A C. elegans mutant that lives twice as long as wild type.

C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang

December 1993 Nature

Synopsis of Social media discussions

The collective discussions emphasize the groundbreaking nature of the 1993 discovery, with references to the original paper and subsequent advancements, such as new methods to manipulate longevity genes, illustrating sustained scholarly interest and perceived impact on aging research.

A
Agreement
 Strong agreement

Most posts recognize and support the significance of the 1993 discovery by Kenyon and colleagues about gene mutations extending lifespan, indicating strong consensus on its importance.

I
Interest
 High level of interest

Posts demonstrate high interest through references to foundational research, ongoing studies, and questions about implications for human aging, showing curiosity and engagement with the topic.

E
Engagement
 High engagement

Many posts discuss the specifics of the research methods, historical context, and potential for future applications, reflecting deep involvement in understanding the science.

I
Impact
 High level of impact

The discussions highlight how the research has shaped the field of aging, suggesting it has had a lasting influence on scientific understanding and future research directions.

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257

Total Likes

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554,374

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137

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  • Javier Apfeld
    @javierapfeld.bsky.social (Bluesky)

    Mutations in the daf-2 gene double the lifespan of C. elegans worms, but they have no effect on lifespan if the daf-16 gene is mutated. From Keyon et al. 1993. pubmed.ncbi.nlm.nih.gov/8247153/
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  • Tim Proctor
    @tpr720 (Twitter)

    sources https://t.co/wpkM2d1dKh https://t.co/6pVo4AYATk
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  • Salil Sharma
    @salilssharma (Twitter)

    In 1993 #scientist discovered that a single #gene #mutation can double the life of a #roundworm (C. Elegans). How many years will it take to double human's #lifespan? #research #science #immortality Source : https://t.co/qt7NRDUu2p
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  • Nathalia Le Hen
    @NathaliaLeHen (Twitter)

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  • Jessica L. Preston, PhD
    @jesscaperson (Twitter)

    RT @NikoMcCarty: Day 24 "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). https://t.co/9eQOoHzarh
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    @ProfCantu (Twitter)

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  • STEPHEN NEWHOUSE
    @s_j_newhouse (Twitter)

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  • Niko McCarty.
    @NikoMcCarty (Twitter)

    Day 24 "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). https://t.co/9eQOoHzarh
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  • Dr Mario HMG
    @mgmglobal (Twitter)

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  • Juan Enriquez
    @EvolvingJuan (Twitter)

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  • Abdul Hafeez Khan
    @khan_saahaab (Twitter)

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  • microsatellite instability
    @chudsommeleir (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Egberto F. Selerio Jr.
    @egberto_selerio (Twitter)

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  • JIM
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  • The Mondoux Lab
    @MondouxLab (Twitter)

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  • Ana Yagüe Relimpio
    @scientific_ana (Twitter)

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  • Elizabeth Marsh
    @marsh_ek (Twitter)

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  • Galymzhan
    @moldagulovg (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Amber Amparo
    @ambermamparo (Twitter)

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  • Sameer Ahmed
    @SameerA41115539 (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Rijk Gans
    @Gansrob (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Byan Dalam Berita
    @ByanDalamBerita (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Kalidasu Giridhar
    @KalidasuGirid (Twitter)

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  • The Innovation | Medicine
    @Innov_Medicine (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Lucas Tafur
    @structureltp (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Anson Zhou
    @ansonyzhou (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Fay
    @fay90028966 (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Yuta Aoki, D.Sc.
    @YutaMAoki (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Jamie_Park
    @BacZemin (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Mateus d'Ávila
    @OMateusDavila (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Nathan
    @ngamarra91 (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Antonio-Campos et al ;)
    @aac_phd (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Kurtis Edwards
    @_kurtisedwards (Twitter)

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  • Arpit Sharma, PhD
    @arpit_science (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Burak Özkan
    @Buraku_Arc (Twitter)

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  • Mike Fatah
    @mfatah281 (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Hami (Top 0.0001% of Researchgate)
    @Kabarcheota (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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    @jimin926 (Twitter)

