医（PhD, MD, 中の人は獰猛かなぁ）

@shh_toyama · X

Xenotransplant：39歳脳出血による脳死者に、CRISPERの遺伝子改変で６つ程のヒトへの免疫応答ゲノムを潰したブタの肺を移植。 Pig-to-human lung xenotransplantation into a brain-dead recipient | Nature Medicine https://t.co/Tr5odqYFa9

Aug 25, 2025 · 284 followers View post →

Pig-to-human lung xenotransplantation into a brain-dead recipient.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Successful Pig Lung Transplant: A Breakthrough in Xenotransplantation

Successful Pig-to-Human Lung Xenotransplantation Insights