Publications by authors named "Adam Root"

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Illuminating protein space with a programmable generative model.
John B Ingraham, Max Baranov, Zak Costello, Karl W Barber, Wujie Wang, Adam R Root

Nature· November 2023

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Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3.
Pragya Rampuria, Lidia Mosyak, Adam R Root, Kristine Svenson, Michael J Agostino

Sci Rep· August 2023

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Preclinical Evaluation of Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy.
Kevin P Maresca, Jianqing Chen, Divya Mathur, Anand Giddabasappa, Adam Root

Mol Imaging Biol· December 2021

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
Adam R Root, Gurkan Guntas, Madan Katragadda, James R Apgar, Jatin Narula

MAbs· October 2021

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United States Emergency Department Use of Medications with Pharmacogenetic Recommendations.
Alexander T Limkakeng, Pratik Manandhar, Alaatin Erkanli, Stephanie A Eucker, Adam Root

West J Emerg Med· September 2021

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Initiation of Emicizumab Therapy in an Adult Patient With Hemophilia A With Inhibitors and Associated Drug Cost Savings.
Adam G Root, Robert D Raiff, Thomas L Ortel, Kimberly L Hodulik

J Pharm Technol· June 2020

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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Divya Mathur, Adam R Root, Bozena Bugaj-Gaweda, Stephanie Bisulco, Xingzhi Tan

Clin Cancer Res· May 2020

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Understanding the state of pharmacogenomic testing for thiopurine methyltransferase within a large health system.
Adam Root, Randall Johnson, Ann McGee, Hui-Jie Lee, Siyun Yang

Pharmacogenomics· April 2020

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Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model.
Vijay R Gupta, Adam Root, Timothy Fisher, Rand Norberg, John David

Oncotarget· April 2020

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A Retrospective Analysis of Adherence to Risk Evaluation and Mitigation Strategies Requirements for Pulmonary Arterial Hypertension Drugs.
Mackenzie Prokes, Adam Root

Hosp Pharm· October 2019

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Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®.
Alison Betts, Nahor Haddish-Berhane, Dhaval K Shah, Piet H van der Graaf, Frank Barletta, Adam Root

AAPS J· June 2019

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Effects of therapeutic plasma exchange on anticoagulants in patients receiving therapeutic anticoagulation: a systematic review.
Kimberly L Hodulik, Adam G Root, Leila S Ledbetter, Oluwatoyosi A Onwuemene

Transfusion· May 2019

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Three-factor prothrombin complex concentrates for refractory bleeding after cardiovascular surgery within an algorithmic approach to haemostasis.
Nazish K Hashmi, Kamrouz Ghadimi, Amudan J Srinivasan, Yi-Ju Li, Robert D Raiff, Adam G Root

Vox Sang· May 2019

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A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART.
Alison Betts, Nahor Haddish-Berhane, Dhaval K Shah, Piet H van der Graaf, Frank Barletta, Adam Root

AAPS J· May 2019

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A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice.
Timothy S Fisher, Andrea T Hooper, Justin Lucas, Tracey H Clark, Allison K Rohner, Adam R Root

Cancer Immunol Immunother· February 2018

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Adam R Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade

Antibodies (Basel)· March 2016

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Oligomerization is required for the activity of recombinant soluble LOX-1.
Wei Cao, Valerie Calabro, Adam Root, Grace Yan, Khetemenee Lam

FEBS J· September 2009

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Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin.
Carl R Flannery, Richard Zollner, Chris Corcoran, Aled R Jones, Adam Root

Arthritis Rheum· March 2009

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Cloning and characterization of a functional type II gonadotropin-releasing hormone receptor with a lengthy carboxy-terminal tail from an ancestral vertebrate, the sea lamprey.
Matthew R Silver, Nathaniel V Nucci, Adam R Root, Karen L Reed, Stacia A Sower

Endocrinology· August 2005

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In situ characterization of gonadotropin- releasing hormone-I, -III, and glutamic acid decarboxylase expression in the brain of the sea lamprey, Petromyzon marinus.
Adam R Root, Nathaniel V Nucci, Jocelyn D Sanford, Beverly S Rubin, Vance L Trudeau

Brain Behav Evol· March 2005

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Distribution of gonadotropin-releasing hormone (GnRH) by in situ hybridization in the tunicate Ciona intestinalis.
Scott I Kavanaugh, Adam R Root, Stacia A Sower

Gen Comp Endocrinol· March 2005

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In vitro and in vivo effects of GABA, muscimol, and bicuculline on lamprey GnRH concentration in the brain of the sea lamprey (Petromyzon marinus).
Adam R Root, Jocelyn D Sanford, Scott I Kavanaugh, Stacia A Sower

Comp Biochem Physiol A Mol Integr Physiol· August 2004

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