N Engl J Med November 2025 PMID 40960239

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.

Sean Wharton, Louis J Aronne, Adam Stefanski, Nasreen F Alfaris, Andreea Ciudin, Koutaro Yokote, Bruno Halpern, Alpana P Shukla, Chunmei Zhou, Lisa Macpherson, Sheryl E Allen, Nadia N Ahmad, Suzanne R Klise, ATTAIN-1 Trial Investigators

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Mentions

720
Peak: 178 in Nov 2025
across 9 sources since May 2025

Extended reach

8,816,993
potential audience

Total likes

8,249

Video views

557,898

Mentions per month

May 2025 – Oct 2026

Where it's discussed

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AI synopsis

What people are saying

Numerous mentions, such as the one stating that orforglipron 'significantly reduces body weight in obesity patients' and another describing it as a 'potential game-changer,' demonstrate a high level of interest and recognition of its impactful role. The tone and detailed discussion, including trial results of up to 11.2% weight loss over 72 weeks, reflect deep engagement, while the emphasis on FDA approval and market implications indicates a high potential impact on treatment paradigms.

AgreementModerate agreement

Many mentions highlight the promising results and safety of orforglipron, indicating general agreement with the article's findings.

InterestHigh interest

The mentions express strong curiosity about the drug's potential and market impact, reflecting high interest.

EngagementHigh engagement

Participants delve into specific trial data, safety profiles, and implications, showing deep engagement with the research.

ImpactHigh impact

The widespread coverage, mention of regulatory approval, and implications for obesity treatment suggest that this development could significantly change clinical practice.

Abstract in brief

  • Orforglipron, an oral GLP-1 receptor agonist, is being tested for weight loss in adults with obesity, showing promising results in a phase 3 trial over 72 weeks.
  • Patients taking higher doses of orforglipron (36 mg) lost an average of 11.2% of their body weight, compared to only 2.1% loss in the placebo group, with many achieving significant weight reductions.
  • While adverse events were noted, primarily gastrointestinal issues, they were mostly mild to moderate, with a higher discontinuation rate in the orforglipron groups compared to placebo.

Top posts

Most liked on X and Bluesky
Massimo
@Rainmaker1973 · X

Scientists reveal pill that helps you lose 20% body weight. For years, powerful obesity medications have meant injections. But now, scientists say a daily pill may offer similar results – and greater access. Researchers have published results from a massive international trial of orforglipron, an oral drug that mimics GLP-1 hormones. The study followed more than 3,100 adults with obesity but not diabetes, across nine countries, for 72 weeks. Patients took either a placebo or one of three daily doses of orforglipron, alongside diet and activity. The results were striking. At the highest dose, patients lost an average of 11% of their body weight. More than half lost at least 10%, over one third lost 15% or more, and nearly one in five shed at least 20%. For comparison, the placebo group averaged just a 2% drop. Beyond weight, the pill improved waist size, blood pressure, triglycerides,

Sep 27, 2025 · 227 likes · 30 shares · 4,437,430 followers View post →
Eric Topol
@erictopol.bsky.social · Bluesky

Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss www.nejm.org/doi/full/10....

Sep 16, 2025 · 160 likes · 47 shares View post →
NEJM
@NEJM · X

Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) https://t.co/avDbBYKZDr #Endocrinology https://t.co/xFALCq2XqV

Nov 12, 2025 · 108 likes · 25 shares · 931,969 followers View post →
The Lancet
@TheLancet · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/ElGCZnxmHB

Nov 25, 2025 · 106 likes · 30 shares · 734,029 followers View post →
NEJM
@NEJM · X

Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 trial) https://t.co/avDbBYKZDr

Oct 3, 2025 · 96 likes · 18 shares · 931,969 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 https://t.co/EdAknfDkki

Nov 28, 2025 · 75 likes · 20 shares · 3,153 followers View post →

All mentions

Yoel | Un Biotec Mas
@UnBiotecMas · X

20/32 ATTAIN-1 — Orforglipron (2025). Tras 72 semanas, la pérdida media de peso osciló entre el 7,5 % y el 11,2 %, según la dosis, frente al 2,1 % con placebo. Adultos con obesidad sin diabetes. ? https://t.co/8vI3RuEkMD

Oct 13, 2026 · 8 followers View post →
Peptides Decoded
@PeptidesDecoded · X

Sources: https://t.co/XPouU7jcwI https://t.co/camcwGuLMQ

Oct 11, 2026 · 30 followers View post →
Peptides Decoded
@PeptidesDecoded · X

Sources: https://t.co/XPouU7jKmg https://t.co/camcwGvjCo

Oct 10, 2026 · 30 followers View post →
Bernardo Martinez
@ingeberna · X

@DrChavezDiaz No pues prefiero orfoglipron... https://t.co/oX9BPTqNu4 y me quiero las molestias del viaje al más allá... ?

Oct 10, 2026 · 123 followers View post →
太宰おさる
@DazaiOsaru · X

飲むだけで11%痩せる新薬は安全なのか?【GLP-1の効果・副作用】 https://t.co/fD1ohpH1Ig via @YouTube

Sep 29, 2026 · 23 followers View post →
Héctor Rodrigo Rodríguez
@HRodrigoRV · X

ATTAIN-1: Orforglipron para obesidad DOI: 10.1056/NEJMoa2511774 https://t.co/XKQMzc5j0v

Sep 29, 2026 · 11 followers View post →
医学のすゝめ@ブログ書くダブルライセンスDr
@fukamire_medic · X

【肥満治療:経口非ペプチドGLP-1受容体作動薬orforglipron】 タイトル:Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment(ATTAIN-1) ✅️【出典】 New England Journal of Medicine, 2025 ✅️【研究デザイン】 第3相・国際多施設共同・二重盲検・無作為化・プラセボ対照試験。 ✅️【対象】 糖尿病のない成人肥満患者3,127例。 ✅️【介入・比較】 健康的な食事と身体活動に加え、経口orforglipron 6mg、12mg、36mgまたはプラセボを1日1回、72週間投与。 ✅️【主要評価項目】 72週時点におけるベースラインからの体重変化率。 ✅️【主要結果】 平均体重変化率は6mg群−7.5%、12mg群−8.4%、36mg群−11.2%、プラセボ群−2.1%で、すべての用量がプラセボより有意に大きな減量と関連しました。36mg群では、体重が10%以上減少した患者54.6%、15%以上36.0%、20%以上18.4%で、プラセボ群ではそれぞれ12.9%、5.9%、2.8%でした。 腹囲、収縮期血圧、中性脂肪、非HDLコレステロールも改善しました。有害事象による中止はorforglipron群5.3~10.3%、プラセボ群2.7%で、主な有害事象は軽度~中等度の消化器症状でした。 ✅️【臨床的解釈】 注射を必要としない低分子のGLP-1(glucagon-like peptide-1:食欲や血糖調節に関与する消化管ホルモン)受容体作動薬でも、用量依存的な体重減少が得られる可能性が示されました。注射製剤を希望しない患者の選択肢になり得ます。 ただし、本試験は既存の注射型GLP-1製剤との直接比較ではありません。心血管イベントの抑制、減量の長期維持、投与終了後の体重変化もこの試験だけでは判断できません。 ✅️【限界】 糖尿病のない肥満患者を対象とした72週間の試験で、長期安全性や心血管転帰は評価されていませ

Sep 23, 2026 · 620 followers View post →
Dr. Maha Alenazy
@MahaDahmashi · X

It has also shown consistent results relative to other similar drugs .. The American FDA has approved it in April of this year following several successful clinical trials. This article can help provide more info on the drug: https://t.co/1Uj6Pr2Rm2

