Numerous mentions, such as the one stating that orforglipron 'significantly reduces body weight in obesity patients' and another describing it as a 'potential game-changer,' demonstrate a high level of interest and recognition of its impactful role. The tone and detailed discussion, including trial results of up to 11.2% weight loss over 72 weeks, reflect deep engagement, while the emphasis on FDA approval and market implications indicates a high potential impact on treatment paradigms.
AgreementModerate agreement
Many mentions highlight the promising results and safety of orforglipron, indicating general agreement with the article's findings.
InterestHigh interest
The mentions express strong curiosity about the drug's potential and market impact, reflecting high interest.
EngagementHigh engagement
Participants delve into specific trial data, safety profiles, and implications, showing deep engagement with the research.
ImpactHigh impact
The widespread coverage, mention of regulatory approval, and implications for obesity treatment suggest that this development could significantly change clinical practice.
Abstract in brief
Orforglipron, an oral GLP-1 receptor agonist, is being tested for weight loss in adults with obesity, showing promising results in a phase 3 trial over 72 weeks.
Patients taking higher doses of orforglipron (36 mg) lost an average of 11.2% of their body weight, compared to only 2.1% loss in the placebo group, with many achieving significant weight reductions.
While adverse events were noted, primarily gastrointestinal issues, they were mostly mild to moderate, with a higher discontinuation rate in the orforglipron groups compared to placebo.
Scientists reveal pill that helps you lose 20% body weight.
For years, powerful obesity medications have meant injections. But now, scientists say a daily pill may offer similar results – and greater access.
Researchers have published results from a massive international trial of orforglipron, an oral drug that mimics GLP-1 hormones. The study followed more than 3,100 adults with obesity but not diabetes, across nine countries, for 72 weeks. Patients took either a placebo or one of three daily doses of orforglipron, alongside diet and activity.
The results were striking. At the highest dose, patients lost an average of 11% of their body weight. More than half lost at least 10%, over one third lost 15% or more, and nearly one in five shed at least 20%. For comparison, the placebo group averaged just a 2% drop.
Beyond weight, the pill improved waist size, blood pressure, triglycerides,
Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) https://t.co/avDbBYKZDr
#Endocrinology https://t.co/xFALCq2XqV
Nov 12, 2025 · 108 likes · 25 shares · 931,969 followersView post →
TL
The Lancet
@TheLancet · X
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/ElGCZnxmHB
Nov 25, 2025 · 106 likes · 30 shares · 734,029 followersView post →
N
NEJM
@NEJM · X
Here are three Original Articles from September that made big news:
1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 trial) https://t.co/avDbBYKZDr
Oct 3, 2025 · 96 likes · 18 shares · 931,969 followersView post →
AM
Ahmed Bennis MD
@drbennisahmed · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 https://t.co/EdAknfDkki
Nov 28, 2025 · 75 likes · 20 shares · 3,153 followersView post →
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Orforglipron, an oral small-molecule GLP-1 receptor agonist, is showing promise in phase 3 trials for obesity treatment. Higher doses resulted in significant weight loss of up to 11.2%, with manageable mild to moderate…
Orforglipron, an oral GLP-1 receptor agonist, is being tested for weight loss in adults with obesity, showing promising results in a phase 3 trial over 72 weeks. Higher doses resulted in significant weight reduction…
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GLP-1 obesity drugs are peptide-based and destroy their structure in the stomach, making digestion a challenge. Orforglipron offers a different approach as a small-molecule, non-peptide drug that passes through the…
Orforglipron, an oral GLP-1 receptor agonist, is being tested for weight loss in adults with obesity, showing promising results in a phase 3 trial over 72 weeks. High doses led to significant weight reductions, with…
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ATTAIN-1 — Orforglipron (2025).
Tras 72 semanas, la pérdida media de peso osciló entre el 7,5 % y el 11,2 %, según la dosis, frente al 2,1 % con placebo.
Adultos con obesidad sin diabetes.
? https://t.co/8vI3RuEkMD
It has also shown consistent results relative to other similar drugs ..
