Publications by authors named "Adam Lazorchak"

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A precision gene-engineered B cell medicine producing sustained levels of active factor IX for hemophilia B therapy.
Hanlan Liu, Swati Singh, Timothy J Mullen, Caroline Bullock, Sean Keegan, Adam Lazorchak

Mol Ther· September 2025

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In vivo tracking of ex-vivo-generated Zr-oxine-labeled plasma cells by PET in a non-human primate model.
David J Young, Abigail J Edwards, Kevin G Quiroz Caceda, Ella Liberzon, Johana Barrientos, Adam S Lazorchak

Mol Ther· February 2025

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tracking of generated Zr-oxine labeled plasma cells by PET in a non-human primate model.
David J Young, Abigail J Edwards, Kevin G Quiroz Caceda, Ella Liberzon, Johana Barrientos, Adam S Lazorchak

bioRxiv· May 2024

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Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
Yan Lan, Tsz-Lun Yeung, Hui Huang, Ansgar A Wegener, Somdutta Saha, Adam Lazorchak

J Immunother Cancer· July 2022

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DNA-PK Inhibitor Peposertib Amplifies Radiation-Induced Inflammatory Micronucleation and Enhances TGFβ/PD-L1 Targeted Cancer Immunotherapy.
Michael I Carr, Li-Ya Chiu, Yige Guo, Chunxiao Xu, Adam S Lazorchak

Mol Cancer Res· April 2022

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Yan Lan, Mahmoud Moustafa, Maximilian Knoll, Chunxiao Xu, Jennifer Furkel, Adam Lazorchak

Cancer Cell· October 2021

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Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis.
Xiaofang Wang, Erin A Kimbrel, Kumiko Ijichi, Debayon Paul, Adam S Lazorchak

Stem Cell Reports· February 2021

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Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.
Man Li, Adam S Lazorchak, Xinxing Ouyang, Huihui Zhang, Hongzhi Liu

Cell Mol Immunol· September 2019

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Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao

Nat Cell Biol· May 2019

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Immune modulatory mesenchymal stem cells derived from human embryonic stem cells through a trophoblast-like stage.
Xiaofang Wang, Adam S Lazorchak, Li Song, Enqin Li, Zhenwu Zhang

Stem Cells· February 2016

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Human ESC-derived MSCs outperform bone marrow MSCs in the treatment of an EAE model of multiple sclerosis.
Xiaofang Wang, Erin A Kimbrel, Kumiko Ijichi, Debayon Paul, Adam S Lazorchak

Stem Cell Reports· July 2014

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao

Nat Cell Biol· November 2013

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Inhibition of the mTORC2 and chaperone pathways to treat leukemia.
Fan Zhang, Adam S Lazorchak, Dou Liu, Fangping Chen, Bing Su

Blood· June 2012

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Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation.
Xing Chang, Adam S Lazorchak, Dou Liu, Bing Su

Eur J Immunol· June 2012

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Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis.
Adam S Lazorchak, Bing Su

Protein Cell· July 2011

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mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.
You-Tong Wu, Weiming Ouyang, Adam S Lazorchak, Dou Liu, Han-Ming Shen

J Biol Chem· April 2011

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Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Adam S Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C Sessa

Mol Cell· August 2010

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak

EMBO J· July 2008

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E2A promotes the survival of precursor and mature B lymphocytes.
Adam S Lazorchak, Jason Wojciechowski, Meifang Dai, Yuan Zhuang

J Immunol· August 2006

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E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.
Adam S Lazorchak, Mark S Schlissel, Yuan Zhuang

Mol Cell Biol· February 2006

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New insights into E-protein function in lymphocyte development.
Adam Lazorchak, Mary Elizabeth Jones, Yuan Zhuang

Trends Immunol· June 2005

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Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
Stephen Greenbaum, Adam S Lazorchak, Yuan Zhuang

J Biol Chem· October 2004

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