Publications by authors named "Abbas Walji"

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Promoting Secretion of Pathological Tau Species Using an Induced Proximity Platform That Engages the Autophagy Pathway.
Yekaterina Kovalyova, Cesar De Leon, Alicja Krasowska-Zoladek, Sokreine Suon, Jacky Wong, Abbas Walji

ACS Chem Neurosci· May 2025

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Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition.
Morgan E Walker, Wei Zhu, Janine H Peterson, Hao Wang, Jon Patteson, Abbas Walji

Nat Commun· April 2025

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Douglas G Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Abbas M Walji

Circulation· July 2023

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Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.
Vladimir Simov, Michael D Altman, Elisabetta Bianchi, Sonia DelRizzo, Edward N DiNunzio, Abbas Walji

Eur J Med Chem· November 2021

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A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
Thomas J Tucker, Mark W Embrey, Candice Alleyne, Rupesh P Amin, Alan Bass, Abbas Walji

J Med Chem· November 2021

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Inhibition of Myc transcriptional activity by a mini-protein based upon Mxd1.
Mark J Demma, Michael J Hohn, Angie Sun, Claudio Mapelli, Brian Hall, Abbas Walji

FEBS Lett· May 2020

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Preclinical Safety Evaluation and Human Dosimetry of [F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles.
Michel Koole, Talakad G Lohith, John L Valentine, Idriss Bennacef, Ruben Declercq, Abbas Walji

Mol Imaging Biol· February 2020

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Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain Truncations.
Zachary Z Brown, Claudio Mapelli, Iman Farasat, Alycia V Shoultz, Scott A Johnson, Abbas Walji

J Org Chem· February 2020

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Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene.
Mark J Demma, Claudio Mapelli, Angie Sun, Smaranda Bodea, Benjamin Ruprecht, Abbas Walji

Mol Cell Biol· November 2019

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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles.
Talakad G Lohith, Idriss Bennacef, Rik Vandenberghe, Mathieu Vandenbulcke, Cristian A Salinas, Abbas Walji

J Nucl Med· January 2019

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
John M Sanders, Douglas C Beshore, J Christopher Culberson, James I Fells, Jason E Imbriglio, Abbas Walji

J Med Chem· August 2017

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cGMP production of the radiopharmaceutical [ F]MK-6240 for PET imaging of human neurofibrillary tangles.
Thomas Lee Collier, Daniel L Yokell, Eli Livni, Peter A Rice, Sofie Celen, Abbas Walji

J Labelled Comp Radiopharm· May 2017

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Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
John D Schreier, Mark W Embrey, Izzat T Raheem, Guillaume Barbe, Louis-Charles Campeau, Abbas Walji

Bioorg Med Chem Lett· May 2017

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Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles.
Eric D Hostetler, Abbas M Walji, Zhizhen Zeng, Patricia Miller, Idriss Bennacef

J Nucl Med· October 2016

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Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).
Abbas M Walji, Eric D Hostetler, Harold Selnick, Zhizhen Zeng, Patricia Miller

J Med Chem· May 2016

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Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell

J Med Chem· January 2016

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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell

J Med Chem· October 2015

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Discovery of MK-8970: an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.
Abbas M Walji, Rosa I Sanchez, Sophie-Dorothee Clas, Rebecca Nofsinger, Manuel de Lera Ruiz

ChemMedChem· February 2015

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Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.
Rebecca Nofsinger, Sophie-Dorothee Clas, Rosa I Sanchez, Abbas Walji, Kimberly Manser

Pharmaceuticals (Basel)· February 2014

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Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors.
Hemaka A Rajapakse, Abbas M Walji, Keith P Moore, Hong Zhu, Aurpon W Mitra

ChemMedChem· February 2011

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Direct and enantioselective {alpha}-allylation of ketones via singly occupied molecular orbital (SOMO) catalysis.
Anthony Mastracchio, Alexander A Warkentin, Abbas M Walji, David W C MacMillan

Proc Natl Acad Sci U S A· November 2010

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Cycle-specific organocascade catalysis: application to olefin hydroamination, hydro-oxidation, and amino-oxidation, and to natural product synthesis.
Bryon Simmons, Abbas M Walji, David W C MacMillan

Angew Chem Int Ed Engl· September 2009

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Enantioselective organocatalytic transfer hydrogenation reactions using Hantzsch esters.
Stéphane G Ouellet, Abbas M Walji, David W C MacMillan

Acc Chem Res· December 2007

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Enantioselective organo-cascade catalysis.
Yong Huang, Abbas M Walji, Catharine H Larsen, David W C MacMillan

J Am Chem Soc· November 2005

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Universal strategy for the immobilization of chiral dirhodium catalysts.
Huw M L Davies, Abbas M Walji

Org Lett· July 2005

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