The American FDA has approved it in April of this year following several successful clinical trials. This article can help provide more info on the drug:
https://t.co/1Uj6Pr2Rm2
Ozempic in a Pill. Here's the Catch. https://t.co/s7EJt3ClDE via @YouTube
Jun 29, 2026 · 2 likes · 2,702 followersView post →
AR
Avi Roy
@agingroy · X
The board, each number tied to that drug’s own trial dose (no mixing arms):
Retatrutide: 28.3% mean weight loss at 80 weeks, 12mg (TRIUMPH-1, Phase 3, n=2,335 per https://t.co/iRktt1QRB4). https://t.co/25mCtaMDL3
Tirzepatide: 22.5% at 15mg (SURMOUNT-1, n=2,539). https://t.co/5Ww4tKE1ie
CagriSema: 22.7% on-treatment estimand (20.4% intention-to-treat), REDEFINE-1, n=3,417, peer-reviewed in NEJM 2025. https://t.co/anoXRiL0Yg
Eloralintide: ~20% over 48 weeks at the top dose (Phase 2, selective amylin, no GLP-1; nausea is dose-specific). Lancet 2025: https://t.co/cfKAnzfzzP
Orforglipron: oral, 11.2% weight loss at 36mg over 72 weeks in obesity (ATTAIN-1, the first oral once-daily GLP-1 pill; treatment-regimen estimand, ITT). NEJM Sept 2025, DOI 10.1056/NEJMoa2511774.
Survodutide (a two-hormone GLP-1/glucagon agonist, not on the board above but worth knowing): about 17% (SYNCHRONIZ
Jun 10, 2026 · 2 likes · 13,178 followersView post →
FC
Fight Club
@pdfreader1231 · X
GLP-1 Medications: What’s New and What’s Next for Clinicians https://t.co/yfk89uLu7m via @YouTube #medicine
May 11, 2026 · 1 like · 10,769 followersView post →
AT
Abraham Trueba
@CRISPRKING · X
https://t.co/EMKsaFrLG8
May 11, 2026 · 2 likes · 10,769 followersView post →
AT
Abraham Trueba
@CRISPRKING · X
https://t.co/2DHZCHwxKL
May 11, 2026 · 3 likes · 1 share · 10,769 followersView post →
PO
Prof. Wasim Hanif OBE
@docwas · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. There is a lot of interest among patients about this drug. It makes you loose about 11% body weight and could be cheaper then some of the current medication https://t.co/lqLNildrw3
Eli Lilly plans to invest USD3 billion over the next decade to expand its supply chain capacity in China, the US drugmaker said today. The firm will set up a local production and supply network for tablets and capsules and build manufacturing capabilities for orforglipron, an oral small-molecule GLP-1 receptor agonist for treating type 2 diabetes and obesity. @EliLillyandCo
Mar 11, 2026 · 5 likes · 210,952 followersView post →
LL
Leonard LN
@leonard49411022 · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Jan 21, 2026 · 21 shares · 220 followersView post →
Tで
Tom Hsiung ???????⚕️ですね??!? ?
@TomHsiung · X
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial - The Lancet https://t.co/pXyxXZZdDS - administered by oral route
HOT TOPIC OF THE WEEK
Most viewed paper on BioFingertips:
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.
This is what healthcare professionals are reading right now.
Read it on BioFingertips:
https://t.co/w2fEjD0vKT
#BioFingertips #HotTopicOfTheWeek #GLP1 #ObesityTreatment #HealthcareProfessionals
UKY Endocrine, Diabetes, and Metabolism Fellowship
@ukyendocrine · X
For today's journal club, Dr. K C discussed the ??? ??????? ??????? ?? ???????? article “Orforglipron, an Oral Small Molecule GLP 1 Receptor Agonist for Obesity Treatment.” https://t.co/Hz36cwmQee
EvidenceAlerts | Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. https://t.co/Ghr7pWJYrt
EvidenceAlerts | Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. www.evidencealerts.com/Social/Artic...
EvidenceAlerts | Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. www.evidencealerts.com/Social/Artic...
2026'da sağlık teknolojilerinde neler değişecek dersiniz?
Videonun tamamı YouTube kanalımızda. Gelin birlikte 2026'da sağlıkta neler değişecek göz atalım.
https://t.co/vgpzJ9Ffao
#saglik #saglikteknolojileri #sağlıkhaberleri https://t.co/ESBOAf2ZT8
“Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial.”
Publié ce jour dans @thelancet.com.
#MedSky #EndoSky
www.thelancet.com/journals/lan...
[Articles] Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/nWjxMHw4HK
2026 sağlık dünyası nasıl olacak?
Yapay zekâ kişisel sağlık koçuna mı dönüşüyor?
Zayıflama iğneleri yerini haplara mı bırakacak?
Obezite cerrahisi azalacak mı?
Kanser aşıları gerçekten yakın mı?
