Publications by authors named "Fu-Yang Lin"

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Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling.
Meghan F Monroy, Megan Krumpoch, T Andrew McTeague, Angela Fee, Dooyoung Lee, Fu-Yang Lin

MAbs· December 2025

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Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies.
Sarah-Eve Lemay, Mónica S Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Fu-Yang Lin, James E Dowling

Circulation· April 2025

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The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis.
Bryce A Harrison, James E Dowling, Matthew G Bursavich, Dawn M Troast, Katherine M Chong, Fu-Yang Lin

J Med Chem· November 2024

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Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies.
Sarah-Eve Lemay, Monica S Montesinos, Yann Grobs, Tetsuro Yokokawa, Tsukasa Shimauchi, Fu-Yang Lin, James E Dowling

bioRxiv· June 2024

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A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding.
Sergei P Boudko, Elizabeth H Konopka, Woojin Kim, Yuki Taga, Kazunori Mizuno, Fu-Yang Lin

J Biol Chem· July 2023

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A general chemical principle for creating closure-stabilizing integrin inhibitors.
Fu-Yang Lin, Jing Li, Yonghua Xie, Jianghai Zhu, Thi Thu Huong Nguyen

Cell· September 2022

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High integrin αβ affinity reached by hybrid domain deletion slows ligand-binding on-rate.
Xianchi Dong, Bo Zhao, Fu-Yang Lin, Chafen Lu, Bruce N Rogers

Proc Natl Acad Sci U S A· February 2018

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β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece.
Fu-Yang Lin, Jianghai Zhu, Edward T Eng, Nathan E Hudson, Timothy A Springer

J Biol Chem· February 2016

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Head-to-head prenyl tranferases: anti-infective drug targets.
Fu-Yang Lin, Yi-Liang Liu, Kai Li, Rong Cao, Wei Zhu

J Med Chem· May 2012

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Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.
Fu-Yang Lin, Yonghui Zhang, Mary Hensler, Yi-Liang Liu, Ohn A Chow

ChemMedChem· April 2012

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HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.
Yonghui Zhang, Fu-Yang Lin, Kai Li, Wei Zhu, Yi-Liang Liu

ACS Med Chem Lett· April 2012

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Terpene biosynthesis: modularity rules.
Eric Oldfield, Fu-Yang Lin

Angew Chem Int Ed Engl· January 2012

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E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.
Yu-Fang Shen, Yu-Hou Chen, Shao-Ying Chu, Meng-I Lin, Hua-Ting Hsu, Fu-Yang Lin, Gialih Lin

Proc Natl Acad Sci U S A· October 2011

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Mechanism of action and inhibition of dehydrosqualene synthase.
Fu-Yang Lin, Chia-I Liu, Yi-Liang Liu, Yonghui Zhang, Ke Wang

Proc Natl Acad Sci U S A· December 2010

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Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP.
Isabela B Ramos, Kildare Miranda, Douglas A Pace, Katherine C Verbist, Fu-Yang Lin

Biochem J· August 2010

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Diterpene cyclases and the nature of the isoprene fold.
Rong Cao, Yonghui Zhang, Francis M Mann, Cancan Huang, Dushyant Mukkamala, Fu-Yang Lin

Proteins· August 2010

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Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators.
Yonghui Zhang, Rong Cao, Fenglin Yin, Fu-Yang Lin, Hong Wang

Angew Chem Int Ed Engl· February 2010

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Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Yongcheng Song, Chia-I Liu, Fu-Yang Lin, Joo Hwan No, Mary Hensler

J Med Chem· July 2009

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Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
Yonghui Zhang, Rong Cao, Fenglin Yin, Michael P Hudock, Rey-Ting Guo, Fu-Yang Lin

J Am Chem Soc· April 2009

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Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
Yongcheng Song, Fu-Yang Lin, Fenglin Yin, Mary Hensler, Carlos A Rodrígues Poveda

J Med Chem· February 2009

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A putative polyketide-synthesis protein XC5357 from Xanthomonas campestris: heterologous expression, crystallization and preliminary X-ray analysis.
Chiao-Li Chu, Ko-Hsin Chin, Fu-Yang Lin, Chia-Cheng Chou, Cheng-Chung Lee, Hui-Lin Shr

Acta Crystallogr Sect F Struct Biol Cryst Commun· July 2005

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NMR structure note--solution structure of a bacterial BolA-like protein XC975 from a plant pathogen Xanthomonas campestris pv. campestris.
Ko-Hsin Chin, Fu-Yang Lin, Yu-Chen Hu, Kong Hung Sze, Ping-Chiang Lyu

J Biomol NMR· February 2005

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