Neuron November 2025 PMID 40939593

Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity.

Taylor Landry, Laura Perrault, David Melville, Zhe Chen, Ya-Dong Li, Ping Dong, W Todd Farmer, Brent Asrican, Hannah Lee, Libo Zhang, Ryan N Sheehy, Corina Damian, Thomas Collins, Nehemiah Stewart, E S Anton

Mentions

146
Peak: 22 in Sep 2025
across 9 sources since Sep 2025

Extended reach

481,133
potential audience

Total likes

127

Video views

1,883

Mentions per month

Sep 2025 – Dec 2025

Where it's discussed

  • Facebook50 posts
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  • News21 articles
  • Reddit9 posts
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  • LinkedIn1 posts

AI synopsis

What people are saying

Many discussions focus on the groundbreaking aspect of the research, with comments like 'excited to share our new paper' or 'congrats to the co-authors,' which reflect enthusiasm and acknowledgment of its importance. The tone, words like 'prevents cognitive impairment' and 'quickly disrupt' underscore their recognition of the study’s potential to influence future therapy developments, although the overall conversation remains focused on appreciation rather than critical analysis.

AgreementModerate agreement

Most discussions express support and enthusiasm for the research findings, highlighting the potential of targeting specific interneurons to prevent cognitive decline.

InterestHigh interest

Posts show high interest by emphasizing the significance of the study, with phrases like 'excited to share,' 'congrats,' and mentioning the detailed research implications.

EngagementHigh engagement

Several posts actively engage with the content, referencing the publication, sharing URLs, and congratulating the research team, demonstrating deep involvement.

ImpactModerate impact

There is recognition that the findings could influence future treatments for obesity-related cognitive issues, suggesting moderate but meaningful impact.

Abstract in brief

  • Short-term high-fat diet (HFD) intake causes hyperactivity in hippocampal CCK interneurons, which impairs memory processing.
  • These CCK interneurons are glucose-inhibited and become hyperactive when glucose availability in the dentate gyrus decreases, linked to increased PKM2 enzyme activity.
  • Interventions that reduce CCK interneuron hyperactivity or PKM2 activity can prevent or reverse cognitive impairments in diet-induced obesity, suggesting new therapeutic targets for metabolic-related cognitive decline.]

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Juan Song
@Songlaboratory · X

Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity,’ published online in Neuron today! Congrats to all the co-authors! https://t.co/bmLNdraUKZ

Sep 11, 2025 · 27 likes · 7 shares · 731 followers View post →
Nutrition Science
@NutrioSci · X

Junk food can scramble memory in just 4 days "Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity" https://t.co/4XCojjlmAE https://t.co/3mZ8dzVXac

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Neuron
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Online now: Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity https://t.co/PMKsY3QIsP https://t.co/TEAPpaJ4AH

Sep 11, 2025 · 18 likes · 1 share · 147,293 followers View post →
BryanRoth
@zenbrainest · X

Wow!! Congrats Song lab @UNC Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity: Neuron https://t.co/cVppooV6VK

Sep 11, 2025 · 15 likes · 5 shares · 17,145 followers View post →
Science News
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Junk food can scramble memory in just 4 days "Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity" www.sciencedirect.com/science/arti...

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Andy_Weeble_Weaver
@AndrewW66619812 · X

@nexta_tv The paper in "Neuron" the above "Nexta" article is based upon: “Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity” https://t.co/DClKT1c1gy

Sep 12, 2025 · 11 likes · 1 share · 4,363 followers View post →

All mentions

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Tại Sao "ĐƯỜNG" Khiến Bạn Thi Rớt 15/11/2025 https://t.co/1I4OCeFVo1 via @YouTube

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RT @NutrioSci: Junk food can scramble memory in just 4 days "Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive i…

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Nutrition Science
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Junk food can scramble memory in just 4 days "Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity" https://t.co/4XCojjlmAE https://t.co/3mZ8dzVXac

Oct 5, 2025 · 19 likes · 5 shares · 64,156 followers View post →
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Junk food can scramble memory in just 4 days "Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity" www.sciencedirect.com/science/arti...

