Publications by authors named "Aaron Patrick"

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Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.
Fabian Hulpia, Wim Schepens, Susan Lepri, Johan Nicolaï, Zhengyu Jiang, Aaron N Patrick

J Med Chem· November 2025

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A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library.
Marcos E Milla, Jonathan M Blevitt, Steven D Goldberg, Anthony A Armstrong, Katherine Y Blain, Aaron N Patrick

ACS Med Chem Lett· November 2025

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A New Fragment-Based Pharmacophore Virtual Screening Workflow Identifies Potent Inhibitors of SARS-CoV-2 NSP13 Helicase.
Jordi Doijen, Jiexiong Xie, Simone Marsili, Trpta Bains, Mandeep Kaur Mann, Aaron Patrick

J Comput Chem· September 2025

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Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
Jay H Kalin, Yanting Yin, Minh T Tran, Madison Piassek, Amy Fung, Aaron Patrick

J Virol· July 2025

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DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
Sean M Carney, Sandrine Grosse, Yanting Yin, Minh T Tran, Jay H Kalin, Aaron N Patrick

J Med Chem· March 2025

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JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase.
Brecht Bonneux, Afzaal Shareef, Sergey Tcherniuk, Brandon Anson, Suzanne de Bruyn, Aaron Patrick

Antiviral Res· July 2024

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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
Lindsey G DeRatt, Zhuming Zhang, Christine Pietsch, Justin S Cisar, Xiaochun Zhang, Aaron Patrick

J Med Chem· July 2024

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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans.
Anne M Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Aaron Patrick

Sci Rep· July 2024

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Probing the CRL4 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons.
Germanna Lima Righetto, Yanting Yin, David M Duda, Victoria Vu, Magdalena M Szewczyk, Aaron N Patrick

PNAS Nexus· April 2024

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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
Xiaodi Yu, Pravien Abeywickrema, Brecht Bonneux, Ishani Behera, Brandon Anson, Aaron Patrick

Commun Biol· October 2023

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Identification of Two Non-Peptidergic Small Molecule Inhibitors of CBX2 Binding to K27 Trimethylated Oligonucleosomes.
Lukas Lercher, Nina Simon, Andreas Bergmann, Marcel Tauchert, David Bochmann, Aaron Patrick

SLAS Discov· July 2022

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Community Transmission of SARS-CoV-2 Associated with a Local Bar Opening Event - Illinois, February 2021.
Samira Sami, Caitlin R Turbyfill, Shelby Daniel-Wayman, Stacy Shonkwiler, Kiva A Fisher, Aaron M Patrick

MMWR Morb Mortal Wkly Rep· April 2021

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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Jonathan M Blevitt, Michael D Hack, Krystal L Herman, Paul F Jackson, Paul J Krawczuk, Aaron N Patrick

J Med Chem· April 2017

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The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
Melanie A Blevins, Christina G Towers, Aaron N Patrick, Rui Zhao, Heide L Ford

Expert Opin Ther Targets· February 2015

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CDK6 binds and promotes the degradation of the EYA2 protein.
Dawn Kohrt, Jennifer Crary, Marc Zimmer, Aaron N Patrick, Heide L Ford

Cell Cycle· September 2014

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Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
Aaron B Krueger, David J Drasin, Wendy A Lea, Aaron N Patrick, Samarjit Patnaik

J Biol Chem· June 2014

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Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Aaron N Patrick, Joshua H Cabrera, Anna L Smith, Xiaojiang S Chen, Heide L Ford

Nat Struct Mol Biol· April 2013

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Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer.
Lubna Qamar, Erin Deitsch, Aaron N Patrick, Miriam D Post, Monique A Spillman

Gynecol Oncol· May 2012

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SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
Chu-An Wang, Paul Jedlicka, Aaron N Patrick, Douglas S Micalizzi, Kimberly C Lemmer

J Clin Invest· May 2012

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Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.
Aaron N Patrick, Barbara J Schiemann, Kui Yang, Rui Zhao, Heide L Ford

J Biol Chem· July 2009

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The six family of homeobox genes in development and cancer.
Kimberly L Christensen, Aaron N Patrick, Erica L McCoy, Heide L Ford

Adv Cancer Res· January 2009

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The genome of epsilon15, a serotype-converting, Group E1 Salmonella enterica-specific bacteriophage.
Andrew M Kropinski, Irina V Kovalyova, Stephen J Billington, Aaron N Patrick, Brent D Butts

Virology· December 2007

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The roles of the residues on the channel beta-hairpin and loop structures of simian virus 40 hexameric helicase.
Jingping Shen, Dahai Gai, Aaron Patrick, William B Greenleaf, Xiaojiang S Chen

Proc Natl Acad Sci U S A· August 2005

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