Longevity neden yükselişte?
https://t.co/4KPS9kyDkk
#saglik #saglikhaberleri https://t.co/iS0u3qlZ45
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial - The Lancet https://t.co/WBgZgB9CHR
Good news for folk with excess weight and type 2 diabetes - an oral alternative to injectable GLP-1 receptor agonists. Dose response r/ship in weight loss and majority of participants getting below HbA1c of 6.5%.
www.sciencedirect.com/science/arti...
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 30, 2025 · 20 shares · 359 followersView post →
DJ
Dr.AMiT JAiSWAL
@aadvikmedics · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 62 followersView post →
L
Liftfy
@laliftlalift · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 21 shares · 147 followersView post →
A
Almansour
@malmansour81 · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 214 followersView post →
ER
Elvis Amao Ruiz
@elvisjar · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 255 followersView post →
DM
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 11,329 followersView post →
AM
Adipose Tissue: The Circadian clock of Metabolism
@Prashan69344151 · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 55 followersView post →
LC
Luis Eduardo Celi C.
@luchitoceli · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 165 followersView post →
JM
Jesse Haven, MD
@jhaven99 · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 121 followersView post →
DK
Dr Ashish Kumar
@DrAshish_Kumar · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 19,260 followersView post →
IP
Ilenia Pantano
@PantanoIlenia · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 92 followersView post →
NH
Nada Hassib
@NadaHassib1 · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 29, 2025 · 20 shares · 764 followersView post →
S
sophia
@sophia8666ac · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 1,581 followersView post →
AM
Ashley Wei MD
@AshleyWeiMD · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 713 followersView post →
AW
Anna wei
@yxmfn55642275 · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 425 followersView post →
S
Sherif
@Sherifdotcom · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 136 followersView post →
KD
Karl Dujardin
@KDujardin · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 662 followersView post →
O
Ondo(✸,✸)
@ArianaPantasy · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 676 followersView post →
BF
Biljana Parapid, MD, PhD, FESC
@biljana_parapid · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 28, 2025 · 20 shares · 8,632 followersView post →
AM
Ahmed Bennis MD
@drbennisahmed · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 https://t.co/EdAknfDkki
Nov 28, 2025 · 75 likes · 20 shares · 3,153 followersView post →
Z
Zoey
@Zoeynzyjo1122 · X
RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
https://t.co/DwMDkvsXg7 @NEJM https://t.co…
Nov 26, 2025 · 70 shares · 1,297 followersView post →
DC
Dr Chris Duncombe CMO
@DrDuncombe · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 332 followersView post →
A
Amjad
@Amjaduuu1 · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 29 shares · 121 followersView post →
GD
Gary Deed
@garydeed · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 115 followersView post →
DD
D.Dash
@dr_debu · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 91 followersView post →
DD
Dr Ashok Dalal
@DrAshokGastro · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 1,475 followersView post →
VB
Vikas bhargava
@Vikasbh40772075 · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 16 followersView post →
MM
Mehdi Maanaoui
@MaanaouiMehdi · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 999 followersView post →
JY
Javier Escalada #Yoelijoendocrino
@fjavesc · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 26, 2025 · 30 shares · 3,631 followersView post →
A
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 197 followersView post →
CP
Carlos Palacio
@CAPE1223 · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 1,023 followersView post →
E
ElenaJerezLanza
@helejtf · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 31 followersView post →
TR
Thomas Round
@drtomround · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 3,424 followersView post →
MP
María Argente Pla
@ArgentePla · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 467 followersView post →
IT
Instructor TX
@InstructorTX · X
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. https://t.co/mgXNdNFFqL
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 19,260 followersView post →
JC
Juan Carlos
@carlos1184 · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 1,543 followersView post →
DD
darcy darnoc
@darcydarnoc · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 3,149 followersView post →
DA
Dr. Jorge Acosta
@DocJorgeAcosta · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 15,426 followersView post →
NF
Nicolas Renna, MD PhD ISHF FESC
@nicolasrennamd · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 932 followersView post →
AR
Arshad Rashid
@arshadkema · X
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial - The Lancet https://t.co/qeiVoRpYfR
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 53,037 followersView post →
Sシ
syawal™ シ
@syawal · X
RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…
Nov 25, 2025 · 30 shares · 3,095 followersView post →
TL
The Lancet
@TheLancet · X
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/ElGCZnxmHB
Nov 25, 2025 · 106 likes · 30 shares · 734,029 followersView post →
SG
Shicheng Guo
@shihcheng.bsky.social · Bluesky
Orforglipron, a once-daily oral GLP-1 agonist, shows promise for obesity. Tested 6mg, 12mg, 36mg vs. placebo in a 72-week study. Outcomes look positive! PMID:40960239, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2511774 #Medsky #Pharmsky #RNA #ASHG #ESHG
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind.