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Syed Monzur Morshed
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RT @Songlaboratory: Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment…

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joyvgeerestein
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From a recent study done by UNC School of Medicine, DOI: 10.1016/j.neuron.2025.08.016

Sep 30, 2025 · 1 followers View post →
Esteban Jódar Gimeno
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Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity: Neuron https://t.co/kUcg8ucbmf

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NikkeNyfiken
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RT @zenbrainest: Wow!! Congrats Song lab @UNC Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in di…

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Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity #science #publication #research #journal https://t.co/DtNYxdDM9I

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RT @Songlaboratory: Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment…

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Yi "Joey" Zhou
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RT @Songlaboratory: Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment…

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な bot
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[Neuron] Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity https://t.co/dPiy7xEhxS

Sep 13, 2025 · 29 followers View post →
Han Tan
@Han_L_Tan · X

RT @Songlaboratory: Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment…

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サイエンスあれこれ
@sarekore · X

ニューロンの過活動を抑制すると、食事誘発性肥満マウスモデルにおける長期的な認知機能障害を予防することもわかりました。https://t.co/WxcVmYZubi

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RT @zenbrainest: Wow!! Congrats Song lab @UNC Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in di…

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John West
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RT @AndrewW66619812: @nexta_tv The paper in "Neuron" the above "Nexta" article is based upon: “Targeting glucose-inhibited hippocampal CCK…

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Andy_Weeble_Weaver
@AndrewW66619812 · X

@nexta_tv The paper in "Neuron" the above "Nexta" article is based upon: “Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity” https://t.co/DClKT1c1gy

Sep 12, 2025 · 11 likes · 1 share · 4,363 followers View post →
us-nb.bsky.social
@us-nb.bsky.social · Bluesky

Junk food diet can quickly disrupt memory circuits in the brain, study finds https://www.newsbeep.com/us/151470/ Graphical abstract. Credit: Neuron (2025). DOI: 10.1016/j.neuron.2025.08.016 A new study from UNC School of Medicine researchers, published this…

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Shuntaro Izawa
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RT @NeuroCellPress: Online now: Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obe…

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Neuron
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Online now: Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity https://t.co/PMKsY3QIsP https://t.co/TEAPpaJ4AH

Sep 11, 2025 · 18 likes · 1 share · 147,293 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @zenbrainest: Wow!! Congrats Song lab @UNC Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in di…

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Zhenggang Zhu
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RT @Songlaboratory: Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment…

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David Solecki (pronounced so_lets_ki
@So_lets_kiLab70 · X

RT @Songlaboratory: Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment…

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Juan Song
@Songlaboratory · X

Excited to share our new paper, ‘Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity,’ published online in Neuron today! Congrats to all the co-authors! https://t.co/bmLNdraUKZ

Sep 11, 2025 · 27 likes · 7 shares · 731 followers View post →
BryanRoth
@zenbrainest · X

Wow!! Congrats Song lab @UNC Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity: Neuron https://t.co/cVppooV6VK

Sep 11, 2025 · 15 likes · 5 shares · 17,145 followers View post →
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... 2025.08.016 دراسة جديدة تكشف عن خطر خفي بعد الإصابة ... https://dx.doi.org/10.1016/j.neuron.2025.08.014 #طبيبي #تطبيق_طبيبي #ابن_سينا_الطبي.

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org/10.1016/j.neuron.2025.08.016. 打开网易新闻查看精彩图片. 特别声明:本文为网易自媒体平台“网易号”作者上传并发布,仅代表该作者观点。网易仅提供 ...

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... Neuron, DOI: 10.1016/j.neuron.2025.08.016 · May be an image of 3 people and text that says 'codigooculto Solo unos pocos. Alberto Gongora and ...

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... Neuron, shows how diets high in junk food can rapidly ... Anton and Juan Song, 11 September 2025, Neuron. DOI: 10.1016/j.neuron.2025.08.016.

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[Article] Targeting glucose-inhibited hippocampal CCK interneurons ...
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[บทความ] เล็งเป้าไปที่ CCK interneurons ในฮิปโปแคมปัสที่ถูกยับยั้งด้วย ...
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Credit: Neuron (2025). DOI: 10.1016/j.neuron.2025.08.016. A new study from UNC School of Medicine researchers, published this week in Neuron ...

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Neuron, 2025; DOI: 10.1016/j.neuron.2025.08.016 · May be an image of 1 person, apple and text that says '吃junkfood4. Aloysius Sia ·

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Neuron (2025). “Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet- induced obesity.” DOI: 10.1016/j ...

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Neuron (2025). “Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet- induced obesity.” DOI: 10.1016/j ...

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Neuron (2025). “Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet- induced obesity.” DOI: 10.1016/j ...

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Neuron 78, 785–798 (2013). GO TO REFERENCE. Crossref · PubMed · Web ... https://doi.org/10.1016/j.biochi.2025.08.016 · Crossref. Jingchuan Luo ...

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... 10.1016/j.neuron.2025.08.016 دراسة جديدة تكشف عن خطر خفي بعد الإصابة بسرطان عنق الرحم https://dx.doi.org/10.1001/jamanetworkopen. 2025.31362 ...

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Neuron (2025). “Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet- induced obesity.” DOI: 10.1016/j ...

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