Publications by authors named "Jonathan D Douros"

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Sex-specific metabolic and central effects of GLP-1-estradiol conjugate in middle-aged rats on a standard or western diet.
Jennifer E Richard, Ahmad Mohammad, Kimberly A Go, Andrew J McGovern, Rebecca K Rechlin, Jonathan D Douros

Brain Behav Immun· November 2025

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Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat.
Sulayman A Lyons, Micah B S Lea, Mihir Parikh, Zhengzhang Guo, Samrin Kagdi, Jonathan D Douros

EMBO Rep· November 2025

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A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.
Jonathan D Douros, Aaron Novikoff, Barent DuBois, Rebecca Rohlfs, Jacek Mokrosinski

Mol Metab· October 2025

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β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion.
Megan E Capozzi, David Bouslov, Ashot Sargsyan, Michelle Y Chan, Alex Chen, Jonathan D Douros

J Clin Invest· August 2025

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A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans.
Brian Finan, Jonathan D Douros, Ronald Goldwater, Ann Maria Kruse Hansen, Julie B Hjerpsted

Mol Metab· June 2025

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Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism.
Callum Coupland, Na Sun, Ahmed Khalil, Özüm Ezgi Karaoglu, Arkadiusz Liskiewicz, Jonathan D Douros

Mol Metab· June 2025

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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Jonathan D Douros

Nat Metab· June 2025

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Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.
Robert M Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Jonathan D Douros

Nat Metab· June 2025

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Glucose-dependent insulinotropic polypeptide (GIP).
Timo D Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L Birkenfeld, Jonathan D Douros

Mol Metab· May 2025

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The Premise of the Paradox: Examining the Evidence That Motivated GIPR Agonist and Antagonist Drug Development Programs.
Jonathan D Douros, Stephanie A Mowery, Patrick J Knerr

J Clin Med· May 2025

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The agony and the efficacy: central mechanisms of GLP-1 induced adverse events and their mitigation by GIP.
Jonathan D Douros, Jonathan N Flak, Patrick J Knerr

Front Endocrinol (Lausanne)· February 2025

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GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells.
Natália da Silva Lima, Alba Cabaleiro, Eva Novoa, Cristina Riobello, Patrick J Knerr, Jonathan D Douros

Cell Mol Life Sci· November 2024

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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy.
Miguel A Sánchez-Garrido, Víctor Serrano-López, Francisco Ruiz-Pino, María Jesús Vázquez, Andrea Rodríguez-Martín, Jonathan D Douros

Nat Commun· October 2024

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Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice.
Margit Wunderlich, Manuel Miller, Bärbel Ritter, Ronan Le Gleut, Hannah Marchi, Jonathan D Douros

Mol Metab· September 2024

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Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes.
Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros

Nat Metab· July 2024

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The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines.
Jonathan D Douros, Jacek Mokrosinski, Brian Finan

J Endocrinol· May 2024

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Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Jonathan D Douros

Mol Metab· May 2024

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GLP-1-directed NMDA receptor antagonism for obesity treatment.
Jonas Petersen, Mette Q Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Jonathan D Douros

Nature· May 2024

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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.
Arkadiusz Liskiewicz, Ahmed Khalil, Daniela Liskiewicz, Aaron Novikoff, Gerald Grandl, Jonathan D Douros

Nat Metab· December 2023

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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.
Kimberley El, Jonathan D Douros, Francis S Willard, Aaron Novikoff, Ashot Sargsyan

Nat Metab· June 2023

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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems.
Bin Yang, Vasily M Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Jonathan D Douros

Mol Metab· December 2022

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Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice.
Patrick J Knerr, Stephanie A Mowery, Jonathan D Douros, Bhavesh Premdjee, Karina Rahr Hjøllund

Mol Metab· September 2022

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Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.
Rashmi Chandra, Dipendra K Aryal, Jonathan D Douros, Rafiq Shahid, Supriya J Davis

PLoS One· June 2022

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GLP-1/GIP/glucagon receptor triagonism gets its try in humans.
Brian Finan, Jonathan D Douros

Cell Metab· January 2022

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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists.
Bin Yang, Vasily M Gelfanov, Diego Perez-Tilve, Barent DuBois, Rebecca Rohlfs, Jonathan D Douros

J Med Chem· April 2021

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