Orforglipron, in people with diabetes and obesity shows significant weight loss. https://t.co/mgXNdNFFqL
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial
https://t.co/BkWNPBcty8
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial
"We aimed to evaluate orforglipron, an oral small-molecule
Nov 20, 2025 · 9 likes · 1 share · 43,178 followersView post →
J
Jessica
@Jessica27511l · X
RT @alexanderperse: I wonder if patient census in hospitals will go down due to this. Absolutely insane
https://t.co/l1Hh3Uw0UU
Orforglipron significantly reduces body weight in obesity patients, outperforming placebo and showing favorable safety profile over 72 weeks.
by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med
https://t.co/OMCh2O5F2z #MedX #MedResearch
Orforglipron significantly reduces body weight in obesity patients, outperforming placebo and showing favorable safety profile over 72 weeks.
by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med #MedSky
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 14, 2025 · 25 shares · 159 followersView post →
IT
Instructor TX
@InstructorTX · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.
This new drug is way more effective for dropping pounds, and the best part is it's just a pill you swallow!
Read. https://t.co/ggGKN8l1YK
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 14, 2025 · 25 shares · 6,439 followersView post →
IN
Int Society of Nephrology
@ISNkidneycare · X
8/
Nov 13, 2025 · 6 likes · 29,483 followersView post →
CP
Carlos Palacio
@CAPE1223 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 1,023 followersView post →
DM
Dr.Lama Amer, MD
@Dr_Lama_Amer · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 4,294 followersView post →
MT
Miguel Turégano
@tureyedro · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 816 followersView post →
JM
Janet Chiang, MD
@JanetMD87 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 810 followersView post →
JR
John Rodriguez
@rodrig39386 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 967 followersView post →
SX
Stavra Xanthakos
@DrStavra · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 322 followersView post →
BF
Biljana Parapid, MD, PhD, FESC
@biljana_parapid · X
RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treat…
Nov 13, 2025 · 2 shares · 8,632 followersView post →
PF
Pawan Rao MD, FASN
@nephronus · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 1,009 followersView post →
MR
Maria Jesus Gonzalez Rellan
@ChusaGzlzRellan · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 795 followersView post →
JC
Javier Carrera
@Javier_CarreraH · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 1,833 followersView post →
SP
Sá Peliteiro
@Peliteiro · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 2,866 followersView post →
DB
Dan Baciu
@fnz4sgr5jc · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 51 followersView post →
DG
DIEGO FERNANDEZ GARCIA
@diegofe21784801 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 1,646 followersView post →
AM
Ahmed Bennis MD
@drbennisahmed · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 https://t.co/rDlejWVqyO
Nov 13, 2025 · 9 likes · 2 shares · 3,153 followersView post →
WM
Wendy Trejo MD., MSc.
@md_wentrejo · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 13, 2025 · 25 shares · 429 followersView post →
A
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 12, 2025 · 25 shares · 197 followersView post →
GP
GLASS_PhD
@joybeingfree99 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 12, 2025 · 25 shares · 6,625 followersView post →
DA
Dr. Nasreen Alfaris
@nasreenalfaris · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 12, 2025 · 25 shares · 2,275 followersView post →
N
nephronking
@nephronking · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 12, 2025 · 25 shares · 133 followersView post →
PM
Peter Edmonds MD
@pjedmonds · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 12, 2025 · 25 shares · 1,032 followersView post →
DS
@docbio.bsky.social
@DocBio1509 · X
RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…
Nov 12, 2025 · 25 shares · 460 followersView post →
N
NEJM
@NEJM · X
Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) https://t.co/avDbBYKZDr
#Endocrinology https://t.co/xFALCq2XqV
Nov 12, 2025 · 108 likes · 25 shares · 931,969 followersView post →
GM
Gabe Wilson MD
@Gabe__MD · X
Oral easy-to-take GLP-1 Agonists are going to transform the market even more than injectables making them broadly adoptable.