Aug 3, 2026 · 872 followers View post →
Fjletona
@fjletona · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/F3EewHorca

Jul 2, 2026 · 488 followers View post →
survivefromcancer@gmail.com
@CancerTherapy1 · X

Ozempic in a Pill. Here's the Catch. https://t.co/s7EJt3ClDE via @YouTube

Jun 29, 2026 · 2 likes · 2,702 followers View post →
Avi Roy
@agingroy · X

The board, each number tied to that drug’s own trial dose (no mixing arms): Retatrutide: 28.3% mean weight loss at 80 weeks, 12mg (TRIUMPH-1, Phase 3, n=2,335 per https://t.co/iRktt1QRB4). https://t.co/25mCtaMDL3 Tirzepatide: 22.5% at 15mg (SURMOUNT-1, n=2,539). https://t.co/5Ww4tKE1ie CagriSema: 22.7% on-treatment estimand (20.4% intention-to-treat), REDEFINE-1, n=3,417, peer-reviewed in NEJM 2025. https://t.co/anoXRiL0Yg Eloralintide: ~20% over 48 weeks at the top dose (Phase 2, selective amylin, no GLP-1; nausea is dose-specific). Lancet 2025: https://t.co/cfKAnzfzzP Orforglipron: oral, 11.2% weight loss at 36mg over 72 weeks in obesity (ATTAIN-1, the first oral once-daily GLP-1 pill; treatment-regimen estimand, ITT). NEJM Sept 2025, DOI 10.1056/NEJMoa2511774. Survodutide (a two-hormone GLP-1/glucagon agonist, not on the board above but worth knowing): about 17% (SYNCHRONIZ

Jun 10, 2026 · 2 likes · 13,178 followers View post →
Fight Club
@pdfreader1231 · X

GLP-1 Medications: What’s New and What’s Next for Clinicians https://t.co/yfk89uLu7m via @YouTube #medicine

Jun 1, 2026 · 938 followers View post →
Abraham Trueba
@CRISPRKING · X

https://t.co/ama7yRMNGs

May 11, 2026 · 1 like · 10,769 followers View post →
Abraham Trueba
@CRISPRKING · X

https://t.co/EMKsaFrLG8

May 11, 2026 · 2 likes · 10,769 followers View post →
Abraham Trueba
@CRISPRKING · X

https://t.co/2DHZCHwxKL

May 11, 2026 · 3 likes · 1 share · 10,769 followers View post →
Prof. Wasim Hanif OBE
@docwas · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. There is a lot of interest among patients about this drug. It makes you loose about 11% body weight and could be cheaper then some of the current medication https://t.co/lqLNildrw3

Apr 18, 2026 · 3 likes · 2 shares · 5,175 followers View post →
Lidong @pharmato
@Lidong_Pei · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/9LYvheUUbX

Apr 7, 2026 · 1 like · 10 followers View post →
GLP-1 LIFE!
@GLP1_LIFE · X

#foundayo #glp1 #orforglipron #elilly https://t.co/OQciSLnopa

Apr 3, 2026 · 26 followers View post →
자연철학의 수학적 원리
@NaturaPrinciple · X

https://t.co/SW0j7JZcBL

Apr 3, 2026 · 13 likes · 4 shares · 274 followers View post →
????? ?????, DO
@KazemOsmanDO · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/si9OEMXjcI

Apr 2, 2026 · 1 like · 60 followers View post →
Yicai 第一财经
@yicaichina · X

Eli Lilly plans to invest USD3 billion over the next decade to expand its supply chain capacity in China, the US drugmaker said today. The firm will set up a local production and supply network for tablets and capsules and build manufacturing capabilities for orforglipron, an oral small-molecule GLP-1 receptor agonist for treating type 2 diabetes and obesity. @EliLillyandCo

Mar 11, 2026 · 5 likes · 210,952 followers View post →
Leonard LN
@leonard49411022 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Jan 21, 2026 · 21 shares · 220 followers View post →
Tom Hsiung ???????‍⚕️ですね??!? ?
@TomHsiung · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial - The Lancet https://t.co/pXyxXZZdDS - administered by oral route

Jan 15, 2026 · 1 like · 473 followers View post →
BioFingertips
@biofingertips · X

HOT TOPIC OF THE WEEK Most viewed paper on BioFingertips: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. This is what healthcare professionals are reading right now. Read it on BioFingertips: https://t.co/w2fEjD0vKT #BioFingertips #HotTopicOfTheWeek #GLP1 #ObesityTreatment #HealthcareProfessionals

Jan 12, 2026 · 1 like · 289 followers View post →
UKY Endocrine, Diabetes, and Metabolism Fellowship
@ukyendocrine · X

For today's journal club, Dr. K C discussed the ??? ??????? ??????? ?? ???????? article “Orforglipron, an Oral Small Molecule GLP 1 Receptor Agonist for Obesity Treatment.” https://t.co/Hz36cwmQee

Jan 9, 2026 · 1 like · 14 followers View post →
ARYAN®
@gladeolie · X

EvidenceAlerts | Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. https://t.co/Ghr7pWJYrt

Jan 3, 2026 · 1,468 followers View post →
ARYAN
@gladeolie.bsky.social · Bluesky

EvidenceAlerts | Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. www.evidencealerts.com/Social/Artic...

Jan 3, 2026 View post →
ARYAN
@gladeolie.bsky.social · Bluesky

EvidenceAlerts | Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. www.evidencealerts.com/Social/Artic...

Jan 3, 2026 View post →
Editörün Gözünden
@editorgozunden · X

2026'da sağlık teknolojilerinde neler değişecek dersiniz? Videonun tamamı YouTube kanalımızda. Gelin birlikte 2026'da sağlıkta neler değişecek göz atalım. https://t.co/vgpzJ9Ffao #saglik #saglikteknolojileri #sağlıkhaberleri https://t.co/ESBOAf2ZT8

Dec 23, 2025 · 1 share · 62 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

“Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial.” Publié ce jour dans @thelancet.com. #MedSky #EndoSky www.thelancet.com/journals/lan...

Dec 20, 2025 · 1 like View post →
Un1v3rs0 Z3r0
@Un1v3rs0Z3r0 · X

[Articles] Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/nWjxMHw4HK

Dec 18, 2025 · 549 followers View post →
Laborgeflüster-Podcast
@laborgefluester.bsky.social · Bluesky

www.nejm.org/doi/full/10.... www.thelancet.com/journals/lan...

Dec 13, 2025 · 1 like View post →
Editörün Gözünden
@editorgozunden · X

2026 sağlık dünyası nasıl olacak? Yapay zekâ kişisel sağlık koçuna mı dönüşüyor? Zayıflama iğneleri yerini haplara mı bırakacak? Obezite cerrahisi azalacak mı? Kanser aşıları gerçekten yakın mı? Longevity neden yükselişte? https://t.co/4KPS9kyDkk #saglik #saglikhaberleri https://t.co/iS0u3qlZ45

Dec 10, 2025 · 62 followers View post →
ボソすば
@BoSoBoSoSan · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial - The Lancet https://t.co/WBgZgB9CHR

Dec 5, 2025 · 217 followers View post →
旅人 tabito
@tabibito250 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/U3MIokvSsH

Dec 3, 2025 · 995 followers View post →
Andrew Jull NZRN (he/him)
@andrewjull.bsky.social · Bluesky

Good news for folk with excess weight and type 2 diabetes - an oral alternative to injectable GLP-1 receptor agonists. Dose response r/ship in weight loss and majority of participants getting below HbA1c of 6.5%. www.sciencedirect.com/science/arti...

