Publications by authors named "Adam Locke"

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Adam E Locke

Nat Med· September 2025

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Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways.
Marijana Vujkovic, David E Kaplan, Jonas Ghouse, Bao-Li Loza, Joseph Brancale, Adam Locke

medRxiv· September 2025

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Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia.
Runjia Li, Sarah A Gagliano Taliun, Kevin Liao, Matthew Flickinger, Janet L Sobell, Adam E Locke

HGG Adv· August 2025

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Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia.
Runjia Li, Sarah A Gagliano Taliun, Kevin Liao, Matthew Flickinger, Janet L Sobell, Adam E Locke

medRxiv· February 2025

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Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.
Yasminka A Jakubek, Xiaolong Ma, Adrienne M Stilp, Fulong Yu, Jason Bacon, Adam E Locke

Am J Hum Genet· February 2025

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Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals.
Kathie Y Sun, Xiaodong Bai, Siying Chen, Suying Bao, Chuanyi Zhang, Adam E Locke

Nature· January 2025

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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Adam E Locke

Nature· January 2025

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Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings.
Shek Man Chim, Kristen Howell, John Dronzek, Weizhen Wu, Cristopher Van Hout, Adam E Locke

Elife· December 2024

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Variants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency.
Edgar N Tafaleng, Jie Li, Yan Wang, Tunda Hidvegi, Alex Soto-Gutierrez, Adam E Locke

Hepatology· October 2024

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Joint testing of rare variant burden scores using non-negative least squares.
Andrey Ziyatdinov, Joelle Mbatchou, Anthony Marcketta, Joshua Backman, Sheila Gaynor, Adam Locke

Am J Hum Genet· October 2024

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Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone.
Michael E Dunn, Aaron Kithcart, Jee Hae Kim, Andre Jo-Hao Ho, Matthew C Franklin, Adam Locke

Nature· September 2024

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A deep catalogue of protein-coding variation in 983,578 individuals.
Kathie Y Sun, Xiaodong Bai, Siying Chen, Suying Bao, Chuanyi Zhang, Adam E Locke

Nature· July 2024

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J Taylor, Xianyong Yin, Adam E Locke

Nature· March 2024

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A deep catalog of protein-coding variation in 985,830 individuals.
Kathie Y Sun, Xiaodong Bai, Siying Chen, Suying Bao, Manav Kapoor, Adam Locke

bioRxiv· November 2023

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Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
Tanmoy Roychowdhury, Derek Klarin, Michael G Levin, Joshua M Spin, Yae Hyun Rhee, Adam E Locke

Nat Genet· November 2023

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids.
Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, Greg J M Zajac, Adam E Locke

Nature· June 2023

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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Adam E Locke

Nature· March 2023

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Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.
Ken Suzuki, Konstantinos Hatzikotoulas, Lorraine Southam, Henry J Taylor, Xianyong Yin, Adam E Locke

medRxiv· March 2023

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Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Adam E Locke

Nature· December 2022

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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Adam E Locke

Genome Biol· December 2022

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Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.
Xianyong Yin, Debraj Bose, Annie Kwon, Sarah C Hanks, Anne U Jackson, Adam E Locke

Am J Hum Genet· October 2022

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A saturated map of common genetic variants associated with human height.
Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Adam E Locke

Nature· October 2022

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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Shweta Ramdas, Jonathan Judd, Sarah E Graham, Stavroula Kanoni, Yuxuan Wang, Adam E Locke

Am J Hum Genet· August 2022

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Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.
Parsa Akbari, Olukayode A Sosina, Jonas Bovijn, Karl Landheer, Jonas B Nielsen, Adam E Locke

Nat Commun· August 2022

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Germline Mutations in and Protection against Liver Disease.
Niek Verweij, Mary E Haas, Jonas B Nielsen, Olukayode A Sosina, Minhee Kim, Adam E Locke

N Engl J Med· July 2022

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