Nature December 1993 PMID 8247153

A C. elegans mutant that lives twice as long as wild type.

C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang

Mentions

137
Peak: 88 in Jul 2023
across 6 sources since Oct 2021

Extended reach

554,374
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Total likes

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257

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AI synopsis

What people are saying

The collective discussions emphasize the groundbreaking nature of the 1993 discovery, with references to the original paper and subsequent advancements, such as new methods to manipulate longevity genes, illustrating sustained scholarly interest and perceived impact on aging research.

AgreementStrong agreement

Most posts recognize and support the significance of the 1993 discovery by Kenyon and colleagues about gene mutations extending lifespan, indicating strong consensus on its importance.

InterestHigh interest

Posts demonstrate high interest through references to foundational research, ongoing studies, and questions about implications for human aging, showing curiosity and engagement with the topic.

EngagementHigh engagement

Many posts discuss the specifics of the research methods, historical context, and potential for future applications, reflecting deep involvement in understanding the science.

ImpactHigh impact

The discussions highlight how the research has shaped the field of aging, suggesting it has had a lasting influence on scientific understanding and future research directions.

Abstract in brief

  • Mutations in the daf2 gene in *C. elegans* can nearly double their lifespan, and this longevity depends on the activity of another gene, daf16.
  • Both daf2 and daf16 are involved in controlling the formation of dauer larvae, which are long-lived, developmentally arrested forms triggered by environmental stress.
  • The research suggests that the increased lifespan is due to a specific longevity mechanism that can be separated from dauer formation, offering new insights into how lifespan can be regulated.]

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Niko McCarty.
@NikoMcCarty · X

Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). The paper that defined a field. A single mutation, in a single gene, doubles worm lifespan. There are genes that affect ageing rates and they can be altered. https://t.co/ht6UbayFX2

Jul 2, 2023 · 518 likes · 92 shares · 44,480 followers View post →
Niko McCarty.
@NikoMcCarty · X

Day 24 "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). https://t.co/9eQOoHzarh

Jul 8, 2023 · 8 likes · 1 share · 44,480 followers View post →
Agingdoc
@agingdoc1 · X

A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mannick's career: "Our findings raise the possibility that the longevity... results from a regulated lifespan extension mechanism."

Feb 22, 2023 · 7 likes · 2 shares · 43,836 followers View post →
Tim Proctor
@tpr720 · X

sources https://t.co/wpkM2d1dKh https://t.co/6pVo4AYATk

Jul 23, 2025 · 3 likes · 1,037 followers View post →
Javier Apfeld
@javierapfeld.bsky.social · Bluesky

Mutations in the daf-2 gene double the lifespan of C. elegans worms, but they have no effect on lifespan if the daf-16 gene is mutated. From Keyon et al. 1993. pubmed.ncbi.nlm.nih.gov/8247153/

Sep 4, 2025 · 3 likes View post →
Agingdoc
@agingdoc1 · X

A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon & Ramon Tabtiang https://t.co/azHv109ohk

Mar 22, 2022 · 1 like · 43,836 followers View post →

All mentions

Javier Apfeld
@javierapfeld.bsky.social · Bluesky

Mutations in the daf-2 gene double the lifespan of C. elegans worms, but they have no effect on lifespan if the daf-16 gene is mutated. From Keyon et al. 1993. pubmed.ncbi.nlm.nih.gov/8247153/

Sep 4, 2025 · 3 likes View post →
Tim Proctor
@tpr720 · X

sources https://t.co/wpkM2d1dKh https://t.co/6pVo4AYATk

Jul 23, 2025 · 3 likes · 1,037 followers View post →
Salil Sharma
@salilssharma · X

In 1993 #scientist discovered that a single #gene #mutation can double the life of a #roundworm (C. Elegans). How many years will it take to double human's #lifespan? #research #science #immortality Source : https://t.co/qt7NRDUu2p

Sep 17, 2023 · 1 like · 22 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

Jul 17, 2023 · 92 shares · 2,811 followers View post →
Jessica L. Preston, PhD
@jesscaperson · X

RT @NikoMcCarty: Day 24 "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). https://t.co/9eQOoHzarh

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Jorge A Cantú
@ProfCantu · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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STEPHEN NEWHOUSE
@s_j_newhouse · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Niko McCarty.
@NikoMcCarty · X

Day 24 "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). https://t.co/9eQOoHzarh

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Dr Mario HMG
@mgmglobal · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Jyoti ranjan puhan
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Walied Elshenawy
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ha-
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Abdul Hafeez Khan
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Amarisa
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microsatellite instability
@chudsommeleir · X

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Egberto F. Selerio Jr.
@egberto_selerio · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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JIM
@Jim_Contreras_ · X