Dec 2, 2025 · 1 share View post →
Dr.Casey Bonk
@DrCaseyBonk · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Dec 2, 2025 · 21 shares · 44 followers View post →
Nitin Gandhi, M Pharm
@NitinGa35829582 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 30, 2025 · 20 shares · 359 followers View post →
Dr.AMiT JAiSWAL
@aadvikmedics · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 62 followers View post →
Liftfy
@laliftlalift · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 21 shares · 147 followers View post →
Almansour
@malmansour81 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 214 followers View post →
Elvis Amao Ruiz
@elvisjar · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 255 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 11,329 followers View post →
Adipose Tissue: The Circadian clock of Metabolism
@Prashan69344151 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 55 followers View post →
Luis Eduardo Celi C.
@luchitoceli · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 165 followers View post →
Jesse Haven, MD
@jhaven99 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 121 followers View post →
Dr Ashish Kumar
@DrAshish_Kumar · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 19,260 followers View post →
Ilenia Pantano
@PantanoIlenia · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 92 followers View post →
Nada Hassib
@NadaHassib1 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 29, 2025 · 20 shares · 764 followers View post →
sophia
@sophia8666ac · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 1,581 followers View post →
Ashley Wei MD
@AshleyWeiMD · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 713 followers View post →
Anna wei
@yxmfn55642275 · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 425 followers View post →
Sherif
@Sherifdotcom · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 136 followers View post →
Karl Dujardin
@KDujardin · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 662 followers View post →
Ondo(✸,✸)
@ArianaPantasy · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 676 followers View post →
Biljana Parapid, MD, PhD, FESC
@biljana_parapid · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 28, 2025 · 20 shares · 8,632 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 https://t.co/EdAknfDkki

Nov 28, 2025 · 75 likes · 20 shares · 3,153 followers View post →
Zoey
@Zoeynzyjo1122 · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Nov 26, 2025 · 70 shares · 1,297 followers View post →
Dr Chris Duncombe CMO
@DrDuncombe · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 332 followers View post →
Amjad
@Amjaduuu1 · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 29 shares · 121 followers View post →
Gary Deed
@garydeed · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 115 followers View post →
D.Dash
@dr_debu · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 91 followers View post →
Dr Ashok Dalal
@DrAshokGastro · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 1,475 followers View post →
Vikas bhargava
@Vikasbh40772075 · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 5 followers View post →
Fadi Hassan
@OnePatientFH · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 16 followers View post →
Mehdi Maanaoui
@MaanaouiMehdi · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 999 followers View post →
Javier Escalada #Yoelijoendocrino
@fjavesc · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 26, 2025 · 30 shares · 3,631 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 197 followers View post →
Carlos Palacio
@CAPE1223 · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 1,023 followers View post →
ElenaJerezLanza
@helejtf · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 31 followers View post →
Thomas Round
@drtomround · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 3,424 followers View post →
María Argente Pla
@ArgentePla · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 467 followers View post →
Instructor TX
@InstructorTX · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. https://t.co/mgXNdNFFqL

Nov 25, 2025 · 378 followers View post →
Dr Ashish Kumar
@DrAshish_Kumar · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 19,260 followers View post →
Juan Carlos
@carlos1184 · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 1,543 followers View post →
darcy darnoc
@darcydarnoc · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 3,149 followers View post →
Dr. Jorge Acosta
@DocJorgeAcosta · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 15,426 followers View post →
Nicolas Renna, MD PhD ISHF FESC
@nicolasrennamd · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 932 followers View post →
Arshad Rashid
@arshadkema · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial - The Lancet https://t.co/qeiVoRpYfR

Nov 25, 2025 · 1,006 followers View post →
Justin Ryder, PhD
@jryder1123 · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 233 followers View post →
Mina Hunjan
@MinaHunjan · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 479 followers View post →
Dr.Lama Amer, MD
@Dr_Lama_Amer · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 4,294 followers View post →
Trapezoedro resplandeciente
@jastinmus · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 185 followers View post →
Javier Carrera
@Javier_CarreraH · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 1,833 followers View post →
Iyad Happy-Life
@iyad_e_s · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 7 followers View post →
The Lancet Diabetes & Endocrinology
@TheLancetEndo · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 53,037 followers View post →
syawal™ シ
@syawal · X

RT @TheLancet: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 25, 2025 · 30 shares · 3,095 followers View post →
The Lancet
@TheLancet · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/ElGCZnxmHB

Nov 25, 2025 · 106 likes · 30 shares · 734,029 followers View post →
Shicheng Guo
@shihcheng.bsky.social · Bluesky

Orforglipron, a once-daily oral GLP-1 agonist, shows promise for obesity. Tested 6mg, 12mg, 36mg vs. placebo in a 72-week study. Outcomes look positive! PMID:40960239, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2511774 #Medsky #Pharmsky #RNA #ASHG #ESHG

Nov 22, 2025 · 1 like View post →
Shicheng Guo
@ShihchengGuo · X

Orforglipron, a once-daily oral GLP-1 agonist, shows promise for obesity. Tested 6mg, 12mg, 36mg vs. placebo in a 72-week study. Outcomes look positive! PMID:40960239, N Engl J Med 2025, @NEJM https://t.co/O1bZlcZb00 #AI #Pharma #BioMed #RNA #ASHG #ESHG

Nov 22, 2025 · 1 like · 564 followers View post →
Instructor TX
@InstructorTX · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind. Orforglipron, in people with diabetes and obesity shows significant weight loss. https://t.co/mgXNdNFFqL

Nov 21, 2025 · 378 followers View post →
Ken Watanabe
@kwplancity · X

RT @agingdoc1: Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (AT…

Nov 20, 2025 · 1 share · 8 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial https://t.co/BkWNPBcty8

Nov 20, 2025 · 2,072 followers View post →
Agingdoc
@agingdoc1 · X

Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial "We aimed to evaluate orforglipron, an oral small-molecule

Nov 20, 2025 · 9 likes · 1 share · 43,178 followers View post →
Jessica
@Jessica27511l · X

RT @alexanderperse: I wonder if patient census in hospitals will go down due to this. Absolutely insane https://t.co/l1Hh3Uw0UU

Nov 17, 2025 · 1 share · 802 followers View post →
@DUH4Healthcare
@duh4healthcare.bsky.social · Bluesky

www.nejm.org/doi/full/10....