Implications are immense:
Fewer hospital admissions (11% lower for heart failure, 20-24% lower among patients with diabetes for stroke and MI)
Less money spent on food and possibly alcohol (5-10% lower grocery spend per user)
Lower rates of hypertension, diabetes, high lipids
Decreased obesity surgery by 10-15%
12% reduction in all-cause mortality
Lower rates of kidney disease patients needing dialysis
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/QIqgGBbUUU
(I have no interest in any pharmaceutical company and this will actually decrease the number of patients we get in the ER; it will make life tougher to finance hospitals)
Nov 11, 2025 · 6 likes · 2,482 followersView post →
In the ATTAIN-1 phase 3, randomized trial, the use of orforglipron, an oral glucagon-like peptide-1 receptor agonist, led to significant mean body-weight reductions in patients with #obesity, as compared with placebo. Full trial results and Research Summary: nej.md/4n1nSl2
#MedSky #EndoSky
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 178 followersView post →
CT
Cristina Tejera
@cristinatejerap · X
RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity
Nov 6, 2025 · 9 shares · 11,604 followersView post →
CM
Cristobal Morales
@CristobMorales · X
RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity
Nov 6, 2025 · 9 shares · 17,185 followersView post →
AV
Alfonso Valle
@ValleAlfonso · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity
Nov 6, 2025 · 15 likes · 9 shares · 21,708 followersView post →
AM
Andrew J Sauer MD
@AndrewJSauer · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 19,603 followersView post →
W
Wimen
@1a31551c566e43d · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 672 followersView post →
RM
Ranganath Muniyappa
@dr_muniyappa · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 1,094 followersView post →
AG
Andy Grannell
@Grannell_ · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 991 followersView post →
BV
Blad Villavicencio
@bladDV · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 820 followersView post →
M
mdjungle
@mdjungle1 · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 114 followersView post →
DA
Dr. Nasreen Alfaris
@nasreenalfaris · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 2,275 followersView post →
CP
Carlos Palacio
@CAPE1223 · X
RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…
Nov 6, 2025 · 21 shares · 1,023 followersView post →
BM
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky
“Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.”
Publié ce jour dans le @nejm.org.
#MedSky #EndoSky
www.nejm.org/doi/full/10....
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/GNhaj2cf7G this week in @NEJM
Nov 6, 2025 · 73 likes · 21 shares · 11,604 followersView post →
MR
Marc Vincent Barcelona, MD, FPCR, DPBR-RO
@MarcBarcieMD · X
RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…
RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…
Nov 5, 2025 · 4 shares · 3,890 followersView post →
UD
Umut. Dişel
@UmutDisel · X
RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…
Nov 5, 2025 · 4 shares · 1,281 followersView post →
PB
Prof. Dr. Sanjeev Bagai
@BagaiDr · X
Orforglipron, Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Rx. mean change in body weight from baseline to week 72 was −7.5% with 6 mg of orforglipron, −8.4% with 12 mg of orforglipron,& −11.2% with 36 mg of orforglipron,vs −2.1% with placebo https://t.co/lYOuJqpnO6
RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
https://t.co/DwMDkvsXg7 @NEJM https://t.co…
Oct 23, 2025 · 70 shares · 29 followersView post →
PB
Prof. Dr. Sanjeev Bagai
@BagaiDr · X
Orforglipron, Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM. 3127 patients. mean change in body weight from baseline to week 72 was −7.5%, −8.2 to −6.8 with 6 mg of orforglipron, −8.4% with 12 mg of orforglipron, https://t.co/lYOuJqpnO6
Here are three Original Articles from September that made big news:
1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 trial) https://t.co/avDbBYKZDr
Oct 3, 2025 · 96 likes · 18 shares · 931,969 followersView post →
LU
Lilly Medical US
@LillyMedical · X
New Results from the ATTAIN-1 Phase 3 Trial: An Oral Small Molecule GLP-1 Receptor Agonist for Obesity Treatment.
Click here to read the full results: https://t.co/HPqVcoKZ5Y https://t.co/hA4IrxqD0v
Sep 30, 2025 · 1 like · 8,177 followersView post →
Scientists reveal pill that helps you lose 20% body weight.
For years, powerful obesity medications have meant injections. But now, scientists say a daily pill may offer similar results – and greater access.
Researchers have published results from a massive international trial of orforglipron, an oral drug that mimics GLP-1 hormones. The study followed more than 3,100 adults with obesity but not diabetes, across nine countries, for 72 weeks. Patients took either a placebo or one of three daily doses of orforglipron, alongside diet and activity.
The results were striking. At the highest dose, patients lost an average of 11% of their body weight. More than half lost at least 10%, over one third lost 15% or more, and nearly one in five shed at least 20%. For comparison, the placebo group averaged just a 2% drop.
