Publications by authors named "Adam Hey"

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Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Hsiao-Tzu Chien, Helen Prior, Laura Andrews, Leon van Aerts, Annick Cauvin, Adam Hey

Regul Toxicol Pharmacol· February 2023

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The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Helen Prior, Laura Andrews, Annick Cauvin, Hsiaotzu Chien, David O Clarke, Adam Hey

Regul Toxicol Pharmacol· February 2023

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Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use.
Adam Hey, Andreas Baumann, Sven Kronenberg, Guenter Blaich, Silke Mohl

Int J Toxicol· January 2022

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Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting.
Thomas Kissner, Guenter Blaich, Andreas Baumann, Sven Kronenberg, Adam Hey

MAbs· December 2021

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Nonclinical Safety Assessment of an Inhaled Formulation of Serelaxin: A Recombinant Human Protein in Rats and Cynomolgus Monkeys ().
Thierry D Flandre, Adam S Hey, Fiona J Spence

Toxicol Pathol· February 2021

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"Simulect" as a model compound for assessing placental transfer of monoclonal antibodies in minipigs.
Adam Hey, Marilyn Hill, Claudio Calonder, Anthony M DeLise, Anette B Grossi

Reprod Toxicol· January 2020

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Safety and General Considerations for the Use of Antibodies in Infectious Diseases.
Adam Seidelin Hey

Adv Exp Med Biol· August 2018

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Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.
Peter Ulrich, Guenter Blaich, Andreas Baumann, Rajni Fagg, Adam Hey

Regul Toxicol Pharmacol· April 2018

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FcRn Expression on Placenta and Fetal Jejunum during Early, Mid-, and Late Gestation in Minipigs.
Björn Jacobsen, Marilyn Hill, Lucie Reynaud, Adam Hey, Paul Barrow

Toxicol Pathol· April 2016

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History and Practice: Antibodies in Infectious Diseases.
Adam Hey

Microbiol Spectr· April 2015

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Preclinical pharmacokinetics and safety of Sym004: a synergistic antibody mixture directed against epidermal growth factor receptor.
Niels Jørgen Østergaard Skartved, Helle Jane Jacobsen, Mikkel Wandahl Pedersen, Pernille Foged Jensen, Jette Wagtberg Sen, Adam Hey

Clin Cancer Res· September 2011

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Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies.
Frank R Brennan, Laura Dill Morton, Sebastian Spindeldreher, Andrea Kiessling, Roy Allenspach, Adam Hey

MAbs· December 2010

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Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy.
Mikkel Wandahl Pedersen, Helle Jane Jacobsen, Klaus Koefoed, Adam Hey, Charles Pyke

Cancer Res· January 2010

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IL-21 induces apoptosis of antigen-specific CD8+ T lymphocytes.
Brianne R Barker, Jenny G Parvani, Debra Meyer, Adam S Hey, Kresten Skak

J Immunol· September 2007

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