Nov 15, 2025 View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Orforglipron significantly reduces body weight in obesity patients, outperforming placebo and showing favorable safety profile over 72 weeks. by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med https://t.co/OMCh2O5F2z #MedX #MedResearch

Nov 15, 2025 · 93 followers View post →
STITCHES Medicine - the Best of Medical Research
@medicine.stitches.today · Bluesky

Orforglipron significantly reduces body weight in obesity patients, outperforming placebo and showing favorable safety profile over 72 weeks. by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med #MedSky

Nov 15, 2025 · 3 likes · 2 shares View post →
Andres Felipe Florez
@Andresffmed · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 14, 2025 · 25 shares · 159 followers View post →
Instructor TX
@InstructorTX · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. This new drug is way more effective for dropping pounds, and the best part is it's just a pill you swallow! Read. https://t.co/ggGKN8l1YK

Nov 14, 2025 · 378 followers View post →
Dr.Renée Rossi
@DrReneeRossi · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 14, 2025 · 25 shares · 450 followers View post →
Khushboo Agarwal
@DrKhushboo_Endo · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 14, 2025 · 25 shares · 255 followers View post →
ISNkidneycare
@theisn.org · Bluesky

8/

Nov 14, 2025 · 1 share View post →
DrNithi
@DrNithi · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 14, 2025 · 25 shares · 6,439 followers View post →
Int Society of Nephrology
@ISNkidneycare · X

8/

Nov 13, 2025 · 6 likes · 29,483 followers View post →
Carlos Palacio
@CAPE1223 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 1,023 followers View post →
Dr.Lama Amer, MD
@Dr_Lama_Amer · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 4,294 followers View post →
Miguel Turégano
@tureyedro · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 816 followers View post →
Janet Chiang, MD
@JanetMD87 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 810 followers View post →
John Rodriguez
@rodrig39386 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 967 followers View post →
Stavra Xanthakos
@DrStavra · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 322 followers View post →
Biljana Parapid, MD, PhD, FESC
@biljana_parapid · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Nov 13, 2025 · 2 shares · 8,632 followers View post →
Pawan Rao MD, FASN
@nephronus · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 1,009 followers View post →
Maria Jesus Gonzalez Rellan
@ChusaGzlzRellan · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 795 followers View post →
Javier Carrera
@Javier_CarreraH · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 1,833 followers View post →
Sá Peliteiro
@Peliteiro · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 2,866 followers View post →
Dan Baciu
@fnz4sgr5jc · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 51 followers View post →
DIEGO FERNANDEZ GARCIA
@diegofe21784801 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 1,646 followers View post →
Ahmed Bennis MD
@drbennisahmed · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 https://t.co/rDlejWVqyO

Nov 13, 2025 · 9 likes · 2 shares · 3,153 followers View post →
Wendy Trejo MD., MSc.
@md_wentrejo · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 13, 2025 · 25 shares · 429 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 12, 2025 · 25 shares · 197 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 12, 2025 · 25 shares · 6,625 followers View post →
Dr. Nasreen Alfaris
@nasreenalfaris · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 12, 2025 · 25 shares · 2,275 followers View post →
nephronking
@nephronking · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 12, 2025 · 25 shares · 133 followers View post →
Peter Edmonds MD
@pjedmonds · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 12, 2025 · 25 shares · 1,032 followers View post →
@docbio.bsky.social
@DocBio1509 · X

RT @NEJM: Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) http…

Nov 12, 2025 · 25 shares · 460 followers View post →
NEJM
@NEJM · X

Original Article: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 phase 3 trial) https://t.co/avDbBYKZDr #Endocrinology https://t.co/xFALCq2XqV

Nov 12, 2025 · 108 likes · 25 shares · 931,969 followers View post →
Gabe Wilson MD
@Gabe__MD · X

Oral easy-to-take GLP-1 Agonists are going to transform the market even more than injectables making them broadly adoptable. Implications are immense: Fewer hospital admissions (11% lower for heart failure, 20-24% lower among patients with diabetes for stroke and MI) Less money spent on food and possibly alcohol (5-10% lower grocery spend per user) Lower rates of hypertension, diabetes, high lipids Decreased obesity surgery by 10-15% 12% reduction in all-cause mortality Lower rates of kidney disease patients needing dialysis Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/QIqgGBbUUU (I have no interest in any pharmaceutical company and this will actually decrease the number of patients we get in the ER; it will make life tougher to finance hospitals)

Nov 11, 2025 · 6 likes · 2,482 followers View post →
Snehalmdr
@snehalmdr · X

https://t.co/b41lTXfxD5

Nov 11, 2025 · 1,759 followers View post →
Avel con V chica
@AvelRomanNeph · X

Nov 11, 2025 · 2,980 followers View post →
NEJM.org
@nejm.org · Bluesky

In the ATTAIN-1 phase 3, randomized trial, the use of orforglipron, an oral glucagon-like peptide-1 receptor agonist, led to significant mean body-weight reductions in patients with #obesity, as compared with placebo. Full trial results and Research Summary: nej.md/4n1nSl2 #MedSky #EndoSky

Nov 11, 2025 · 7 likes · 11 shares View post →
Hiroki Iume
@iume_YUMINO · X

RT @yumino_medical: 【DrゆみのWeekly Journal Scan】 ■非糖尿病肥満成人に対する経口GLP1RAの効果 from NEJM https://t.co/O3R8IU3XP3…

Nov 11, 2025 · 2 shares · 68 followers View post →
弓野大(Dai Yumino)
@daiyumino · X

RT @yumino_medical: 【DrゆみのWeekly Journal Scan】 ■非糖尿病肥満成人に対する経口GLP1RAの効果 from NEJM https://t.co/O3R8IU3XP3…

Nov 10, 2025 · 2 shares · 1,245 followers View post →
医療法人社団ゆみの
@yumino_medical · X

【DrゆみのWeekly Journal Scan】 ■非糖尿病肥満成人に対する経口GLP1RAの効果 from NEJM https://t.co/O3R8IU3XP3

Nov 10, 2025 · 2 likes · 2 shares · 1,250 followers View post →
Baglikov Andrey
@baglikov · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 8, 2025 · 9 shares · 603 followers View post →
Elvia Cuauro
@elvia_cuauro · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 8, 2025 · 9 shares · 7,873 followers View post →
SAEDYN
@SAEDYN_ · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 8, 2025 · 9 shares · 3,801 followers View post →
Martín López de la Torre
@elendocrino · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 8, 2025 · 9 shares · 2,964 followers View post →
Jose Seijas Amigo
@AmigoSeijas · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 8, 2025 · 21 shares · 356 followers View post →
Roxana González
@RoxOsler · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 7, 2025 · 21 shares · 1,146 followers View post →
José Mª Gª Quintana
@jose_g_quintana · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 7, 2025 · 21 shares · 852 followers View post →
Hernandez Edgar
@Internistacl · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/zHzwg0rJ3A

Nov 7, 2025 · 517 followers View post →
Dr. Osmar Perez S.
@osmarperse · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 7, 2025 · 9 shares · 2,466 followers View post →
Srikanth Bellary
@sribellary · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 279 followers View post →
ale g.
@alend2_0 · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 20 shares · 4 followers View post →
Dr. Robert Glatter
@DrRobertGlatter · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 6, 2025 · 9 shares · 5,899 followers View post →
Juanmarcosgg
@juanmarcosgg · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 6, 2025 · 9 shares · 510 followers View post →
Daniel of the Shire
@countrsignal · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 780 followers View post →
andres
@palacioendocrin · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/HrFHV5wO6Q

Nov 6, 2025 · 357 followers View post →
Rx Readmore Livemore
@SopitaSirirata1 · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 178 followers View post →
Cristina Tejera
@cristinatejerap · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 6, 2025 · 9 shares · 11,604 followers View post →
Cristobal Morales
@CristobMorales · X

RT @ValleAlfonso: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 6, 2025 · 9 shares · 17,185 followers View post →
Alfonso Valle
@ValleAlfonso · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity

Nov 6, 2025 · 15 likes · 9 shares · 21,708 followers View post →
Andrew J Sauer MD
@AndrewJSauer · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 19,603 followers View post →
Wimen
@1a31551c566e43d · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 672 followers View post →
Ranganath Muniyappa
@dr_muniyappa · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 1,094 followers View post →
Andy Grannell
@Grannell_ · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 991 followers View post →
Blad Villavicencio
@bladDV · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 820 followers View post →
mdjungle
@mdjungle1 · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 114 followers View post →
Dr. Nasreen Alfaris
@nasreenalfaris · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 2,275 followers View post →
Carlos Palacio
@CAPE1223 · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 1,023 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

“Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.” Publié ce jour dans le @nejm.org. #MedSky #EndoSky www.nejm.org/doi/full/10....

