Publications by authors named "Adam Gates"

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Comparing perceptions of student abilities in diabetes self-management education and support among students, faculty and patients.
Jill Augustine, Maria Miller Thurston, Adam W Gates, Kendra R Manigault

Curr Pharm Teach Learn· April 2021

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P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
Michael T Rudd, John W Butcher, Kevin T Nguyen, Charles J McIntyre, Joseph J Romano, Adam Gates

ChemMedChem· April 2015

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Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Michael T Rudd, John A McCauley, Joseph J Romano, John W Butcher, Kimberly Bush, Adam Gates

Bioorg Med Chem Lett· December 2012

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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Michael T Rudd, Charles J McIntyre, Joseph J Romano, John W Butcher, M Katharine Holloway, Adam Gates

Bioorg Med Chem Lett· December 2012

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MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.
Vincenzo Summa, Steven W Ludmerer, John A McCauley, Christine Fandozzi, Christine Burlein, Adam T Gates

Antimicrob Agents Chemother· August 2012

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Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.
Rosanna Tedesco, Deping Chai, Michael G Darcy, Dashyant Dhanak, Duke M Fitch, Adam Gates

Bioorg Med Chem Lett· August 2009

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Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Antony N Shaw, Rosanna Tedesco, Ramesh Bambal, Deping Chai, Nestor O Concha, Adam Gates

Bioorg Med Chem Lett· August 2009

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A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression.
Kara S Keedy, Nancie M Archin, Adam T Gates, Amy Espeseth, Daria J Hazuda

J Virol· May 2009

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
Sethu Sankaranarayanan, Marie A Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Adam T Gates

J Pharmacol Exp Ther· January 2009

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Genome-scale RNAi screen for host factors required for HIV replication.
Honglin Zhou, Min Xu, Qian Huang, Adam T Gates, Xiaohua D Zhang

Cell Host Microbe· November 2008

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Hit selection with false discovery rate control in genome-scale RNAi screens.
Xiaohua Douglas Zhang, Pei Fen Kuan, Marc Ferrer, Xiaohua Shu, Yingxue C Liu, Adam T Gates

Nucleic Acids Res· August 2008

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Integrating experimental and analytic approaches to improve data quality in genome-wide RNAi screens.
Xiaohua Douglas Zhang, Amy S Espeseth, Eric N Johnson, Jayne Chin, Adam Gates

J Biomol Screen· June 2008

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A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels.
Amy S Espeseth, Qian Huang, Adam Gates, Min Xu, Yuanjiang Yu

Mol Cell Neurosci· November 2006

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LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
John Majercak, William J Ray, Amy Espeseth, Adam Simon, Xiao-Ping Shi, Adam Gates

Proc Natl Acad Sci U S A· November 2006

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ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling.
Rene Chapados, Khotaro Abe, Kaori Ihida-Stansbury, David McKean, Adam T Gates

Circ Res· October 2006

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Robust statistical methods for hit selection in RNA interference high-throughput screening experiments.
Xiaohua Douglas Zhang, Xiting Cindy Yang, Namjin Chung, Adam Gates, Erica Stec

Pharmacogenomics· April 2006

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3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Rosanna Tedesco, Antony N Shaw, Ramesh Bambal, Deping Chai, Nestor O Concha, Adam Gates

J Med Chem· February 2006

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The RNA-unwinding activity of hepatitis C virus non-structural protein 3 (NS3) is positively modulated by its protease domain.
Baohua Gu, Cynthia M Pruss, Adam T Gates, Sanjay S Khandekar

Protein Pept Lett· May 2005

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Sequence requirements for the development of a chimeric HCV replicon system.
Adam T Gates, Robert T Sarisky, Baohua Gu

Virus Res· March 2004

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Resistance profile of a hepatitis C virus RNA-dependent RNA polymerase benzothiadiazine inhibitor.
Tammy T Nguyen, Adam T Gates, Lester L Gutshall, Victor K Johnston, Baohua Gu

Antimicrob Agents Chemother· November 2003

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Replication studies using genotype 1a subgenomic hepatitis C virus replicons.
Baohua Gu, Adam T Gates, Olaf Isken, Sven-Erik Behrens, Robert T Sarisky

J Virol· May 2003

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Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Dashyant Dhanak, Kevin J Duffy, Victor K Johnston, Juili Lin-Goerke, Michael Darcy, Adam T Gates

J Biol Chem· October 2002

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