Publications by authors named "Aaron Novikoff"

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One small molecule for man, one giant leap for mankind with obesity.
Aaron Novikoff, Timo D Müller

Med· December 2025

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GLP-1/GIP/GCG receptor triagonist (IUB447) enhances insulin secretion via GLP-1 receptor and Gαq signalling pathway in mice.
Pascale C F Schreier, Philipp Beyerle, Severin Boulassel, Andreas Beck, Aaron Novikoff

Diabetologia· November 2025

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A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.
Jonathan D Douros, Aaron Novikoff, Barent DuBois, Rebecca Rohlfs, Jacek Mokrosinski

Mol Metab· October 2025

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Tirzepatide differentially affects body weight in mice and humans.
Aaron Novikoff, Timo D Müller

Nat Rev Endocrinol· August 2025

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Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism.
Callum Coupland, Na Sun, Ahmed Khalil, Özüm Ezgi Karaoglu, Arkadiusz Liskiewicz, Aaron Novikoff

Mol Metab· June 2025

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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff

Nat Metab· June 2025

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Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff

Nat Metab· June 2025

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Glucose-dependent insulinotropic polypeptide (GIP).
Timo D Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L Birkenfeld, Aaron Novikoff

Mol Metab· May 2025

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Recent achievements and future directions of anti-obesity medications.
Gerald Grandl, Aaron Novikoff, Xue Liu, Timo D Müller

Lancet Reg Health Eur· December 2024

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Why are we still in need for novel anti-obesity medications?
Aaron Novikoff, Gerald Grandl, Xue Liu, Timo D Müller

Lancet Reg Health Eur· December 2024

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Antagonizing GIPR adds fire to the GLP-1R flame.
Aaron Novikoff, Timo D Müller

Trends Endocrinol Metab· July 2024

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Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don't.
Aaron Novikoff, Timo D Müller

Physiology (Bethesda)· May 2024

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Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Aaron Novikoff

Mol Metab· May 2024

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Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.
Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Aaron Novikoff

Nat Metab· March 2024

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.
Arkadiusz Liskiewicz, Ahmed Khalil, Daniela Liskiewicz, Aaron Novikoff, Gerald Grandl

Nat Metab· December 2023

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SURMOUNTing body weight barriers in type 2 diabetes.
Aaron Novikoff, Timo D Müller

Med· December 2023

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The molecular pharmacology of glucagon agonists in diabetes and obesity.
Aaron Novikoff, Timo D Müller

Peptides· July 2023

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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.
Kimberley El, Jonathan D Douros, Francis S Willard, Aaron Novikoff, Ashot Sargsyan

Nat Metab· June 2023

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TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
Noushafarin Khajavi, Andreas Beck, Klea Riçku, Philipp Beyerle, Katharina Jacob, Aaron Novikoff

JCI Insight· February 2023

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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg

Cell Metab· December 2022

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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.
Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg

Cell Metab· November 2022

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GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber

Nat Metab· August 2022

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Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.
Aaron Novikoff, Shannon L O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert

Mol Metab· July 2021

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Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.
Sigrid Jall, Meri De Angelis, Anne-Marie Lundsgaard, Andreas M Fritzen, Trine S Nicolaisen, Aaron Novikoff

Diabetologia· June 2020

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Gut Peptide Agonism in the Treatment of Obesity and Diabetes.
Gerald Grandl, Aaron Novikoff, Richard DiMarchi, Matthias H Tschöp, Timo D Müller

Compr Physiol· December 2019

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