Nov 6, 2025 View post →
VinnDoc
@DocPawXP · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 38 followers View post →
Dr. Robert Glatter
@DrRobertGlatter · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 5,899 followers View post →
Reumatología Clinic
@Reumaclinic · X

Dos nuevos fármacos orales

Nov 6, 2025 · 3 likes · 1 share · 2,968 followers View post →
Jaime
@JaimeGMD · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 1,902 followers View post →
Fernando Vidal-Ostos De Lara
@drvidalostos · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 459 followers View post →
Nithyanan Annamalai
@BlackSamrat · X

RT @agingdoc1: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/ifTueKLWh7

Nov 6, 2025 · 2 shares · 377 followers View post →
SANCYD
@SANCYDnutricion · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Nov 6, 2025 · 21 shares · 3,030 followers View post →
Racha Prati
@PratiRacha · X

RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…

Nov 6, 2025 · 4 shares · 11 followers View post →
Cristina Tejera
@cristinatejerap · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/GNhaj2cf7G this week in @NEJM

Nov 6, 2025 · 73 likes · 21 shares · 11,604 followers View post →
Marc Vincent Barcelona, MD, FPCR, DPBR-RO
@MarcBarcieMD · X

RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…

Nov 6, 2025 · 4 shares · 308 followers View post →
Elad Sharon
@EladSharonMD · X

RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…

Nov 5, 2025 · 4 shares · 3,890 followers View post →
Umut. Dişel
@UmutDisel · X

RT @VivekSubbiah: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https…

Nov 5, 2025 · 4 shares · 1,281 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Orforglipron, Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Rx. mean change in body weight from baseline to week 72 was −7.5% with 6 mg of orforglipron, −8.4% with 12 mg of orforglipron,& −11.2% with 36 mg of orforglipron,vs −2.1% with placebo https://t.co/lYOuJqpnO6

Nov 5, 2025 · 34,661 followers View post →
Dr. Gerald Davies
@GeraldDavies2 · X

RT @agingdoc1: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/ifTueKLWh7

Nov 5, 2025 · 2 shares · 154 followers View post →
Agingdoc
@agingdoc1 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/ifTueKLWh7

Nov 5, 2025 · 7 likes · 2 shares · 43,178 followers View post →
Vivek Subbiah, MD
@VivekSubbiah · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/SyI4OEeiom

Nov 5, 2025 · 18 likes · 4 shares · 39,368 followers View post →
Lina Park
@LinaParkxaZZZ · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Nov 4, 2025 · 70 shares · 38 followers View post →
Alice lee
@Alice5744jv · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Nov 4, 2025 · 70 shares · 30 followers View post →
Aria Lim
@AriaLimZZZ · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Nov 4, 2025 · 70 shares · 32 followers View post →
Parmariu17
@parmariu17 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/R3Ye5VVhAg

Nov 1, 2025 · 108 followers View post →
Lydia
@Lydia18963 · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Oct 23, 2025 · 70 shares · 29 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Orforglipron, Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM. 3127 patients. mean change in body weight from baseline to week 72 was −7.5%, −8.2 to −6.8 with 6 mg of orforglipron, −8.4% with 12 mg of orforglipron, https://t.co/lYOuJqpnO6

Oct 3, 2025 · 34,661 followers View post →
Monika Stangl
@stanglmonika · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 1,085 followers View post →
zino
@zinojeng · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 151 followers View post →
Prof. Wasim Hanif
@docwas · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/lqLNildrw3

Oct 3, 2025 · 5,047 followers View post →
Dr. Che-Tzu Chang, MD, MS (AIR Jack)
@ILoveWen0224 · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 68 followers View post →
Javi
@ecaballeroaudaz · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 117 followers View post →
unré
@unre__ · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 334 followers View post →
Mneee3
@crafty8798 · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 286 followers View post →
Flavio Enrique Díaz Trueba
@Flaviodiazt · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 61 followers View post →
土屋淳紀
@Mishima_Fuji · X

RT @NEJM: Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agon…

Oct 3, 2025 · 18 shares · 8 followers View post →
NEJM
@NEJM · X

Here are three Original Articles from September that made big news: 1️⃣ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment (ATTAIN-1 trial) https://t.co/avDbBYKZDr

Oct 3, 2025 · 96 likes · 18 shares · 931,969 followers View post →
Lilly Medical US
@LillyMedical · X

New Results from the ATTAIN-1 Phase 3 Trial: An Oral Small Molecule GLP-1 Receptor Agonist for Obesity Treatment. Click here to read the full results: https://t.co/HPqVcoKZ5Y https://t.co/hA4IrxqD0v

Sep 30, 2025 · 1 like · 8,177 followers View post →
さいびー/3iB@元SE医学生
@saibi_3ib · X

現代のやせ薬ことマンジャロは週1回の注射薬なので、まだ患者さんに通院の手間がかかる。 イーライリリーが臨床研究中のオルフォルグリプロンは常温の経口薬なので、もっと爆発的な市場を作る期待大! 薬価収載前に自由診療で出回りそう https://t.co/UiBaN4iGYN

Sep 28, 2025 · 736 followers View post →
Massimo
@Rainmaker1973 · X

Scientists reveal pill that helps you lose 20% body weight. For years, powerful obesity medications have meant injections. But now, scientists say a daily pill may offer similar results – and greater access. Researchers have published results from a massive international trial of orforglipron, an oral drug that mimics GLP-1 hormones. The study followed more than 3,100 adults with obesity but not diabetes, across nine countries, for 72 weeks. Patients took either a placebo or one of three daily doses of orforglipron, alongside diet and activity. The results were striking. At the highest dose, patients lost an average of 11% of their body weight. More than half lost at least 10%, over one third lost 15% or more, and nearly one in five shed at least 20%. For comparison, the placebo group averaged just a 2% drop. Beyond weight, the pill improved waist size, blood pressure, triglycerides,

Sep 27, 2025 · 227 likes · 30 shares · 4,437,430 followers View post →
STITCHES Medicine - the Best of Medical Research
@medicine.stitches.today · Bluesky

Orforglipron significantly reduces body weight in adults with obesity, outperforming placebo, while maintaining a tolerable safety profile. by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med #MedSky

Sep 25, 2025 · 5 likes · 1 share View post →
STITCHES Medicine - the Best of Medical Research
@STITCHESMed · X

Orforglipron significantly reduces body weight in adults with obesity, outperforming placebo, while maintaining a tolerable safety profile. by Wharton S, Aronne LJ (...) Klise SR et 10 al. in N Engl J Med https://t.co/OMCh2O5F2z #MedX #MedResearch

Sep 25, 2025 · 93 followers View post →
Black Physicians' Association of Ontario
@thebpao · X

We are proud to celebrate Dr. @SeanWharton, a founding member of BPAO, for publishing two groundbreaking studies in the New England Journal of Medicine on obesity treatment.

