The social discussions extensively highlight the trial’s positive outcomes, such as 'reduced VTE recurrence from 10% to 1.3%', and use language like 'benefit', 'remarkable', and 'practice-changing' to convey excitement and significance. The tone reflects a focus on clinical impact and implications for treatment guidelines, indicating a high level of engagement and recognition of the trial’s importance.
AgreementStrong agreement
Most discussions specifically support the findings of the trial, emphasizing the benefits of low-dose apixaban in preventing recurrent VTE and highlighting key results like reduced risk and low bleeding rates.
InterestHigh interest
The social discussions clearly demonstrate high interest, with numerous mentions of the trial's significance, detailed results, and potential practice changes, indicating engagement with the research topic.
EngagementModerate engagement
Many posts reference specific trial results, clinical implications, and trial leadership, showing thoughtfulness and depth, although some are more generalized, resulting in a moderate engagement score.
ImpactHigh impact
Given the emphasis on practice-changing results, dissemination at a major congress, and inclusion in a prominent journal, the discussions suggest substantial potential impact on clinical guidelines and practice.
Abstract in brief
The study investigated the use of apixaban, an anticoagulant, for preventing recurrent venous thromboembolism (VTE) in patients with initial provoking factors and ongoing risk factors, after at least 3 months of standard treatment.
Results showed that patients taking apixaban had a significantly lower rate of symptomatic recurrent VTE (1.3%) compared to those taking placebo (10%), with minimal major bleeding incidents.
While apixaban reduced recurrent VTE risk, it was associated with a higher rate of nonmajor bleeding, but no deaths were directly linked to cardiovascular or bleeding causes among participants.
Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Editorial: Art within Evidence — Balancing Anticoagulant Duration in VTE Care https://t.co/IdJp3T20rM
#ESCCongress | @escardio https://t.co/C55yCySJzf
Aug 31, 2025 · 65 likes · 20 shares · 934,655 followersView post →
N
NEJM
@NEJM · X
Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Editorial: Art within Evidence — Balancing Anticoagulant Duration in VTE Care https://t.co/IdJp3T20rM
#Hematology https://t.co/djXZWMdglw
New in the September 25, 2025, issue of NEJM:
Digitoxin in Heart Failure with Reduced EF (DIGIT-HF phase 4 trial) https://t.co/8mpwOpVo7U
Apixaban for Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Measurable Residual Disease–Guided Therapy for CLL https://t.co/8e5qUOXjY6
Apixaban for Extended Treatment of Provoked Venous Thromboembolism. #NEJM
"Low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding."
https://t.co/7rIrMATAZh https://t.co/yM15y9HRgy
2| HI-PRO
For provoked VTE standard tx is 3 months
but what if has ongoing risks (ie autoimmune dz, obesity)?
In a single-center RCT extended low-dose apixaban (2.5mg BID) reduced recurrent VTE vs placebo at 1 year (NNT=10)
KM curves still diverging
https://t.co/qGgiBN0LLW https://t.co/rBGgkd9uDI
A bold trial in valvular heart disease and a cardiovascular prevention trial highlight the importance of humility in medical practice. Discussing new approaches to TAVI, CV risk management, and the impact of full…
Prof. Bikdeli and Prof. Didier discuss the HIPRO study on extended treatment of provoked venous thromboembolism, presented at the 2025 European Society of Cardiology meeting. The study compares rivaroxaban monotherapy…
RT @SinaRsh: Honored to be a part of the HI-PRO trial, presented today by my mentor @GregoryPiazza4 at #ESCCongress2025
Published @NEJM…
Nov 13, 2025 · 14 shares · 1,264 followersView post →
دا
د.فارس الصالح
@Faris8x · X
كذلك هناك دراسة HI-PRO للمرضى الغير مصابين بالسرطان وعلى نفس المبدىء تم استخدام Apixaban 2.5 mg وكانت النتائج ايجابية حيث انها تحمي من حدوث خثرات اخرى وتقلل النزف.
https://t.co/7MsFFYrBhZ https://t.co/G80D61gaqR
En TEV provocada con riesgo persistente, apixabán a baja intensidad 12 meses redujo TEV recurrente sintomática vs placebo, con bajo riesgo de sangrado mayor. https://t.co/FCEnEfA4N6?