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  • drfeelgood
    @drfeelgood049 (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Miguel Ramírez-Otero
    @MickeRzO (Twitter)

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    @lamarcelavega (Twitter)

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  • T2W
    @haikouhainan (Twitter)

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    @drypoffin (Twitter)

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  • Cahir O'Kane
    @OKaneCahir (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Gregor Rot
    @gregor_rot (Twitter)

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  • Rodrigo Moreno Campos
    @RodrigoMoreC (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • WILLIAM DARAN(daranwilliam.bsky.social)
    @DaranWilliam (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Aleksandra Stęplowska
    @stepelka (Twitter)

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  • Hao Yin
    @HaoYin20 (Twitter)

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  • Coke on the rocks (he/him)
    @OneAlchemist (Twitter)

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  • Saad Bin Maqsood
    @SaadBinMaqsood1 (Twitter)

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  • Writawrik Bhattacharya
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  • छपरा का धुरंधर
    @meioticdrrive (Twitter)

    RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…
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  • Dani
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  • Aidan O’B
    @aidano_b (Twitter)

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  • Juan Miranda
    @jumiri44 (Twitter)

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  • Seth Corey, MD MPH
    @sethcorey (Twitter)

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  • Tatiana Popovitchenko
    @tatianapopo (Twitter)

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  • Roberto Munita
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  • Infidel
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  • Manifesting
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  • FIROZ MOLLA
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    @ControllingLMNT (Twitter)

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  • Avantika Negi
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  • Martín Méndez
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  • Carlos Rozas
    @CarlosR22040015 (Twitter)

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  • Stephen Jackson
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  • Kingsley Ikpa-agodo
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  • Ian Hay
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  • -Joe Rogan
    @RealJoeRogan12 (Twitter)

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  • Niko McCarty.
    @NikoMcCarty (Twitter)

    Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). The paper that defined a field. A single mutation, in a single gene, doubles worm lifespan. There are genes that affect ageing rates and they can be altered. https://t.co/ht6UbayFX2
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    July 2, 2023

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  • Andrea McBeth
    @DreMcBeth (Twitter)

    RT @agingdoc1: A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mann…
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    February 23, 2023

    2

  • Mitchell B Lee, PhD
    @mitchellblee33 (Twitter)

    RT @agingdoc1: A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mann…
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    February 22, 2023

    2

  • Agingdoc
    @agingdoc1 (Twitter)

    A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mannick's career: "Our findings raise the possibility that the longevity... results from a regulated lifespan extension mechanism."
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    February 22, 2023

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  • whynot
    @hullalulu (Twitter)

    @nir_eynon @HealthyLongeviT stupid question but: hasn't it been known for almost three decades? https://t.co/yWr7Ak3xr9
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    July 30, 2022

  • Agingdoc
    @agingdoc1 (Twitter)

    A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon & Ramon Tabtiang https://t.co/azHv109ohk
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    March 22, 2022

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  • Collin Ewald
    @CollinEwald (Twitter)

    @__JosephWilk A.1.3. BTW, after all these years, our lab just showed that degrading DAF-2 at the end of life is possible to double the lifespan. https://t.co/9jXAvYyU6m. A follow-up to Cynthia Kenyon’s original 1993 paper.
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    October 29, 2021

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  • Collin Ewald
    @CollinEwald (Twitter)

    @__JosephWilk A.1.2. Of course, I read then the famous 1993 paper from Cynthia Kenyon (CK) about daf-2 doubling the lifespan of C. elegans https://t.co/9jXAvYyU6m. And begged a former post doc of CK, Joy Alcedo, who had a lab @FMIscience to take me on to do a masters working on aging.
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    October 29, 2021

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Abstract Synopsis

  • Mutations in the daf2 gene in *C. elegans* can nearly double their lifespan, and this longevity depends on the activity of another gene, daf16.
  • Both daf2 and daf16 are involved in controlling the formation of dauer larvae, which are long-lived, developmentally arrested forms triggered by environmental stress.
  • The research suggests that the increased lifespan is due to a specific longevity mechanism that can be separated from dauer formation, offering new insights into how lifespan can be regulated.]