Sep 25, 2025 · 1 like · 1,801 followers View post →
geneXplain GmbH
@geneXplain · X

A groundbreaking international trial has revealed an oral drug called orforglipron that’s changing the obesity game. Unlike current injectable therapies, this is a once daily pill and its results are stunning. #OralTherapy #WeightLossScience #ScienceIsGood https://t.co/kk7vSNA9Ki https://t.co/K4Fqo8ZOXs

Sep 25, 2025 · 1 like · 408 followers View post →
サイエンスあれこれ
@sarekore · X

がより身近なものとなる可能性があります。オルフォルグリプロンは、米国食品医薬品局 (FDA) や世界中の他の同様の機関によってまだ承認されていません。https://t.co/hlkwAu8Opb

Sep 25, 2025 · 938 followers View post →
Jose Carlos Del Castillo MD, MPH (c)
@RunRunlover · X

RT @EvidentisHQ: ATTAIN-1: once-daily oral GLP-1 agonist orforglipron cut weight by up to 11.2% at 72 wks vs 2.1% placebo in adults w/ obes…

Sep 24, 2025 · 3 shares · 653 followers View post →
Motoshi Hayano
@HayanoMotoshi · X

Orforglipron(経口小分子GLP‑1受容体作動薬)、肥満(糖尿病なし)成人を対象とした72週の第3相で、体重減少がプラセボより有意に大。 脂肪量 −13.8% 除脂肪量(lean mass) −4.5% 内臓脂肪 −19.0% 体重減少の内訳は 脂肪減少73%:除脂肪減少27%。 https://t.co/3sdLNnZeEu

Sep 24, 2025 · 7 likes · 3,885 followers View post →
Texas Liver Care (TLC)
@TexasLiverCare · X

RT @EvidentisHQ: ATTAIN-1: once-daily oral GLP-1 agonist orforglipron cut weight by up to 11.2% at 72 wks vs 2.1% placebo in adults w/ obes…

Sep 24, 2025 · 3 shares · 2,793 followers View post →
Taher Modarressi, MD
@tmodarressi · X

RT @nasreenalfaris: Thrilled to share our latest publication in @NEJM ,the ATTAIN-1 trial, the first phase 3 study of oral orforglipron in…

Sep 22, 2025 · 4 shares · 1,714 followers View post →
diabetuit
@diabetuit · X

RT @CristobMorales: La democratización y uso temprano de los GLP1 pudiese llegar con los NUEVOS GLP1 orales https://t.co/df6shoUnMf Oral S…

Sep 21, 2025 · 3 shares · 308 followers View post →
Fatima Villafañe Sanz
@FatimaVillaf · X

RT @SemergenGTDM: ¿Inicio de una nueva era en el tto de la obesidad? Orforglipron podría cambiar el acceso a terapias GLP1: ✔️Vía de adm o…

Sep 21, 2025 · 2 shares · 462 followers View post →
GT Diabetes Semergen
@SemergenGTDM · X

¿Inicio de una nueva era en el tto de la obesidad? Orforglipron podría cambiar el acceso a terapias GLP1: ✔️Vía de adm oral diaria ✔️Sin necesidad de conservación especial ✔️Mejorando la adherencia y biodisponibilidad ✔️Eficacia clínicamente relevante https://t.co/Hxofi8F6aK

Sep 21, 2025 · 1 like · 2 shares · 3,349 followers View post →
Dymkó Křepelka
@3dattempt · X

RT @NutrioSci: In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than plac…

Sep 20, 2025 · 4 shares · 122 followers View post →
Medical Advances
@MedicalAdv · X

RT @NutrioSci: In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than plac…

Sep 20, 2025 · 4 shares · 29,701 followers View post →
Kujon Naukowski
@Nerd_kujon · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Sep 20, 2025 · 70 shares · 32 followers View post →
Science News
@scinews.bsky.social · Bluesky

In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. #NEJM www.nejm.org/doi/full/10....

Sep 20, 2025 · 5 likes View post →
Jana Peciva
@pecivova1 · X

RT @NutrioSci: In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than plac…

Sep 20, 2025 · 4 shares · 186 followers View post →
Nutrition Science
@NutrioSci · X

In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. @NEJM https://t.co/L9C3AGaFH7 https://t.co/m0AL980VUt

Sep 20, 2025 · 15 likes · 4 shares · 64,159 followers View post →
diabetuit
@diabetuit · X

RT @DanielJDrucker: Oral orforglipron over 72 weeks for #weightloss #obesity #EASD2025 https://t.co/wuHNF2Jich

Sep 19, 2025 · 7 shares · 308 followers View post →
The Liver Summit™ (TLS)
@TheLiverSummit · X

RT @EvidentisHQ: ATTAIN-1: once-daily oral GLP-1 agonist orforglipron cut weight by up to 11.2% at 72 wks vs 2.1% placebo in adults w/ obes…

Sep 19, 2025 · 3 shares · 478 followers View post →
Hernandez Edgar
@Internistacl · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/zHzwg0rJ3A

Sep 19, 2025 · 517 followers View post →
Ruba Khalil
@AIbookwormRK · X

RT @DrSamuelBHume: Here are the sources: 1. Oral obesity drugs: https://t.co/91u4a6BLRt, https://t.co/21Z8Gg2C1X 2. Aspirin after colore…

Sep 19, 2025 · 1 share · 12 followers View post →
Samuel Hume
@DrSamuelBHume · X

Here are the sources: 1. Oral obesity drugs: https://t.co/91u4a6BLRt, https://t.co/21Z8Gg2C1X 2. Aspirin after colorectal cancer surgery https://t.co/KrGnVtz4jz 3. Trikafta in cystic fibrosis https://t.co/zd1vgzbask 4. Apple watch detects hypertension https://t.co/MTHhO5oCfH

Sep 19, 2025 · 29 likes · 1 share · 30,074 followers View post →
JC Stanford
@JCDarnestown · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Sep 19, 2025 · 70 shares · 122 followers View post →
medicopenia_155
@medicopenia_155 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment #MedTwitter

Sep 19, 2025 · 2,958 followers View post →
Dr. Nazifa Kadery, PharmD, RPh
@dose_of_naz · X

Ph3 ATTAIN-1 published in the #NEJM: #Lilly's PO GLP-1 (36mg), #orforglipron, demonstrated meaningful WL (~12.4%) & #cardiometabolic improvements @ wk 72 https://t.co/92OpaclqaN https://t.co/5qjQHKEhCg

Sep 19, 2025 · 271 followers View post →
Hussain Alquraini, MD, FACE
@qurainihussain · X

RT @nasreenalfaris: Thrilled to share our latest publication in @NEJM ,the ATTAIN-1 trial, the first phase 3 study of oral orforglipron in…

Sep 19, 2025 · 4 shares · 2,142 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @EricTopol: Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss https://t.co/DwMDkvsXg7 @NEJM https://t.co…

Sep 19, 2025 · 70 shares · 2,593 followers View post →
Diana Isaacs, PharmD, BC-ADM, CDCES
@DianaMIsaacs · X

RT @medpedshosp: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https:…

Sep 18, 2025 · 4 shares · 3,155 followers View post →
Anjan Gupta
@ACSCardiology · X

In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists https://t.co/LvCFmJhA1z

Sep 18, 2025 · 435 followers View post →
あっこ@便秘大好きナース
@ibsnurse · X

RT @tarou_ymd_: マンジャロ打ってる人に朗報。 飲めるGLP-1作動薬の結果が報告されました。経口の小分子GLP-1作動薬「オルフォグリプロン」は ☑72週間で体重−11%減 ☑血圧・脂質も改善 「注射じゃなくても効く」時代、始まるかもしれません https://…

Sep 18, 2025 · 1 share · 1,876 followers View post →
ACP Ohio
@OhioAcp · X

RT @medpedshosp: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https:…

Sep 18, 2025 · 4 shares · 933 followers View post →
Javier Escalada #Yoelijoendocrino
@fjavesc · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Sep 18, 2025 · 12 shares · 3,631 followers View post →
Abstream
@abstreamme · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment #science #publication #research #publications https://t.co/VK62hraqjm