RT @OPCILive: Watch the latest OPCI Journal Club featuring @GregoryPiazza4 presenting “Apixaban for Extended Treatment of Provoked Venous…
Oct 11, 2025 · 1 share · 19,071 followersView post →
O
OPCI
@OPCILive · X
Watch the latest OPCI Journal Club featuring @GregoryPiazza4 presenting “Apixaban for Extended Treatment of Provoked Venous Thromboembolism.” Along with esteemed panelists @djc795 @JWMoses @DrAllenJ and Dr. Kiran Reddy. https://t.co/zZn7TtGeoP https://t.co/r7NyXGHFeo
Oct 11, 2025 · 1 like · 1 share · 1,750 followersView post →
SR
STITCHES Medicine - the Best of Medical Research
@medicine.stitches.today · Bluesky
Low-dose apixaban for 12 months slashed recurrent VTE risk in patients with provoking factors, with minimal bleeding complications.
by Piazza G, Bikdeli B (...) Goldhaber SZ et 16 al. in N Engl J Med #MedSky
Low-dose apixaban for 12 months slashed recurrent VTE risk in patients with provoking factors, with minimal bleeding complications.
by Piazza G, Bikdeli B (...) Goldhaber SZ et 16 al. in N Engl J Med
https://t.co/nCXd5S9P0f #MedX #MedResearch
Apixaban for Extended Treatment of Provoked Venous Thromboembolism. #NEJM
"Low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding."
www.nejm.org/doi/full/10....
Apixaban for Extended Treatment of Provoked Venous Thromboembolism. #NEJM
"Low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding."
https://t.co/7rIrMATAZh https://t.co/yM15y9HRgy
Among patients with provoked VTE and enduring risk factors, low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding. @NEJM
https://t.co/oANyHrLOcA https://t.co/nytdfs7jMX
In patients with provoked venous thromboembolism and ongoing risk factors, extended treatment with low-dose apixaban for 12 months resulted in a lower risk of recurrent VTE than placebo, with a low risk of major bleeding. Full HI-PRO trial results and Research Summary: nej.md/4p6tIDo
Provoked VTEに対する抗凝固療法3ヶ月後、さらにエリキュースを1年間内服することでVTEリスクが低下(1.3% vs 10.0%、HR 0.13)。
Apixaban for Extended Treatment of Provoked Venous Thromboembolism | New England Journal of Medicine https://t.co/IWN3u1wVkQ https://t.co/eXK292MIPx
Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Editorial: Art within Evidence — Balancing Anticoagulant Duration in VTE Care https://t.co/IdJp3T20rM
#Hematology https://t.co/djXZWMdglw
⚠️Reported in @NEJM today:
Apixaban for Extended Treatment of Provoked Venous Thromboembolism.
After a provoked DVT standard practise is to treat patients with blood thinners like apixaban for 3 to 6 months.
This trial confirms that continuing low dose apixaban out to a year https://t.co/vRWDc1Jcjr
New in the September 25, 2025, issue of NEJM:
Digitoxin in Heart Failure with Reduced EF (DIGIT-HF phase 4 trial) https://t.co/8mpwOpVo7U
Apixaban for Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Measurable Residual Disease–Guided Therapy for CLL https://t.co/8e5qUOXjY6
For patients with a provoked VTE but enduring risk factors, this trial offers a clear path. Extending therapy with low-dose apixaban for 12 months cut recurrent VTE risk from 10.0% to just 1.3% vs. placebo, with a low incidence of major bleeding.
https://t.co/3duwdPJHzC
Apixaban for Extended Treatment of Provoked Venous Thromboembolism | New England Journal of Medicine https://t.co/jjrfnoLDwR 静脈血栓症の長期治療には抗凝固薬減量が理にかなっている
Apixaban for Extended Treatment of Provoked Venous Thromboembolism
Among patients with provoked VTE and enduring risk factors, low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding https://t.co/UaVWtyiD7A
@escardio Bottom Line: Extended low-dose apixaban significantly reduces recurrent VTE in patients with provoked VTE + enduring risk factors, with low major bleeding risk. This will likely change practice and guidelines.
https://t.co/1ryPLBgxHy
8/8
Apixaban significantly reduces symptomatic recurrent VTE risk in patients with transient triggers and enduring risk factors, with minimal bleeding.
by Piazza G, Bikdeli B (...) Goldhaber SZ et 16 al. in N Engl J Med
https://t.co/nCXd5S9P0f #MedX #MedResearch
2| HI-PRO
For provoked VTE standard tx is 3 months
but what if has ongoing risks (ie autoimmune dz, obesity)?