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The Mondoux Lab
@MondouxLab · X

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Ana Yagüe Relimpio
@scientific_ana · X

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Elizabeth Marsh
@marsh_ek · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Amber Amparo
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RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Sameer Ahmed
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Rijk Gans
@Gansrob · X

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Byan Dalam Berita
@ByanDalamBerita · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Kalidasu Giridhar
@KalidasuGirid · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

Jul 3, 2023 · 92 shares · 429 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Lucas Tafur
@structureltp · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Anson Zhou
@ansonyzhou · X

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Fay
@fay90028966 · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Yuta Aoki, D.Sc.
@YutaMAoki · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

Jul 3, 2023 · 92 shares · 634 followers View post →
Jamie_Park
@BacZemin · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Mateus d'Ávila
@OMateusDavila · X

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Nathan
@ngamarra91 · X

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Antonio-Campos et al ;)
@aac_phd · X

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Birdie_Song_HK
@Birdie_Song_HK · X

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Kurtis Edwards
@_kurtisedwards · X

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Arpit Sharma, PhD
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Burak Özkan
@Buraku_Arc · X

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Wridhani
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Mike Fatah
@mfatah281 · X

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Hami (Top 0.0001% of Researchgate)
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kspt
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@drfeelgood049 · X

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Miguel Ramírez-Otero
@MickeRzO · X

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hmap
@hmap01337406 · X

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GenMol-icious
@lamarcelavega · X

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T2W
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Cahir O'Kane
@OKaneCahir · X

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Gregor Rot
@gregor_rot · X

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Rodrigo Moreno Campos
@RodrigoMoreC · X

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WILLIAM DARAN(daranwilliam.bsky.social)
@DaranWilliam · X

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Aleksandra Stęplowska
@stepelka · X

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Hao Yin
@HaoYin20 · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Coke on the rocks (he/him)
@OneAlchemist · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Saad Bin Maqsood
@SaadBinMaqsood1 · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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@writawrik · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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छपरा का धुरंधर
@meioticdrrive · X

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@_arroba_daniel · X

RT @NikoMcCarty: Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993).…

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Aidan O’B
@aidano_b · X

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Juan Miranda
@jumiri44 · X

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Seth Corey, MD MPH
@sethcorey · X

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@tatianapopo · X

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Manifesting
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FIROZ MOLLA
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Edward Grow, PhD
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liv ☮️ (they/them)
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Niko McCarty.
@NikoMcCarty · X

Day 24 of great biology papers. "A C. elegans mutant that lives twice as long as wild type," by Kenyon C. et al. (1993). The paper that defined a field. A single mutation, in a single gene, doubles worm lifespan. There are genes that affect ageing rates and they can be altered. https://t.co/ht6UbayFX2

Jul 2, 2023 · 518 likes · 92 shares · 44,480 followers View post →
Andrea McBeth
@DreMcBeth · X

RT @agingdoc1: A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mann…

Feb 23, 2023 · 2 shares · 257 followers View post →
Mitchell B Lee, PhD
@mitchellblee33 · X

RT @agingdoc1: A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mann…

Feb 22, 2023 · 2 shares · 1,102 followers View post →
Agingdoc
@agingdoc1 · X

A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon's Letter to @Nature that inspired Joan Mannick's career: "Our findings raise the possibility that the longevity... results from a regulated lifespan extension mechanism."

Feb 22, 2023 · 7 likes · 2 shares · 43,836 followers View post →
whynot
@hullalulu · X

@nir_eynon @HealthyLongeviT stupid question but: hasn't it been known for almost three decades? https://t.co/yWr7Ak3xr9

Jul 30, 2022 · 97 followers View post →
Agingdoc
@agingdoc1 · X

A C. elegans mutant that lives twice as long as wild type (1993) Cynthia Kenyon & Ramon Tabtiang https://t.co/azHv109ohk

Mar 22, 2022 · 1 like · 43,836 followers View post →
Collin Ewald
@CollinEwald · X

@__JosephWilk A.1.3. BTW, after all these years, our lab just showed that degrading DAF-2 at the end of life is possible to double the lifespan. https://t.co/9jXAvYyU6m. A follow-up to Cynthia Kenyon’s original 1993 paper.

Oct 29, 2021 · 1 like · 4,537 followers View post →
Collin Ewald
@CollinEwald · X

@__JosephWilk A.1.2. Of course, I read then the famous 1993 paper from Cynthia Kenyon (CK) about daf-2 doubling the lifespan of C. elegans https://t.co/9jXAvYyU6m. And begged a former post doc of CK, Joy Alcedo, who had a lab @FMIscience to take me on to do a masters working on aging.

Oct 29, 2021 · 1 like · 4,537 followers View post →