Sep 18, 2025 · 553 followers View post →
JOSE ALVA
@kmaldades · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/rWSnCVEQRh

Sep 18, 2025 · 233 followers View post →
Philipp Lopatka
@LopatkaPhilipp · X

RT @CristobMorales: La democratización y uso temprano de los GLP1 pudiese llegar con los NUEVOS GLP1 orales https://t.co/df6shoUnMf Oral S…

Sep 18, 2025 · 3 shares · 201 followers View post →
Mohammad Aleidi
@aleidimed · X

RT @medpedshosp: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https:…

Sep 18, 2025 · 4 shares · 352 followers View post →
Jen Can NuSH
@JCanNuSH · X

Congrats to @seanwharton for two big oral GLP-1 papers in NEJM this week! ATTAIN-1 https://t.co/JliXctfaz1 OASIS-4 https://t.co/jFAnC572B4

Sep 18, 2025 · 3 likes · 125 followers View post →
Med Peds Hospitalist
@medpedshosp · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/PK5E4J7YMg

Sep 18, 2025 · 6 likes · 4 shares · 14,290 followers View post →
bibliotecahuvh.bsky.social
@bibliotecahuvh.bsky.social · Bluesky

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment www.nejm.org/doi/10.1056/... #hvhebron #endo

Sep 18, 2025 View post →
BibliotecaHUVH
@BibliotecaHUVH · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/Fd2WEsNMxw #hvhebron #endo

Sep 18, 2025 · 2,311 followers View post →
やまだ@腸活×アンチエイジング
@tarou_ymd_ · X

マンジャロ打ってる人に朗報。 飲めるGLP-1作動薬の結果が報告されました。経口の小分子GLP-1作動薬「オルフォグリプロン」は ☑72週間で体重−11%減 ☑血圧・脂質も改善 「注射じゃなくても効く」時代、始まるかもしれません https://t.co/mSHasGCtTD

Sep 18, 2025 · 15 likes · 1 share · 7,961 followers View post →
BaladoCritique : club de lecture médical
@baladocritique.bsky.social · Bluesky

“Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes.”” Publié ce jour dans le @nejm.org. #MedSky #EndoSky www.nejm.org/doi/full/10....

Sep 18, 2025 · 1 like View post →
María Ballesteros #yoelijoEndocrino
@mdballesteros · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Sep 18, 2025 · 12 shares · 4,919 followers View post →
Cristobal Morales
@CristobMorales · X

La democratización y uso temprano de los GLP1 pudiese llegar con los NUEVOS GLP1 orales https://t.co/aqxJPwS90c Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity AND https://t.co/ZsK10EeNkQ Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment #EASD2025

Sep 18, 2025 · 17 likes · 3 shares · 17,797 followers View post →
M. Merchán
@mmerchb · X

RT @SANCYDnutricion: Orforglipron, un agonista oral del receptor GLP-1 de moléculas pequeñas para el tratamiento de la obesidad Orforglipr…

Sep 18, 2025 · 3 shares · 479 followers View post →
Cláudia
@claudianutri · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Sep 18, 2025 · 12 shares · 123 followers View post →
Juan Ignacio Arano
@AranoIgnacio · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Sep 18, 2025 · 12 shares · 91 followers View post →
Ananya Vihaan
@ananya_vihaan · X

RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

Sep 18, 2025 · 3 shares · 44 followers View post →
Joe Zucchi, PA-C, CPT
@JPZfitness · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/KoQ1oUc8s4

Sep 17, 2025 · 261 followers View post →
SENCAR®
@sencartagena · X

RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

Sep 17, 2025 · 12 shares · 76 followers View post →
旅人 tabito
@tabibito250 · X

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/U3MIokvSsH

Sep 17, 2025 · 995 followers View post →
George Ferzli
@drferzli · X

In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | NEJM https://t.co/5Hox1DZcLh

Sep 17, 2025 · 838 followers View post →
SANCYD
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Orforglipron, un agonista oral del receptor GLP-1 de moléculas pequeñas para el tratamiento de la obesidad Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/3aXXSmFxgf

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RT @cristinatejerap: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine ht…

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????? ?????, DO
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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/TCwn2bK6zX

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ATTAIN-1: once-daily oral GLP-1 agonist orforglipron cut weight by up to 11.2% at 72 wks vs 2.1% placebo in adults w/ obesity, also improving BP & lipids. GI AEs mild–mod 1st oral small-molecule GLP-1 with robust efficacy—potential game-changer in obesity https://t.co/x5GVydB79E

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RT @drbennisahmed: Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treat…

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine?✅ https://t.co/isRidvOoab

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νάτο και το χαπάκι! Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/7pi2joNvDu

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In adults with obesity, 72-week treatment with orforglipron led to significantly greater reductions in body weight than placebo; the adverse-event profile was consistent with that of other GLP-1 receptor agonists. @NEJM @CMichaelGibson @DrMarthaGulati @hvanspall @lamcardio @AndrewJSauer @dranulala @ankeetbhatt @BiykemB @Drroxmehran @JACCJournals @ACCinTouch https://t.co/5t36x0kt8E

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/qQ9Eu6YFZp #EASD2025

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Oral orforglipron over 72 weeks for #weightloss #obesity #EASD2025 www.nejm.org/doi/full/10....

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment | New England Journal of Medicine https://t.co/kYh2db5YxS

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment https://t.co/6p24qpMKnz

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment: NEJM; 3127 patients; mean change in body weight from baseline to week 72 was −7.5% , −8.2 to −6.8) with 6 mg of orforglipron, −8.4% with 12 mg of orforglipron, −11.2% https://t.co/lYOuJqpnO6

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Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss www.nejm.org/doi/full/10....

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caloriesproper.bsky.social
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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes www.nejm.org/doi/full/10....

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine www.nejm.org/doi/full/10....

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | New England Journal of Medicine www.nejm.org/doi/full/10....

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Orforglipron, an oral small-molecule GLP-1 agonist, significantly lowered blood glucose compared with placebo in a phase III trial. Read more on MIMS Pharma

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). Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N. Engl. J. Med. 2025, 393, 1796–1806. [Google Scholar] [CrossRef] ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. Available from https://www.nejm.org/doi/10.1056/NEJMoa2511774 [Accessed 10th ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N Engl J Med. 2025 Nov 6;393(18):1796-1806. doi: 10.1056/NEJMoa2511774. Epub ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment – NEJM 4. Dementia Risk in People With Type 1 Diabetes and Associated Risk ...

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... 10.1056/NEJMoa2511774. Overweight and obesity affect more than 2.5 billion persons worldwide and increase the risk of multiple health complications. 1. Long ...

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This article was published on September. 16, 2025, at NEJM.org. DOI: 10.1056/NEJMoa2511774. Copyright © 2025 Massachusetts Medical Society. BACKGROUND.

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doi:10.1056/NEJMoa2511774 2. Wharton S et al. OASIS 4 (oral semaglutide 25 mg). NEJM 2025;393:1077–1087 3. Sanyal AJ et al. ESSENCE Part 1 (semaglutide for ...

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org/10.1056/NEJMoa2511774 2. Aronne, L. J., Horn, D. B., le Roux, C. W., et al. (2026). Orforglipron for maintenance of body weight reduction: The double ...

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nejm.org/doi/full/10.1056/NEJMoa2511774 2. https://www.nejm. org/doi/full/10.1056/NEJMoa2504650 3. https://www.nejm. org/doi/full/10.1056/NEJMcibr2510197 4.

