Publications by authors named "Adam Flegg"

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Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
Hidenori Takahashi, Doris Riether, Alessandra Bartolozzi, Todd Bosanac, Valentina Berger, Adam Flegg

J Med Chem· February 2015

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An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.
Stephen P East, Samantha Bamford, Matthias G A Dietz, Christian Eickmeier, Adam Flegg

Bioorg Med Chem Lett· August 2010

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A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.
Neil Moss, Younggi Choi, Derek Cogan, Adam Flegg, Andreas Kahrs

Bioorg Med Chem Lett· April 2009

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Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Andrew D Napper, Jeffrey Hixon, Thomas McDonagh, Kenneth Keavey, Jean-Francois Pons, Adam Flegg

J Med Chem· December 2005

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