Publications by authors named "Aaron Pawlyk"

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Advances in Maternal, Fetal, and Pediatric Safety and Precision Therapeutics Supported by Programs at the National Institute of Child Health and Human Development.
Alison H Harrill, Lesly-Anne Samedy-Bates, Aaron C Pawlyk, Zhaoxia Ren

J Clin Pharmacol· September 2022

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Drug development research in pregnant and lactating women.
Zhaoxia Ren, Andrew A Bremer, Aaron C Pawlyk

Am J Obstet Gynecol· July 2021

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A Call for Objective Dose Selection to Increase Success in Pediatric Clinical Trials: A Perspective From NICHD and NIMH Program Staff.
George Giacoia, Margaret C Grabb, Aaron C Pawlyk, Zhaoxia Ren, Lesly Samedy-Bates

J Clin Pharmacol· June 2021

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Scientific and Regulatory Considerations for an Ontogeny Knowledge Base for Pediatric Clinical Pharmacology.
Gilbert J Burckart, Shirley Seo, Aaron C Pawlyk, Susan K McCune, Lynne P Yao

Clin Pharmacol Ther· April 2020

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Glimmers in illuminating the druggable genome.
Griffin Rodgers, Christopher Austin, James Anderson, Aaron Pawlyk, Christine Colvis

Nat Rev Drug Discov· May 2018

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Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction.
Luke E Stoeckel, Zoe Arvanitakis, Sam Gandy, Dana Small, C Ronald Kahn, Aaron Pawlyk

F1000Res· June 2016

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Metformin pharmacogenomics: current status and future directions.
Aaron C Pawlyk, Kathleen M Giacomini, Catherine McKeon, Alan R Shuldiner, Jose C Florez

Diabetes· August 2014

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Advances in geroscience: impact on healthspan and chronic disease.
John B Burch, Alison Deckhut Augustine, Leslie A Frieden, Evan Hadley, T Kevin Howcroft, Aaron C Pawlyk

J Gerontol A Biol Sci Med Sci· June 2014

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A generalized model and high throughput data analysis system for functional modulation of receptor-agonist systems suitable for use in drug discovery.
Aaron C Pawlyk, R Kyle Palmer, Dennis Sprous, Chip Allee

Comb Chem High Throughput Screen· March 2013

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Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel.
R Kyle Palmer, Karnail Atwal, Ivona Bakaj, Stacy Carlucci-Derbyshire, M Tulu Buber, Aaron Pawlyk

Assay Drug Dev Technol· December 2010

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Current nervous system related drug targets for the treatment of amyotrophic lateral sclerosis.
Aaron C Pawlyk, Joel A Cassel, Allen B Reitz

Curr Pharm Des· October 2010

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Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology.
Joel A Cassel, Benjamin E Blass, Allen B Reitz, Aaron C Pawlyk

J Biomol Screen· October 2010

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Estradiol increases catecholamine levels in the hypothalamus of ovariectomized rats during the dark-phase.
Peter D Alfinito, Xiaohong Chen, Robert Mastroeni, Aaron C Pawlyk, Darlene C Deecher

Eur J Pharmacol· August 2009

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Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.
Scott Cosmi, Aaron C Pawlyk, Peter D Alfinito, Janet Roman, Tianhui Zhou

J Neurosci Methods· April 2009

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Characterization of ligands for thyroid receptor subtypes and their interactions with co-regulators.
Elizabeth J Koury, Aaron C Pawlyk, Thomas J Berrodin, Christa L Smolenski, Sunil Nagpal

Steroids· February 2009

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Effect of 17alpha-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture.
Aaron C Pawlyk, Peter D Alfinito, Darlene C Deecher

Eur J Pharmacol· September 2008

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Stress-induced changes in sleep in rodents: models and mechanisms.
Aaron C Pawlyk, Adrian R Morrison, Richard J Ross, Francis X Brennan

Neurosci Biobehav Rev· February 2008

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Subchronic 17alpha-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats.
Aaron C Pawlyk, Peter D Alfinito, Grace H Johnston, Darlene C Deecher

Horm Behav· January 2008

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Proteomic analysis of the effects and interactions of sleep deprivation and aging in mouse cerebral cortex.
Aaron C Pawlyk, Megan Ferber, Aanal Shah, Allan I Pack, Nirinjini Naidoo

J Neurochem· December 2007

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IIAGlc inhibition of glycerol kinase: a communications network tunes protein motions at the allosteric site.
Peng Yu, Mauricio Lasagna, Aaron C Pawlyk, Gregory D Reinhart, Donald W Pettigrew

Biochemistry· October 2007

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Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation.
Aaron C Pawlyk, Scott Cosmi, Peter D Alfinito, Navin Maswood, Darlene C Deecher

Brain Res· December 2006

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Corticotropin-releasing factor microinjection into the central nucleus of the amygdala alters REM sleep.
Aaron C Pawlyk, Larry D Sanford, Francis X Brennan, Adrian R Morrison, Richard J Ross

Pharmacol Rep· November 2006

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A rodent model of sleep disturbances in posttraumatic stress disorder: the role of context after fear conditioning.
Aaron C Pawlyk, Sushil K Jha, Francis X Brennan, Adrian R Morrison, Richard J Ross

Biol Psychiatry· February 2005

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REM sleep: a sensitive index of fear conditioning in rats.
Sushil K Jha, Francis X Brennan, Aaron C Pawlyk, Richard J Ross, Adrian R Morrison

Eur J Neurosci· February 2005

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Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.
Aaron C Pawlyk, Benoit I Giasson, Deepak M Sampathu, Francisco A Perez, Kah Leong Lim

J Biol Chem· November 2003

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