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ORFORGLIPRON: AN ORAL SMALL- MOLECULE GLP-1 RECEPTOR AGONIST FOR OBESITY TREATMENT AUTHORS. LEARNING OBJECTIVES Obesity , classification, management ...

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15150 [747] doi:10.1056/NEJMoa2302392 [748] doi:10.1007/s13300-024-01554-1 [749] doi:10.1056/NEJMoa2511774 [750] doi:10.1016/S0140-6736(26) ...

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doi:10.1056/NEJMoa2500969 4. ATTAIN-1. NEJM 2025. doi: 10.1056/NEJMoa2511774 5. COR-I. Lancet 2010. doi: 10.1016/S0140-6736(10)60888-4 6. SCALE, ...

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... Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment." New England Journal of Medicine. 2025. NCT05869903 ...

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DOI: 10.1056/NEJMoa2511774 3. Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment. N Engl. J. Med. 2025, 393(18), 1796–1806. [Google Scholar] ...

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By validating that orforglipron is a small molecule rather than a trad Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for …

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doi: 10.1056/NEJMoa2511774; Foundayo [prescribing information]. 4/2026. Eli Lilly & Co. Indianapolis, IN. Accessed April 8, 2026 at https ...

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DOI: 10.1056/NEJMoa2511774 ATTAIN-MAINTAIN phase 3b, Nature Medicine (May 2026) — weight-loss maintenance after switching from injectables.

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Unlike traditional Orforglipron: An Oral Small-Molecule GLP-1 Receptor Agonist for therapies that mimic natural amino acid chains—which are ...

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Aquí te dejamos el artículo. Jastreboff AM et al. Orforglipron for the Treatment of Obesity without Diabetes. N Engl J Med. 2025; DOI: 10.1056/NEJMoa2511774 # ...

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treat population. DOI: 10.1056/NEJMoa2511774. Copyright © 2025 Massachusetts Medical Society. RESULTS A total of 3127 patients underwent randomization. The ...

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NEJM, 2025: [DOI: 10.1056/NEJMoa2505669] (Eficácia em Obesidade - ATTAIN-1). 3. NEJM, 2025: [DOI: 10.1056/NEJMoa2511774] (Resultados em Diabetes ...

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[Article] Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. 1. 2. [article]Dynamic control of Na-Cl ...

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[Article] Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. 1. 2. [Article]The impact of cannabis and ...

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NEJM, 2025: [DOI: 10.1056/NEJMoa2505669] (Eficácia em Obesidade - ATTAIN-1). 3. NEJM, 2025: [DOI: 10.1056/NEJMoa2511774] (Resultados em Diabetes ...

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2025;393(18):1796-1806. 15. Krüger N, Schneeweiss S, Fuse K, et al. maintenance of body weight reduction in doi:10.1056/NEJMoa2511774

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N Engl J Med 2025;393:1796-806. DOI: 10.1056/NEJMoa2511774 . . #sobrepeso #obesidad #endocrinologia #pokeendocrino #MedicinaInterna #Residentes ...

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New England Journal of Medicine, Article NEJMoa2511774. https://doi.org/10.1056/NEJMoa2511774; Horn, D. B., Ryan, D. H., Giljanovic Kis, S ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. NEJM 2025. An oral GLP-1 shows clinically meaningful ...

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doi:10.1056/NEJMoa2511774. Garvey WT, Blüher M, Contreras CKO, et al. Coadministered cagrilintide and semaglutide in adults with overweight ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, ...

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Read the study: “Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.” New England Journal of Medicine, 2025 ...

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Read the study: “Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.” New England Journal of Medicine, 2025 ...

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Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase ...

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... 10.1056/NEJMoa2511774 Published on September 16, 2025 Patients GLP-1 receptor agonist •3127 adults •Mean age, 45 years •Women: 64%; Men: 36 ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment In patients with #obesity, incretin-based therapies such ...

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... 10.1056/NEJMoa2511774| Published September 16, 2025 Patients GLP-1 receptor agonist 3127 adults •Mean age, 45 years •Women: 64%; Men: 36 ...

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Published in NEJM (2025): DOI 10.1056/NEJMoa2511774 #ObesityCare #GLP1 #Orforglipron #NEJM #PharmaInnovation #WeightLoss #MetabolicHealth ...

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... 10.1056/NEJMoa2511774 Published on September 16, 2025 Patients GLP-1 receptor agonist •3127 adults •Mean age, 45 years ·Women: 64%; Men: 36 ...

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... 10.1056/NEJMoa2511774 Published on September 16, 2025 Patients GLP-1 receptor agonist •3127 adults •Mean age, 45 years ·Women: 64%; Men: 36 ...

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7.7) 36 mg of orforglipron: Average weight loss of −11.2% (95% CI
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NEJM, 2025: [DOI: 10.1056/NEJMoa2505669] (Eficácia em Obesidade - ATTAIN-1). 3. NEJM, 2025: [DOI: 10.1056/NEJMoa2511774] (Resultados em Diabetes ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity November 5, 2025. DOI: 10.1056/NEJMdo008238

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... treatment. N Engl J Med. 2025;393:1796‑1806. DOI:10.1056/NEJMoa2511774 · HC Shih and 191 others ·

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[Article] Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. 1. 2. [ARTICLE] AJM300 (carotegrast methyl), an ...

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NEJM, 2025: [DOI: 10.1056/NEJMoa2505669] (Eficácia em Obesidade - ATTAIN-1). 3. NEJM, 2025: [DOI: 10.1056/NEJMoa2511774] (Resultados em Diabetes ...

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... injection. 11% while I think the injection is closer to 15%. https://www.nejm.org/doi/full/10.1056/NEJMoa2511774 · Lucky_Army_5324. • 14d ago.

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https://www.nejm.org/doi/full/10.1056/NEJMoa2511774. I got my previous comment deleted because the link wasn't great I guess? So 2nd attempt ...

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DOI: 10.1056/NEJMoa2511774. URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2511774. अपवोट करें 1 डाउनवोट करें 2 ...

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DOI: 10.1056/NEJMoa2511774 URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2511774.

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DOI: 10.1056/NEJMoa2511774 URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2511774.

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... treatment. N Engl J Med. 2025;393:1796‑1806. DOI:10.1056/NEJMoa2511774 · 丁噹and 130 others ·

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. N Engl J Med. 2025. doi:10.1056/NEJMoa2511774. ¿Crees que ...

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N Engl J Med. 2025;393:1796‑1806. DOI:10.1056/NEJMoa2511774 · Yuhyea Chen and 69 others ·

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doi:10.1056/NEJMoa2511774. S. Wharton et al. Oral semaglutide at a dose of 25 mg in adults with overweight or obesity. The New England ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. Wharton S, Aronne LJ, Stefanski A, et al. The New England ...

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N Engl J Med 2025;393:1796-806. DOI: 10.1056/NEJMoa2511774 . . #sobrepeso #obesidad #endocrinologia #pokeendocrino #MedicinaInterna #Residentes ...

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Kaynak: https://www.nejm. org/doi/pdf/10.1056/NEJMoa2511774 Semaglutid (Ozempic, Wegovy) veya tirzepatid (Mounjaro, Zepbound) gibi ilaçlar ...

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doi:10.1056/NEJMoa2511774. S. Wharton et al. Oral semaglutide at a dose of 25 mg in adults with overweight or obesity. The New England ...

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Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment. New England Journal of Medicine . DOI: 10.1056/NEJMoa2511774.

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DOI: 10.1056/nejmoa2511774. Journal information: New England Journal of Medicine. Key medical concepts. orforglipronObesity. Clinical categories.

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