Beyond weight, the pill improved waist size, blood pressure, triglycerides,
Orforglipron significantly reduces body weight in adults with obesity, outperforming placebo, while maintaining a tolerable safety profile.
by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med #MedSky
Orforglipron significantly reduces body weight in adults with obesity, outperforming placebo, while maintaining a tolerable safety profile.
by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med
https://t.co/OMCh2O5F2z #MedX #MedResearch
We are proud to celebrate Dr. @SeanWharton, a founding member of BPAO, for publishing two groundbreaking studies in the New England Journal of Medicine on obesity treatment.
Sep 25, 2025 · 1 like · 1,801 followersView post →
GG
geneXplain GmbH
@geneXplain · X
A groundbreaking international trial has revealed an oral drug called orforglipron that’s changing the obesity game. Unlike current injectable therapies, this is a once daily pill and its results are stunning.
#OralTherapy #WeightLossScience #ScienceIsGood https://t.co/kk7vSNA9Ki https://t.co/K4Fqo8ZOXs
¿Inicio de una nueva era en el tto de la obesidad?
Orforglipron podría cambiar el acceso a terapias GLP1:
✔️Vía de adm oral diaria
✔️Sin necesidad de conservación especial
✔️Mejorando la adherencia y biodisponibilidad
✔️Eficacia clínicamente relevante
https://t.co/Hxofi8F6aK
Sep 21, 2025 · 1 like · 2 shares · 3,349 followersView post →
DK
Dymkó Křepelka
@3dattempt · X
RT @NutrioSci: In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than plac…
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. #NEJM
www.nejm.org/doi/full/10....
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. @NEJM
https://t.co/L9C3AGaFH7 https://t.co/m0AL980VUt
Here are the sources:
1. Oral obesity drugs: https://t.co/91u4a6BLRt, https://t.co/21Z8Gg2C1X
2. Aspirin after colorectal cancer surgery https://t.co/KrGnVtz4jz
3. Trikafta in cystic fibrosis https://t.co/zd1vgzbask
4. Apple watch detects hypertension https://t.co/MTHhO5oCfH
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists https://t.co/LvCFmJhA1z
“Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes.””
Publié ce jour dans le @nejm.org.
#MedSky #EndoSky
www.nejm.org/doi/full/10....
La democratización y uso temprano de los GLP1 pudiese llegar con los NUEVOS GLP1 orales https://t.co/aqxJPwS90c Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity
AND https://t.co/ZsK10EeNkQ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment #EASD2025
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM https://t.co/5Hox1DZcLh
Orforglipron, un agonista oral del receptor GLP-1 de moléculas pequeñas para el tratamiento de la obesidad
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/3aXXSmFxgf
ATTAIN-1: once-daily oral GLP-1 agonist orforglipron cut weight by up to 11.2% at 72 wks vs 2.1% placebo in adults w/ obesity, also improving BP & lipids. GI AEs mild–mod
1st oral small-molecule GLP-1 with robust efficacy—potential game-changer in obesity
https://t.co/x5GVydB79E
νάτο και το χαπάκι!
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/7pi2joNvDu
Sep 17, 2025 · 1 like · 2,370 followersView post →
AM
Ahmed Bennis MD ?
@drbennisahmed · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists.
@NEJM @CMichaelGibson @DrMarthaGulati @hvanspall @lamcardio @AndrewJSauer @dranulala @ankeetbhatt @BiykemB @Drroxmehran @JACCJournals @ACCinTouch
https://t.co/5t36x0kt8E
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/kYh2db5YxS
Sep 17, 2025 · 1 like · 3,283 followersView post →
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Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment
https://t.co/6p24qpMKnz
Sep 17, 2025 · 1 like · 1,975 followersView post →
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Prof. Dr. Sanjeev Bagai
@BagaiDr · X
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment: NEJM; 3127 patients; mean change in body weight from baseline to week 72 was −7.5% , −8.2 to −6.8) with 6 mg of orforglipron, −8.4% with 12 mg of orforglipron, −11.2% https://t.co/lYOuJqpnO6
Sep 17, 2025 · 1 like · 34,445 followersView post →
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Eric Topol
@erictopol.bsky.social · Bluesky
Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss
www.nejm.org/doi/full/10....
Orforglipron, an oral small-molecule GLP-1 agonist, significantly lowered blood glucose compared with placebo in a phase III trial.
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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind ...
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Aquí te dejamos el artículo. Jastreboff AM et al. Orforglipron for the Treatment of Obesity without Diabetes. N Engl J Med. 2025; DOI: 10.1056/NEJMoa2511774 # ...
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