In a single-center RCT extended low-dose apixaban (2.5mg BID) reduced recurrent VTE vs placebo at 1 year (NNT=10)
KM curves still diverging
https://t.co/qGgiBN0LLW https://t.co/rBGgkd9uDI
Apixaban for Extended Treatment of Provoked Venous Thromboembolism | New England Journal of Medicine https://t.co/lnPo5yB6XQ
Will you change your practice ?
(NEJM) Apixabán para el tratamiento prolongado del TEV
https://t.co/0mI3OY8Yfx
✅Resultados: <riesgo TEV recurrente sintomático vs placebo, con bajo riesgo hemorragia grave.
Sep 4, 2025 · 1 like · 1 share · 8,431 followersView post →
N
Nina
@NinaRicciMD · X
Excelente artículo aunque no se puede generalizar con todos los pacientes! Otro salto en la MBE
Apixaban para el tratamiento
Apixaban para el tratamiento prolongado del tromboembolismo venoso provocado | New England Journal of Medicine https://t.co/3FXLIO4XUI
RT @NEJM: Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Edi…
Aug 31, 2025 · 20 shares · 606 followersView post →
JT
Joseph KAMTCHUM TATUENE
@JTatuene · X
RT @bbikdeli: Absolutely incredible @GregoryPiazza4 leading this @NEJM @MGBResearchNews #RCT!!
Aug 31, 2025 · 23 shares · 606 followersView post →
AG
Anjan Gupta
@ACSCardiology · X
Among patients with provoked VTE and enduring risk factors, low-intensity therapy with apixaban for 12 months resulted in a lower risk of symptomatic recurrent VTE than placebo, with a low risk of major bleeding. https://t.co/1DP9JIFP1H
RT @NEJM: Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Edi…
Aug 31, 2025 · 20 shares · 221 followersView post →
CD
Carmelo Espinosa M.D.
@carmelografo · X
RT @NEJM: Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Edi…
Aug 31, 2025 · 20 shares · 632 followersView post →
BM
Brendan Curley DO, MPH
@Dr_Curley · X
RT @NEJM: Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Edi…
Aug 31, 2025 · 20 shares · 629 followersView post →
NP
Nikola Pantic
@kolja_pantic · X
RT @NEJM: Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Edi…
Aug 31, 2025 · 20 shares · 176 followersView post →
N
NEJM
@NEJM · X
Original Article: Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) https://t.co/Epe4Q957pV
Editorial: Art within Evidence — Balancing Anticoagulant Duration in VTE Care https://t.co/IdJp3T20rM
#ESCCongress | @escardio https://t.co/C55yCySJzf
Aug 31, 2025 · 65 likes · 20 shares · 934,655 followersView post →
LL
Luciano López
@lucedulop · X
RT @CordobaETV: ✅ APIXABAN EN EL TRATAMIENTO EXTENDIDO DE LA ETV PROVOCADA. NEJM 2025
Aug 31, 2025 · 2 shares · 265 followersView post →
MM
María Moral
@twittmariamoral · X
RT @CordobaETV: ✅ APIXABAN EN EL TRATAMIENTO EXTENDIDO DE LA ETV PROVOCADA. NEJM 2025
Aug 30, 2025 · 2 shares · 853 followersView post →
NO
NEJM.org
@nejm.org · Bluesky
Apixaban for Extended Treatment of Provoked Venous Thromboembolism (HI-PRO trial) nej.md/4p6tIDo
“Apixaban for Extended Treatment of Provoked Venous Thromboembolism.”
Présenté ce jour a #ESCCongress et publié dans le @nejm.org.
#MedSky #ESC2025
www.nejm.org/doi/full/10....
Dr. Gregory Piazza presents: “HI-PRO: Apixaban for Extended Treatment of Provoked Venous Thromboembolism”
Aug 30, 2025 · 5 likes · 1 share · 28,892 followersView post →
T
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